LOCUS       NM_007005               4886 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens TLE family member 4, transcriptional corepressor
            (TLE4), transcript variant 3, mRNA.
ACCESSION   NM_007005 XM_351835
VERSION     NM_007005.6
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4886)
  AUTHORS   Agarwal,M., Bharadwaj,A. and Mathew,S.J.
  TITLE     TLE4 regulates muscle stem cell quiescence and skeletal muscle
            differentiation
  JOURNAL   J Cell Sci 135 (4) (2022)
   PUBMED   35099008
  REMARK    GeneRIF: TLE4 regulates muscle stem cell quiescence and skeletal
            muscle differentiation.
REFERENCE   2  (bases 1 to 4886)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 4886)
  AUTHORS   Chen,J.B., Zhang,J., Hu,H.Z., Xue,M. and Jin,Y.J.
  TITLE     Polymorphisms of TGFB1, TLE4 and MUC22 are associated with
            childhood asthma in Chinese population
  JOURNAL   Allergol Immunopathol (Madr) 45 (5), 432-438 (2017)
   PUBMED   28262390
  REMARK    GeneRIF: Genes TGFB1, TLE4 and MUC22 are associated with the risk
            of childhood asthma in Chinese population.
REFERENCE   4  (bases 1 to 4886)
  AUTHORS   van Tienen,L.M., Mieszczanek,J., Fiedler,M., Rutherford,T.J. and
            Bienz,M.
  TITLE     Constitutive scaffolding of multiple Wnt enhanceosome components by
            Legless/BCL9
  JOURNAL   Elife 6, e20882 (2017)
   PUBMED   28296634
  REMARK    Erratum:[Elife. 2017 Mar 30;6:e27150. doi: 10.7554/eLife.27150..
            PMID: 28358670]
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4886)
  AUTHORS   Shin,T.H., Brynczka,C., Dayyani,F., Rivera,M.N. and Sweetser,D.A.
  TITLE     TLE4 regulation of wnt-mediated inflammation underlies its role as
            a tumor suppressor in myeloid leukemia
  JOURNAL   Leuk Res 48, 46-56 (2016)
   PUBMED   27486062
  REMARK    GeneRIF: the loss of TLE4 confers proliferative advantage to
            leukemic cells, simultaneous with an upregulation of a pro-
            inflammatory signature mediated through aberrant increases in Wnt
            signaling activity
REFERENCE   6  (bases 1 to 4886)
  AUTHORS   Beausoleil,S.A., Jedrychowski,M., Schwartz,D., Elias,J.E.,
            Villen,J., Li,J., Cohn,M.A., Cantley,L.C. and Gygi,S.P.
  TITLE     Large-scale characterization of HeLa cell nuclear phosphoproteins
  JOURNAL   Proc Natl Acad Sci U S A 101 (33), 12130-12135 (2004)
   PUBMED   15302935
REFERENCE   7  (bases 1 to 4886)
  AUTHORS   Humphray,S.J., Oliver,K., Hunt,A.R., Plumb,R.W., Loveland,J.E.,
            Howe,K.L., Andrews,T.D., Searle,S., Hunt,S.E., Scott,C.E.,
            Jones,M.C., Ainscough,R., Almeida,J.P., Ambrose,K.D., Ashwell,R.I.,
            Babbage,A.K., Babbage,S., Bagguley,C.L., Bailey,J., Banerjee,R.,
            Barker,D.J., Barlow,K.F., Bates,K., Beasley,H., Beasley,O.,
            Bird,C.P., Bray-Allen,S., Brown,A.J., Brown,J.Y., Burford,D.,
            Burrill,W., Burton,J., Carder,C., Carter,N.P., Chapman,J.C.,
            Chen,Y., Clarke,G., Clark,S.Y., Clee,C.M., Clegg,S., Collier,R.E.,
            Corby,N., Crosier,M., Cummings,A.T., Davies,J., Dhami,P., Dunn,M.,
            Dutta,I., Dyer,L.W., Earthrowl,M.E., Faulkner,L., Fleming,C.J.,
            Frankish,A., Frankland,J.A., French,L., Fricker,D.G., Garner,P.,
            Garnett,J., Ghori,J., Gilbert,J.G., Glison,C., Grafham,D.V.,
            Gribble,S., Griffiths,C., Griffiths-Jones,S., Grocock,R., Guy,J.,
            Hall,R.E., Hammond,S., Harley,J.L., Harrison,E.S., Hart,E.A.,
            Heath,P.D., Henderson,C.D., Hopkins,B.L., Howard,P.J., Howden,P.J.,
            Huckle,E., Johnson,C., Johnson,D., Joy,A.A., Kay,M., Keenan,S.,
            Kershaw,J.K., Kimberley,A.M., King,A., Knights,A., Laird,G.K.,
            Langford,C., Lawlor,S., Leongamornlert,D.A., Leversha,M., Lloyd,C.,
            Lloyd,D.M., Lovell,J., Martin,S., Mashreghi-Mohammadi,M.,
            Matthews,L., McLaren,S., McLay,K.E., McMurray,A., Milne,S.,
            Nickerson,T., Nisbett,J., Nordsiek,G., Pearce,A.V., Peck,A.I.,
            Porter,K.M., Pandian,R., Pelan,S., Phillimore,B., Povey,S.,
            Ramsey,Y., Rand,V., Scharfe,M., Sehra,H.K., Shownkeen,R.,
            Sims,S.K., Skuce,C.D., Smith,M., Steward,C.A., Swarbreck,D.,
            Sycamore,N., Tester,J., Thorpe,A., Tracey,A., Tromans,A.,
            Thomas,D.W., Wall,M., Wallis,J.M., West,A.P., Whitehead,S.L.,
            Willey,D.L., Williams,S.A., Wilming,L., Wray,P.W., Young,L.,
            Ashurst,J.L., Coulson,A., Blocker,H., Durbin,R., Sulston,J.E.,
            Hubbard,T., Jackson,M.J., Bentley,D.R., Beck,S., Rogers,J. and
            Dunham,I.
  TITLE     DNA sequence and analysis of human chromosome 9
  JOURNAL   Nature 429 (6990), 369-374 (2004)
   PUBMED   15164053
REFERENCE   8  (bases 1 to 4886)
  AUTHORS   Milili,M., Gauthier,L., Veran,J., Mattei,M.G. and Schiff,C.
  TITLE     A new Groucho TLE4 protein may regulate the repressive activity of
            Pax5 in human B lymphocytes
  JOURNAL   Immunology 106 (4), 447-455 (2002)
   PUBMED   12153506
REFERENCE   9  (bases 1 to 4886)
  AUTHORS   Miyasaka,H., Choudhury,B.K., Hou,E.W. and Li,S.S.
  TITLE     Molecular cloning and expression of mouse and human cDNA encoding
            AES and ESG proteins with strong similarity to Drosophila enhancer
            of split groucho protein
  JOURNAL   Eur J Biochem 216 (1), 343-352 (1993)
   PUBMED   8365415
REFERENCE   10 (bases 1 to 4886)
  AUTHORS   Stifani,S., Blaumueller,C.M., Redhead,N.J., Hill,R.E. and
            Artavanis-Tsakonas,S.
  TITLE     Human homologs of a Drosophila Enhancer of split gene product
            define a novel family of nuclear proteins
  JOURNAL   Nat Genet 2 (2), 119-127 (1992)
   PUBMED   1303260
  REMARK    Erratum:[Nat Genet. 1992 Dec;2(4):343. doi: 10.1038/ng1292-343a..
            PMID: 1303292]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL358975.8, AL445252.13 and AL353813.12.
            
            On Feb 27, 2020 this sequence version replaced NM_007005.5.
            
            Transcript Variant: This variant (3) lacks an alternate in-frame
            exon in the coding region compared to variant 1. It encodes isoform
            3 which is shorter than isoform 1.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038193.1513855.1,
                                           SRR14038194.1864768.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376552.8/ ENSP00000365735.2
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-871               AL358975.8         145885-146755
            872-969             AL358975.8         147609-147706
            970-1033            AL358975.8         148793-148856
            1034-1078           AL358975.8         150053-150097
            1079-1141           AL358975.8         186576-186638
            1142-1216           AL445252.13        6958-7032
            1217-1418           AL353813.12        12499-12700
            1419-1435           AL353813.12        13965-13981
            1436-1555           AL353813.12        64689-64808
            1556-1609           AL353813.12        65795-65848
            1610-1762           AL353813.12        66653-66805
            1763-1895           AL353813.12        68024-68156
            1896-2089           AL353813.12        68499-68692
            2090-2166           AL353813.12        69529-69605
            2167-2416           AL353813.12        78628-78877
            2417-2664           AL353813.12        79952-80199
            2665-2812           AL353813.12        81647-81794
            2813-2963           AL353813.12        82357-82507
            2964-3040           AL353813.12        82865-82941
            3041-4886           AL353813.12        84943-86788
FEATURES             Location/Qualifiers
     source          1..4886
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.31"
     gene            1..4886
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /note="TLE family member 4, transcriptional corepressor"
                     /db_xref="GeneID:7091"
                     /db_xref="HGNC:HGNC:11840"
                     /db_xref="MIM:605132"
     exon            1..871
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     CDS             827..3148
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /note="isoform 3 is encoded by transcript variant 3;
                     transducin-like enhancer of split 4, homolog of Drosophila
                     E(sp1); enhancer of split groucho 4; transducin like
                     enhancer of split 4; transducin-like enhancer protein 4; B
                     lymphocyte gene 1; transducin-like enhancer of split 4
                     (E(sp1) homolog, Drosophila); groucho-related protein 4"
                     /codon_start=1
                     /product="transducin-like enhancer protein 4 isoform 3"
                     /protein_id="NP_008936.2"
                     /db_xref="CCDS:CCDS43837.1"
                     /db_xref="GeneID:7091"
                     /db_xref="HGNC:HGNC:11840"
                     /db_xref="MIM:605132"
                     /translation="MIRDLSKMYPQTRHPAPHQPAQPFKFTISESCDRIKEEFQFLQA
                     QYHSLKLECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLNAICAQVIPFL
                     SQEHQQQVVQAVERAKQVTMAELNAIIGQQLQAQHLSHGHGLPVPLTPHPSGLQPPAI
                     PPIGSSAGLLALSSALGGQSHLPIKDEKKHHDNDHQRDRDSIKSSSVSPSASFRGAEK
                     HRNSADYSSESKKQKTEEKEIAARYDSDGEKSDDNLVVDVSNEDPSSPRGSPAHSPRE
                     NGLDKTRLLKKDAPISPASIASSSSTPSSKSKELSLNEKSTTPVSKSNTPTPRTDAPT
                     PGSNSTPGLRPVPGKPPGVDPLASSLRTPMAVPCPYPTPFGIVPHAGMNGELTSPGAA
                     YAGLHNISPQMSAAAAAAAAAAAYGRSPVVGFDPHHHMRVPAIPPNLTGIPGGKPAYS
                     FHVSADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKG
                     CVKVWDISHPGNKSPVSQLDCLNRDNYIRSCRLLPDGRTLIVGGEASTLSIWDLAAPT
                     PRIKAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASC
                     IDISNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMENS
                     NVEVLHVTKPDKYQLHLHESCVLSLKFAHCGKWFVSTGKDNLLNAWRTPYGASIFQSK
                     ESSSVLSCDISVDDKYIVTGSGDKKATVYEVIY"
     exon            872..969
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            970..1033
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1034..1078
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1079..1141
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1142..1216
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1217..1418
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1419..1435
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1436..1555
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1556..1609
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1610..1762
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1763..1895
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..2089
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            2090..2166
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            2167..2416
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            2417..2664
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            2665..2812
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            2813..2963
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            2964..3040
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     exon            3041..4886
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4724..4729
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /note="hexamer: ATTAAA"
     polyA_site      4744
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /note="major polyA site"
     regulatory      4820..4825
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /note="hexamer: ATTAAA"
     polyA_site      4847
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
     regulatory      4860..4865
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
                     /note="hexamer: AGTAAA"
     polyA_site      4886
                     /gene="TLE4"
                     /gene_synonym="BCE-1; BCE1; E(spI); E(spl); ESG; ESG4;
                     Grg-4; GRG4"
ORIGIN      
        1 agagcgtgtt gttagagctg tgctgagcgg gtgtttgggt tgttggctgc tttcttcccc
       61 ctttctcaca cacttgtata ttattttgag gtggtgttcg cagagtttga aaggagagag
      121 aattaaaaaa aaaagccgca agcgtttcac tcttttattt ttataatccc cttcaatttg
      181 gggttaaaaa aaagacaaga aaacaggaag gaagagaaat aaggaaatga gatgtggtaa
      241 aagaagctaa aaggtgcctt ttaaaagatc gttgctgtga agtgaaaaaa atctccagag
      301 aaaccaaaaa gcaccgccga gacctcttcc gaaccaaagg agtttgtgtt tgcttttagg
      361 gaagaagaaa gatcattcat tcggaggaat aacaaccaat taaaagacaa ataaaaaaag
      421 tttggagtgg gacgcagagc gagcgagagg agctgccggc gggcggtggg gcgcggagcc
      481 cgcactttcc cggccgggtg agcggcggcc gcggcgccgg gctcggcggg tgcgcctcgg
      541 cggagcgaac gtcggagcgt tgccttggga gacgcgcgcc ggacaatgcc cgcggcgggc
      601 cagtgacgcc cgcggggaat gcggagcggc ccggcagccg gcacccagcc gccgccgcgc
      661 gttcctgccg cccgtgtcac gcgagacccg gcgggggccg ggaccgcccg agccgcccct
      721 cagaccgagc cggccgcctc cgctgccgcg gccgcctcct cttcggggtc attaaagcca
      781 atgagccgcg cgcctctgcc gagcgcagcc aactaaatcg gcttggatga ttcgcgacct
      841 gagcaagatg tacccgcaga ccagacaccc agcaccgcat cagcctgctc aaccctttaa
      901 atttacaatt tccgaatcct gtgatcggat taaggaagag tttcagtttt tacaggctca
      961 ataccacagt ctgaagctgg aatgtgagaa actcgccagt gagaagacag agatgcagcg
     1021 gcattatgtc atgtattatg aaatgtccta tgggttgaat atagaaatgc acaagcaggc
     1081 agagattgtc aagaggctga atgctatctg tgcacaagtc attcctttcc tgtcccaaga
     1141 gcaccagcaa caagtggtgc aggctgtgga acgggccaag caggtgacca tggcagaact
     1201 gaacgccatc attgggcaac aactccaggc ccagcattta tcacatggac atggtctccc
     1261 cgtacctctg actccacacc cttcagggct ccagccccct gccattccac ccatcggtag
     1321 cagtgccggg cttctggccc tctccagtgc tctaggaggt cagtcccatc ttccaattaa
     1381 agatgagaag aagcaccatg acaatgatca ccaaagagac agagactcca tcaagagctc
     1441 ttcagtatcc ccatcagcca gtttccgagg tgctgagaag cacagaaact ccgcagacta
     1501 ctcctcagag agcaaaaagc agaaaactga agaaaaggaa attgcagctc gttatgacag
     1561 cgatggtgag aaaagtgatg acaacttggt ggttgacgtt tccaatgagg atccatcttc
     1621 ccctcgaggg agcccagcac attcccccag agagaatggc ctagacaaga cacgcctgct
     1681 caagaaagat gccccgatta gtccagcctc tattgcatct tccagcagta ctccctcctc
     1741 caaatccaaa gaacttagcc ttaatgaaaa atctactact cccgtctcaa agtccaatac
     1801 ccctactcca cgaactgatg cgcccacccc aggcagtaac tctactcccg gattgaggcc
     1861 tgtacctgga aaaccaccag gagttgaccc tttggcctca agcctaagga ccccaatggc
     1921 agtaccttgt ccatatccaa ctccatttgg gattgtgccc catgctggaa tgaacggaga
     1981 gctgaccagc cccggagcgg cctacgctgg gctccacaac atctcccctc agatgagcgc
     2041 agctgctgcc gccgccgctg ctgctgctgc ctatgggaga tcaccagtgg tgggatttga
     2101 tccacaccat cacatgcgtg tgccagcaat acctccaaac ctgacaggca ttccaggagg
     2161 aaaaccagca tactccttcc atgttagcgc agatggtcag atgcagcctg tcccttttcc
     2221 acccgacgcc ctcatcggac ctggaatccc ccggcatgct cgccagatca acaccctcaa
     2281 ccacggggag gtggtgtgcg cggtgaccat cagcaacccc acgagacacg tgtacacggg
     2341 tgggaagggc tgcgtcaagg tctgggacat cagccaccca ggcaataaga gtcctgtctc
     2401 ccagctcgac tgtctgaaca gggataacta catccgttcc tgcagattgc tccctgatgg
     2461 tcgcacccta attgttggag gggaagccag tactttgtcc atttgggacc tggcggctcc
     2521 aaccccacgc atcaaggcag agctgacatc ctcggccccc gcctgctatg ccctggccat
     2581 cagccccgat tccaaggtct gcttctcatg ctgcagcgac ggcaacatcg ctgtgtggga
     2641 tctgcacaac cagaccttgg tgaggcaatt ccagggccac acagatggag ccagctgtat
     2701 tgacatttct aatgatggca ccaagctctg gacaggtggt ttggacaaca cggtcaggtc
     2761 ctgggacctg cgcgaggggc ggcagctgca gcagcacgac ttcacctccc agatcttttc
     2821 tctgggctac tgcccaactg gagagtggct tgcagtgggg atggagaaca gcaatgtgga
     2881 agttttgcat gtcaccaagc cagacaaata ccaactacat cttcatgaga gctgtgtgct
     2941 gtcgctcaag tttgcccatt gtggcaaatg gtttgtaagc actggaaagg acaaccttct
     3001 gaatgcctgg agaacacctt atggggccag tatattccag tccaaagaat cctcatcggt
     3061 gcttagctgt gacatctccg tggacgacaa atacattgtc actggctctg gggataagaa
     3121 ggccacagtt tatgaagtta tttattaaag acaaatcttc atgcagactg gacttctcct
     3181 cctggtagca ctttgctctg tcatcctttt tgttcacccc catccccgca tctaaaacca
     3241 aggatttcag atactcattg cagttgtgga gtttaatccc ctttcttaac ctcacttccc
     3301 acttgctatt gaattgtgaa tagtcattaa aaacctgtga taccaaatct tcagctgtct
     3361 acttggaaga acatggaata agcatactta acagtgaaaa gaatctttaa ttatgtatta
     3421 tatctgtaat atatttattt tgtttaaaga aggctttcta acaatgactg actaaataaa
     3481 gctgtctgct cctgcattga taatgaaggt gcgttgtatt tgatacccct cccccccttt
     3541 ttttggcaaa ggaggggaaa ggaaggttta aaataattga tttaaaatgt cactaagtgt
     3601 agactgatga ctgtatagag atgtgaaatg tataattaca catggaagca atatgttgct
     3661 gtgttgttat taggtttttt ttgtttttgt tttctacatc ttttaaagac ttttggaaat
     3721 ttggctgaac aattagaaca caacaggcca actcatactc atttggatct atttagacaa
     3781 cgttaaccaa tatatctata gctttagatt atattcgata aaagtaattg gacttttttt
     3841 ctttttttga ctcgttgaca agtgtctttg taatatgttt ttagttccct ttttttgttg
     3901 tattataggc agatgaacaa attaaatttg gcctcaaaga gagaacttac tcccttctgg
     3961 atatttttgc cacatttctt tgcaaaagga gatatatata tctttagtca gttttgttgt
     4021 tatgagaaat tatgggttat tttgtggcat gctctttggg agctgcacag ttatggggag
     4081 gactcccact gctgtgcaag ttaagtcttt tacaaaacaa ggacagcaga ggagggtttg
     4141 cagagacctc cctctgaaaa acacaaagaa tggactctct cctgggatga ggacttgctt
     4201 tctttacctc cggttctttc catgtcttag ttggatgtcc ctgaaatgga cacaggctgt
     4261 gccattgtgc cagaaacatt gtgttatctt ttatgttgtt gttgttgctg ttaaactata
     4321 atatgtgact tcttttttta ttattttttg tttgaatgct ttaaaaatct tttaagtctg
     4381 tggatctgct gatgtacagt gcctttgctg ctatggatca aaatcaaaag aaccgtgtag
     4441 atatacttta ttgtataagt agaaaattac ttaatttcat actagaaatg gatggatgct
     4501 gcaagttgaa atggactgtc cattgacgtt cctaatgtgg tagcagaaaa aaaaaaatgg
     4561 tgtcttaagt gcttagtgtt tgatgtcatt aacagtttcg taaaactcta cagtgtagaa
     4621 agattttgat actaaactgt gcgttgtaca tagttctaat gcattgtatt gaccaccagt
     4681 acttctataa tggtagattg tttgtgaatt cagactttta agcattaaac ataaataact
     4741 tctagtatgc ttatttttct aattctttgt cttgatgaca ttagtttatt ttttatcttt
     4801 ggctgtgcca ctcctatata ttaaaaatgc ctagtttttt caagggagat tgttgttaaa
     4861 gtaaagtggt tttttttgtt gttaaa
//
