LOCUS       NM_001105192            5736 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens TLE family member 3, transcriptional corepressor
            (TLE3), transcript variant 2, mRNA.
ACCESSION   NM_001105192
VERSION     NM_001105192.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5736)
  AUTHORS   Kalita,B., Sahu,S., Bharadwaj,A., Panneerselvam,L.,
            Martinez-Cebrian,G., Agarwal,M. and Mathew,S.J.
  TITLE     The Wnt-pathway corepressor TLE3 interacts with the histone
            methyltransferase KMT1A to inhibit differentiation in
            Rhabdomyosarcoma
  JOURNAL   Oncogene 43 (7), 524-538 (2024)
   PUBMED   38177411
  REMARK    GeneRIF: The Wnt-pathway corepressor TLE3 interacts with the
            histone methyltransferase KMT1A to inhibit differentiation in
            Rhabdomyosarcoma.
REFERENCE   2  (bases 1 to 5736)
  AUTHORS   Xu,Z., Feng,Y., Yan,Y., Jin,H., Chen,Y., Han,Y., Huang,S., Feng,F.,
            Fu,H., Yin,Y., Huang,Y., Wang,H. and Cheng,W.
  TITLE     HHEX suppresses advanced thyroid cancer by interacting with TLE3
  JOURNAL   Mol Cell Endocrinol 574, 111988 (2023)
   PUBMED   37302518
  REMARK    GeneRIF: HHEX suppresses advanced thyroid cancer by interacting
            with TLE3.
REFERENCE   3  (bases 1 to 5736)
  AUTHORS   Simeoni,F., Romero-Camarero,I., Camera,F., Amaral,F.M.R.,
            Sinclair,O.J., Papachristou,E.K., Spencer,G.J., Lie-A-Ling,M.,
            Lacaud,G., Wiseman,D.H., Carroll,J.S. and Somervaille,T.C.P.
  TITLE     Enhancer recruitment of transcription repressors RUNX1 and TLE3 by
            mis-expressed FOXC1 blocks differentiation in acute myeloid
            leukemia
  JOURNAL   Cell Rep 36 (12), 109725 (2021)
   PUBMED   34551306
  REMARK    GeneRIF: Enhancer recruitment of transcription repressors RUNX1 and
            TLE3 by mis-expressed FOXC1 blocks differentiation in acute myeloid
            leukemia.
REFERENCE   4  (bases 1 to 5736)
  AUTHORS   Samimi,G., Ring,B.Z., Ross,D.T., Seitz,R.S., Sutherland,R.L.,
            O'Brien,P.M., Hacker,N.F. and Huh,W.K.
  TITLE     TLE3 expression is associated with sensitivity to taxane treatment
            in ovarian carcinoma
  JOURNAL   Cancer Epidemiol Biomarkers Prev 21 (2), 273-279 (2012)
   PUBMED   22194527
  REMARK    GeneRIF: High TLE3 expression predicts a favorable response to
            taxane containing chemotherapy regimens in ovarian carcinoma.
REFERENCE   5  (bases 1 to 5736)
  AUTHORS   Nakaya,H.I., Beckedorff,F.C., Baldini,M.L., Fachel,A.A., Reis,E.M.
            and Verjovski-Almeida,S.
  TITLE     Splice variants of TLE family genes and up-regulation of a TLE3
            isoform in prostate tumors
  JOURNAL   Biochem Biophys Res Commun 364 (4), 918-923 (2007)
   PUBMED   18273443
  REMARK    GeneRIF: results demonstrate that different isoforms of TLE genes
            are commonly transcribed in human tissues and suggest that TLE3
            could be involved in prostate cancer development
REFERENCE   6  (bases 1 to 5736)
  AUTHORS   Yao,J., Lai,E. and Stifani,S.
  TITLE     The winged-helix protein brain factor 1 interacts with groucho and
            hes proteins to repress transcription
  JOURNAL   Mol Cell Biol 21 (6), 1962-1972 (2001)
   PUBMED   11238932
REFERENCE   7  (bases 1 to 5736)
  AUTHORS   Wang,J.C., Waltner-Law,M., Yamada,K., Osawa,H., Stifani,S. and
            Granner,D.K.
  TITLE     Transducin-like enhancer of split proteins, the human homologs of
            Drosophila groucho, interact with hepatic nuclear factor 3beta
  JOURNAL   J Biol Chem 275 (24), 18418-18423 (2000)
   PUBMED   10748198
REFERENCE   8  (bases 1 to 5736)
  AUTHORS   Liu,Y., Dehni,G., Purcell,K.J., Sokolow,J., Carcangiu,M.L.,
            Artavanis-Tsakonas,S. and Stifani,S.
  TITLE     Epithelial expression and chromosomal location of human TLE genes:
            implications for notch signaling and neoplasia
  JOURNAL   Genomics 31 (1), 58-64 (1996)
   PUBMED   8808280
REFERENCE   9  (bases 1 to 5736)
  AUTHORS   Miyasaka,H., Choudhury,B.K., Hou,E.W. and Li,S.S.
  TITLE     Molecular cloning and expression of mouse and human cDNA encoding
            AES and ESG proteins with strong similarity to Drosophila enhancer
            of split groucho protein
  JOURNAL   Eur J Biochem 216 (1), 343-352 (1993)
   PUBMED   8365415
REFERENCE   10 (bases 1 to 5736)
  AUTHORS   Stifani,S., Blaumueller,C.M., Redhead,N.J., Hill,R.E. and
            Artavanis-Tsakonas,S.
  TITLE     Human homologs of a Drosophila Enhancer of split gene product
            define a novel family of nuclear proteins
  JOURNAL   Nat Genet 2 (2), 119-127 (1992)
   PUBMED   1303260
  REMARK    Erratum:[Nat Genet. 1992 Dec;2(4):343. doi: 10.1038/ng1292-343a..
            PMID: 1303292]
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC043247.2, AC026583.10,
            AK315058.1, AC068327.14, AB046767.1 and BM676381.1.
            
            On Jun 2, 2019 this sequence version replaced NM_001105192.2.
            
            Summary: This gene encodes a transcriptional co-repressor protein
            that belongs to the transducin-like enhancer family of proteins.
            The members of this family function in the Notch signaling pathway
            that regulates determination of cell fate during development.
            Expression of this gene has been associated with a favorable
            outcome to chemotherapy with taxanes for ovarian carcinoma.
            Alternate splicing results in multiple transcript variants.
            Additional alternatively spliced transcript variants of this gene
            have been described, but their full-length nature is not known.
            [provided by RefSeq, Sep 2013].
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site in the coding region compared to variant 1. The encoded
            isoform (b) is shorter than isoform a.
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            RNAseq introns :: mixed sample support SAMEA1965299, SAMEA1966682
                              [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000451782.7/ ENSP00000394717.3
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-100               BC043247.2         1-100
            101-470             AC026583.10        74442-74811         c
            471-1068            BC043247.2         470-1067
            1069-1844           AK315058.1         397-1172
            1845-1845           AC068327.14        157559-157559       c
            1846-2798           AK315058.1         1174-2126
            2799-2799           AC068327.14        152694-152694       c
            2800-3032           AK315058.1         2128-2360
            3033-3033           AC068327.14        151397-151397       c
            3034-3429           AK315058.1         2362-2757
            3430-4010           AB046767.1         3385-3965
            4011-4878           AC068327.14        146758-147625       c
            4879-5249           AB046767.1         4833-5203
            5250-5265           AC068327.14        146371-146386       c
            5266-5353           BM676381.1         399-486             c
            5354-5497           AC068327.14        146139-146282       c
            5498-5736           BM676381.1         16-254              c
FEATURES             Location/Qualifiers
     source          1..5736
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q23"
     gene            1..5736
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /note="TLE family member 3, transcriptional corepressor"
                     /db_xref="GeneID:7090"
                     /db_xref="HGNC:HGNC:11839"
                     /db_xref="MIM:600190"
     exon            1..1143
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     CDS             1120..3429
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /note="isoform b is encoded by transcript variant 2;
                     transducin-like enhancer protein 3; enhancer of split
                     groucho 3; enhancer of split groucho-like protein 3;
                     transducin-like enhancer of split 3, homolog of Drosophila
                     E(sp1); transducin-like enhancer of split 3 (E(sp1)
                     homolog, Drosophila); transducin like enhancer of split 3"
                     /codon_start=1
                     /product="transducin-like enhancer protein 3 isoform b"
                     /protein_id="NP_001098662.1"
                     /db_xref="CCDS:CCDS45294.1"
                     /db_xref="GeneID:7090"
                     /db_xref="HGNC:HGNC:11839"
                     /db_xref="MIM:600190"
                     /translation="MYPQGRHPAPHQPGQPGFKFTVAESCDRIKDEFQFLQAQYHSLK
                     VEYDKLANEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTILAQIMPFLSQEHQQ
                     QVAQAVERAKQVTMTELNAIIGQQQLQAQHLSHATHGPPVQLPPHPSGLQPPGIPPVT
                     GSSSGLLALGALGSQAHLTVKDEKNHHELDHRERESSANNSVSPSESLRASEKHRGSA
                     DYSMEAKKRKAEEKDSLSRYDSDGDKSDDLVVDVSNEDPATPRVSPAHSPPENGLDKA
                     RSLKKDAPTSPASVASSSSTPSSKTKDLGHNDKSSTPGLKSNTPTPRNDAPTPGTSTT
                     PGLRSMPGKPPGMDPIASALRTPISITSSYAAPFAMMSHHEMNGSLTSPGAYAGLHNI
                     PPQMSAAAAAAAAAYGRSPMVSFGAVGFDPHPPMRATGLPSSLASIPGGKPAYSFHVS
                     ADGQMQPVPFPHDALAGPGIPRHARQINTLSHGEVVCAVTISNPTRHVYTGGKGCVKI
                     WDISQPGSKSPISQLDCLNRDNYIRSCKLLPDGRTLIVGGEASTLTIWDLASPTPRIK
                     AELTSSAPACYALAISPDAKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDIS
                     HDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVEV
                     LHHTKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESSS
                     VLSCDISADDKYIVTGSGDKKATVYEVIY"
     exon            1144..1244
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            1245..1308
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            1309..1353
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            1354..1416
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            1417..1491
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            1492..1696
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            1697..1713
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            1714..1833
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            1834..1884
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..2037
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            2038..2170
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            2171..2370
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2447
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            2448..2697
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            2698..2945
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            2946..3093
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            3094..3244
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            3245..3321
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     exon            3322..5736
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3686..3691
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /note="hexamer: AATAGA"
     polyA_site      3725
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /note="major polyA site"
     polyA_site      5322
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
     regulatory      5719..5724
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
                     /note="hexamer: AATGAA"
     polyA_site      5736
                     /gene="TLE3"
                     /gene_synonym="ESG; ESG3; GRG3; HsT18976"
ORIGIN      
        1 agtccctatt tggaactgct ctcgcggcag ttcagacctc gtgctcgtcc ccttcgcctg
       61 tctgtgtgtg gtatccgtag gtccggggca cttttttttt tggtgtgtgt gtgtgtgcgt
      121 gcgcgcgtgt gtgtgtgttg ggtgtgtgtg ttttgggggt ttgccggggc gcggagagga
      181 gagccgggcc gaggggaagg aaggaagccg tagagctccc cggtctcggg ctgcgtctcc
      241 cctccagcgc tctcctgcct gtgcgctccg acgcggcagc ggcggtggcg ctgagcgctc
      301 ctcggtgggg acgcggtgct caagctggga gcagcgagaa ccctttgcgg aggcttcccg
      361 tgcccgctgg acttaggatg ccagggcgtt tgatttgcac ctactgagcc cggagttcct
      421 ccccggccct gggaagggct tgcagcggcg gcggcggcgg cggcagcggc agtagcagac
      481 ggaacagcag gctctcctct ccgagggggg gcgtcgaagc gcccgcgccg ggctcccgcc
      541 ctcaccctcc ggcgctcctg cggccccaag ccaccacctc gtagcccgcc tccttcctct
      601 tctcgccgcg agccccaggc ccggacgcct ctaggatcgg acccgcgcgc cccggatgct
      661 tggggctgcc ccggcgcgcc cccctacagg cgcgacccgc tgagtgaccc ggagggggcc
      721 cgagctcgcc ccaggagggg cccccggcct cgggaccccg cgccggacct gctggggagc
      781 cgacgatgtc cgcgcagtcc caggcattga cgcgctcgac gcagcccagg gaaggcggcc
      841 ggccgctgcc cgccgagccc taggcgcaca aagcccgcgc ccgccgcccg gccccggcgc
      901 ccgccgacga ctttgccgcc tgctccgcgg ctctttgtct ccacttgggg cgggcgcccg
      961 actctgggat ttcgctgcga gaacgagctg ggggggccgg gggcgagctc tcggtttccc
     1021 ggccgccccc cgctcgggct cggctccccc ctcccccgca cctccccggc ccgggctctc
     1081 ggcgcttcca cgctctcgga atcacgaccc ctccctgcca tgtatccgca gggcagacat
     1141 ccggctcccc atcaacccgg gcagccggga tttaaattca cggtggctga gtcttgtgac
     1201 aggatcaaag acgaattcca gttcctgcaa gctcagtatc acagcctcaa agtggagtac
     1261 gacaagctgg caaacgagaa gacggagatg cagcgccatt atgtgatgta ctatgagatg
     1321 tcctatggct tgaacattga aatgcacaag cagacagaga ttgcgaagag actgaacaca
     1381 attttagcac agatcatgcc tttcctgtca caagagcacc agcagcaggt ggcgcaggca
     1441 gtggagcgcg ccaagcaggt caccatgacg gagctgaacg ccatcatcgg gcagcagcag
     1501 ctccaggcgc agcacctctc ccatgccaca cacggccccc cggtccagtt gccaccccac
     1561 ccgtcaggtc tccagcctcc aggaatcccc ccagtgacag ggagcagctc cgggctgctg
     1621 gcactgggcg ccctgggcag ccaggcccat ctgacggtga aggatgagaa gaaccaccat
     1681 gaactcgatc acagagagag agaatccagt gcgaataact ctgtgtcacc ctcggaaagc
     1741 ctccgggcca gtgagaagca ccggggctct gcggactaca gcatggaagc caagaagcgg
     1801 aaggcggagg agaaggacag cttgagccga tacgacagtg atggagacaa gagtgatgat
     1861 ctggtggtgg atgtttccaa tgaggacccc gcaacgcccc gggtcagccc ggcacactcc
     1921 cctcctgaaa atgggctgga caaggcccgt agcctgaaaa aagatgcccc caccagccct
     1981 gcctcggtgg cctcttccag tagcacacct tcctccaaga ccaaagacct tggtcataac
     2041 gacaaatcct ccacccctgg gctcaagtcc aacacaccaa ccccaaggaa cgacgcccca
     2101 actccaggca ccagcacgac cccagggctc aggtcgatgc cgggtaaacc tccgggcatg
     2161 gacccgatag cctcggctct gcgcacgccc atctccatca ccagctccta tgcggcgccc
     2221 ttcgccatga tgagccacca tgagatgaac ggctccctca ccagtcctgg cgcctacgcc
     2281 ggcctccaca acatcccacc ccagatgagc gccgccgccg ctgctgcagc cgctgcctat
     2341 ggccgatcgc caatggtgag ctttggagct gttggttttg accctcaccc cccgatgcgg
     2401 gccacaggcc tcccctcaag cctggcctcc attcctggag gaaaaccagc gtactcattc
     2461 catgtgagtg ctgatgggca gatgcagccc gtgcccttcc cccacgacgc cctggcaggc
     2521 cccggcatcc cgaggcacgc ccggcagatc aacacactca gccacgggga ggtggtgtgt
     2581 gccgtgacca tcagcaaccc cacgaggcac gtctacacag gtggcaaggg ctgcgtgaag
     2641 atctgggaca tcagccagcc aggcagcaag agccccatct cccagctgga ctgcctgaac
     2701 agggacaatt acatccgctc ctgcaagctg ctccctgatg ggcgcacgct catcgtgggc
     2761 ggcgaggcca gcacgctcac catctgggac ctggcctcgc ccacgccccg catcaaggcc
     2821 gagctgacgt cctcggctcc cgcctgttat gccctggcca ttagccctga cgccaaagtc
     2881 tgcttctcct gctgcagcga tgggaacatt gctgtctggg acctgcacaa ccagaccctg
     2941 gtcaggcagt tccagggcca cacagatggg gccagctgca tagacatctc ccatgatggc
     3001 accaaactgt ggacaggggg cctggacaac acggtgcgct cctgggacct gcgggagggc
     3061 cgacagctac agcagcatga cttcacttcc cagatcttct cgctgggcta ctgccccact
     3121 ggggagtggc tggctgtggg catggagagc agcaacgtgg aggtgctgca ccacaccaag
     3181 cctgacaagt accagctgca cctgcacgag agctgcgtgc tctccctcaa gttcgcctac
     3241 tgcggcaagt ggttcgtgag cactgggaaa gataaccttc tcaacgcctg gaggacgcct
     3301 tatggagcca gcatattcca gtctaaagaa tcctcgtctg tcttgagttg tgacatttca
     3361 gcggatgaca aatacattgt aacaggctct ggtgacaaga aggccacagt ttatgaggtc
     3421 atctactaaa caagaactcc agcagggctg tcaaactctg ggagaaaccg actcggctct
     3481 gacagggaga cccccaggcg aggggccccg aggatggcgg aggatgggcc gcaggcagcc
     3541 gagcgttcag ggctgcgctc cggccggctg agagggcacg tgccccgtca cagtctggac
     3601 tcctgggcct ggattgatgt gtctcacaga ctcggaaggg ttctgctcct cctcctcccc
     3661 ctgaacaatg ctggcagttg ctacaaatag atttattgga ggcttatggc tccggttccc
     3721 ccacagaccc gctcatgagt ctctgtttgt tcttcccttt tcttttgccc tgtccctcac
     3781 cttgggtcgg gggtgctgga gtggaccaca atgttgtgct gggggatggg ggggtctctc
     3841 tttgccgatt gtgcagtgca caagatttgt gaaaaatgta aataacagac tcctattgcg
     3901 gactgatcag tgggagagga ggccccttcc caccggaaac tctgagtgtg tatttcgcct
     3961 gctgtatttg taatccactc gtggtggtgg cttttttttt tttttttttt taaataaaca
     4021 gatgctctca cctgggaaga ggagacaggg aggggaacca attgaagaaa gaggagaaaa
     4081 gtcttagagt gtggaaaagg caaccaggtt ggccgtaagg tgcctgctgg aatgcgtgtg
     4141 cctccacacg ggtctgggca tccggactga taaccagccg gccagactga gggatggaag
     4201 gcactgagat gggggcccgt ccaggcggac acccgcagaa atggagcttt ctgtggtctc
     4261 ttgcactctg gctgcctctt gccctctctg tgtctctctt tcttggtctc tccctctctc
     4321 ctcctcagcc tggtctttct ctttggtgca cacttagtta ttgttgtgag caatggaagt
     4381 tcaaaggaac tccctctcca gctcttctga atcttgggac acagcctaaa aaggacaaaa
     4441 agttagaaga cagcatagca actcagctca gggagctacc agagaaaaat agcaactgat
     4501 gtgggtgctt tttttttttt tttaatttga ataaaaagaa ttagaagtga tgtcctttta
     4561 taaaatgcct tctccccctt cccgcctaca gtctcttcct ctccccttag aggggggaaa
     4621 gtgtataaac ctacagggtt gtgagtctga aaagaggatc cccctcaccc ccaccctggg
     4681 cagagcagtg ggggttgggg ggtgggagag ggggacacag atcctggcac actgtggata
     4741 tttcttgcag attgcagtct cttgtggccc aaacaggtta ggtagactat cgcctctggc
     4801 aggtgccacc ttttggtacc aacatgttct gaggtgttag gatttgggtt gggttttttt
     4861 tgtttgtttt ttttttcctt ttggtctttt tttttttctc cttttaaaga aaagctaaag
     4921 gccgctgtga gtcctggtgg caggctctcc atggatgtag catatcgaag ataattttta
     4981 tactgcattt ttatggatta ttttgtaatg tgtgattccg tctgctgagg aggtgggagg
     5041 ggctccaggg aaagccaccc accttcagtg aggttgctcc ccagctgagc gcaccgggca
     5101 tgggatgtgg aggctggcga cacaccctgt gcctctccaa ggctgggcgc gtggggcgtc
     5161 cagagtctct ctgggtctca gatgtccatc tgccacctct tgttaaggct ctagccagaa
     5221 gggagggtga gggtagaaga aagttattcc cgaagaaaaa aagaatgaaa agtcattgta
     5281 ctgaactgtt tttatatttt taaaagttac tatttaaagg ttggtttgat tgttgcgtct
     5341 taattgcctc tccccccagt ttgccagtcc cgccccccgc cccccgggaa aacagccagg
     5401 ccactgttgc tgtcacattc tggagcctgg gccagggcca tttcccatcg atgtgagctc
     5461 ttctcatctc acagcattcc ctgcgctgct tccaccccct tctccccttc cagataccca
     5521 gcatcgcagc agggatttca caatcccata ctgtgtcgcc tcccatccaa gcgccaggga
     5581 gggtgggggg taggagctaa gacttcctct ggacagatgg gcagggcaga gttcactgag
     5641 gtgaaggaag accacaggtt aacaccaaag tattgtacag ctgtcaatgc aaaacttttt
     5701 tggaaaaaaa ttaaacgtaa tgaacttgaa gcgaaa
//
