LOCUS       NM_020908               5709 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens TLE family member 3, transcriptional corepressor
            (TLE3), transcript variant 3, mRNA.
ACCESSION   NM_020908
VERSION     NM_020908.3
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5709)
  AUTHORS   Kalita,B., Sahu,S., Bharadwaj,A., Panneerselvam,L.,
            Martinez-Cebrian,G., Agarwal,M. and Mathew,S.J.
  TITLE     The Wnt-pathway corepressor TLE3 interacts with the histone
            methyltransferase KMT1A to inhibit differentiation in
            Rhabdomyosarcoma
  JOURNAL   Oncogene 43 (7), 524-538 (2024)
   PUBMED   38177411
  REMARK    GeneRIF: The Wnt-pathway corepressor TLE3 interacts with the
            histone methyltransferase KMT1A to inhibit differentiation in
            Rhabdomyosarcoma.
REFERENCE   2  (bases 1 to 5709)
  AUTHORS   Xu,Z., Feng,Y., Yan,Y., Jin,H., Chen,Y., Han,Y., Huang,S., Feng,F.,
            Fu,H., Yin,Y., Huang,Y., Wang,H. and Cheng,W.
  TITLE     HHEX suppresses advanced thyroid cancer by interacting with TLE3
  JOURNAL   Mol Cell Endocrinol 574, 111988 (2023)
   PUBMED   37302518
  REMARK    GeneRIF: HHEX suppresses advanced thyroid cancer by interacting
            with TLE3.
REFERENCE   3  (bases 1 to 5709)
  AUTHORS   Simeoni,F., Romero-Camarero,I., Camera,F., Amaral,F.M.R.,
            Sinclair,O.J., Papachristou,E.K., Spencer,G.J., Lie-A-Ling,M.,
            Lacaud,G., Wiseman,D.H., Carroll,J.S. and Somervaille,T.C.P.
  TITLE     Enhancer recruitment of transcription repressors RUNX1 and TLE3 by
            mis-expressed FOXC1 blocks differentiation in acute myeloid
            leukemia
  JOURNAL   Cell Rep 36 (12), 109725 (2021)
   PUBMED   34551306
  REMARK    GeneRIF: Enhancer recruitment of transcription repressors RUNX1 and
            TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid
            leukemia.
REFERENCE   4  (bases 1 to 5709)
  AUTHORS   Samimi,G., Ring,B.Z., Ross,D.T., Seitz,R.S., Sutherland,R.L.,
            O'Brien,P.M., Hacker,N.F. and Huh,W.K.
  TITLE     TLE3 expression is associated with sensitivity to taxane treatment
            in ovarian carcinoma
  JOURNAL   Cancer Epidemiol Biomarkers Prev 21 (2), 273-279 (2012)
   PUBMED   22194527
  REMARK    GeneRIF: High TLE3 expression predicts a favorable response to
            taxane containing chemotherapy regimens in ovarian carcinoma.
REFERENCE   5  (bases 1 to 5709)
  AUTHORS   Nakaya,H.I., Beckedorff,F.C., Baldini,M.L., Fachel,A.A., Reis,E.M.
            and Verjovski-Almeida,S.
  TITLE     Splice variants of TLE family genes and up-regulation of a TLE3
            isoform in prostate tumors
  JOURNAL   Biochem Biophys Res Commun 364 (4), 918-923 (2007)
   PUBMED   18273443
  REMARK    GeneRIF: results demonstrate that different isoforms of TLE genes
            are commonly transcribed in human tissues and suggest that TLE3
            could be involved in prostate cancer development
REFERENCE   6  (bases 1 to 5709)
  AUTHORS   Yao,J., Lai,E. and Stifani,S.
  TITLE     The winged-helix protein brain factor 1 interacts with groucho and
            hes proteins to repress transcription
  JOURNAL   Mol Cell Biol 21 (6), 1962-1972 (2001)
   PUBMED   11238932
REFERENCE   7  (bases 1 to 5709)
  AUTHORS   Wang,J.C., Waltner-Law,M., Yamada,K., Osawa,H., Stifani,S. and
            Granner,D.K.
  TITLE     Transducin-like enhancer of split proteins, the human homologs of
            Drosophila groucho, interact with hepatic nuclear factor 3beta
  JOURNAL   J Biol Chem 275 (24), 18418-18423 (2000)
   PUBMED   10748198
REFERENCE   8  (bases 1 to 5709)
  AUTHORS   Liu,Y., Dehni,G., Purcell,K.J., Sokolow,J., Carcangiu,M.L.,
            Artavanis-Tsakonas,S. and Stifani,S.
  TITLE     Epithelial expression and chromosomal location of human TLE genes:
            implications for notch signaling and neoplasia
  JOURNAL   Genomics 31 (1), 58-64 (1996)
   PUBMED   8808280
REFERENCE   9  (bases 1 to 5709)
  AUTHORS   Miyasaka,H., Choudhury,B.K., Hou,E.W. and Li,S.S.
  TITLE     Molecular cloning and expression of mouse and human cDNA encoding
            AES and ESG proteins with strong similarity to Drosophila enhancer
            of split groucho protein
  JOURNAL   Eur J Biochem 216 (1), 343-352 (1993)
   PUBMED   8365415
REFERENCE   10 (bases 1 to 5709)
  AUTHORS   Stifani,S., Blaumueller,C.M., Redhead,N.J., Hill,R.E. and
            Artavanis-Tsakonas,S.
  TITLE     Human homologs of a Drosophila Enhancer of split gene product
            define a novel family of nuclear proteins
  JOURNAL   Nat Genet 2 (2), 119-127 (1992)
   PUBMED   1303260
  REMARK    Erratum:[Nat Genet. 1992 Dec;2(4):343. doi: 10.1038/ng1292-343a..
            PMID: 1303292]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC043247.2, AC026583.10,
            AB046767.1, AC068327.14 and BM676381.1.
            
            On Jun 3, 2019 this sequence version replaced NM_020908.2.
            
            Summary: This gene encodes a transcriptional co-repressor protein
            that belongs to the transducin-like enhancer family of proteins.
            The members of this family function in the Notch signaling pathway
            that regulates determination of cell fate during development.
            Expression of this gene has been associated with a favorable
            outcome to chemotherapy with taxanes for ovarian carcinoma.
            Alternate splicing results in multiple transcript variants.
            Additional alternatively spliced transcript variants of this gene
            have been described, but their full-length nature is not known.
            [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (3) uses an alternate in-frame
            splice site in the 3' coding region compared to variant 1. The
            encoded isoform (c) is shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AB046767.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               BC043247.2         1-100
            101-101             AC026583.10        74811-74811         c
            102-1733            AB046767.1         84-1715
            1734-1734           AC068327.14        158739-158739       c
            1735-1844           AB046767.1         1717-1826
            1845-1845           AC068327.14        157559-157559       c
            1846-3983           AB046767.1         1828-3965
            3984-4851           AC068327.14        146758-147625       c
            4852-5222           AB046767.1         4833-5203
            5223-5238           AC068327.14        146371-146386       c
            5239-5326           BM676381.1         399-486             c
            5327-5470           AC068327.14        146139-146282       c
            5471-5709           BM676381.1         16-254              c
FEATURES             Location/Qualifiers
     source          1..5709
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q23"
     gene            1..5709
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /note="TLE family member 3, transcriptional corepressor"
                     /db_xref="GeneID:7090"
                     /db_xref="HGNC:HGNC:11839"
                     /db_xref="MIM:600190"
     exon            1..1143
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     CDS             1120..3402
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /note="isoform c is encoded by transcript variant 3;
                     transducin-like enhancer protein 3; enhancer of split
                     groucho 3; enhancer of split groucho-like protein 3;
                     transducin-like enhancer of split 3, homolog of Drosophila
                     E(sp1); transducin-like enhancer of split 3 (E(sp1)
                     homolog, Drosophila); transducin like enhancer of split 3"
                     /codon_start=1
                     /product="transducin-like enhancer protein 3 isoform c"
                     /protein_id="NP_065959.1"
                     /db_xref="CCDS:CCDS58375.1"
                     /db_xref="GeneID:7090"
                     /db_xref="HGNC:HGNC:11839"
                     /db_xref="MIM:600190"
                     /translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
                     VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
                     QVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVT
                     GSSSGLLALGALGSQAHLTVKDEKNHHELDHRERESSANNSVSPSESLRASEKHRGSA
                     DYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKA
                     RSLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTT
                     PGLRSMPASALRTPISITSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNIPPQMSAAAA
                     AAAAAYGRSPMVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVSADGQMQPVP
                     FPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKIWDISQPGSK
                     SPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIKAELTSSAPA
                     CYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDISHDGTKLWTG
                     GLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEVLHHTKPDKY
                     QLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISAD
                     DKYIVTGSGDKKATVYEVIY"
     exon            1144..1244
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1308
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1353
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1416
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1491
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1696
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1713
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1833
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1884
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2037
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2143
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            2144..2343
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            2344..2420
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            2421..2670
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            2671..2918
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            2919..3066
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            3067..3217
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            3218..3294
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            3295..5709
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3659..3664
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /note="hexamer: AATAGA"
     polyA_site      3698
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /note="major polyA site"
     polyA_site      5295
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
     regulatory      5692..5697
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /note="hexamer: AATGAA"
     polyA_site      5709
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
ORIGIN      
        1 agtccctatt tggaactgct ctcgcggcag ttcagacctc gtgctcgtcc ccttcgcctg
       61 tctgtgtgtg gtatccgtag gtccggggca cttttttttt tggtgtgtgt gtgtgtgcgt
      121 gcgcgcgtgt gtgtgtgttg ggtgtgtgtg ttttgggggt ttgccggggc gcggagagga
      181 gagccgggcc gaggggaagg aaggaagccg tagagctccc cggtctcggg ctgcgtctcc
      241 cctccagcgc tctcctgcct gtgcgctccg acgcggcagc ggcggtggcg ctgagcgctc
      301 ctcggtgggg acgcggtgct caagctggga gcagcgagaa ccctttgcgg aggcttcccg
      361 tgcccgctgg acttaggatg ccagggcgtt tgatttgcac ctactgagcc cggagttcct
      421 ccccggccct gggaagggct tgcagcggcg gcggcggcgg cggcagcggc agtagcagac
      481 ggaacagcag gctctcctct ccgagggggg gcgtcgaagc gcccgcgccg ggctcccgcc
      541 ctcaccctcc ggcgctcctg cggccccaag ccaccacctc gtagcccgcc tccttcctct
      601 tctcgccgcg agccccaggc ccggacgcct ctaggatcgg acccgcgcgc cccggatgct
      661 tggggctgcc ccggcgcgcc cccctacagg cgcgacccgc tgagtgaccc ggagggggcc
      721 cgagctcgcc ccaggagggg cccccggcct cgggaccccg cgccggacct gctggggagc
      781 cgacgatgtc cgcgcagtcc caggcattga cgcgctcgac gcagcccagg gaaggcggcc
      841 ggccgctgcc cgccgagccc taggcgcaca aagcccgcgc ccgccgcccg gccccggcgc
      901 ccgccgacga ctttgccgcc tgctccgcgg ctctttgtct ccacttgggg cgggcgcccg
      961 actctgggat ttcgctgcga gaacgagctg ggggggccgg gggcgagctc tcggtttccc
     1021 ggccgccccc cgctcgggct cggctccccc ctcccccgca cctccccggc ccgggctctc
     1081 ggcgcttcca cgctctcgga atcacgaccc ctccctgcca tgtatccgca gggcagacat
     1141 ccggctcccc atcaacccgg gcagccggga tttaaattca cggtggctga gtcttgtgac
     1201 aggatcaaag acgaattcca gttcctgcaa gctcagtatc acagcctcaa agtggagtac
     1261 gacaagctgg caaacgagaa gacggagatg cagcgccatt atgtgatgta ctatgagatg
     1321 tcctatggct tgaacattga aatgcacaag cagacagaga ttgcgaagag actgaacaca
     1381 attttagcac agatcatgcc tttcctgtca caagagcacc agcagcaggt ggcgcaggca
     1441 gtggagcgcg ccaagcaggt caccatgacg gagctgaacg ccatcatcgg gcagcagcag
     1501 ctccaggcgc agcacctctc ccatgccaca cacggccccc cggtccagtt gccaccccac
     1561 ccgtcaggtc tccagcctcc aggaatcccc ccagtgacag ggagcagctc cgggctgctg
     1621 gcactgggcg ccctgggcag ccaggcccat ctgacggtga aggatgagaa gaaccaccat
     1681 gaactcgatc acagagagag agaatccagt gcgaataact ctgtgtcacc ctcggaaagc
     1741 ctccgggcca gtgagaagca ccggggctct gcggactaca gcatggaagc caagaagcgg
     1801 aaggcggagg agaaggacag cttgagccga tacgacagtg atggagacaa gagtgatgat
     1861 ctggtggtgg atgtttccaa tgaggacccc gcaacgcccc gggtcagccc ggcacactcc
     1921 cctcctgaaa atgggctgga caaggcccgt agcctgaaaa aagatgcccc caccagccct
     1981 gcctcggtgg cctcttccag tagcacacct tcctccaaga ccaaagacct tggtcataac
     2041 gacaaatcct ccacccctgg gctcaagtcc aacacaccaa ccccaaggaa cgacgcccca
     2101 actccaggca ccagcacgac cccagggctc aggtcgatgc cggcctcggc tctgcgcacg
     2161 cccatctcca tcaccagctc ctatgcggcg cccttcgcca tgatgagcca ccatgagatg
     2221 aacggctccc tcaccagtcc tggcgcctac gccggcctcc acaacatccc accccagatg
     2281 agcgccgccg ccgctgctgc agccgctgcc tatggccgat cgccaatggt gagctttgga
     2341 gctgttggtt ttgaccctca ccccccgatg cgggccacag gcctcccctc aagcctggcc
     2401 tccattcctg gaggaaaacc agcgtactca ttccatgtga gtgctgatgg gcagatgcag
     2461 cccgtgccct tcccccacga cgccctggca ggccccggca tcccgaggca cgcccggcag
     2521 atcaacacac tcagccacgg ggaggtggtg tgtgccgtga ccatcagcaa ccccacgagg
     2581 cacgtctaca caggtggcaa gggctgcgtg aagatctggg acatcagcca gccaggcagc
     2641 aagagcccca tctcccagct ggactgcctg aacagggaca attacatccg ctcctgcaag
     2701 ctgctccctg atgggcgcac gctcatcgtg ggcggcgagg ccagcacgct caccatctgg
     2761 gacctggcct cgcccacgcc ccgcatcaag gccgagctga cgtcctcggc tcccgcctgt
     2821 tatgccctgg ccattagccc tgacgccaaa gtctgcttct cctgctgcag cgatgggaac
     2881 attgctgtct gggacctgca caaccagacc ctggtcaggc agttccaggg ccacacagat
     2941 ggggccagct gcatagacat ctcccatgat ggcaccaaac tgtggacagg gggcctggac
     3001 aacacggtgc gctcctggga cctgcgggag ggccgacagc tacagcagca tgacttcact
     3061 tcccagatct tctcgctggg ctactgcccc actggggagt ggctggctgt gggcatggag
     3121 agcagcaacg tggaggtgct gcaccacacc aagcctgaca agtaccagct gcacctgcac
     3181 gagagctgcg tgctctccct caagttcgcc tactgcggca agtggttcgt gagcactggg
     3241 aaagataacc ttctcaacgc ctggaggacg ccttatggag ccagcatatt ccagtctaaa
     3301 gaatcctcgt ctgtcttgag ttgtgacatt tcagcggatg acaaatacat tgtaacaggc
     3361 tctggtgaca agaaggccac agtttatgag gtcatctact aaacaagaac tccagcaggg
     3421 ctgtcaaact ctgggagaaa ccgactcggc tctgacaggg agacccccag gcgaggggcc
     3481 ccgaggatgg cggaggatgg gccgcaggca gccgagcgtt cagggctgcg ctccggccgg
     3541 ctgagagggc acgtgccccg tcacagtctg gactcctggg cctggattga tgtgtctcac
     3601 agactcggaa gggttctgct cctcctcctc cccctgaaca atgctggcag ttgctacaaa
     3661 tagatttatt ggaggcttat ggctccggtt cccccacaga cccgctcatg agtctctgtt
     3721 tgttcttccc ttttcttttg ccctgtccct caccttgggt cgggggtgct ggagtggacc
     3781 acaatgttgt gctgggggat gggggggtct ctctttgccg attgtgcagt gcacaagatt
     3841 tgtgaaaaat gtaaataaca gactcctatt gcggactgat cagtgggaga ggaggcccct
     3901 tcccaccgga aactctgagt gtgtatttcg cctgctgtat ttgtaatcca ctcgtggtgg
     3961 tggctttttt tttttttttt ttttaaataa acagatgctc tcacctggga agaggagaca
     4021 gggaggggaa ccaattgaag aaagaggaga aaagtcttag agtgtggaaa aggcaaccag
     4081 gttggccgta aggtgcctgc tggaatgcgt gtgcctccac acgggtctgg gcatccggac
     4141 tgataaccag ccggccagac tgagggatgg aaggcactga gatgggggcc cgtccaggcg
     4201 gacacccgca gaaatggagc tttctgtggt ctcttgcact ctggctgcct cttgccctct
     4261 ctgtgtctct ctttcttggt ctctccctct ctcctcctca gcctggtctt tctctttggt
     4321 gcacacttag ttattgttgt gagcaatgga agttcaaagg aactccctct ccagctcttc
     4381 tgaatcttgg gacacagcct aaaaaggaca aaaagttaga agacagcata gcaactcagc
     4441 tcagggagct accagagaaa aatagcaact gatgtgggtg cttttttttt ttttttaatt
     4501 tgaataaaaa gaattagaag tgatgtcctt ttataaaatg ccttctcccc cttcccgcct
     4561 acagtctctt cctctcccct tagagggggg aaagtgtata aacctacagg gttgtgagtc
     4621 tgaaaagagg atccccctca cccccaccct gggcagagca gtgggggttg gggggtggga
     4681 gagggggaca cagatcctgg cacactgtgg atatttcttg cagattgcag tctcttgtgg
     4741 cccaaacagg ttaggtagac tatcgcctct ggcaggtgcc accttttggt accaacatgt
     4801 tctgaggtgt taggatttgg gttgggtttt ttttgtttgt tttttttttc cttttggtct
     4861 tttttttttt ctccttttaa agaaaagcta aaggccgctg tgagtcctgg tggcaggctc
     4921 tccatggatg tagcatatcg aagataattt ttatactgca tttttatgga ttattttgta
     4981 atgtgtgatt ccgtctgctg aggaggtggg aggggctcca gggaaagcca cccaccttca
     5041 gtgaggttgc tccccagctg agcgcaccgg gcatgggatg tggaggctgg cgacacaccc
     5101 tgtgcctctc caaggctggg cgcgtggggc gtccagagtc tctctgggtc tcagatgtcc
     5161 atctgccacc tcttgttaag gctctagcca gaagggaggg tgagggtaga agaaagttat
     5221 tcccgaagaa aaaaagaatg aaaagtcatt gtactgaact gtttttatat ttttaaaagt
     5281 tactatttaa aggttggttt gattgttgcg tcttaattgc ctctcccccc agtttgccag
     5341 tcccgccccc cgccccccgg gaaaacagcc aggccactgt tgctgtcaca ttctggagcc
     5401 tgggccaggg ccatttccca tcgatgtgag ctcttctcat ctcacagcat tccctgcgct
     5461 gcttccaccc ccttctcccc ttccagatac ccagcatcgc agcagggatt tcacaatccc
     5521 atactgtgtc gcctcccatc caagcgccag ggagggtggg gggtaggagc taagacttcc
     5581 tctggacaga tgggcagggc agagttcact gaggtgaagg aagaccacag gttaacacca
     5641 aagtattgta cagctgtcaa tgcaaaactt ttttggaaaa aaattaaacg taatgaactt
     5701 gaagcgaaa
//
