LOCUS       NM_152487               6805 bp    mRNA    linear   PRI 04-APR-2024
DEFINITION  Homo sapiens TLC domain containing 4 (TLCD4), transcript variant 2,
            mRNA.
ACCESSION   NM_152487
VERSION     NM_152487.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 6805)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 6805)
  AUTHORS   Wu,J.H., Lemaitre,R.N., Manichaikul,A., Guan,W., Tanaka,T., Foy,M.,
            Kabagambe,E.K., Djousse,L., Siscovick,D., Fretts,A.M., Johnson,C.,
            King,I.B., Psaty,B.M., McKnight,B., Rich,S.S., Chen,Y.D.,
            Nettleton,J.A., Tang,W., Bandinelli,S., Jacobs,D.R. Jr.,
            Browning,B.L., Laurie,C.C., Gu,X., Tsai,M.Y., Steffen,L.M.,
            Ferrucci,L., Fornage,M. and Mozaffarian,D.
  TITLE     Genome-wide association study identifies novel loci associated with
            concentrations of four plasma phospholipid fatty acids in the de
            novo lipogenesis pathway: results from the Cohorts for Heart and
            Aging Research in Genomic Epidemiology (CHARGE) consortium
  JOURNAL   Circ Cardiovasc Genet 6 (2), 171-183 (2013)
   PUBMED   23362303
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC095033.2 and AC092802.2.
            
            On Nov 23, 2018 this sequence version replaced NM_152487.2.
            
            Transcript Variant: This variant (1) differs in the 5' UTR compared
            to variant 1. Both variants 1 and 2 encode the same protein.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            transcript and genomic sequence to make the sequence consistent
            with the reference genome assembly. The genomic coordinates used
            for the transcript record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660803.201598.1,
                                           SRR1660805.37839.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000370203.9/ ENSP00000359222.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-263               AC095033.2         76733-76995
            264-429             AC092802.2         18813-18978
            430-519             AC092802.2         23624-23713
            520-578             AC092802.2         25130-25188
            579-673             AC092802.2         26247-26341
            674-747             AC092802.2         48738-48811
            748-6805            AC092802.2         66472-72529
FEATURES             Location/Qualifiers
     source          1..6805
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p21.3"
     gene            1..6805
                     /gene="TLCD4"
                     /gene_synonym="TMEM56"
                     /note="TLC domain containing 4"
                     /db_xref="GeneID:148534"
                     /db_xref="HGNC:HGNC:26477"
     exon            1..263
                     /gene="TLCD4"
                     /gene_synonym="TMEM56"
                     /inference="alignment:Splign:2.1.0"
     exon            264..429
                     /gene="TLCD4"
                     /gene_synonym="TMEM56"
                     /inference="alignment:Splign:2.1.0"
     CDS             275..1066
                     /gene="TLCD4"
                     /gene_synonym="TMEM56"
                     /note="transmembrane protein 56"
                     /codon_start=1
                     /product="TLC domain-containing protein 4"
                     /protein_id="NP_689700.1"
                     /db_xref="CCDS:CCDS753.1"
                     /db_xref="GeneID:148534"
                     /db_xref="HGNC:HGNC:26477"
                     /translation="MEINTKLLISVTCISFFTFQLLFYFVSYWFSAKVSPGFNSLSFK
                     KKIEWNSRVVSTCHSLVVGIFGLYIFLFDEATKADPLWGGPSLANVNIAIASGYLISD
                     LSIIILYWKVIGDKFFIMHHCASLYAYYLVLKNGVLAYIGNFRLLAELSSPFVNQRWF
                     FEALKYPKFSKAIVINGILMTVVFFIVRIASMLPHYGFMYSVYGTEPYIRLGVLIQLS
                     WVISCVVLDVMNVMWMIKISKGCIKVISHIRQEKAKNSLQNGKLD"
     exon            430..519
                     /gene="TLCD4"
                     /gene_synonym="TMEM56"
                     /inference="alignment:Splign:2.1.0"
     exon            520..578
                     /gene="TLCD4"
                     /gene_synonym="TMEM56"
                     /inference="alignment:Splign:2.1.0"
     exon            579..673
                     /gene="TLCD4"
                     /gene_synonym="TMEM56"
                     /inference="alignment:Splign:2.1.0"
     exon            674..747
                     /gene="TLCD4"
                     /gene_synonym="TMEM56"
                     /inference="alignment:Splign:2.1.0"
     exon            748..6805
                     /gene="TLCD4"
                     /gene_synonym="TMEM56"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4130..4135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLCD4"
                     /gene_synonym="TMEM56"
                     /note="hexamer: ATTAAA"
     polyA_site      4147
                     /gene="TLCD4"
                     /gene_synonym="TMEM56"
                     /note="major polyA site"
     regulatory      4580..4585
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLCD4"
                     /gene_synonym="TMEM56"
                     /note="hexamer: AATAAA"
     polyA_site      4598
                     /gene="TLCD4"
                     /gene_synonym="TMEM56"
     regulatory      6778..6783
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLCD4"
                     /gene_synonym="TMEM56"
                     /note="hexamer: AATAAA"
     polyA_site      6805
                     /gene="TLCD4"
                     /gene_synonym="TMEM56"
                     /note="major polyA site"
ORIGIN      
        1 aaggagcagc tctgcggtaa cccgagcccg cagtccgggc gggcgcgacg gccgccgcgg
       61 tagctggagc ctccgcgact gcacctccaa gcggcccgga acccgcggct tccctggctc
      121 ccgtgagcat ctcaccgggc ggcactggcc agcgccagcc ctcgggccgg cccggatgag
      181 cagactcctg tagacacccg ccgccctctc ccggctcggc gcagccgccg cccgcgcgcg
      241 actcgccccg ggacccggca caggttgaag aaatatggag atcaacacaa aactgctcat
      301 cagtgttacc tgtatcagct ttttcacctt tcagcttctt ttctactttg taagttactg
      361 gttttcagca aaagtttctc caggtttcaa tagtctcagc ttcaaaaaga agattgaatg
      421 gaactcaagg gtagtatcca catgccattc tttggtggtt ggtatttttg gcctgtacat
      481 tttcttattc gatgaggcta ctaaagctga tccactttgg ggtggtccat cacttgcaaa
      541 cgtgaatatt gctattgcct caggctacct catttctgat ttgtccatta taattttgta
      601 ttggaaagtg attggtgaca aattttttat aatgcatcat tgtgcgtccc tgtatgcata
      661 ctaccttgta ctgaaaaatg gagtgctggc atacattggg aattttcgcc tgcttgcaga
      721 gctttccagc ccgtttgtga atcagcggtg gttctttgaa gctctgaagt atcccaagtt
      781 ttctaaagct atcgttatca atggaatact catgacagta gtattcttca tcgtgcggat
      841 tgcctcaatg cttcctcatt atggcttcat gtattccgtg tatggaacag aaccctacat
      901 aaggcttgga gttttaatcc agttatcctg ggtcattagt tgtgttgttt tggatgtgat
      961 gaatgtcatg tggatgatca aaatttcaaa aggttgcatc aaagtcatct ctcacatcag
     1021 acaagagaaa gccaaaaata gtcttcagaa tggaaaactt gattaaaaga gtgctaccga
     1081 taagcaaact tcattactac ccagcatatc tgctgatagg atgaattctt ggcatgttct
     1141 tgtgtacctt tcttaattat aattgttatt caggatttca gtgtcatttt ttttaaacct
     1201 tagaaaagag aaggccgggc acggtggctc atgcctgtaa tcccagcact ttgggaggcc
     1261 aaggtgggtc gatcactgag gtcaggagtt cgagactagc ttggccaaca tggtgaaacc
     1321 tcatctctac taaaaataca aaaaaaagta gctgggcgtg gtggttggcg cctgtaatcc
     1381 cagctactcg ggaggctgag gcaggagaat cgcttgaacc cgagagacgg aggttgcagt
     1441 gagctgatat tgtgccactg cactccagcc tgggcgacag agcaagactc tgtctcaaaa
     1501 aaaaaaaaaa gagagaaact aaaattaaaa tttagttttc atcccaagat gtcttttctg
     1561 cctttctttt gccttattta caagcatgga taaaaatctt aaaggtttaa ataaaaatga
     1621 tcaatataat ggtgaatctt ttgagaaatc tcttaactgc attggtattt tttctctgtg
     1681 aaagatgact atgataatct ggtacaaatg gttttatgtc accaattttg ctgcaagaat
     1741 gggaactgct tttaaatctg taaatagctc ttaacatttg ttgtatgcac tcttttctta
     1801 ctatggctgt caacacttgt gtagggttta atttctaaat tgttggcatg ttctttttct
     1861 caggctattc agaagtaaca acatttttca tttcagacat gcaatcacct attaatgatg
     1921 aaatatttta ccactttggg aatatttaat tagtttagtc atggagaata cttcccacat
     1981 tttaagattt tttcaaatat cactgtcatt tctattttag cattttatca aattattgct
     2041 tttttatttt ataataaggc ttaagacaga ttatagacct ccttaagaga tgagtttctt
     2101 cttctaaaaa tgcatgttga tagaggacta tttaggctaa tcggaggaat cattaagaaa
     2161 gaaagtttta acactgttta tccctatctg ctttccttgc actttttctg tgaaaaatat
     2221 tttctgtttg caaaatcttc cctgagttct gaacccagca ccatcagtac caaagtctta
     2281 tgcaatatgt atttattatg ctcctgaaat aggcctcttc ttgatgagac ccaaactatt
     2341 acaaaaatat cagtattcat attttactca caattcatac ccgtgcttac ttagttggca
     2401 ttttagtgct ttgaatttct atcttaaagc acagaaaaaa aaaggtaatt taatccaagt
     2461 attctatcat caaaattatt gtctgattat atgaagataa atgactggcg actctggttg
     2521 tgtgtgtatg tgttttgctt ttactttaat tcttgcaatc caaatataga attatatatt
     2581 tatctattat tgcctttatt ctttaagcac ttgagtttaa tgattattct tacctgagaa
     2641 aggaagaaat ttaattctac cagtgatgaa tacttgaaat taattgaact cataccaaaa
     2701 gatgtaatcc agtttctcag tttgaaggag aacgtttgac tcactttcat tgttcatgct
     2761 agctgaatat aatcaagact tttgatttga tttgctttta ttattcaatg cagatagagc
     2821 ctgataagtt ttagaacatt taaagaagat tgaaatctca gtcagtaact aaatgataaa
     2881 atgagattga ttggcttata ctaggtacat ttatttttga aagaattaat gtaaaataat
     2941 agttattttt aaagcagcta atattacact gataatttgt tgctaaattt agtgctgtcc
     3001 acatcatagg tgcttaaata tgtactggtt aactagaggg gggtaggaaa gcaagcggtt
     3061 ttatcttgtt cttacctttt tgcaggaaaa gtggctttaa aaaaatttat ataataaaac
     3121 tattttggaa attcattctt ttagaaagag accttgagat aaatattttt tgactctgga
     3181 tatttctata gttctgaaca cagattttaa acccactatc aaaatgaaaa caatataaag
     3241 ctatattagt gagtctccat gtagcagttt gtttttatag ttactgtttc atgcttaaaa
     3301 cttcattctt actttcatta atgttaccct tcactggtat agccactcac taaataagta
     3361 tatttaaaac atcaaaattt tgaactaaag tttgtgattc tcttattcag caatccttat
     3421 cttatgctgg ctgcatgagt taattcaaca tccagattaa atatcctgaa gtaggttcta
     3481 tatatttcct catacaacag acatggaatg gaaatgccac tagaaactgc cctgctactt
     3541 ttaagtctga cctttgcagg aggtacactt tgctgttcta tgattgtatt cacctaccta
     3601 aaatacaaat gaagacagaa catatcattt actgcacgat gaatttttca tttattaaat
     3661 gaaaaacgtt tgctagacat tttaaatatt aagtattttg actacacgga ttaatttaaa
     3721 tgattctatc aggcattctg atatttaaca actctattaa aatatttata gaaaaataaa
     3781 agcaaattga tataaatttt tgagcaattc tatttttgta gaaaaaagat aacctgtaat
     3841 tataaagatg ttttttgaat gtgtagtatc ctagaaaata aaagttcttg tgaaacttaa
     3901 aaaatgaatg aaaaccaact aatagcatgc aagatcatag atcctgcatt aaatttttat
     3961 ttgtgaaaat ttgaaaatta tgagctataa cttataaagt ttgccttctt atgtctaaaa
     4021 tcttttaaag gattatttgc atttatgtaa aactggaaat gaagttatat atgagtgcaa
     4081 agaaattgac ttctgctcaa atatgtgttg ataccctaca gtaaattgaa ttaaattttt
     4141 atcccaactg tttgatttta ttatttcatg gactagcctt acgttaagtg aaatactatt
     4201 tatgttgtta ccacccctaa gagtgactct gatatattat ggatgaccca ggacggtctt
     4261 aaaggtctag ttttaaaaac tgcctagttt gtaagtattt gaatccagtt cttttctaaa
     4321 ttttaataat ttgactcaaa atttttgcta cagggtcaac ttttaaattg tatatttcct
     4381 ctgaggcaca ctgggcattt ggagaatggt tcttcactgg tgtagagagc caggtttact
     4441 gttggttgca ccatctgtta tcaggcatgc agaaacattt ttcttctgga gaaacagagg
     4501 ggaaggtgtt gttacagtgt acatgtttcc tctgtgtcgt ttttaaggga aataaacatg
     4561 ttccaaaaga tgctgttaaa ataaatattt gaacacgttt tctgtttcta ggttgctctt
     4621 aattccaaac atttaaataa atgtgcattt gaatagcttt aggtggttta gtctattagc
     4681 tgaaatggaa aagttcatgt attgacatca tcaataatac ttcataaagg tttatgtatt
     4741 tttatgtgtt tggattccat aagaagttga acttagataa ttttatcaag agtagcacag
     4801 tgtttctcag gtgcgagcca gcatacagcg agacccttca tgtgtctctg gatgcacata
     4861 tatcttccca accttaaaca cagctcattg aaatacatta aagctactga aagtgagttc
     4921 tgatgcaaaa cacatgtgag gtgtgtagga acaatgaaaa gctagaggat ctggagttag
     4981 aggaggcatt gagagtgctt ttcccttaaa cgccgtgata gtcctccctt gatctagaag
     5041 tattctcttt gaatccttcc atctcttcct cctggtacac cagatgactt catcagcatc
     5101 tccctctttt atgctaacac ctttcgctgt caacttttga gacctcccca tgtatctata
     5161 agcttcccag tctcttatgg caaatttaaa agtttacaaa taggttctct cattgaaaaa
     5221 aagcattgta gtaaagttta aagtggagct cagacaaatc atgacttatt aagagactac
     5281 aggaagccat tcagcattta ataataactg tttacaacat gaggcaaagc taataatgtt
     5341 atggttttat taagagatct gtcatctctg tttttcttaa actggtttaa cagtcagagc
     5401 tttgtaatgt gtttcagctg aagatttatt ataggcttgt aaattatcta aatgttcttt
     5461 ttagacccca tgacaggagc acagaggaac tgagataact ctgtgttatg agagggtgga
     5521 tgctggcttg tgccaaaatt attttagagt cctgctcttt agggaaaact ttgctatggt
     5581 aatgtttctt tgaaaacaaa tttaccagca actgcgttac ttggtgtttt ccaaagtaca
     5641 acatccaagg cttgaacctt acccgtttct aggccagact aggccagcct ctagttttga
     5701 taataattca tacctttatt ggaatatatt ttggatagca gtgaagaatt gaaagcagct
     5761 cctaaagatt ggtttgtttg ctttgaaaat gtttacactt attcactcta agcagtggac
     5821 cattttgata tcaggcccta tacataagac caaaaccaga aatatttcta aatctcaaag
     5881 atttataagt acagtacctc tggctgaaaa ctcgttaaac atctttggat attttttctt
     5941 tatatcttta tgtaattatt tctgtaatta agtgtacatt agggttattt gctacttaac
     6001 aagcctaaag gtatagctgt atatagaatg tgctctgtgt ttttctgttt cctgcttggt
     6061 ttgtttctgg tatgactatg tctacttttt atttaaggaa ttttgtgtag ataatactct
     6121 cactaacttg taaataggat aagttatgag attttttggt attagaattt gtaataataa
     6181 tgacttttag attttatttg aaaaagctac ttggaaagca gtaaatagaa ctatagtgat
     6241 atatatagat acatagatat atactttttt ctgagaatgt ataatatata attgtcaaag
     6301 atttttggaa gtctttcaaa atatacttaa taccattttg agaacatacc ttctaattta
     6361 tttccataag gctgaagaac ttttatttac aaaatgtaag actagataat gtatgaatca
     6421 gtgttactag gacttatcag tacttaaaat agcaacttgg cattctttat tttgtttcct
     6481 ggttgtttta tttggaggga taataaatgt ctaagttatt tccattaaaa ttttgaaatg
     6541 tttgtatact ttatgtgtgc cattttaaag tatatgcaag ttctaagcaa taatctgcat
     6601 gttatacaag gttgacatat tttgtcctga aatttttagt taacatttca agaatgataa
     6661 aatgaacacc ctgtaaatta cccttctccc cctcccctcc atgaaaacct tgggattttc
     6721 ttgtgctaga acactaccac aatgtggtgc aaagctttgt attttgtgga aaaaaacaat
     6781 aaaatcacaa ttatttagtg caaaa
//
