LOCUS       NM_001144762            2284 bp    mRNA    linear   PRI 10-FEB-2025
DEFINITION  Homo sapiens TLE family member 2, transcriptional corepressor
            (TLE2), transcript variant 3, mRNA.
ACCESSION   NM_001144762
VERSION     NM_001144762.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2284)
  AUTHORS   Bohm,D., Keller,K., Pieter,J., Boehm,N., Wolters,D., Siggelkow,W.,
            Lebrecht,A., Schmidt,M., Kolbl,H., Pfeiffer,N. and Grus,F.H.
  TITLE     Comparison of tear protein levels in breast cancer patients and
            healthy controls using a de novo proteomic approach
  JOURNAL   Oncol Rep 28 (2), 429-438 (2012)
   PUBMED   22664934
REFERENCE   2  (bases 1 to 2284)
  AUTHORS   He,Z., Liu,Y., Liang,D., Wang,Z., Robertson,E.S. and Lan,K.
  TITLE     Cellular corepressor TLE2 inhibits replication-and-transcription-
            activator-mediated transactivation and lytic reactivation of
            Kaposi's sarcoma-associated herpesvirus
  JOURNAL   J Virol 84 (4), 2047-2062 (2010)
   PUBMED   19939918
  REMARK    GeneRIF: Immunofluorescence analysis showed that TLE2 and RTA were
            colocalized in the same nuclear compartment in KSHV-infected cells.
REFERENCE   3  (bases 1 to 2284)
  AUTHORS   Arce,L., Pate,K.T. and Waterman,M.L.
  TITLE     Groucho binds two conserved regions of LEF-1 for HDAC-dependent
            repression
  JOURNAL   BMC Cancer 9, 159 (2009)
   PUBMED   19460168
  REMARK    Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2284)
  AUTHORS   Javed,A., Guo,B., Hiebert,S., Choi,J.Y., Green,J., Zhao,S.C.,
            Osborne,M.A., Stifani,S., Stein,J.L., Lian,J.B., van Wijnen,A.J.
            and Stein,G.S.
  TITLE     Groucho/TLE/R-esp proteins associate with the nuclear matrix and
            repress RUNX (CBF(alpha)/AML/PEBP2(alpha)) dependent activation of
            tissue-specific gene transcription
  JOURNAL   J Cell Sci 113 (Pt 12), 2221-2231 (2000)
   PUBMED   10825294
REFERENCE   5  (bases 1 to 2284)
  AUTHORS   Grbavec,D., Lo,R., Liu,Y., Greenfield,A. and Stifani,S.
  TITLE     Groucho/transducin-like enhancer of split (TLE) family members
            interact with the yeast transcriptional co-repressor SSN6 and
            mammalian SSN6-related proteins: implications for evolutionary
            conservation of transcription repression mechanisms
  JOURNAL   Biochem J 337 (Pt 1) (Pt 1), 13-17 (1999)
   PUBMED   9854018
REFERENCE   6  (bases 1 to 2284)
  AUTHORS   Grbavec,D., Lo,R., Liu,Y. and Stifani,S.
  TITLE     Transducin-like Enhancer of split 2, a mammalian homologue of
            Drosophila Groucho, acts as a transcriptional repressor, interacts
            with Hairy/Enhancer of split proteins, and is expressed during
            neuronal development
  JOURNAL   Eur J Biochem 258 (2), 339-349 (1998)
   PUBMED   9874198
REFERENCE   7  (bases 1 to 2284)
  AUTHORS   Palaparti,A., Baratz,A. and Stifani,S.
  TITLE     The Groucho/transducin-like enhancer of split transcriptional
            repressors interact with the genetically defined amino-terminal
            silencing domain of histone H3
  JOURNAL   J Biol Chem 272 (42), 26604-26610 (1997)
   PUBMED   9334241
REFERENCE   8  (bases 1 to 2284)
  AUTHORS   Liu,Y., Dehni,G., Purcell,K.J., Sokolow,J., Carcangiu,M.L.,
            Artavanis-Tsakonas,S. and Stifani,S.
  TITLE     Epithelial expression and chromosomal location of human TLE genes:
            implications for notch signaling and neoplasia
  JOURNAL   Genomics 31 (1), 58-64 (1996)
   PUBMED   8808280
REFERENCE   9  (bases 1 to 2284)
  AUTHORS   Miyasaka,H., Choudhury,B.K., Hou,E.W. and Li,S.S.
  TITLE     Molecular cloning and expression of mouse and human cDNA encoding
            AES and ESG proteins with strong similarity to Drosophila enhancer
            of split groucho protein
  JOURNAL   Eur J Biochem 216 (1), 343-352 (1993)
   PUBMED   8365415
REFERENCE   10 (bases 1 to 2284)
  AUTHORS   Stifani,S., Blaumueller,C.M., Redhead,N.J., Hill,R.E. and
            Artavanis-Tsakonas,S.
  TITLE     Human homologs of a Drosophila Enhancer of split gene product
            define a novel family of nuclear proteins
  JOURNAL   Nat Genet 2 (2), 119-127 (1992)
   PUBMED   1303260
  REMARK    Erratum:[Nat Genet. 1992 Dec;2(4):343. doi: 10.1038/ng1292-343a..
            PMID: 1303292]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011549.7, AK293407.1 and BC017364.2.
            
            On Aug 13, 2020 this sequence version replaced NM_001144762.1.
            
            Transcript Variant: This variant (3) differs in the 5' UTR and has
            multiple coding region differences compared to variant 4. This
            results in a shorter isoform (2) with a shorter N-terminus compared
            to isoform 4.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK293407.1 [ECO:0000332]
            RNAseq introns              :: partial sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0000350]
            ##Evidence-Data-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-8                 AC011549.7         22129-22136         c
            9-64                AK293407.1         1-56
            65-988              AK293407.1         59-982
            989-2284            BC017364.2         1261-2556
FEATURES             Location/Qualifiers
     source          1..2284
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..2284
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /note="TLE family member 2, transcriptional corepressor"
                     /db_xref="GeneID:7089"
                     /db_xref="HGNC:HGNC:11838"
                     /db_xref="MIM:601041"
     exon            1..73
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            74..171
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            172..235
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     CDS             215..2080
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /note="isoform 3 is encoded by transcript variant 3;
                     transducin-like enhancer of split 2, homolog of Drosophila
                     E(sp1); transducin-like enhancer protein 2; transducin
                     like enhancer of split 2; enhancer of split groucho-like
                     protein 2; transducin-like enhancer of split 2 (E(sp1)
                     homolog, Drosophila)"
                     /codon_start=1
                     /product="transducin-like enhancer protein 2 isoform 3"
                     /protein_id="NP_001138234.1"
                     /db_xref="CCDS:CCDS45912.1"
                     /db_xref="GeneID:7089"
                     /db_xref="HGNC:HGNC:11838"
                     /db_xref="MIM:601041"
                     /translation="MQRHYVMYYEMSYGLNIEMHKQAEIVKRLSGICAQIIPFLTQEH
                     QQQVLQAVERAKQVTVGELNSLIGSASPSPPESLVEEERPSGPGGGGKQRADEKEPSG
                     PYESDEDKSDYNLVVDEDQPSEPPSPATTPCGKVPICIPARRDLVDSPASLASSLGSP
                     LPRAKELILNDLPASTPASKSCDSSPPQDASTPGPSSASHLCQLAAKPAPSTDSVALR
                     SPLTLSSPFTTSFSLGSHSTLNGDLSVPSSYVSLHLSPQVSSSVVYGRSPVMAFESHP
                     HLRGSSVSSSLPSIPGGKPAYSFHVSADGQMQPVPFPSDALVGAGIPRHARQLHTLAH
                     GEVVCAVTISGSTQHVYTGGKGCVKVWDVGQPGAKTPVAQLDCLNRDNYIRSCKLLPD
                     GRSLIVGGEASTLSIWDLAAPTPRIKAELTSSAPACYALAVSPDAKVCFSCCSDGNIV
                     VWDLQNQTMVRQFQGHTDGASCIDISDYGTRLWTGGLDNTVRCWDLREGRQLQQHDFS
                     SQIFSLGHCPNQDWLAVGMESSNVEILHVRKPEKYQLHLHESCVLSLKFASCGRWFVS
                     TGKDNLLNAWRTPYGASIFQSKESSSVLSCDISRNNKYIVTGSGDKKATVYEVVY"
     exon            236..280
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            281..343
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            344..418
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            419..526
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            527..571
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            572..721
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            722..860
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            861..1021
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1022..1098
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1099..1348
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1349..1596
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1597..1744
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1745..1895
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1896..1972
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     exon            1973..2284
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2265..2270
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /note="hexamer: AATAAA"
     polyA_site      2284
                     /gene="TLE2"
                     /gene_synonym="ESG; ESG2; GRG2"
                     /note="major polyA site"
ORIGIN      
        1 acttgctcag aaaagccatt tccgactcca gactggtccc cgctccccgc aagccccccc
       61 ccccgctccc acgaccccgc tccagtccgg ccagcccttc aagttctcga tcttggagat
      121 ctgcgaccgc atcaaagaag aattccagtt tcttcaggct caataccaca gcctcaagct
      181 agaatgtgag aagctggcca gcgagaagac ggaaatgcag cgacattatg tcatgtatta
      241 tgagatgtcg tacgggctca acattgaaat gcataagcag gcggagattg tgaagcgtct
      301 gagcggtatc tgcgctcaga ttatcccctt cctgacccag gagcatcagc agcaggtgct
      361 ccaggccgta gaacgcgcca agcaggtcac cgtgggggag ctgaacagcc tcatcgggag
      421 tgcatctccc tcgccccctg agagtctcgt ggaggaggag cgaccgagtg gccctggtgg
      481 tggcgggaag cagagagcag atgagaagga gccatcagga ccttatgaaa gcgacgaaga
      541 caagagtgat tacaatctgg tggtggacga ggaccaaccc tcagagcccc ccagcccggc
      601 taccaccccc tgcggaaagg tacccatctg cattcctgcc cgtcgggacc tggtggacag
      661 tccagcctcc ttggcctcta gccttggctc accgctgcct agagccaagg agctcatcct
      721 gaatgacctt cccgccagca ctcctgcctc caaatcctgt gactcctccc cgccccagga
      781 cgcttccacc cccgggccca gctcggccag tcacctctgc cagcttgctg ccaagccagc
      841 accttccacg gacagcgtcg ccctgaggag ccccctgact ctgtccagtc ccttcaccac
      901 gtccttcagc ctgggctccc acagcactct caacggagac ctctccgtgc ccagctccta
      961 cgtcagcctc cacctgtccc cccaggtcag cagctctgtg gtgtacggac gctcccccgt
     1021 gatggcattt gagtctcatc cccatctccg agggtcatcc gtctcttcct ccctacccag
     1081 catccctggg ggaaagccgg cctactcctt ccacgtgtct gcggacgggc agatgcagcc
     1141 ggttcccttc ccctcggatg cactggtagg cgcgggcatc ccgcggcacg cccggcagct
     1201 gcacacgctg gcccatggcg aggtggtctg cgcggtcacc atcagcggct ccacacagca
     1261 tgtgtacacg ggcggcaagg gctgtgtgaa ggtgtgggac gtgggccagc ctggggccaa
     1321 gacgcccgtg gcccagctcg actgcctgaa ccgagacaac tacattcgtt cctgcaagtt
     1381 gctgccggat ggccggagtc tgatcgtggg cggtgaggcc agcaccttgt ccatttggga
     1441 cctggcggcg cccacccccc gtatcaaggc cgagctgact tcctcagccc cagcctgcta
     1501 cgccctggcc gtcagccccg acgccaaggt ttgcttctcc tgctgcagcg atggcaacat
     1561 tgtggtctgg gacctgcaga atcagactat ggtcaggcag ttccagggcc acacggacgg
     1621 cgccagctgc attgatattt ccgattacgg cactcggctc tggacagggg gcctggacaa
     1681 cacggtgcgc tgctgggacc tgcgggaggg ccgccagctg cagcagcatg acttcagctc
     1741 ccagattttc tccctgggcc actgccctaa ccaggactgg ctggcggtcg gaatggagag
     1801 tagcaacgtg gagatcctgc acgtccgcaa gccggagaaa taccagctgc acctccacga
     1861 gagctgcgtg ctgtccctga agtttgcctc ctgcggacgg tggtttgtga gcaccgggaa
     1921 ggacaacctg ctcaacgcct ggaggacgcc gtacggggcc agcattttcc agtccaagga
     1981 gtcgtcctca gtcctgagtt gtgacatctc cagaaataac aaatacatcg tgacaggctc
     2041 gggggacaag aaggccaccg tgtatgaggt ggtctactga gacatgaccc cccttcctgt
     2101 acccgaagtc cagactccca ggggaatcag cagccaggac agacatccta gcagccgcct
     2161 cccagccctg cctaggaacc gtacatccca tctgctctct ggccaacggc ttcacacctt
     2221 cccctgctgc atgtgggggc cgatgggcag gggacctcgg tggaaataaa atgtatctat
     2281 caca
//
