LOCUS       NM_001130               1798 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens TLE family member 5, transcriptional modulator (TLE5),
            transcript variant 2, mRNA.
ACCESSION   NM_001130
VERSION     NM_001130.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1798)
  AUTHORS   Chung,I.C., Huang,W.C., Huang,Y.T., Chen,M.L., Tsai,A.W., Wu,P.Y.
            and Yuan,T.T.
  TITLE     Unrevealed roles of extracellular enolase-1 (ENO1) in promoting
            glycolysis and pro-cancer activities in multiple myeloma via
            hypoxia-inducible factor 1alpha
  JOURNAL   Oncol Rep 50 (5) (2023)
   PUBMED   37800625
  REMARK    GeneRIF: Unrevealed roles of extracellular enolase-1 (ENO1) in
            promoting glycolysis and pro-cancer activities in multiple myeloma
            via hypoxia-inducible factor 1alpha.
REFERENCE   2  (bases 1 to 1798)
  AUTHORS   Goos,H., Kinnunen,M., Salokas,K., Tan,Z., Liu,X., Yadav,L.,
            Zhang,Q., Wei,G.H. and Varjosalo,M.
  TITLE     Human transcription factor protein interaction networks
  JOURNAL   Nat Commun 13 (1), 766 (2022)
   PUBMED   35140242
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1798)
  AUTHORS   Wang,Z., Zhou,L., Wang,Y., Peng,Q., Li,H., Zhang,X., Su,Z.,
            Song,J., Sun,Q., Sayed,S., Liu,S. and Lu,D.
  TITLE     The CK1delta/epsilon-AES axis regulates tumorigenesis and
            metastasis in colorectal cancer
  JOURNAL   Theranostics 11 (9), 4421-4435 (2021)
   PUBMED   33754069
  REMARK    GeneRIF: The CK1delta/epsilon-AES axis regulates tumorigenesis and
            metastasis in colorectal cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1798)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1798)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1798)
  AUTHORS   Tetsuka,T., Uranishi,H., Imai,H., Ono,T., Sonta,S., Takahashi,N.,
            Asamitsu,K. and Okamoto,T.
  TITLE     Inhibition of nuclear factor-kappaB-mediated transcription by
            association with the amino-terminal enhancer of split, a
            Groucho-related protein lacking WD40 repeats
  JOURNAL   J Biol Chem 275 (6), 4383-4390 (2000)
   PUBMED   10660609
REFERENCE   7  (bases 1 to 1798)
  AUTHORS   Ren,B., Chee,K.J., Kim,T.H. and Maniatis,T.
  TITLE     PRDI-BF1/Blimp-1 repression is mediated by corepressors of the
            Groucho family of proteins
  JOURNAL   Genes Dev 13 (1), 125-137 (1999)
   PUBMED   9887105
REFERENCE   8  (bases 1 to 1798)
  AUTHORS   Babcock,B., Anderson,B.W., Papayannopoulos,I., Castilleja,A.,
            Murray,J.L., Stifani,S., Kudelka,A.P., Wharton,J.T. and
            Ioannides,C.G.
  TITLE     Ovarian and breast cytotoxic T lymphocytes can recognize peptides
            from the amino enhancer of split protein of the Notch complex
  JOURNAL   Mol Immunol 35 (17), 1121-1133 (1998)
   PUBMED   10395201
REFERENCE   9  (bases 1 to 1798)
  AUTHORS   Hou,E.W. and Li,S.S.
  TITLE     Genomic organization and chromosome localization to band 19p13.3 of
            the human AES gene: gene product exhibits strong similarity to the
            N-terminal domain of Drosophila enhancer of Split Groucho protein
  JOURNAL   DNA Cell Biol 17 (10), 911-913 (1998)
   PUBMED   9809752
REFERENCE   10 (bases 1 to 1798)
  AUTHORS   Miyasaka,H., Choudhury,B.K., Hou,E.W. and Li,S.S.
  TITLE     Molecular cloning and expression of mouse and human cDNA encoding
            AES and ESG proteins with strong similarity to Drosophila enhancer
            of split groucho protein
  JOURNAL   Eur J Biochem 216 (1), 343-352 (1993)
   PUBMED   8365415
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC005944.1, BM908356.1,
            BM550097.1, AK094591.1 and AF269289.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Jun 2, 2019 this sequence version replaced NM_001130.5.
            
            Summary: The protein encoded by this gene is similar in sequence to
            the amino terminus of Drosophila enhancer of split groucho, a
            protein involved in neurogenesis during embryonic development. The
            encoded protein, which belongs to the groucho/TLE family of
            proteins, can function as a homooligomer or as a heteroologimer
            with other family members to dominantly repress the expression of
            other family member genes. Three transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Jul 2008].
            
            Transcript Variant: This variant (2) differs in the 5' UTR and
            coding region compared to variant 1. The resulting isoform (b) is
            shorter and has a distinct N-terminus compared to isoform a.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.631645.1,
                                           SRR3476690.962296.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968189, SAMEA1968540
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000327141.9/ ENSP00000317537.4
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-122               AC005944.1         13622-13743         c
            123-255             BM908356.1         29-161
            256-926             BM550097.1         91-761
            927-1630            AK094591.1         1014-1717
            1631-1639           AF269289.1         1025-1033
            1640-1798           AK094591.1         1726-1884
FEATURES             Location/Qualifiers
     source          1..1798
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1798
                     /gene="TLE5"
                     /gene_synonym="AES; AES-1; AES-2; ESP1; GRG; Grg-5; GRG5"
                     /note="TLE family member 5, transcriptional modulator"
                     /db_xref="GeneID:166"
                     /db_xref="HGNC:HGNC:307"
                     /db_xref="MIM:600188"
     exon            1..322
                     /gene="TLE5"
                     /gene_synonym="AES; AES-1; AES-2; ESP1; GRG; Grg-5; GRG5"
                     /inference="alignment:Splign:2.1.0"
     CDS             296..889
                     /gene="TLE5"
                     /gene_synonym="AES; AES-1; AES-2; ESP1; GRG; Grg-5; GRG5"
                     /note="isoform b is encoded by transcript variant 2;
                     gp130-associated protein GAM; groucho-related protein 5;
                     amino-terminal enhancer of split"
                     /codon_start=1
                     /product="TLE family member 5 isoform b"
                     /protein_id="NP_001121.2"
                     /db_xref="CCDS:CCDS12102.1"
                     /db_xref="GeneID:166"
                     /db_xref="HGNC:HGNC:307"
                     /db_xref="MIM:600188"
                     /translation="MMFPQSRHSGSSHLPQQLKFTTSDSCDRIKDEFQLLQAQYHSLK
                     LECDKLASEKSEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNGICAQVLPYLSQEHQQ
                     QVLGAIERAKQVTAPELNSIIRQQLQAHQLSQLQALALPLTPLPVGLQPPSLPAVSAG
                     TGLLSLSALGSQAHLSKEDKNGHDGDTHQEDDGEKSD"
     exon            323..420
                     /gene="TLE5"
                     /gene_synonym="AES; AES-1; AES-2; ESP1; GRG; Grg-5; GRG5"
                     /inference="alignment:Splign:2.1.0"
     exon            421..484
                     /gene="TLE5"
                     /gene_synonym="AES; AES-1; AES-2; ESP1; GRG; Grg-5; GRG5"
                     /inference="alignment:Splign:2.1.0"
     exon            485..529
                     /gene="TLE5"
                     /gene_synonym="AES; AES-1; AES-2; ESP1; GRG; Grg-5; GRG5"
                     /inference="alignment:Splign:2.1.0"
     exon            530..592
                     /gene="TLE5"
                     /gene_synonym="AES; AES-1; AES-2; ESP1; GRG; Grg-5; GRG5"
                     /inference="alignment:Splign:2.1.0"
     exon            593..667
                     /gene="TLE5"
                     /gene_synonym="AES; AES-1; AES-2; ESP1; GRG; Grg-5; GRG5"
                     /inference="alignment:Splign:2.1.0"
     exon            668..1798
                     /gene="TLE5"
                     /gene_synonym="AES; AES-1; AES-2; ESP1; GRG; Grg-5; GRG5"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1529..1534
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLE5"
                     /gene_synonym="AES; AES-1; AES-2; ESP1; GRG; Grg-5; GRG5"
                     /note="hexamer: AATAAA"
     polyA_site      1549
                     /gene="TLE5"
                     /gene_synonym="AES; AES-1; AES-2; ESP1; GRG; Grg-5; GRG5"
                     /note="major polyA site"
     regulatory      1778..1783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLE5"
                     /gene_synonym="AES; AES-1; AES-2; ESP1; GRG; Grg-5; GRG5"
                     /note="hexamer: AATAAA"
     polyA_site      1798
                     /gene="TLE5"
                     /gene_synonym="AES; AES-1; AES-2; ESP1; GRG; Grg-5; GRG5"
                     /note="major polyA site"
ORIGIN      
        1 actgccggcg tcgccgccat tagacaatag cggtggggcc ggggagcggg gaggcgggcg
       61 gcggggaggg gcggggaggg gcgccgggcg cgcaggaagc ggggcccggg gcgcgccggg
      121 gccgggcgcg cggggagggg gcgcaggaag cgggcgaggc cgggcgcggg aggcggcggc
      181 ggccccggga gctgccgatc ggcgccggga caaaggcgcg gccgcccggc gcccccagca
      241 gcccgagccg gggcgcacag ccggggcgca gcccgcgccc cccgccgcga ttgacatgat
      301 gtttccacaa agcaggcatt cgggctcctc gcacctaccc cagcaactca aattcaccac
      361 ctcggactcc tgcgaccgca tcaaagacga atttcagcta ctgcaagctc agtaccacag
      421 cctcaagctc gaatgtgaca agttggccag tgagaagtca gagatgcagc gtcactatgt
      481 gatgtactac gagatgtcct acggcttgaa catcgagatg cacaaacagg ctgagatcgt
      541 caaaaggctg aacgggattt gtgcccaggt cctgccctac ctctcccaag agcaccagca
      601 gcaggtcttg ggagccattg agagggccaa gcaggtcacc gctcccgagc tgaactctat
      661 catccgacag cagctccaag cccaccagct gtcccagctg caggccctgg ccctgccctt
      721 gaccccacta cccgtggggc tgcagccgcc ttcgctgccg gcggtcagcg caggcaccgg
      781 cctcctctcg ctgtccgcgc tgggttccca ggcccacctc tccaaggaag acaagaacgg
      841 gcacgatggt gacacccacc aggaggatga tggcgagaag tcggattagc agggggccgg
      901 gacagggagg ttgggagggg ggacagaggg gagacagagg cacggagaga aaggaatgtt
      961 tagcacaaga cacagcggag ctcgggattg gctaaactcc catagtattt atggtggccg
     1021 ccggcggggg ccccagccca gcttgcaggc cacctctagc tttcttccta ccccattccc
     1081 ggcttccctc ctcctcccct gcagcctggt taggtggata cctgccctga catgtgaggc
     1141 aagctaaggc ctggagggtc agatgggaga ccaggtccca agggagcaag acctcgcgaa
     1201 gcgcagcagc cccggccctt cccccgtttt gaacatgtgt aaccgacagt ctgcctgggc
     1261 cacagccctc tcaccctggt actgcatgca cgcaatgcta gctgcccctt tcccgtcctg
     1321 ggcaccccga gtctcccccg accccgggtc ccaggtatgc tcccacctcc acctgcccca
     1381 ctcaccacct ctgctagttc cagacacctc cacgcccacc tggtcctctc ccatcgccca
     1441 caaaaggggg ggcacgaggg acgagcttag ctgagctggg aggagcaggg tgagggtggg
     1501 cgacccagga ttccccctcc ccttcccaaa taaagatgag ggtactaaag ttgtcttggt
     1561 ttttatttta ttattatttt tttctttttc cagtatacta gcttgtcttt taagaaaggg
     1621 gatattaaaa aaaaaaaaag acaaaagtgt ttttaaaaaa aagcaacacc cacacctgtg
     1681 tctgtatata gtcagcttat ctcgtgttca atcgtctgat ctctacagag agaagtggaa
     1741 aatgctgtat caagggtggg cttagctgtg cctttccaat aaagatgtga gaagcttc
//
