LOCUS       NM_005077               4135 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens TLE family member 1, transcriptional corepressor
            (TLE1), transcript variant 2, mRNA.
ACCESSION   NM_005077
VERSION     NM_005077.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 4135)
  AUTHORS   Xue,L., Hu,M., Zhu,Q., Li,Y., Zhou,G., Zhang,X., Zhou,Y., Zhang,J.
            and Ding,P.
  TITLE     GRg1 inhibits the TLR4/NF-kB signaling pathway by upregulating
            miR-216a-5p to reduce growth factors and inflammatory cytokines in
            DR
  JOURNAL   Mol Biol Rep 50 (11), 9379-9394 (2023)
   PUBMED   37819496
  REMARK    GeneRIF: GRg1 inhibits the TLR4/NF-kB signaling pathway by
            upregulating miR-216a-5p to reduce growth factors and inflammatory
            cytokines in DR.
REFERENCE   2  (bases 1 to 4135)
  AUTHORS   Hasbay,B. and kayaselCuk,F.
  TITLE     Expression of TLE-1 in Gastrointestinal Stromal Tumour and Its
            Relationship to Clinicopathological Parameters
  JOURNAL   J Coll Physicians Surg Pak 33 (3), 286-291 (2023)
   PUBMED   36945158
  REMARK    GeneRIF: Expression of TLE-1 in Gastrointestinal Stromal Tumour and
            Its Relationship to Clinicopathological Parameters.
REFERENCE   3  (bases 1 to 4135)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 4135)
  AUTHORS   Aref,S., El-Ghonemy,M.S., Atia,D.M., Elbaiomy,M.M.,
            Abdelsalam,S.A., Tawfik,A. and El-Sebaie,A.
  TITLE     Prognostic Value of TLE1 Gene Expression in Patients with T-cell
            Acute Lymphoblastic Leukemia
  JOURNAL   Asian Pac J Cancer Prev 22 (5), 1653-1658 (2021)
   PUBMED   34048198
  REMARK    GeneRIF: Prognostic Value of TLE1 Gene Expression in Patients with
            T-cell Acute Lymphoblastic Leukemia.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 4135)
  AUTHORS   Sivakoti,S., Uppin,S.G., Uppin,M.S., Tara,R.P., Prayaga,A.K. and
            Challa,S.
  TITLE     Tissue microarray based immunohistochemical study of TLE1 in
            synovial sarcoma and its histologic mimics
  JOURNAL   Indian J Pathol Microbiol 64 (2), 310-315 (2021)
   PUBMED   33851625
  REMARK    GeneRIF: Tissue microarray based immunohistochemical study of TLE1
            in synovial sarcoma and its histologic mimics.
REFERENCE   6  (bases 1 to 4135)
  AUTHORS   Husain,J., Lo,R., Grbavec,D. and Stifani,S.
  TITLE     Affinity for the nuclear compartment and expression during cell
            differentiation implicate phosphorylated Groucho/TLE1 forms of
            higher molecular mass in nuclear functions
  JOURNAL   Biochem J 317 (Pt 2) (Pt 2), 523-531 (1996)
   PUBMED   8713081
REFERENCE   7  (bases 1 to 4135)
  AUTHORS   Grbavec,D. and Stifani,S.
  TITLE     Molecular interaction between TLE1 and the carboxyl-terminal domain
            of HES-1 containing the WRPW motif
  JOURNAL   Biochem Biophys Res Commun 223 (3), 701-705 (1996)
   PUBMED   8687460
REFERENCE   8  (bases 1 to 4135)
  AUTHORS   Liu,Y., Dehni,G., Purcell,K.J., Sokolow,J., Carcangiu,M.L.,
            Artavanis-Tsakonas,S. and Stifani,S.
  TITLE     Epithelial expression and chromosomal location of human TLE genes:
            implications for notch signaling and neoplasia
  JOURNAL   Genomics 31 (1), 58-64 (1996)
   PUBMED   8808280
REFERENCE   9  (bases 1 to 4135)
  AUTHORS   Miyasaka,H., Choudhury,B.K., Hou,E.W. and Li,S.S.
  TITLE     Molecular cloning and expression of mouse and human cDNA encoding
            AES and ESG proteins with strong similarity to Drosophila enhancer
            of split groucho protein
  JOURNAL   Eur J Biochem 216 (1), 343-352 (1993)
   PUBMED   8365415
REFERENCE   10 (bases 1 to 4135)
  AUTHORS   Stifani,S., Blaumueller,C.M., Redhead,N.J., Hill,R.E. and
            Artavanis-Tsakonas,S.
  TITLE     Human homologs of a Drosophila Enhancer of split gene product
            define a novel family of nuclear proteins
  JOURNAL   Nat Genet 2 (2), 119-127 (1992)
   PUBMED   1303260
  REMARK    Erratum:[Nat Genet. 1992 Dec;2(4):343. doi: 10.1038/ng1292-343a..
            PMID: 1303292]
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AL365190.16, AB209854.1, BC010100.2 and DB211613.1.
            
            On Nov 23, 2018 this sequence version replaced NM_005077.4.
            
            Transcript Variant: This variant (2) uses an alternate in-frame
            splice site compared to variant 1. The encoded isoform (2) is
            shorter than isoform 1.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010100.2, SRR1660807.122192.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000376499.8/ ENSP00000365682.3
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                AL365190.16        63199-63210         c
            13-866              AB209854.1         1-854
            867-1660            BC010100.2         1-794
            1661-1661           DB211613.1         222-222
            1662-4135           BC010100.2         796-3269
FEATURES             Location/Qualifiers
     source          1..4135
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
                     /map="9q21.32"
     gene            1..4135
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /note="TLE family member 1, transcriptional corepressor"
                     /db_xref="GeneID:7088"
                     /db_xref="HGNC:HGNC:11837"
                     /db_xref="MIM:600189"
     exon            1..1331
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     CDS             1308..3620
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /note="isoform 2 is encoded by transcript variant 2;
                     transducin-like enhancer protein 1; enhancer of split
                     groucho-like protein 1; transducin-like enhancer of split
                     1 (E(sp1) homolog, Drosophila); transducin like enhancer
                     of split 1"
                     /codon_start=1
                     /product="transducin-like enhancer protein 1 isoform 2"
                     /protein_id="NP_005068.2"
                     /db_xref="CCDS:CCDS6661.1"
                     /db_xref="GeneID:7088"
                     /db_xref="HGNC:HGNC:11837"
                     /db_xref="MIM:600189"
                     /translation="MFPQSRHPTPHQAAGQPFKFTIPESLDRIKEEFQFLQAQYHSLK
                     LECEKLASEKTEMQRHYVMYYEMSYGLNIEMHKQTEIAKRLNTICAQVIPFLSQEHQQ
                     QVAQAVERAKQVTMAELNAIIGQQQLQAQHLSHGHGPPVPLTPHPSGLQPPGIPPLGG
                     SAGLLALSSALSGQSHLAIKDDKKHHDAEHHRDREPGTSNSLLVPDSLRGTDKRRNGP
                     EFSNDIKKRKVDDKDSSHYDSDGDKSDDNLVVDVSNEDPSSPRASPAHSPRENGIDKN
                     RLLKKDASSSPASTASSASSTSLKSKEMSLHEKASTPVLKSSTPTPRSDMPTPGTSAT
                     PGLRPGLGKPPAIDPLVNQAAAGLRTPLAVPGPYPAPFGMVPHAGMNGELTSPGAAYA
                     SLHNMSPQMSAAAAAAAVVAYGRSPMVGFDPPPHMRVPTIPPNLAGIPGGKPAYSFHV
                     TADGQMQPVPFPPDALIGPGIPRHARQINTLNHGEVVCAVTISNPTRHVYTGGKGCVK
                     VWDISHPGNKSPVSQLDCLNRDNYIRSCKLLPDGCTLIVGGEASTLSIWDLAAPTPRI
                     KAELTSSAPACYALAISPDSKVCFSCCSDGNIAVWDLHNQTLVRQFQGHTDGASCIDI
                     SNDGTKLWTGGLDNTVRSWDLREGRQLQQHDFTSQIFSLGYCPTGEWLAVGMESSNVE
                     VLHVNKPDKYQLHLHESCVLSLKFAYCGKWFVSTGKDNLLNAWRTPYGASIFQSKESS
                     SVLSCDISVDDKYIVTGSGDKKATVYEVIY"
     exon            1332..1432
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1433..1496
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1497..1541
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1542..1604
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1605..1679
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1680..1884
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1885..1901
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            1902..2018
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2019..2072
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2073..2225
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2226..2370
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2371..2561
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2562..2638
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2639..2888
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            2889..3136
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3137..3284
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3285..3435
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3436..3512
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     exon            3513..4135
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4113..4118
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /note="hexamer: AGTAAA"
     polyA_site      4135
                     /gene="TLE1"
                     /gene_synonym="ESG; ESG1; GRG1; TLE-1"
                     /note="major polyA site"
ORIGIN      
        1 aatgtaagcg gcgcgagagg cgcgggcggc ggcggcggtg ggagcggcgg ctgcagaagc
       61 agcagcagca gaaacagcgg cgggtactct gtgccccgcg tcccggaggc agccgactgc
      121 gccaccccac cctcgcacgg ccgggcggga cccgcgccac cagcccggac ctccgtcgtc
      181 ccgcggcgac caaaaccccc gctggcccca ccgctgtgac tactctggac tcgcccgcag
      241 agtttgcccg ccggggaggg tggccgattg gcggagcgca ctcctgctgt tttccccacc
      301 atctcgtgga tgtcgtccct cgggtggtga gagaactttg cagtgggctg gagcgccctt
      361 tgcggagaag cacacgaagg tgaaggaagg aaagaaagaa gaccgaggaa gaaggagctc
      421 ggaagaaggg tccggagcgg ccggtccggc cgtgcagggc gagtgcgccc gaggcgcggc
      481 gccctgatgc tccccgggct cgaggagcat tgggcacttg cgggactgct ctcggtggag
      541 tagccccgtc gggcccggag ggtttgtgca accgcggaga acaccgagtg ctggtcgcac
      601 ggggcgtgcc gagccgcctc ccggcgcgcc ctccgcactt tccccgcctc gtcatccgtc
      661 gctccccggc caggagcctc cgctgcgtct tcaacctcgc tcccctttgc gtcccgggag
      721 cctgcgagca cccggccgaa ggcgcagccg aatcttgcgg gagtcgcccc gaaagcgtcg
      781 ggtttgtgtg gggttagcgg gggccgccgc gccacctgca cctcgcccgc cgccgcctcg
      841 gggaaagccc gaagaggagg cggaccagga gaagagcaaa gaaaagcagt ccgtctggat
      901 ttgtttgccc aggactggcg ccgcgcacgc ggatcgccga ggggagtgcg gtcggagtca
      961 ccgcgccccc gcctccccgc ccgggcagct gaggccgggg gttggagcgc tgcccccgcg
     1021 cacagtcccc gagcgcccga cgtctccgcg caggttcttg aagcagctgg gcctggggcg
     1081 cccactaatg tggccctgag ggccggagcc cgcaccgacg ggagcgggag ccggagcagc
     1141 tgcgggcgcc gagtggccgg tgcgcccggc ggagcgcgcg tgcgtggcca gcgcgctccc
     1201 cgcttctgct tggctttccg gcttaatttt cctcggcggg attaaagttg gaaattgacc
     1261 ggagaattga gttgccgggg aacagagccc cggccgccgc cagagcgatg ttcccgcaga
     1321 gccggcaccc gacgccgcac caggctgcag gccagccctt caagttcact atcccggagt
     1381 ccctggaccg gattaaagag gaattccagt tcctgcaggc gcagtatcac agccttaaat
     1441 tggaatgtga gaaactggca agtgaaaaga cagaaatgca gaggcactat gtgatgtatt
     1501 atgaaatgtc atatggatta aacattgaaa tgcacaaaca gactgaaatc gccaagagat
     1561 tgaatacgat ttgtgcacaa gtcatcccat ttctgtctca ggaacatcaa caacaggtgg
     1621 cccaggctgt tgaacgtgcc aaacaggtga ccatggcaga attgaatgcc atcatcgggc
     1681 agcagcagtt gcaagctcag catctttctc atggccacgg acccccagtt ccccttacgc
     1741 ctcacccttc gggacttcag cctcctggaa tcccgcccct cgggggcagt gccggccttc
     1801 ttgcgctgtc tagtgctctg agtgggcagt ctcacttggc aataaaagat gacaagaagc
     1861 accacgatgc agagcaccac agagacagag agccgggcac aagtaattcc ctcctggtcc
     1921 cagacagtct aagaggcaca gataaacgca gaaatggacc tgaattttcc aatgacatca
     1981 agaaaaggaa ggtggatgat aaggactcca gccactatga cagtgatggt gacaaaagcg
     2041 atgacaactt agttgtggat gtgtctaatg aggacccttc ttctccgcga gcaagccctg
     2101 cccactcgcc ccgggaaaat ggaatcgaca aaaatcgcct gctaaagaag gatgcttcta
     2161 gcagtccagc ttccacggcc tcctcggcaa gttccacttc tttgaaatcc aaagaaatga
     2221 gcttgcatga aaaagccagc acgcctgttc tgaaatccag cacaccaacg cctcggagcg
     2281 acatgccaac gccgggcacc agcgccactc caggcctccg tccaggtctc ggcaagcctc
     2341 cagccataga ccccctcgtt aaccaagcgg cagctggctt gaggacaccc ctggcagtgc
     2401 ccggcccata tcctgctcct tttgggatgg tcccccacgc tggcatgaac ggcgagctga
     2461 ccagcccagg cgctgcctac gccagtttac acaacatgtc gccccagatg agcgccgcag
     2521 ccgccgcggc cgccgtggtg gcctacgggc gctcccccat ggtggggttt gatcctcccc
     2581 ctcacatgag agtacctacc attcctccaa acctggcagg aatccctggg gggaaacctg
     2641 catactcctt ccacgttact gcagacggtc agatgcagcc tgtccctttt ccccccgacg
     2701 ccctcatcgg acccggaatc ccccggcatg ctcgccagat caacaccctc aaccacgggg
     2761 aggtggtgtg cgctgtgacc atcagcaacc ccacgagaca cgtgtacaca ggcgggaagg
     2821 gctgcgtcaa ggtctgggac atcagccacc ctggcaataa gagccctgtc tcccagctcg
     2881 actgtctgaa cagagacaat tatatccgtt cctgtaaatt gctacccgat ggctgcactc
     2941 tcatagtggg aggggaagcc agtactttgt ccatttggga cctggcggct ccaaccccgc
     3001 gcatcaaggc ggagctgacg tcctcggccc ccgcctgcta cgccctggcc atcagccccg
     3061 attccaaggt ctgcttctca tgctgcagcg acggcaacat cgctgtgtgg gatctgcaca
     3121 accagacact agtgaggcaa ttccagggcc acacagacgg agccagctgt attgacattt
     3181 ctaatgatgg caccaagctc tggacgggtg gtttggacaa cacagtcagg tcctgggacc
     3241 tgcgcgaggg gcggcagctg cagcagcacg acttcacctc ccagatcttc tccctggggt
     3301 actgccccac cggggagtgg ctggcagtgg gcatggagag cagcaatgtg gaggtgctgc
     3361 acgtgaacaa gcctgacaag taccagctgc acctgcatga gagctgcgtg ctgtccctga
     3421 aatttgctta ctgtggtaaa tggtttgtga gtactggaaa agataacctc ctcaatgctt
     3481 ggcggacccc ctatggagcc agcatattcc agtccaaaga gtcctcgtca gtgcttagct
     3541 gtgacatctc tgtggatgat aagtacatag tcactggctc gggggacaag aaggctacag
     3601 tctatgaagt catctactga aaacattatg tggtttaacg tttatagttg aattgggcca
     3661 aaatgtttcg aatttataga aatagaaaag ttgtaacttt aaaagagaaa aaaaattaca
     3721 aacacctgtt tccaaacctt gacagaaaac tactttgagt ctacaaagag gaggcgacaa
     3781 gtccatcagc agaaagtcac ctgtctacat agaccaaatg gagcaccaag gccaagcgga
     3841 cagaggggcc atgggttgta ggattgagga acggaatctg ccgactcaca tgacagccca
     3901 ttctttcttt ctgggtgatc tggggatcac gccttgccca agtgtgagat tacctttctg
     3961 ttccttgcag ttcacctcac tttccgtcct ttgtagagca gtggtgtctc caatgaactt
     4021 gtttcctggt tttgcatctt gtgaaatgtt tttttgtatt tttgttgaag gttaaacatt
     4081 tgtataaatt gtaaatatat ttggtttatt acagtaaagg ctttagtacc aataa
//
