LOCUS       XM_011524215            5317 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens tousled like kinase 2 (TLK2), transcript
            variant X5, mRNA.
ACCESSION   XM_011524215
VERSION     XM_011524215.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000017.11) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011524215.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5317
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
     gene            1..5317
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /note="tousled like kinase 2; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 2
                     mRNAs, 47 ESTs, 499 long SRA reads, 1 Protein, and 96%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 2 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:11011"
                     /db_xref="HGNC:HGNC:11842"
                     /db_xref="MIM:608439"
     CDS             35..2401
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /codon_start=1
                     /product="serine/threonine-protein kinase tousled-like 2
                     isoform X5"
                     /protein_id="XP_011522517.2"
                     /db_xref="GeneID:11011"
                     /db_xref="HGNC:HGNC:11842"
                     /db_xref="MIM:608439"
                     /translation="MGEAQAAPAWDWGRRPEERRGPPGSWRPRQPPGRPREPALPSSV
                     TAEMMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGSLSDKEVETPEK
                     KQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGRSVPPVARSSPQ
                     HSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLDTEQLAQRGAGL
                     CFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQANCDLRRQIDEQQKMLEKYK
                     ERLNRCVTMSKKLLIEKSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAF
                     QNLIKQQERINSQREEIERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETPS
                     SGNTELKDTAPALGAHSLLRLTLAEYHEQEEIFKLRLGHLKKEEAEIQAELERLERVR
                     NLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGGFSEVYKAFDLTEQRYVAVKI
                     HQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLYDYFSLDTDSFCTVLEYCEGN
                     DLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPIIHYDLKPGNILLVNGTACGE
                     IKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPPECFVVGKEPPKISNKVDVWS
                     VGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQFPPKPVVTPEAKAFIRRCLAY
                     RKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIASTSGASNNSSSN"
ORIGIN      
        1 gagggctgcg ggtcgctgag gggccgggca gaagatgggg gaggcccagg cggccccggc
       61 ctgggattgg ggccggcggc cggaggagag acgggggccc ccaggcagct ggaggcctcg
      121 gcagcctccc gggcgccccc gagagccggc cctcccttcc tccgtgacag cagaaatgat
      181 ggaagaattg catagcctgg acccacgacg gcaggaatta ttggaggcca ggtttactgg
      241 agtaggtgtt agtaagggac cacttaatag tgagtcttcc aaccagagct tgtgcagcgt
      301 cggatccttg agtgataaag aagtagagac tcccgagaaa aagcagaatg accagcgaaa
      361 tcggaaaaga aaagctgaac catatgaaac tagccaaggg aaaggcactc ctaggggaca
      421 taaaattagt gattactttg agtttgctgg gggaagcgcg ccaggaacca gccctggcag
      481 aagtgttcca ccagttgcac gatcctcacc gcaacattcc ttatccaatc ccttaccgcg
      541 acgagtagaa cagcccctct atggtttaga tggcagtgct gcaaaggagg caacggagga
      601 gcagtctgct ctgccaaccc tcatgtcagt gatgctagca aaacctcggc ttgacacaga
      661 gcagctggcg caaaggggag ctggcctctg cttcactttt gtttcagctc agcaaaacag
      721 tccctcatct acgggatctg gcaacacaga gcattcctgc agctcccaaa aacagatctc
      781 catccagcac agacagaccc aggccaactg tgatttgaga cggcagattg atgaacagca
      841 aaagatgcta gagaaataca aggaacgatt aaatagatgt gtgacaatga gcaagaaact
      901 ccttatagaa aagtcaaaac aagagaagat ggcgtgtaga gataagagca tgcaagaccg
      961 cttgagactg ggccacttta ctactgtccg acacggagcc tcatttactg aacagtggac
     1021 agatggttat gcttttcaga atcttatcaa gcaacaggaa aggataaatt cacagaggga
     1081 agagatagaa agacaacgga aaatgttagc aaagcggaaa cctcctgcca tgggtcaggc
     1141 ccctcctgca accaatgagc agaaacagcg gaaaagcaag accaatggag ctgaaaatga
     1201 aacgccctct tctgggaata cagagctaaa ggatacagcc ccagccttag gagcccacag
     1261 tttacttagg ttaacgttag cagaatacca tgaacaagaa gaaatcttca aactcagatt
     1321 aggtcatctt aaaaaggagg aagcagagat ccaggcagag ctggagagac tagaaagggt
     1381 tagaaatcta catatcaggg aactaaaaag gatacataat gaagataatt cacaatttaa
     1441 agatcatcca acgctaaatg acagatattt gttgttacat cttttgggta gaggaggttt
     1501 cagtgaagtt tacaaggcat ttgatctaac agagcaaaga tacgtagctg tgaaaattca
     1561 ccagttaaat aaaaactgga gagatgagaa aaaggagaat taccacaagc atgcatgtag
     1621 ggaataccgg attcataaag agctggatca tcccagaata gttaagctgt atgattactt
     1681 ttcactggat actgactcgt tttgtacagt attagaatac tgtgagggaa atgatctgga
     1741 cttctacctg aaacagcaca aattaatgtc ggagaaagag gcccggtcca ttatcatgca
     1801 gattgtgaat gctttaaagt acttaaatga aataaaacct cccatcatac actatgacct
     1861 caaaccaggt aatattcttt tagtaaatgg tacagcgtgt ggagagataa aaattacaga
     1921 ttttggtctt tcgaagatca tggatgatga tagctacaat tcagtggatg gcatggagct
     1981 aacatcacaa ggtgctggta cttattggta tttaccacca gagtgttttg tggttgggaa
     2041 agaaccacca aagatctcaa ataaagttga tgtgtggtcg gtgggtgtga tcttctatca
     2101 gtgtctttat ggaaggaagc cttttggcca taaccagtct cagcaagaca tcctacaaga
     2161 gaatacgatt cttaaagcta ctgaagtgca gttcccgcca aagccagtag taacacctga
     2221 agcaaaggcg tttattcgac gatgcttggc ctaccgaaag gaggaccgca ttgatgtcca
     2281 gcagctggcc tgtgatccct acttgttgcc tcacatccga aagtcagtct ctacaagtag
     2341 ccctgctgga gctgctattg catcaacctc tggggcgtcc aataacagtt cttctaattg
     2401 agactgactc caaggccaca aactgttcaa cacacacaaa gtggacaaat ggcgttcagc
     2461 agcgggtttg gaacatagcg aatccgaatg gatctgatga aacctgtacc aggtgctttt
     2521 attttcttgc ttttttccca tccatagagc atgacagcat cgattctcat tgaggagaaa
     2581 ccttgggcag ctccggccag gccttgtagg aaaaggcccc gcccgaggtt ccagcgtcaa
     2641 cggccactgt gtgtggctgc tctgagtgag gaaaaaatta aaaagaaaaa ctggttccat
     2701 gtactgtgaa cttgaaaact tgcagactca ggggggtccc tgatgcagtg cttcagatga
     2761 agaatgtgga cttgaaaata cagactgggc tagtccagtg tctatattta aacttgttct
     2821 tttcttttaa taaagtttag gtaacatctc ctgaaaagct tgtagcacaa aggctcagct
     2881 ggggatggtg tttgacttcg gaggaaaaaa gttgctattg cccgttaaag gcactagagt
     2941 tagtgtttta tccctaaata atttcaattt ttaaaaacat gcagcttccc tctccccttt
     3001 tttatttttg aaagaataca tttggtcata aagtgaaacc cgtattagca agtacgtggc
     3061 aatgttcatt ccaatcagat gcagctttct cctccgtctg gtctcctgtt tgcaattgct
     3121 tccctcatct cagtagggaa aaaattgagt gggagtactg agatgtgtgg gtttttgcca
     3181 ttggacaaag aatgaggtta gaagactgca gcttggagtc tctctaggtt ttcaactatt
     3241 tcttcacaat ttgaacactt gacggttgtc ccttttaatt tatttgaagt gctatttttt
     3301 taaataaagg ttcatctgtc catgcagtcc tcttggattc tctgaatgta gtaactatga
     3361 agctatgcca aaggtaggca gaaaatgggc ttgggagcca gacactccag ggatcagtag
     3421 ttcctaccca tagtctttgt gtgcttgcta aatggtgtac atttcttgtt aaccacgtta
     3481 ttaaaacttg atcagcacat aagctttctt ctgttagatc ttttggcagc aaacaacctt
     3541 ccccccaagc ctctgaattt tgtgggtgtg tggtggtgtg tgtctgtgtg tgcatgtaca
     3601 cacacacttt gtctagctca ctttaaaaga ttcatcaaat ggaattttaa aaataatctg
     3661 aaaagaaata gatatttcag gccgggcctg gtggttcacg cctgtaatcc cagcactttg
     3721 ggaggccgag gtgggtggat cacgaggtcg ggagttcgag atcagtctgg tcaacatggt
     3781 gaaacgccat ctctactaaa aatataaaaa ttagcctggc gtggtggcgt gtgcctctag
     3841 tcccagctac ccgggaggct gaggcaggag aatttctgga acccaggagg cggaggttgc
     3901 agtgagccga gatggcacca ctgcaatcca gcctaggcaa cagaatgaga ctctgtctca
     3961 gaaaaaaaaa aaaaaaaaaa aggagaaata gatgtttcaa atatgaacat tcttttggca
     4021 ccaattttct tttttaattt ggttgtttct gagatgtatg atcaactgaa gatggagctg
     4081 aaatgggaga cgggtggccc caccgtgccc ttgaaacagc agagcactcc tcagtagaga
     4141 gggagggagc caagagcctg aacatgtggt cgccagcttg gaatgttact gacatatgtg
     4201 gcgagggctt agccagaaat atttaaagat gtagtattcc ggcctgtgag ttgtctgggc
     4261 agggaggggg agtcagaaag ggtagagagc tctcaaataa ctcatgactc tagtgttcct
     4321 ttcacatgtg aacagtgtca ctgatgacac attttctagg accttcgttt gttttgtgga
     4381 cctgcctcag tctcctcagt atcaggcgat cttaagggaa gatggagtgt ttcaaattgg
     4441 agagaagttc atgggtaggt atcgtcctgt ggaattctga atgcaaggaa gtcaacccca
     4501 gaggccttgg tacccccagc tttctaaaac tactttatta caatttatat gtatatacac
     4561 atgcacatat aaacgtgtgc atttatgtat gtgtgtatag tacctttttt aaaaaaacat
     4621 ttcctccaag ctgctaagca aagggtctca caggtcgagc acagtgctga gaggatggtg
     4681 tctgcataat gaagacatgg atgaagctga gaccgtgttc aaactcactg aaaacaatga
     4741 agttctattc cttttttctt cctctccaat gatcttgcag ttgatttgtt tgttttttaa
     4801 ttttttaaca tttttttaac gttgaaaaaa tgctgcgtct ttctttaagc cttcccagta
     4861 acttcctgcc ttttttttcc ccgtgggctt ttaagtgaag ctgcaggatt ttatctttca
     4921 atctgccctt tctacccttg tcctattgaa aggatgccct cttcccttgc ttttttggtc
     4981 tagggcctgt ttggagctaa ctaggcttgg ctgagtccgg gcaagacctt cttccgaggc
     5041 atggacaagc cccagagaac atgcagaaca ttgacctttc cattgactgt ctttcaagca
     5101 gccagtgaaa tcactaagtg gggttcttcc atgacatatt ttgttaatat gggtttcact
     5161 ttttccaaga atagtccctt gttgccacaa tgttgattta ctttacacaa tgacagtatg
     5221 tattaatttg taattaaacc catccagatt gttttagcct tttcccaatg gggtggggga
     5281 gggaagaagg atattaaaat aagttttaag aagcaaa
//
