LOCUS       NM_006852               5640 bp    mRNA    linear   PRI 23-JUL-2024
DEFINITION  Homo sapiens tousled like kinase 2 (TLK2), transcript variant A,
            mRNA.
ACCESSION   NM_006852
VERSION     NM_006852.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5640)
  AUTHORS   Liang,B., Yin,J.J., Zhang,S.N., Zhang,C., Hu,Z.L. and Wang,Y.
  TITLE     [Effect of TLK2 Expression Regulated by MiR-21 on Proliferation and
            Apoptosis of Acute Myeloid Leukemia Cells]
  JOURNAL   Zhongguo Shi Yan Xue Ye Xue Za Zhi 32 (3), 658-662 (2024)
   PUBMED   38926950
  REMARK    GeneRIF: [Effect of TLK2 Expression Regulated by MiR-21 on
            Proliferation and Apoptosis of Acute Myeloid Leukemia Cells].
REFERENCE   2  (bases 1 to 5640)
  AUTHORS   Pintacuda,G., Hsu,Y.H., Tsafou,K., Li,K.W., Martin,J.M.,
            Riseman,J., Biagini,J.C., Ching,J.K.T., Mena,D.,
            Gonzalez-Lozano,M.A., Egri,S.B., Jaffe,J., Smit,A.B., Fornelos,N.,
            Eggan,K.C. and Lage,K.
  TITLE     Protein interaction studies in human induced neurons indicate
            convergent biology underlying autism spectrum disorders
  JOURNAL   Cell Genom 3 (3), 100250 (2023)
   PUBMED   36950384
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5640)
  AUTHORS   Ronald,S., Sunavala-Dossabhoy,G., Adams,L., Williams,B. and De
            Benedetti,A.
  TITLE     The expression of Tousled kinases in CaP cell lines and its
            relation to radiation response and DSB repair
  JOURNAL   Prostate 71 (13), 1367-1373 (2011)
   PUBMED   21647934
  REMARK    GeneRIF: TLKs appear to be intimately linked to the pattern of
            resistance to DNA damage, and specifically double-strand breaks.
REFERENCE   4  (bases 1 to 5640)
  AUTHORS   Couch,F.J., Wang,X., Bamlet,W.R., de Andrade,M., Petersen,G.M. and
            McWilliams,R.R.
  TITLE     Association of mitotic regulation pathway polymorphisms with
            pancreatic cancer risk and outcome
  JOURNAL   Cancer Epidemiol Biomarkers Prev 19 (1), 251-257 (2010)
   PUBMED   20056645
  REMARK    GeneRIF: Observational study of gene-disease association and
            gene-environment interaction. (HuGE Navigator)
REFERENCE   5  (bases 1 to 5640)
  AUTHORS   Pilyugin,M., Demmers,J., Verrijzer,C.P., Karch,F. and Moshkin,Y.M.
  TITLE     Phosphorylation-mediated control of histone chaperone ASF1 levels
            by Tousled-like kinases
  JOURNAL   PLoS One 4 (12), e8328 (2009)
   PUBMED   20016786
  REMARK    GeneRIF: ASF1 cellular levels are tightly controlled by distinct
            pathways and provide a molecular mechanism for post-translational
            regulation of dASF1 and hASF1a by TLK kinases.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5640)
  AUTHORS   Groth,A., Lukas,J., Nigg,E.A., Sillje,H.H., Wernstedt,C., Bartek,J.
            and Hansen,K.
  TITLE     Human Tousled like kinases are targeted by an ATM- and
            Chk1-dependent DNA damage checkpoint
  JOURNAL   EMBO J 22 (7), 1676-1687 (2003)
   PUBMED   12660173
REFERENCE   7  (bases 1 to 5640)
  AUTHORS   Sillje,H.H. and Nigg,E.A.
  TITLE     Identification of human Asf1 chromatin assembly factors as
            substrates of Tousled-like kinases
  JOURNAL   Curr Biol 11 (13), 1068-1073 (2001)
   PUBMED   11470414
REFERENCE   8  (bases 1 to 5640)
  AUTHORS   Sillje,H.H., Takahashi,K., Tanaka,K., Van Houwe,G. and Nigg,E.A.
  TITLE     Mammalian homologues of the plant Tousled gene code for
            cell-cycle-regulated kinases with maximal activities linked to
            ongoing DNA replication
  JOURNAL   EMBO J 18 (20), 5691-5702 (1999)
   PUBMED   10523312
REFERENCE   9  (bases 1 to 5640)
  AUTHORS   Zhang,S., Xing,H. and Muslin,A.J.
  TITLE     Nuclear localization of protein kinase U-alpha is regulated by
            14-3-3
  JOURNAL   J Biol Chem 274 (35), 24865-24872 (1999)
   PUBMED   10455159
REFERENCE   10 (bases 1 to 5640)
  AUTHORS   Yamakawa,A., Kameoka,Y., Hashimoto,K., Yoshitake,Y., Nishikawa,K.,
            Tanihara,K. and Date,T.
  TITLE     cDNA cloning and chromosomal mapping of genes encoding novel
            protein kinases termed PKU-alpha and PKU-beta, which have nuclear
            localization signal
  JOURNAL   Gene 202 (1-2), 193-201 (1997)
   PUBMED   9427565
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC008026.7, AI381985.1,
            AF162667.1, AB004884.1, BX647225.1 and AC080038.5.
            
            On Jan 3, 2020 this sequence version replaced NM_006852.5.
            
            Summary: This gene encodes a nuclear serine/threonine kinase that
            was first identified in Arabidopsis. The encoded protein is thought
            to function in the regulation of chromatin assembly in the S phase
            of the cell cycle by regulating the levels of a histone H3/H4
            chaperone. This protein is associated with double-strand break
            repair of DNA damage caused by radiation. Pseudogenes of this gene
            are present on chromosomes 10 and 17. Alternate splicing results in
            multiple transcript variants. [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (A) lacks an alternate in-frame
            exon in the 3' coding region compared to variant C. The encoded
            protein (isoform A) is shorter than isoform C.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AF162667.1, SRR18074967.1468597.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000346027.10/ ENSP00000275780.7
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-293               AC008026.7         74596-74888         c
            294-448             AI381985.1         94-248
            449-1090            AF162667.1         121-762
            1091-2090           AB004884.1         527-1526
            2091-2583           AF162667.1         1763-2255
            2584-3644           AB004884.1         2020-3080
            3645-4304           BX647225.1         1541-2200
            4305-4462           BX647225.1         2202-2359
            4463-4463           AC080038.5         102905-102905       c
            4464-5635           BX647225.1         2361-3532
            5636-5640           AC080038.5         101728-101732       c
FEATURES             Location/Qualifiers
     source          1..5640
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q23.2"
     gene            1..5640
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /note="tousled like kinase 2"
                     /db_xref="GeneID:11011"
                     /db_xref="HGNC:HGNC:11842"
                     /db_xref="MIM:608439"
     exon            1..466
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            467..552
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     CDS             472..2724
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /EC_number="2.7.11.1"
                     /note="isoform A is encoded by transcript variant A;
                     serine/threonine-protein kinase tousled-like 2"
                     /codon_start=1
                     /product="serine/threonine-protein kinase tousled-like 2
                     isoform A"
                     /protein_id="NP_006843.2"
                     /db_xref="CCDS:CCDS11633.1"
                     /db_xref="GeneID:11011"
                     /db_xref="HGNC:HGNC:11842"
                     /db_xref="MIM:608439"
                     /translation="MMEELHSLDPRRQELLEARFTGVGVSKGPLNSESSNQSLCSVGS
                     LSDKEVETPEKKQNDQRNRKRKAEPYETSQGKGTPRGHKISDYFEFAGGSAPGTSPGR
                     SVPPVARSSPQHSLSNPLPRRVEQPLYGLDGSAAKEATEEQSALPTLMSVMLAKPRLD
                     TEQLAQRGAGLCFTFVSAQQNSPSSTGSGNTEHSCSSQKQISIQHRQTQSDLTIEKIS
                     ALENSKNSDLEKKEGRIDDLLRANCDLRRQIDEQQKMLEKYKERLNRCVTMSKKLLIE
                     KSKQEKMACRDKSMQDRLRLGHFTTVRHGASFTEQWTDGYAFQNLIKQQERINSQREE
                     IERQRKMLAKRKPPAMGQAPPATNEQKQRKSKTNGAENETLTLAEYHEQEEIFKLRLG
                     HLKKEEAEIQAELERLERVRNLHIRELKRIHNEDNSQFKDHPTLNDRYLLLHLLGRGG
                     FSEVYKAFDLTEQRYVAVKIHQLNKNWRDEKKENYHKHACREYRIHKELDHPRIVKLY
                     DYFSLDTDSFCTVLEYCEGNDLDFYLKQHKLMSEKEARSIIMQIVNALKYLNEIKPPI
                     IHYDLKPGNILLVNGTACGEIKITDFGLSKIMDDDSYNSVDGMELTSQGAGTYWYLPP
                     ECFVVGKEPPKISNKVDVWSVGVIFYQCLYGRKPFGHNQSQQDILQENTILKATEVQF
                     PPKPVVTPEAKAFIRRCLAYRKEDRIDVQQLACDPYLLPHIRKSVSTSSPAGAAIAST
                     SGASNNSSSN"
     exon            553..624
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            625..694
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            695..738
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            739..834
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            835..1002
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1098
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1191
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1192..1302
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1303..1439
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1440..1592
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1593..1659
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1660..1757
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1758..1839
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1840..1931
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            1932..2021
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            2022..2191
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            2192..2330
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            2331..2442
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            2443..2550
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     exon            2551..5640
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3803..3808
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /note="hexamer: ATTAAA"
     polyA_site      3825
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /note="major polyA site"
     regulatory      5616..5621
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /note="hexamer: ATTAAA"
     regulatory      5621..5626
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
                     /note="hexamer: AATAAG"
     polyA_site      5635
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
     polyA_site      5640
                     /gene="TLK2"
                     /gene_synonym="HsHPK; MRD57; PKU-ALPHA"
ORIGIN      
        1 actactaatc cggaccgaac cgatccggat taaggggccg gaggcgggtc ctgggcacca
       61 gcggttccga cccccccgcc ctccgcgccg cacccgagtg gcccccagcc gagcgggccc
      121 ccacctcctg gcccggcctg ggccctcctg cgcctccctt ggcctttgtc cggcgccagg
      181 aggccggtcc cgcgcccccc gcggccgccc gggcccgggc ccgcgtcggg cgcctggctc
      241 tgtacgcgag cccggggatc tgcggccttc gtgccccccc tcccccgccc gccctctcgt
      301 ggagcccggc gccggcggcg gctgcccggg cggggggttg cggcgctcag gagaggcccc
      361 ggctccgccc cgggcctgcc cagggggaga gcggagcggt ccgcagccgg gtcgggtcgg
      421 ggcccctccc gggaggagcg tggagcggcg gcggcggcgg cggcagcaga aatgatggaa
      481 gaattgcata gcctggaccc acgacggcag gaattattgg aggccaggtt tactggagta
      541 ggtgttagta agggaccact taatagtgag tcttccaacc agagcttgtg cagcgtcgga
      601 tccttgagtg ataaagaagt agagactccc gagaaaaagc agaatgacca gcgaaatcgg
      661 aaaagaaaag ctgaaccata tgaaactagc caagggaaag gcactcctag gggacataaa
      721 attagtgatt actttgagtt tgctggggga agcgcgccag gaaccagccc tggcagaagt
      781 gttccaccag ttgcacgatc ctcaccgcaa cattccttat ccaatccctt accgcgacga
      841 gtagaacagc ccctctatgg tttagatggc agtgctgcaa aggaggcaac ggaggagcag
      901 tctgctctgc caaccctcat gtcagtgatg ctagcaaaac ctcggcttga cacagagcag
      961 ctggcgcaaa ggggagctgg cctctgcttc acttttgttt cagctcagca aaacagtccc
     1021 tcatctacgg gatctggcaa cacagagcat tcctgcagct cccaaaaaca gatctccatc
     1081 cagcacagac agacccagtc cgacctcaca atagaaaaaa tatctgcact agaaaacagt
     1141 aagaattctg acttagagaa gaaggaggga agaatagatg atttattaag agccaactgt
     1201 gatttgagac ggcagattga tgaacagcaa aagatgctag agaaatacaa ggaacgatta
     1261 aatagatgtg tgacaatgag caagaaactc cttatagaaa agtcaaaaca agagaagatg
     1321 gcgtgtagag ataagagcat gcaagaccgc ttgagactgg gccactttac tactgtccga
     1381 cacggagcct catttactga acagtggaca gatggttatg cttttcagaa tcttatcaag
     1441 caacaggaaa ggataaattc acagagggaa gagatagaaa gacaacggaa aatgttagca
     1501 aagcggaaac ctcctgccat gggtcaggcc cctcctgcaa ccaatgagca gaaacagcgg
     1561 aaaagcaaga ccaatggagc tgaaaatgaa acgttaacgt tagcagaata ccatgaacaa
     1621 gaagaaatct tcaaactcag attaggtcat cttaaaaagg aggaagcaga gatccaggca
     1681 gagctggaga gactagaaag ggttagaaat ctacatatca gggaactaaa aaggatacat
     1741 aatgaagata attcacaatt taaagatcat ccaacgctaa atgacagata tttgttgtta
     1801 catcttttgg gtagaggagg tttcagtgaa gtttacaagg catttgatct aacagagcaa
     1861 agatacgtag ctgtgaaaat tcaccagtta aataaaaact ggagagatga gaaaaaggag
     1921 aattaccaca agcatgcatg tagggaatac cggattcata aagagctgga tcatcccaga
     1981 atagttaagc tgtatgatta cttttcactg gatactgact cgttttgtac agtattagaa
     2041 tactgtgagg gaaatgatct ggacttctac ctgaaacagc acaaattaat gtcggagaaa
     2101 gaggcccggt ccattatcat gcagattgtg aatgctttaa agtacttaaa tgaaataaaa
     2161 cctcccatca tacactatga cctcaaacca ggtaatattc ttttagtaaa tggtacagcg
     2221 tgtggagaga taaaaattac agattttggt ctttcgaaga tcatggatga tgatagctac
     2281 aattcagtgg atggcatgga gctaacatca caaggtgctg gtacttattg gtatttacca
     2341 ccagagtgtt ttgtggttgg gaaagaacca ccaaagatct caaataaagt tgatgtgtgg
     2401 tcggtgggtg tgatcttcta tcagtgtctt tatggaagga agccttttgg ccataaccag
     2461 tctcagcaag acatcctaca agagaatacg attcttaaag ctactgaagt gcagttcccg
     2521 ccaaagccag tagtaacacc tgaagcaaag gcgtttattc gacgatgctt ggcctaccga
     2581 aaggaggacc gcattgatgt ccagcagctg gcctgtgatc cctacttgtt gcctcacatc
     2641 cgaaagtcag tctctacaag tagccctgct ggagctgcta ttgcatcaac ctctggggcg
     2701 tccaataaca gttcttctaa ttgagactga ctccaaggcc acaaactgtt caacacacac
     2761 aaagtggaca aatggcgttc agcagcgggt ttggaacata gcgaatccga atggatctga
     2821 tgaaacctgt accaggtgct tttattttct tgcttttttc ccatccatag agcatgacag
     2881 catcgattct cattgaggag aaaccttggg cagctccggc caggccttgt aggaaaaggc
     2941 cccgcccgag gttccagcgt caacggccac tgtgtgtggc tgctctgagt gaggaaaaaa
     3001 ttaaaaagaa aaactggttc catgtactgt gaacttgaaa acttgcagac tcaggggggt
     3061 ccctgatgca gtgcttcaga tgaagaatgt ggacttgaaa atacagactg ggctagtcca
     3121 gtgtctatat ttaaacttgt tcttttcttt taataaagtt taggtaacat ctcctgaaaa
     3181 gcttgtagca caaaggctca gctggggatg gtgtttgact tcggaggaaa aaagttgcta
     3241 ttgcccgtta aaggcactag agttagtgtt ttatccctaa ataatttcaa tttttaaaaa
     3301 catgcagctt ccctctcccc ttttttattt ttgaaagaat acatttggtc ataaagtgaa
     3361 acccgtatta gcaagtacgt ggcaatgttc attccaatca gatgcagctt tctcctccgt
     3421 ctggtctcct gtttgcaatt gcttccctca tctcagtagg gaaaaaattg agtgggagta
     3481 ctgagatgtg tgggtttttg ccattggaca aagaatgagg ttagaagact gcagcttgga
     3541 gtctctctag gttttcaact atttcttcac aatttgaaca cttgacggtt gtccctttta
     3601 atttatttga agtgctattt ttttaaataa aggttcatct gtccatgcag tcctcttgga
     3661 ttctctgaat gtagtaacta tgaagctatg ccaaaggtag gcagaaaatg ggcttgggag
     3721 ccagacactc cagggatcag tagttcctac ccatagtctt tgtgtgcttg ctaaatggtg
     3781 tacatttctt gttaaccacg ttattaaaac ttgatcagca cataagcttt cttctgttag
     3841 atcttttggc agcaaacaac cttcccccca agcctctgaa ttttgtgggt gtgtggtggt
     3901 gtgtgtctgt gtgtgcatgt acacacacac tttgtctagc tcactttaaa agattcatca
     3961 aatggaattt taaaaataat ctgaaaagaa atagatattt caggccgggc ctggtggttc
     4021 acgcctgtaa tcccagcact ttgggaggcc gaggtgggtg gatcacgagg tcgggagttc
     4081 gagatcagtc tggtcaacat ggtgaaacgc catctctact aaaaatataa aaattagcct
     4141 ggcgtggtgg cgtgtgcctc tagtcccagc tacccgggag gctgaggcag gagaatttct
     4201 ggaacccagg aggcggaggt tgcagtgagc cgagatggca ccactgcaat ccagcctagg
     4261 caacagaatg agactctgtc tcagaaaaaa aaaaaaaaaa aaaaggagaa atagatgttt
     4321 caaatatgaa cattcttttg gcaccaattt tcttttttaa tttggttgtt tctgagatgt
     4381 atgatcaact gaagatggag ctgaaatggg agacgggtgg ccccaccgtg cccttgaaac
     4441 agcagagcac tcctcagtag agagggaggg agccaagagc ctgaacatgt ggtcgccagc
     4501 ttggaatgtt actgacatat gtggcgaggg cttagccaga aatatttaaa gatgtagtat
     4561 tccggcctgt gagttgtctg ggcagggagg gggagtcaga aagggtagag agctctcaaa
     4621 taactcatga ctctagtgtt cctttcacat gtgaacagtg tcactgatga cacattttct
     4681 aggaccttcg tttgttttgt ggacctgcct cagtctcctc agtatcaggc gatcttaagg
     4741 gaagatggag tgtttcaaat tggagagaag ttcatgggta ggtatcgtcc tgtggaattc
     4801 tgaatgcaag gaagtcaacc ccagaggcct tggtaccccc agctttctaa aactacttta
     4861 ttacaattta tatgtatata cacatgcaca tataaacgtg tgcatttatg tatgtgtgta
     4921 tagtaccttt tttaaaaaaa catttcctcc aagctgctaa gcaaagggtc tcacaggtcg
     4981 agcacagtgc tgagaggatg gtgtctgcat aatgaagaca tggatgaagc tgagaccgtg
     5041 ttcaaactca ctgaaaacaa tgaagttcta ttcctttttt cttcctctcc aatgatcttg
     5101 cagttgattt gtttgttttt taatttttta acattttttt aacgttgaaa aaatgctgcg
     5161 tctttcttta agccttccca gtaacttcct gccttttttt tccccgtggg cttttaagtg
     5221 aagctgcagg attttatctt tcaatctgcc ctttctaccc ttgtcctatt gaaaggatgc
     5281 cctcttccct tgcttttttg gtctagggcc tgtttggagc taactaggct tggctgagtc
     5341 cgggcaagac cttcttccga ggcatggaca agccccagag aacatgcaga acattgacct
     5401 ttccattgac tgtctttcaa gcagccagtg aaatcactaa gtggggttct tccatgacat
     5461 attttgttaa tatgggtttc actttttcca agaatagtcc cttgttgcca caatgttgat
     5521 ttactttaca caatgacagt atgtattaat ttgtaattaa acccatccag attgttttag
     5581 ccttttccca atggggtggg ggagggaaga aggatattaa aataagtttt aagaagcaaa
//
