LOCUS       NM_001199691            1520 bp    mRNA    linear   PRI 04-DEC-2023
DEFINITION  Homo sapiens TLCD4-RWDD3 readthrough (TLCD4-RWDD3), mRNA.
ACCESSION   NM_001199691
VERSION     NM_001199691.1
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1520)
  AUTHORS   Diao X, Guo C, Zheng H, Zhao K, Luo Y, An M, Lin Y, Chen J, Li Y,
            Li Y, Gao X, Zhang J, Zhou M, Bai W, Liu L, Wang G, Zhang L, He X,
            Zhang R, Li Z, Chen C and Li S.
  TITLE     SUMOylation-triggered ALIX activation modulates extracellular
            vesicles circTLCD4-RWDD3 to promote lymphatic metastasis of
            non-small cell lung cancer
  JOURNAL   Signal Transduct Target Ther 8 (1), 426 (2023)
   PUBMED   37925421
  REMARK    GeneRIF: SUMOylation-triggered ALIX activation modulates
            extracellular vesicles circTLCD4-RWDD3 to promote lymphatic
            metastasis of non-small cell lung cancer.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1520)
  AUTHORS   Wu JH, Lemaitre RN, Manichaikul A, Guan W, Tanaka T, Foy M,
            Kabagambe EK, Djousse L, Siscovick D, Fretts AM, Johnson C, King
            IB, Psaty BM, McKnight B, Rich SS, Chen YD, Nettleton JA, Tang W,
            Bandinelli S, Jacobs DR Jr, Browning BL, Laurie CC, Gu X, Tsai MY,
            Steffen LM, Ferrucci L, Fornage M and Mozaffarian D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
REFERENCE   3  (bases 1 to 1520)
  AUTHORS   Chalasani N, Guo X, Loomba R, Goodarzi MO, Haritunians T, Kwon S,
            Cui J, Taylor KD, Wilson L, Cummings OW, Chen YD and Rotter JI.
  CONSRTM   Nonalcoholic Steatohepatitis Clinical Research Network
  TITLE     Genome-wide association study identifies variants associated with
            histologic features of nonalcoholic Fatty liver disease
  JOURNAL   Gastroenterology 139 (5), 1567-1576 (2010)
   PUBMED   20708005
REFERENCE   4  (bases 1 to 1520)
  AUTHORS   Prakash T, Sharma VK, Adati N, Ozawa R, Kumar N, Nishida Y,
            Fujikake T, Takeda T and Taylor TD.
  TITLE     Expression of conjoined genes: another mechanism for gene
            regulation in eukaryotes
  JOURNAL   PLoS One 5 (10), e13284 (2010)
   PUBMED   20967262
  REMARK    Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BC063464.1 and AC092802.2.
            
            Summary: This locus represents naturally occurring read-through
            transcription between the neighboring TMEM56 (transmembrane protein
            56) and RWDD3 (RWD domain containing 3) genes on chromosome 1. The
            read-through transcript encodes a protein that shares sequence
            identity with the upstream gene product, but it contains a distinct
            C-terminus due to frameshifts versus the downstream gene coding
            sequence. [provided by RefSeq, Dec 2010].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC063464.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145122
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            readthrough transcript :: includes exons from GeneID 25950, 148534
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-918               BC063464.1         1-918
            919-919             AC092802.2         119305-119305
            920-1520            BC063464.1         920-1520
FEATURES             Location/Qualifiers
     source          1..1520
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.3"
     gene            1..1520
                     /gene="TLCD4-RWDD3"
                     /gene_synonym="TMEM56-RWDD3"
                     /note="TLCD4-RWDD3 readthrough"
                     /db_xref="GeneID:100527978"
                     /db_xref="HGNC:HGNC:49388"
     exon            1..169
                     /gene="TLCD4-RWDD3"
                     /gene_synonym="TMEM56-RWDD3"
                     /inference="alignment:Splign:2.1.0"
     exon            170..335
                     /gene="TLCD4-RWDD3"
                     /gene_synonym="TMEM56-RWDD3"
                     /inference="alignment:Splign:2.1.0"
     CDS             181..786
                     /gene="TLCD4-RWDD3"
                     /gene_synonym="TMEM56-RWDD3"
                     /note="TMEM56-RWDD3 readthrough"
                     /codon_start=1
                     /product="TMEM56-RWDD3 protein"
                     /protein_id="NP_001186620.1"
                     /db_xref="GeneID:100527978"
                     /db_xref="HGNC:HGNC:49388"
                     /translation="MEINTKLLISVTCISFFTFQLLFYFVSYWFSAKVSPGFNSLSFK
                     KKIEWNSRVVSTCHSLVVGIFGLYIFLFDEATKADPLWGGPSLANVNIAIASGYLISD
                     LSIIILYWKVIGDKFFIMHHCASLYAYYLVLKNGVLAYIGNFRLLAELSSPFVNQRPK
                     AVVTGNMDLFSSLTLHLSTLSLQSPANNQDRWDRVQNSHKS"
     exon            336..425
                     /gene="TLCD4-RWDD3"
                     /gene_synonym="TMEM56-RWDD3"
                     /inference="alignment:Splign:2.1.0"
     exon            426..484
                     /gene="TLCD4-RWDD3"
                     /gene_synonym="TMEM56-RWDD3"
                     /inference="alignment:Splign:2.1.0"
     exon            485..579
                     /gene="TLCD4-RWDD3"
                     /gene_synonym="TMEM56-RWDD3"
                     /inference="alignment:Splign:2.1.0"
     exon            580..653
                     /gene="TLCD4-RWDD3"
                     /gene_synonym="TMEM56-RWDD3"
                     /inference="alignment:Splign:2.1.0"
     exon            654..746
                     /gene="TLCD4-RWDD3"
                     /gene_synonym="TMEM56-RWDD3"
                     /inference="alignment:Splign:2.1.0"
     exon            747..1491
                     /gene="TLCD4-RWDD3"
                     /gene_synonym="TMEM56-RWDD3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1468..1473
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLCD4-RWDD3"
                     /gene_synonym="TMEM56-RWDD3"
                     /note="hexamer: AATAAA"
     polyA_site      1491
                     /gene="TLCD4-RWDD3"
                     /gene_synonym="TMEM56-RWDD3"
                     /note="major polyA site"
ORIGIN      
        1 ccgggcgccc cgcattcctc tcgcgtttct cgggctgcac gattccggct gccctgtctg
       61 cctggcggtg cctctcgggt ctgagcttaa agcgggtggg tgcaaacctt tgggcatcca
      121 gggagagctt tcttgttaga gcccacacac aatcgggcgc atcaagtggg ttgaagaaat
      181 atggagatca acacaaaact gctcatcagt gttacctgta tcagcttttt cacctttcag
      241 cttcttttct actttgtaag ttactggttt tcagcaaaag tttctccagg tttcaatagt
      301 ctcagcttca aaaagaagat tgaatggaac tcaagggtag tatccacatg ccattctttg
      361 gtggttggta tttttggcct gtacattttc ttattcgatg aggctactaa agctgatcca
      421 ctttggggtg gtccatcact tgcaaacgtg aatattgcta ttgcctcagg ctacctcatt
      481 tctgatttgt ccattataat tttgtattgg aaagtgattg gtgacaaatt ttttataatg
      541 catcattgtg cgtccctgta tgcatactac cttgtactga aaaatggagt gctggcatac
      601 attgggaatt ttcgcctgct tgcagagctt tccagcccgt ttgtgaatca gcgaccaaag
      661 gctgtagtca ctggaaacat ggacttgttt tcatctctaa ctctccacct ctccacactc
      721 agcctgcaga gcccggccaa caatcaagac agatgggacc gtgttcagaa ttcacacaaa
      781 agctgaagga tttatggatg cggatatacc tctggaattg gtgttccatt tgccagtcaa
      841 ttatccttca tgtctacctg gtatctcgat taactctgaa cagttgacca gggcccagtg
      901 tgtgactgtg aaagagaatt tacttgagca agcagagagc cttttgtcgg agcctatggt
      961 tcatgagctg gttctctgga ttcagcagaa tctcaggcat atcctcagcc aaccagaaac
     1021 tggcagtggc agtgaaaagt gtactttttc aacaagcacg accatggatg atggattgtg
     1081 gataactctt ttgcatttag atcacatgag agcaaagact aaatatgtca aaattgtgga
     1141 gaagtgggct tcagatttaa ggctgacagg aagactgatg ttcatgggta aaataatact
     1201 gattttacta cagggagaca gaaacaacct caaggtgcca aaaagttaaa tgttgagtat
     1261 gaatctggct attttctgct ttaaatggtg tgtctttaag tgtgttttat aacaatggga
     1321 tagattaatt attaagatgt ttctgctttc attattacaa tcttaatgga tcttcctttt
     1381 ctttttaaag aatgtctgac tgctaattac aagtacaaac ttgcaaagct tgaagaataa
     1441 gattgcattt taaaaatcat gtcacttaat aaagtgacag gttatttaaa aaaaaaaaaa
     1501 aaaaaaaaaa aaaaaaaaaa
//
