LOCUS       XM_017024053            5346 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens tousled like kinase 2 (TLK2), transcript
            variant X21, mRNA.
ACCESSION   XM_017024053
VERSION     XM_017024053.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000017.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017024053.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5346
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
     gene            1..5346
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /note="tousled like kinase 2; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 3
                     mRNAs, 78 ESTs, 767 long SRA reads, 12 Proteins, and 96%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 30 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:11011"
                     /db_xref="HGNC:HGNC:11842"
                     /db_xref="MIM:608439"
     CDS             274..2430
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /codon_start=1
                     /product="serine/threonine-protein kinase tousled-like 2
                     isoform X16"
                     /protein_id="XP_016879542.1"
                     /db_xref="GeneID:11011"
                     /db_xref="HGNC:HGNC:11842"
                     /db_xref="MIM:608439"
                     /translation="MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGS
                     LSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFERRVEQPLYGLDGS
                     AAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTE
                     HSCSSQKQISIQHRQTQSDLTIEKISALENSKNSDLEKKEGRIDDLLRANCDLRRQID
                     EQQKMLEKYKERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASF
                     TEQWTDGYAFQNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSK
                     TNGAENETLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVRNLHIRELKRIHN
                     EDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKK
                     ENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLM
                     SEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGEIKITDFGLSKIM
                     DDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWSVGVIFYQCLYGR
                     KPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLA
                     CDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN"
ORIGIN      
        1 cttgcccgct agatagttct cattcctcag gagatactct gtgaggggcc ggcgtgtttt
       61 ctccatcttg gcacttaccc tcagaccctc ctaagtaccc gggagggccg tgtttttcat
      121 cggaggttga aatggaacct ccccctgggt gcccggggag agtaccttgg gggcagcgcc
      181 cctccttccg gagggcagca tccccgcggg ggcgggggct cggctttgat cccagggcac
      241 cttttgtccc tggagacgct ctgccagcca gaaatgatgg aagaattgca tagcctggac
      301 ccacgacggc aggaattatt ggaggccagg tttactggag taggtgttag taagggacca
      361 cttaatagtg agtcttccaa ccagagcttg tgcagcgtcg gatccttgag tgataaagaa
      421 gtagagactc ccgagaaaaa gcagaatgac cagcgaaatc ggaaaagaaa agctgaacca
      481 tatgaaacta gccaagggaa aggcactcct aggggacata aaattagtga ttactttgag
      541 cgacgagtag aacagcccct ctatggttta gatggcagtg ctgcaaagga ggcaacggag
      601 gagcagtctg ctctgccaac cctcatgtca gtgatgctag caaaacctcg gcttgacaca
      661 gagcagctgg cgcaaagggg agctggcctc tgcttcactt ttgtttcagc tcagcaaaac
      721 agtccctcat ctacgggatc tggcaacaca gagcattcct gcagctccca aaaacagatc
      781 tccatccagc acagacagac ccagtccgac ctcacaatag aaaaaatatc tgcactagaa
      841 aacagtaaga attctgactt agagaagaag gagggaagaa tagatgattt attaagagcc
      901 aactgtgatt tgagacggca gattgatgaa cagcaaaaga tgctagagaa atacaaggaa
      961 cgattaaata gatgtgtgac aatgagcaag aaactcctta tagaaaagtc aaaacaagag
     1021 aagatggcgt gtagagataa gagcatgcaa gaccgcttga gactgggcca ctttactact
     1081 gtccgacacg gagcctcatt tactgaacag tggacagatg gttatgcttt tcagaatctt
     1141 atcaagcaac aggaaaggat aaattcacag agggaagaga tagaaagaca acggaaaatg
     1201 ttagcaaagc ggaaacctcc tgccatgggt caggcccctc ctgcaaccaa tgagcagaaa
     1261 cagcggaaaa gcaagaccaa tggagctgaa aatgaaacgt taacgttagc agaataccat
     1321 gaacaagaag aaatcttcaa actcagatta ggtcatctta aaaaggagga agcagagatc
     1381 caggcagagc tggagagact agaaagggtt agaaatctac atatcaggga actaaaaagg
     1441 atacataatg aagataattc acaatttaaa gatcatccaa cgctaaatga cagatatttg
     1501 ttgttacatc ttttgggtag aggaggtttc agtgaagttt acaaggcatt tgatctaaca
     1561 gagcaaagat acgtagctgt gaaaattcac cagttaaata aaaactggag agatgagaaa
     1621 aaggagaatt accacaagca tgcatgtagg gaataccgga ttcataaaga gctggatcat
     1681 cccagaatag ttaagctgta tgattacttt tcactggata ctgactcgtt ttgtacagta
     1741 ttagaatact gtgagggaaa tgatctggac ttctacctga aacagcacaa attaatgtcg
     1801 gagaaagagg cccggtccat tatcatgcag attgtgaatg ctttaaagta cttaaatgaa
     1861 ataaaacctc ccatcataca ctatgacctc aaaccaggta atattctttt agtaaatggt
     1921 acagcgtgtg gagagataaa aattacagat tttggtcttt cgaagatcat ggatgatgat
     1981 agctacaatt cagtggatgg catggagcta acatcacaag gtgctggtac ttattggtat
     2041 ttaccaccag agtgttttgt ggttgggaaa gaaccaccaa agatctcaaa taaagttgat
     2101 gtgtggtcgg tgggtgtgat cttctatcag tgtctttatg gaaggaagcc ttttggccat
     2161 aaccagtctc agcaagacat cctacaagag aatacgattc ttaaagctac tgaagtgcag
     2221 ttcccgccaa agccagtagt aacacctgaa gcaaaggcgt ttattcgacg atgcttggcc
     2281 taccgaaagg aggaccgcat tgatgtccag cagctggcct gtgatcccta cttgttgcct
     2341 cacatccgaa agtcagtctc tacaagtagc cctgctggag ctgctattgc atcaacctct
     2401 ggggcgtcca ataacagttc ttctaattga gactgactcc aaggccacaa actgttcaac
     2461 acacacaaag tggacaaatg gcgttcagca gcgggtttgg aacatagcga atccgaatgg
     2521 atctgatgaa acctgtacca ggtgctttta ttttcttgct tttttcccat ccatagagca
     2581 tgacagcatc gattctcatt gaggagaaac cttgggcagc tccggccagg ccttgtagga
     2641 aaaggccccg cccgaggttc cagcgtcaac ggccactgtg tgtggctgct ctgagtgagg
     2701 aaaaaattaa aaagaaaaac tggttccatg tactgtgaac ttgaaaactt gcagactcag
     2761 gggggtccct gatgcagtgc ttcagatgaa gaatgtggac ttgaaaatac agactgggct
     2821 agtccagtgt ctatatttaa acttgttctt ttcttttaat aaagtttagg taacatctcc
     2881 tgaaaagctt gtagcacaaa ggctcagctg gggatggtgt ttgacttcgg aggaaaaaag
     2941 ttgctattgc ccgttaaagg cactagagtt agtgttttat ccctaaataa tttcaatttt
     3001 taaaaacatg cagcttccct ctcccctttt ttatttttga aagaatacat ttggtcataa
     3061 agtgaaaccc gtattagcaa gtacgtggca atgttcattc caatcagatg cagctttctc
     3121 ctccgtctgg tctcctgttt gcaattgctt ccctcatctc agtagggaaa aaattgagtg
     3181 ggagtactga gatgtgtggg tttttgccat tggacaaaga atgaggttag aagactgcag
     3241 cttggagtct ctctaggttt tcaactattt cttcacaatt tgaacacttg acggttgtcc
     3301 cttttaattt atttgaagtg ctattttttt aaataaaggt tcatctgtcc atgcagtcct
     3361 cttggattct ctgaatgtag taactatgaa gctatgccaa aggtaggcag aaaatgggct
     3421 tgggagccag acactccagg gatcagtagt tcctacccat agtctttgtg tgcttgctaa
     3481 atggtgtaca tttcttgtta accacgttat taaaacttga tcagcacata agctttcttc
     3541 tgttagatct tttggcagca aacaaccttc cccccaagcc tctgaatttt gtgggtgtgt
     3601 ggtggtgtgt gtctgtgtgt gcatgtacac acacactttg tctagctcac tttaaaagat
     3661 tcatcaaatg gaattttaaa aataatctga aaagaaatag atatttcagg ccgggcctgg
     3721 tggttcacgc ctgtaatccc agcactttgg gaggccgagg tgggtggatc acgaggtcgg
     3781 gagttcgaga tcagtctggt caacatggtg aaacgccatc tctactaaaa atataaaaat
     3841 tagcctggcg tggtggcgtg tgcctctagt cccagctacc cgggaggctg aggcaggaga
     3901 atttctggaa cccaggaggc ggaggttgca gtgagccgag atggcaccac tgcaatccag
     3961 cctaggcaac agaatgagac tctgtctcag aaaaaaaaaa aaaaaaaaaa ggagaaatag
     4021 atgtttcaaa tatgaacatt cttttggcac caattttctt ttttaatttg gttgtttctg
     4081 agatgtatga tcaactgaag atggagctga aatgggagac gggtggcccc accgtgccct
     4141 tgaaacagca gagcactcct cagtagagag ggagggagcc aagagcctga acatgtggtc
     4201 gccagcttgg aatgttactg acatatgtgg cgagggctta gccagaaata tttaaagatg
     4261 tagtattccg gcctgtgagt tgtctgggca gggaggggga gtcagaaagg gtagagagct
     4321 ctcaaataac tcatgactct agtgttcctt tcacatgtga acagtgtcac tgatgacaca
     4381 ttttctagga ccttcgtttg ttttgtggac ctgcctcagt ctcctcagta tcaggcgatc
     4441 ttaagggaag atggagtgtt tcaaattgga gagaagttca tgggtaggta tcgtcctgtg
     4501 gaattctgaa tgcaaggaag tcaaccccag aggccttggt acccccagct ttctaaaact
     4561 actttattac aatttatatg tatatacaca tgcacatata aacgtgtgca tttatgtatg
     4621 tgtgtatagt acctttttta aaaaaacatt tcctccaagc tgctaagcaa agggtctcac
     4681 aggtcgagca cagtgctgag aggatggtgt ctgcataatg aagacatgga tgaagctgag
     4741 accgtgttca aactcactga aaacaatgaa gttctattcc ttttttcttc ctctccaatg
     4801 atcttgcagt tgatttgttt gttttttaat tttttaacat ttttttaacg ttgaaaaaat
     4861 gctgcgtctt tctttaagcc ttcccagtaa cttcctgcct tttttttccc cgtgggcttt
     4921 taagtgaagc tgcaggattt tatctttcaa tctgcccttt ctacccttgt cctattgaaa
     4981 ggatgccctc ttcccttgct tttttggtct agggcctgtt tggagctaac taggcttggc
     5041 tgagtccggg caagaccttc ttccgaggca tggacaagcc ccagagaaca tgcagaacat
     5101 tgacctttcc attgactgtc tttcaagcag ccagtgaaat cactaagtgg ggttcttcca
     5161 tgacatattt tgttaatatg ggtttcactt tttccaagaa tagtcccttg ttgccacaat
     5221 gttgatttac tttacacaat gacagtatgt attaatttgt aattaaaccc atccagattg
     5281 ttttagcctt ttcccaatgg ggtgggggag ggaagaagga tattaaaata agttttaaga
     5341 agcaaa
//
