LOCUS       XM_005254623            5751 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens TLE family member 3, transcriptional
            corepressor (TLE3), transcript variant X5, mRNA.
ACCESSION   XM_005254623
VERSION     XM_005254623.5
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_005254623.4.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..5751
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     gene            1..5751
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /note="TLE family member 3, transcriptional corepressor;
                     Derived by automated computational analysis using gene
                     prediction method: Gnomon. Supporting evidence includes
                     similarity to: 3 mRNAs, 53 ESTs, 794 long SRA reads, 9
                     Proteins, and 100% coverage of the annotated genomic
                     feature by RNAseq alignments, including 105 samples with
                     support for all annotated introns"
                     /db_xref="GeneID:7090"
                     /db_xref="HGNC:HGNC:11839"
                     /db_xref="MIM:600190"
     CDS             1120..3444
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /codon_start=1
                     /product="transducin-like enhancer protein 3 isoform X5"
                     /protein_id="XP_005254680.1"
                     /db_xref="GeneID:7090"
                     /db_xref="HGNC:HGNC:11839"
                     /db_xref="MIM:600190"
                     /translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
                     VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
                     QVAQAVERAKQVTMTELNAIIGVRGLPNLPLTQQQLQAQHLSHATHGPPVQLPPHPSG
                     LQPPGIPPVTGSSSGLLALGALGSQAHLTVKDEKNHHELDHRERESSANNSVSPSESL
                     RASEKHRGSADYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAH
                     SPPENGLDKARSLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRN
                     DAPTPGTSTTPGLRSMPGKPPGMDPIASALRTPISITSSYAAPFAMMSHHEMNGSLTS
                     PGAYAGLHNIPPQMSAAAAAAAAAYGRSPMVGFDPHPPMRATGLPSSLASIPGGKPAY
                     SFHVSADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGK
                     GCVKIWDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASP
                     TPRIKAELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGAS
                     CIDISHDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMES
                     SNVEVLHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQS
                     KESSSVLSCDISADDKYIVTGSGDKKATVYEVIY"
ORIGIN      
        1 agtccctatt tggaactgct ctcgcggcag ttcagacctc gtgctcgtcc ccttcgcctg
       61 tctgtgtgtg gtatccgtag gtccggggca cttttttttt tggtgtgtgt gtgtgtgcgt
      121 gcgcgcgtgt gtgtgtgttg ggtgtgtgtg ttttgggggt ttgccggggc gcggagagga
      181 gagccgggcc gaggggaagg aaggaagccg tagagctccc cggtctcggg ctgcgtctcc
      241 cctccagcgc tctcctgcct gtgcgctccg acgcggcagc ggcggtggcg ctgagcgctc
      301 ctcggtgggg acgcggtgct caagctggga gcagcgagaa ccctttgcgg aggcttcccg
      361 tgcccgctgg acttaggatg ccagggcgtt tgatttgcac ctactgagcc cggagttcct
      421 ccccggccct gggaagggct tgcagcggcg gcggcggcgg cggcagcggc agtagcagac
      481 ggaacagcag gctctcctct ccgagggggg gcgtcgaagc gcccgcgccg ggctcccgcc
      541 ctcaccctcc ggcgctcctg cggccccaag ccaccacctc gtagcccgcc tccttcctct
      601 tctcgccgcg agccccaggc ccggacgcct ctaggatcgg acccgcgcgc cccggatgct
      661 tggggctgcc ccggcgcgcc cccctacagg cgcgacccgc tgagtgaccc ggagggggcc
      721 cgagctcgcc ccaggagggg cccccggcct cgggaccccg cgccggacct gctggggagc
      781 cgacgatgtc cgcgcagtcc caggcattga cgcgctcgac gcagcccagg gaaggcggcc
      841 ggccgctgcc cgccgagccc taggcgcaca aagcccgcgc ccgccgcccg gccccggcgc
      901 ccgccgacga ctttgccgcc tgctccgcgg ctctttgtct ccacttgggg cgggcgcccg
      961 actctgggat ttcgctgcga gaacgagctg ggggggccgg gggcgagctc tcggtttccc
     1021 ggccgccccc cgctcgggct cggctccccc ctcccccgca cctccccggc ccgggctctc
     1081 ggcgcttcca cgctctcgga atcacgaccc ctccctgcca tgtatccgca gggcagacat
     1141 ccggctcccc atcaacccgg gcagccggga tttaaattca cggtggctga gtcttgtgac
     1201 aggatcaaag acgaattcca gttcctgcaa gctcagtatc acagcctcaa agtggagtac
     1261 gacaagctgg caaacgagaa gacggagatg cagcgccatt atgtgatgta ctatgagatg
     1321 tcctatggct tgaacattga aatgcacaag cagacagaga ttgcgaagag actgaacaca
     1381 attttagcac agatcatgcc tttcctgtca caagagcacc agcagcaggt ggcgcaggca
     1441 gtggagcgcg ccaagcaggt caccatgacg gagctgaacg ccatcatcgg ggtacgtgga
     1501 ctccccaatc tgcctcttac ccagcagcag ctccaggcgc agcacctctc ccatgccaca
     1561 cacggccccc cggtccagtt gccaccccac ccgtcaggtc tccagcctcc aggaatcccc
     1621 ccagtgacag ggagcagctc cgggctgctg gcactgggcg ccctgggcag ccaggcccat
     1681 ctgacggtga aggatgagaa gaaccaccat gaactcgatc acagagagag agaatccagt
     1741 gcgaataact ctgtgtcacc ctcggaaagc ctccgggcca gtgagaagca ccggggctct
     1801 gcggactaca gcatggaagc caagaagcgg aaggcggagg agaaggacag cttgagccga
     1861 tacgacagtg atggagacaa gagtgatgat ctggtggtgg atgtttccaa tgaggacccc
     1921 gcaacgcccc gggtcagccc ggcacactcc cctcctgaaa atgggctgga caaggcccgt
     1981 agcctgaaaa aagatgcccc caccagccct gcctcggtgg cctcttccag tagcacacct
     2041 tcctccaaga ccaaagacct tggtcataac gacaaatcct ccacccctgg gctcaagtcc
     2101 aacacaccaa ccccaaggaa cgacgcccca actccaggca ccagcacgac cccagggctc
     2161 aggtcgatgc cgggtaaacc tccgggcatg gacccgatag cctcggctct gcgcacgccc
     2221 atctccatca ccagctccta tgcggcgccc ttcgccatga tgagccacca tgagatgaac
     2281 ggctccctca ccagtcctgg cgcctacgcc ggcctccaca acatcccacc ccagatgagc
     2341 gccgccgccg ctgctgcagc cgctgcctat ggccgatcgc caatggttgg ttttgaccct
     2401 caccccccga tgcgggccac aggcctcccc tcaagcctgg cctccattcc tggaggaaaa
     2461 ccagcgtact cattccatgt gagtgctgat gggcagatgc agcccgtgcc cttcccccac
     2521 gacgccctgg caggccccgg catcccgagg cacgcccggc agatcaacac actcagccac
     2581 ggggaggtgg tgtgtgccgt gaccatcagc aaccccacga ggcacgtcta cacaggtggc
     2641 aagggctgcg tgaagatctg ggacatcagc cagccaggca gcaagagccc catctcccag
     2701 ctggactgcc tgaacaggga caattacatc cgctcctgca agctgctccc tgatgggcgc
     2761 acgctcatcg tgggcggcga ggccagcacg ctcaccatct gggacctggc ctcgcccacg
     2821 ccccgcatca aggccgagct gacgtcctcg gctcccgcct gttatgccct ggccattagc
     2881 cctgacgcca aagtctgctt ctcctgctgc agcgatggga acattgctgt ctgggacctg
     2941 cacaaccaga ccctggtcag gcagttccag ggccacacag atggggccag ctgcatagac
     3001 atctcccatg atggcaccaa actgtggaca gggggcctgg acaacacggt gcgctcctgg
     3061 gacctgcggg agggccgaca gctacagcag catgacttca cttcccagat cttctcgctg
     3121 ggctactgcc ccactgggga gtggctggct gtgggcatgg agagcagcaa cgtggaggtg
     3181 ctgcaccaca ccaagcctga caagtaccag ctgcacctgc acgagagctg cgtgctctcc
     3241 ctcaagttcg cctactgcgg caagtggttc gtgagcactg ggaaagataa ccttctcaac
     3301 gcctggagga cgccttatgg agccagcata ttccagtcta aagaatcctc gtctgtcttg
     3361 agttgtgaca tttcagcgga tgacaaatac attgtaacag gctctggtga caagaaggcc
     3421 acagtttatg aggtcatcta ctaaacaaga actccagcag ggctgtcaaa ctctgggaga
     3481 aaccgactcg gctctgacag ggagaccccc aggcgagggg ccccgaggat ggcggaggat
     3541 gggccgcagg cagccgagcg ttcagggctg cgctccggcc ggctgagagg gcacgtgccc
     3601 cgtcacagtc tggactcctg ggcctggatt gatgtgtctc acagactcgg aagggttctg
     3661 ctcctcctcc tccccctgaa caatgctggc agttgctaca aatagattta ttggaggctt
     3721 atggctccgg ttcccccaca gacccgctca tgagtctctg tttgttcttc ccttttcttt
     3781 tgccctgtcc ctcaccttgg gtcgggggtg ctggagtgga ccacaatgtt gtgctggggg
     3841 atgggggggt ctctctttgc cgattgtgca gtgcacaaga tttgtgaaaa atgtaaataa
     3901 cagactccta ttgcggactg atcagtggga gaggaggccc cttcccaccg gaaactctga
     3961 gtgtgtattt cgcctgctgt atttgtaatc cactcgtggt ggtggctttt tttttttttt
     4021 ttttttaaat aaacagatgc tctcacctgg gaagaggaga cagggagggg aaccaattga
     4081 agaaagagga gaaaagtctt agagtgtgga aaaggcaacc aggttggccg taaggtgcct
     4141 gctggaatgc gtgtgcctcc acacgggtct gggcatccgg actgataacc agccggccag
     4201 actgagggat ggaaggcact gagatggggg cccgtccagg cggacacccg cagaaatgga
     4261 gctttctgtg gtctcttgca ctctggctgc ctcttgccct ctctgtgtct ctctttcttg
     4321 gtctctccct ctctcctcct cagcctggtc tttctctttg gtgcacactt agttattgtt
     4381 gtgagcaatg gaagttcaaa ggaactccct ctccagctct tctgaatctt gggacacagc
     4441 ctaaaaagga caaaaagtta gaagacagca tagcaactca gctcagggag ctaccagaga
     4501 aaaatagcaa ctgatgtggg tgcttttttt ttttttttaa tttgaataaa aagaattaga
     4561 agtgatgtcc ttttataaaa tgccttctcc cccttcccgc ctacagtctc ttcctctccc
     4621 cttagagggg ggaaagtgta taaacctaca gggttgtgag tctgaaaaga ggatccccct
     4681 cacccccacc ctgggcagag cagtgggggt tggggggtgg gagaggggga cacagatcct
     4741 ggcacactgt ggatatttct tgcagattgc agtctcttgt ggcccaaaca ggttaggtag
     4801 actatcgcct ctggcaggtg ccaccttttg gtaccaacat gttctgaggt gttaggattt
     4861 gggttgggtt ttttttgttt gttttttttt tccttttggt cttttttttt ttctcctttt
     4921 aaagaaaagc taaaggccgc tgtgagtcct ggtggcaggc tctccatgga tgtagcatat
     4981 cgaagataat ttttatactg catttttatg gattattttg taatgtgtga ttccgtctgc
     5041 tgaggaggtg ggaggggctc cagggaaagc cacccacctt cagtgaggtt gctccccagc
     5101 tgagcgcacc gggcatggga tgtggaggct ggcgacacac cctgtgcctc tccaaggctg
     5161 ggcgcgtggg gcgtccagag tctctctggg tctcagatgt ccatctgcca cctcttgtta
     5221 aggctctagc cagaagggag ggtgagggta gaagaaagtt attcccgaag aaaaaaagaa
     5281 tgaaaagtca ttgtactgaa ctgtttttat atttttaaaa gttactattt aaaggttggt
     5341 ttgattgttg cgtcttaatt gcctctcccc ccagtttgcc agtcccgccc cccgcccccc
     5401 gggaaaacag ccaggccact gttgctgtca cattctggag cctgggccag ggccatttcc
     5461 catcgatgtg agctcttctc atctcacagc attccctgcg ctgcttccac ccccttctcc
     5521 ccttccagat acccagcatc gcagcaggga tttcacaatc ccatactgtg tcgcctccca
     5581 tccaagcgcc agggagggtg gggggtagga gctaagactt cctctggaca gatgggcagg
     5641 gcagagttca ctgaggtgaa ggaagaccac aggttaacac caaagtattg tacagctgtc
     5701 aatgcaaaac ttttttggaa aaaaattaaa cgtaatgaac ttgaagcgaa a
//
