LOCUS       NM_003260               2812 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens TLE family member 2, transcriptional corepressor
            (TLE2), transcript variant 1, mRNA.
ACCESSION   NM_003260
VERSION     NM_003260.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2812)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   2  (bases 1 to 2812)
  AUTHORS   He,Z., Liu,Y., Liang,D., Wang,Z., Robertson,E.S. and Lan,K.
  TITLE     Cellular corepressor TLE2 inhibits replication-and-transcription-
            activator-mediated transactivation and lytic reactivation of
            Kaposi's sarcoma-associated herpesvirus
  JOURNAL   J Virol 84 (4), 2047-2062 (2010)
   PUBMED   19939918
  REMARK    GeneRIF: Immunofluorescence analysis showed that TLE2 and RTA were
            colocalized in the same nuclear compartment in KSHV-infected cells.
REFERENCE   3  (bases 1 to 2812)
  AUTHORS   Arce,L., Pate,K.T. and Waterman,M.L.
  TITLE     Groucho binds two conserved regions of LEF-1 for HDAC-dependent
            repression
  JOURNAL   BMC Cancer 9, 159 (2009)
   PUBMED   19460168
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2812)
  AUTHORS   Javed,A., Guo,B., Hiebert,S., Choi,J.Y., Green,J., Zhao,S.C.,
            Osborne,M.A., Stifani,S., Stein,J.L., Lian,J.B., van Wijnen,A.J.
            and Stein,G.S.
  TITLE     Groucho/TLE/R-esp proteins associate with the nuclear matrix and
            repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of
            tissue-specific gene transcription
  JOURNAL   J Cell Sci 113 (Pt 12), 2221-2231 (2000)
   PUBMED   10825294
REFERENCE   5  (bases 1 to 2812)
  AUTHORS   Grbavec,D., Lo,R., Liu,Y., Greenfield,A. and Stifani,S.
  TITLE     Groucho/transducin-like enhancer of split (TLE) family members
            interact with the yeast transcriptional co-repressor SSN6 and
            mammalian SSN6-related proteins: implications for evolutionary
            conservation of transcription repression mechanisms
  JOURNAL   Biochem J 337 (Pt 1) (Pt 1), 13-17 (1999)
   PUBMED   9854018
REFERENCE   6  (bases 1 to 2812)
  AUTHORS   Grbavec,D., Lo,R., Liu,Y. and Stifani,S.
  TITLE     Transducin-like Enhancer of split 2, a mammalian homologue of
            Drosophila Groucho, acts as a transcriptional repressor, interacts
            with Hairy/Enhancer of split proteins, and is expressed during
            neuronal development
  JOURNAL   Eur J Biochem 258 (2), 339-349 (1998)
   PUBMED   9874198
REFERENCE   7  (bases 1 to 2812)
  AUTHORS   Palaparti,A., Baratz,A. and Stifani,S.
  TITLE     The Groucho/transducin-like enhancer of split transcriptional
            repressors interact with the genetically defined amino-terminal
            silencing domain of histone H3
  JOURNAL   J Biol Chem 272 (42), 26604-26610 (1997)
   PUBMED   9334241
REFERENCE   8  (bases 1 to 2812)
  AUTHORS   Liu,Y., Dehni,G., Purcell,K.J., Sokolow,J., Carcangiu,M.L.,
            Artavanis-Tsakonas,S. and Stifani,S.
  TITLE     Epithelial expression and chromosomal location of human TLE genes:
            implications for notch signaling and neoplasia
  JOURNAL   Genomics 31 (1), 58-64 (1996)
   PUBMED   8808280
REFERENCE   9  (bases 1 to 2812)
  AUTHORS   Miyasaka,H., Choudhury,B.K., Hou,E.W. and Li,S.S.
  TITLE     Molecular cloning and expression of mouse and human cDNA encoding
            AES and ESG proteins with strong similarity to Drosophila enhancer
            of split groucho protein
  JOURNAL   Eur J Biochem 216 (1), 343-352 (1993)
   PUBMED   8365415
REFERENCE   10 (bases 1 to 2812)
  AUTHORS   Stifani,S., Blaumueller,C.M., Redhead,N.J., Hill,R.E. and
            Artavanis-Tsakonas,S.
  TITLE     Human homologs of a Drosophila Enhancer of split gene product
            define a novel family of nuclear proteins
  JOURNAL   Nat Genet 2 (2), 119-127 (1992)
   PUBMED   1303260
  REMARK    Erratum:[Nat Genet. 1992 Dec;2(4):343. doi: 10.1038/ng1292-343a..
            PMID: 1303292]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011549.7, AW262763.1 and BC017364.2.
            
            On Nov 22, 2018 this sequence version replaced NM_003260.4.
            
            Transcript Variant: This variant (1) uses an alternate in-frame
            splice site in the 5' coding region, compared to variant 4. It
            encodes isoform 1, which is shorter by an amino acid, compared to
            isoform 4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC017364.2, M99436.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262953.11/ ENSP00000262953.5
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-113               AC011549.7         21682-21794         c
            114-260             AW262763.1         1-147
            261-2812            BC017364.2         5-2556
FEATURES             Location/Qualifiers
     source          1..2812
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2812
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /note="TLE family member 2, transcriptional corepressor"
                     /db_xref="GeneID:7089"
                     /db_xref="HGNC:HGNC:11838"
                     /db_xref="MIM:601041"
     exon            1..400
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             377..2608
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /note="isoform 1 is encoded by transcript variant 1;
                     transducin-like enhancer of split 2, homolog of Drosophila
                     E(sp1); transducin-like enhancer protein 2; transducin
                     like enhancer of split 2; enhancer of split groucho-like
                     protein 2; transducin-like enhancer of split 2 (E(sp1)
                     homolog, Drosophila)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 2 isoform 1"
                     /protein_id="NP_003251.2"
                     /db_xref="CCDS:CCDS45911.1"
                     /db_xref="GeneID:7089"
                     /db_xref="HGNC:HGNC:11838"
                     /db_xref="MIM:601041"
                     /translation="MYPQGRHPTPLQSGQPFKFSILEICDRIKEEFQFLQAQYHSLKL
                     ECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEHQQQ
                     VLQAVERAKQVTVGELNSLIGQQLQPLSHHAPPVPLTPRPAGLVGGSATGLLALSGAL
                     AAQAQLAAAVKEDRAGVEAEGSRVERAPSRSASPSPPESLVEEERPSGPGGGGKQRAD
                     EKEPSGPYESDEDKSDYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLA
                     SSLGSPLPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPST
                     DSVALRSPLTLSSPFTTSFSLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVM
                     AFESHPHLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQ
                     LHTLAHGEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRS
                     CKLLPDGRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCC
                     SDGNIVVWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQL
                     QQHDFSSQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASC
                     GRWFVSTGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYE
                     VVY"
     exon            401..498
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            499..562
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            563..607
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            608..670
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            671..745
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            746..926
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            927..946
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            947..1054
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1055..1099
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1100..1249
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1250..1388
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1389..1549
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1550..1626
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1627..1876
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1877..2124
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2125..2272
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2273..2423
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2424..2500
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            2501..2812
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2793..2798
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /note="hexamer: AATAAA"
     polyA_site      2812
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /note="major polyA site"
ORIGIN      
        1 gccgagcccc gccggaggga ggcggctccg cgcggggccc gccgcccgcg ccgccgccac
       61 cgaaacccgg ccgcggcgcg cccgaccttc tgcgccggct gccgcggccg ccctcgccgc
      121 gctcccgccc cggccgctgc ccctgcccgc cccgctcgcc ccgcgcaccc caacccgggg
      181 aggggctccc acgaccccgg gcgcgcgcgc ttgggggcgc gccagggact ccagggtccc
      241 ttgccccgcg ccgcttctcc ctcctccctc tttcttcggg cagcctcccc accaccccac
      301 ttcagcctcc cccactcttg ccgcctccat atcatcaagc tctggtggcg cctggggggc
      361 ttttcggatc ggcaggatgt acccccaggg aaggcacccg accccgctcc agtccggcca
      421 gcccttcaag ttctcgatct tggagatctg cgaccgcatc aaagaagaat tccagtttct
      481 tcaggctcaa taccacagcc tcaagctaga atgtgagaag ctggccagcg agaagacgga
      541 aatgcagcga cattatgtca tgtattatga gatgtcgtac gggctcaaca ttgaaatgca
      601 taagcaggcg gagattgtga agcgtctgag cggtatctgc gctcagatta tccccttcct
      661 gacccaggag catcagcagc aggtgctcca ggccgtagaa cgcgccaagc aggtcaccgt
      721 gggggagctg aacagcctca tcgggcagca gctccagccg ctgtcccacc acgcaccccc
      781 tgtgcccctc accccccgcc cagccgggct ggtgggcggc agtgctacgg ggctgcttgc
      841 tctgtctgga gccctggctg cccaggctca gctggcggcg gctgtcaagg aggaccgtgc
      901 gggcgtggag gccgaggggt ccagagtgga gagagccccg agcaggagtg catctccctc
      961 gccccctgag agtctcgtgg aggaggagcg accgagtggc cctggtggtg gcgggaagca
     1021 gagagcagat gagaaggagc catcaggacc ttatgaaagc gacgaagaca agagtgatta
     1081 caatctggtg gtggacgagg accaaccctc agagcccccc agcccggcta ccaccccctg
     1141 cggaaaggta cccatctgca ttcctgcccg tcgggacctg gtggacagtc cagcctcctt
     1201 ggcctctagc cttggctcac cgctgcctag agccaaggag ctcatcctga atgaccttcc
     1261 cgccagcact cctgcctcca aatcctgtga ctcctccccg ccccaggacg cttccacccc
     1321 cgggcccagc tcggccagtc acctctgcca gcttgctgcc aagccagcac cttccacgga
     1381 cagcgtcgcc ctgaggagcc ccctgactct gtccagtccc ttcaccacgt ccttcagcct
     1441 gggctcccac agcactctca acggagacct ctccgtgccc agctcctacg tcagcctcca
     1501 cctgtccccc caggtcagca gctctgtggt gtacggacgc tcccccgtga tggcatttga
     1561 gtctcatccc catctccgag ggtcatccgt ctcttcctcc ctacccagca tccctggggg
     1621 aaagccggcc tactccttcc acgtgtctgc ggacgggcag atgcagccgg ttcccttccc
     1681 ctcggatgca ctggtaggcg cgggcatccc gcggcacgcc cggcagctgc acacgctggc
     1741 ccatggcgag gtggtctgcg cggtcaccat cagcggctcc acacagcatg tgtacacggg
     1801 cggcaagggc tgtgtgaagg tgtgggacgt gggccagcct ggggccaaga cgcccgtggc
     1861 ccagctcgac tgcctgaacc gagacaacta cattcgttcc tgcaagttgc tgccggatgg
     1921 ccggagtctg atcgtgggcg gtgaggccag caccttgtcc atttgggacc tggcggcgcc
     1981 caccccccgt atcaaggccg agctgacttc ctcagcccca gcctgctacg ccctggccgt
     2041 cagccccgac gccaaggttt gcttctcctg ctgcagcgat ggcaacattg tggtctggga
     2101 cctgcagaat cagactatgg tcaggcagtt ccagggccac acggacggcg ccagctgcat
     2161 tgatatttcc gattacggca ctcggctctg gacagggggc ctggacaaca cggtgcgctg
     2221 ctgggacctg cgggagggcc gccagctgca gcagcatgac ttcagctccc agattttctc
     2281 cctgggccac tgccctaacc aggactggct ggcggtcgga atggagagta gcaacgtgga
     2341 gatcctgcac gtccgcaagc cggagaaata ccagctgcac ctccacgaga gctgcgtgct
     2401 gtccctgaag tttgcctcct gcggacggtg gtttgtgagc accgggaagg acaacctgct
     2461 caacgcctgg aggacgccgt acggggccag cattttccag tccaaggagt cgtcctcagt
     2521 cctgagttgt gacatctcca gaaataacaa atacatcgtg acaggctcgg gggacaagaa
     2581 ggccaccgtg tatgaggtgg tctactgaga catgaccccc cttcctgtac ccgaagtcca
     2641 gactcccagg ggaatcagca gccaggacag acatcctagc agccgcctcc cagccctgcc
     2701 taggaaccgt acatcccatc tgctctctgg ccaacggctt cacaccttcc cctgctgcat
     2761 gtgggggccg atgggcaggg gacctcggtg gaaataaaat gtatctatca ca
//
