LOCUS       NM_080628               2076 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens TBC/LysM-associated domain containing 2 (TLDC2),
            transcript variant 1, mRNA.
ACCESSION   NM_080628 XM_293104
VERSION     NM_080628.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2076)
  AUTHORS   Gaudet,P., Livstone,M.S., Lewis,S.E. and Thomas,P.D.
  TITLE     Phylogenetic-based propagation of functional annotations within the
            Gene Ontology consortium
  JOURNAL   Brief Bioinform 12 (5), 449-462 (2011)
   PUBMED   21873635
REFERENCE   2  (bases 1 to 2076)
  AUTHORS   Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G.,
            Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D.,
            Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K.,
            Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F.,
            Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L.,
            Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L.,
            Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S.,
            Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J.,
            Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J.,
            McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S.,
            Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W.,
            Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A.,
            Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S.,
            Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y.,
            Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D.,
            Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M.,
            Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E.,
            Schnerch,A., Schein,J.E., Jones,S.J. and Marra,M.A.
  CONSRTM   Mammalian Gene Collection Program Team
  TITLE     Generation and initial analysis of more than 15,000 full-length
            human and mouse cDNA sequences
  JOURNAL   Proc Natl Acad Sci U S A 99 (26), 16899-16903 (2002)
   PUBMED   12477932
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC127688.1, AK123544.1, AL079335.29 and AI537606.1.
            
            On Nov 23, 2018 this sequence version replaced NM_080628.2.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK123544.1, BC130646.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000217320.8/ ENSP00000217320.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-29                BC127688.1         18-46
            30-913              AK123544.1         1-884
            914-914             AL079335.29        54186-54186
            915-2070            AK123544.1         886-2041
            2071-2076           AI537606.1         16-21               c
FEATURES             Location/Qualifiers
     source          1..2076
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="20"
                     /map="20q11.23"
     gene            1..2076
                     /gene="TLDC2"
                     /gene_synonym="C20orf118"
                     /note="TBC/LysM-associated domain containing 2"
                     /db_xref="GeneID:140711"
                     /db_xref="HGNC:HGNC:16112"
     exon            1..70
                     /gene="TLDC2"
                     /gene_synonym="C20orf118"
                     /inference="alignment:Splign:2.1.0"
     CDS             38..685
                     /gene="TLDC2"
                     /gene_synonym="C20orf118"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TBC/LysM-associated domain-containing protein 2; TLD
                     domain-containing protein 2"
                     /codon_start=1
                     /product="TLD domain-containing protein 2 isoform 1"
                     /protein_id="NP_542195.1"
                     /db_xref="CCDS:CCDS33465.1"
                     /db_xref="GeneID:140711"
                     /db_xref="HGNC:HGNC:16112"
                     /translation="MRGLRWRYTRLPSQVEDTLSGEEGNEEEEEEEAAPDPAAAPEDP
                     TVPQLTEASQVLSASEIRQLSFHFPPRVTGHPWSLVFCTSRDGFSLQSLYRRMEGCSG
                     PVLLVLRDQDGQIFGAFSSSAIRLSKGFYGTGETFLFSFSPQLKVFKWTGSNSFFVKG
                     DLDSLMMGSGSGRFGLWLDGDLFRGGSSPCPTFNNEVLARQEQFCIQELEAWLLS"
     exon            71..226
                     /gene="TLDC2"
                     /gene_synonym="C20orf118"
                     /inference="alignment:Splign:2.1.0"
     exon            227..379
                     /gene="TLDC2"
                     /gene_synonym="C20orf118"
                     /inference="alignment:Splign:2.1.0"
     exon            380..475
                     /gene="TLDC2"
                     /gene_synonym="C20orf118"
                     /inference="alignment:Splign:2.1.0"
     exon            476..549
                     /gene="TLDC2"
                     /gene_synonym="C20orf118"
                     /inference="alignment:Splign:2.1.0"
     exon            550..702
                     /gene="TLDC2"
                     /gene_synonym="C20orf118"
                     /inference="alignment:Splign:2.1.0"
     exon            703..2076
                     /gene="TLDC2"
                     /gene_synonym="C20orf118"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2055..2060
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLDC2"
                     /gene_synonym="C20orf118"
                     /note="hexamer: ATTAAA"
     polyA_site      2076
                     /gene="TLDC2"
                     /gene_synonym="C20orf118"
                     /note="major polyA site"
ORIGIN      
        1 actcactgcc cacggccggc tgagcaggga caggagaatg agaggcctcc gctggcgtta
       61 cactcggctg cccagccagg tggaggacac cctgtctggg gaggagggta acgaagagga
      121 agaggaggag gaggcagctc cagacccagc tgctgctcct gaggatccca cggtgcccca
      181 gctgacagaa gccagccagg ttttgagtgc ctcagagatt cggcagctca gctttcactt
      241 cccaccaaga gtcaccggcc atccctggag tctggtcttc tgcacgtcaa gggacggttt
      301 cagcctgcag agcctgtacc ggcggatgga gggctgcagc gggccagtgc tgctggtgct
      361 cagggaccag gacgggcaga tatttggagc cttctcctcc tcggctatcc gactcagcaa
      421 aggcttctat ggtactggcg agacattcct cttctccttc tccccacagc tgaaggtctt
      481 taagtggact ggaagcaact ctttctttgt gaagggagac ttggattcac tgatgatggg
      541 cagtggcagt ggccggtttg ggctgtggtt ggatggagac ttgttccgcg ggggaagctc
      601 cccttgcccg accttcaaca acgaggtgct ggcccggcag gagcagttct gcatccagga
      661 gctggaggct tggcttctca gctgacagcc ctgcggcaac agaattctat gattgaagcc
      721 tctaaatgaa ttgtgcagga gagggagttt gtaaacaact gactacagac attcacattg
      781 ggtcatcttt aaaaagctgg actctgcttt tggatgcttc tcggaggcga gttggatttt
      841 ggactgaagt actgtcgttc cattcctttt tttgaggtgt tatgagtggg gctataacat
      901 cgccatccta ttaggaagag agagaaaaac aggcaataga gaaaagccag tttccatcat
      961 cttatttctg agtgaaagtc tcaagtgcgc acatcctcat cttgcatata gattgcttct
     1021 agctgtcctc aatccaggga aactccaaat tacatatgcc ctgtgcttgg ggcaaattag
     1081 aaacactaca gtcttacgca ggaagagcct tcatgaaaac agccactggc ctctgcagag
     1141 atgactggga gcagcatacc actgcccacc tctatggcct ccttcacaca ccttcacgga
     1201 gcacaaactc tgtcctgttt tcccaggaga aagacgggat gcactgaacc cctagcttct
     1261 ctctcgcctg gtcccctctg caataaaagg cccaggtcta caagatggca aagaagggga
     1321 ggaagaacag tatgtacctg cagaatttaa atttttctct gcatcaaagc tctaacgttg
     1381 gtcccatcag cataggctcc agccaaagaa gctcctccac ccaaaataag ggagagatcc
     1441 aaagggaggc gatacaatga cgtgaaacca tagaggtaag aagcaaggcc tcctaatact
     1501 tgactctatg ctaaactgtt ctgaacttgt gggtagatct tctttggtta caagatgatg
     1561 cacgatcttg gagagcctct gttgtaccag gaatacaatg ctggtgggag gattcgtgct
     1621 cctcatctgc ttatttgctc tcagatccat tcttcactct tcctctccct actctgtctc
     1681 acaggagcta ctccggtaaa ttacatttct cagctcccat gcctgttggt ttccagttag
     1741 atttggtcag tgggaggctc tggtgggaga ctggaggtga gaagagggca gagaagtcag
     1801 gttttttctc tccctacctc ctctggcacg agcggcagtg gcagtgacta ttctgtggtt
     1861 ctagcttttg caggtggccc cagctcctgg actcccacct gctcccttgg tctctcctat
     1921 cctagaggtg gtagcagctt cctgctgttg aatcactgtc ctctatgctc atttagctct
     1981 gccaaaactt ttgtatctca cccccatgtt aaattttttc tgttgaacta cactggatct
     2041 gacttgatag aactattaaa aatagttttt aaaaaa
//
