LOCUS       NM_024792               2224 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens TLC domain containing 3A (TLCD3A), transcript variant
            1, mRNA.
ACCESSION   NM_024792
VERSION     NM_024792.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2224)
  AUTHORS   Yang,D., Strobel,T.D., Bulkescher,J., Tessmer,C., Hofmann,I.,
            Hoppe-Seyler,F. and Hoppe-Seyler,K.
  TITLE     FAM57A (Family with Sequence Similarity 57 Member A) Is a
            Cell-Density-Regulated Protein and Promotes the Proliferation and
            Migration of Cervical Cancer Cells
  JOURNAL   Cells 11 (20), 3309 (2022)
   PUBMED   36291175
  REMARK    GeneRIF: FAM57A (Family with Sequence Similarity 57 Member A) Is a
            Cell-Density-Regulated Protein and Promotes the Proliferation and
            Migration of Cervical Cancer Cells.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2224)
  AUTHORS   Li,Z., Shao,S., Xie,S., Jiao,F., Ma,Y. and Shi,S.
  TITLE     Silencing of CT120 by antisense oligonucleotides could inhibit the
            lung cancer cells growth
  JOURNAL   Ir J Med Sci 179 (2), 217-223 (2010)
   PUBMED   20024628
  REMARK    GeneRIF: The researchers found evidence that CT120 may be a key
            factor in tumor progression and that down-regulation of CT120 may
            be an effective treatment for lung neoplasms.
REFERENCE   3  (bases 1 to 2224)
  AUTHORS   Pan,D., Wei,L., Yao,M., Wan,D. and Gu,J.
  TITLE     Down-regulation of CT120A by RNA interference suppresses lung
            cancer cells growth and sensitizes to ultraviolet-induced apoptosis
  JOURNAL   Cancer Lett 235 (1), 26-33 (2006)
   PUBMED   15927361
REFERENCE   4  (bases 1 to 2224)
  AUTHORS   Pan,D.N., Li,J.J., Wei,L., Yao,M., Wan,D.F. and Gu,J.R.
  TITLE     Inhibitory effect of CT120B, an alternative splice variant of
            CT120A, on lung cancer cell growth
  JOURNAL   Acta Biochim Biophys Sin (Shanghai) 37 (9), 588-592 (2005)
   PUBMED   16143812
  REMARK    GeneRIF: CT120B overexpression resulted in reduction of cell growth
            rate & inhibited tumorigenecity & anchorage-independent growth;
            findings suggest that the delayed G1/S phase transition might
            contribute to the inhibitory activities of CT120B on cell growth
REFERENCE   5  (bases 1 to 2224)
  AUTHORS   He,X.H., Li,J.J., Xie,Y.H., Tang,Y.T., Yao,G.F., Qin,W.X., Wan,D.F.
            and Gu,J.R.
  TITLE     Altered gene expression profiles of NIH3T3 cells regulated by human
            lung cancer associated gene CT120
  JOURNAL   Cell Res 14 (6), 487-496 (2004)
   PUBMED   15625016
REFERENCE   6  (bases 1 to 2224)
  AUTHORS   He,X., Di,Y., Li,J., Xie,Y., Tang,Y., Zhang,F., Wei,L., Zhang,Y.,
            Qin,W., Huo,K., Li,Y., Wan,D. and Gu,J.
  TITLE     Molecular cloning and characterization of CT120, a novel
            membrane-associated gene involved in amino acid transport and
            glutathione metabolism
  JOURNAL   Biochem Biophys Res Commun 297 (3), 528-536 (2002)
   PUBMED   12270127
  REMARK    GeneRIF: Molecular cloning and characterization of this novel
            membrane-associated gene involved in amino acid transport and
            glutathione metabolism
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CN259418.1, AK025935.1,
            AA055841.1 and AC087392.10.
            
            On Nov 23, 2018 this sequence version replaced NM_024792.2.
            
            Summary: The protein encoded by this gene is a membrane-associated
            protein that promotes lung carcinogenesis. The encoded protein may
            be involved in amino acid transport and glutathione metabolism
            since it can interact with a solute carrier family member (SLC3A2)
            and an isoform of gamma-glutamyltranspeptidase-like 3. An
            alternatively spliced variant encoding a protein that lacks a 32 aa
            internal segment showed the opposite effect, inhibiting lung cancer
            cell growth. Knockdown of this gene also inhibited lung
            carcinogenesis and tumor cell growth. Several transcript variants
            encoding different isoforms have been found for this gene.
            [provided by RefSeq, Dec 2015].
            
            Transcript Variant: This variant (1, also known as CT120A)
            represents the longest transcript and encodes the longest isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.31664.1,
                                           SRR3476690.1009455.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000308278.13/ ENSP00000312017.7
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-11                CN259418.1         60-70
            12-2091             AK025935.1         1-2080
            2092-2191           AA055841.1         49-148              c
            2192-2192           AC087392.10        167961-167961       c
            2193-2224           AA055841.1         17-48               c
FEATURES             Location/Qualifiers
     source          1..2224
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..2224
                     /gene="TLCD3A"
                     /gene_synonym="CT120; FAM57A"
                     /note="TLC domain containing 3A"
                     /db_xref="GeneID:79850"
                     /db_xref="HGNC:HGNC:29646"
                     /db_xref="MIM:611627"
     exon            1..174
                     /gene="TLCD3A"
                     /gene_synonym="CT120; FAM57A"
                     /inference="alignment:Splign:2.1.0"
     CDS             53..826
                     /gene="TLCD3A"
                     /gene_synonym="CT120; FAM57A"
                     /note="isoform 1 is encoded by transcript variant 1;
                     membrane protein expressed in epithelial-like lung
                     adenocarcinoma; protein FAM57A; family with sequence
                     similarity 57 member A; TLC domain-containing protein 3A"
                     /codon_start=1
                     /product="TLC domain-containing protein 3A isoform 1"
                     /protein_id="NP_079068.1"
                     /db_xref="CCDS:CCDS10996.1"
                     /db_xref="GeneID:79850"
                     /db_xref="HGNC:HGNC:29646"
                     /db_xref="MIM:611627"
                     /translation="MLLTLAGGALFFPGLFALCTWALRRSQPGWSRTDCVMISTRLVS
                     SVHAVLATGSGIVIIRSCDDVITGRHWLAREYVWFLIPYMIYDSYAMYLCEWCRTRDQ
                     NRAPSLTLRNFLSRNRLMITHHAVILFVLVPVAQRLRGDLGDFFVGCIFTAELSTPFV
                     SLGRVLIQLKQQHTLLYKVNGILTLATFLSCRILLFPFMYWSYGRQQGLSLLQVPFSI
                     PFYCNVANAFLVAPQIYWFCLLCRKAVRLFDTPQAKKDG"
     exon            175..258
                     /gene="TLCD3A"
                     /gene_synonym="CT120; FAM57A"
                     /inference="alignment:Splign:2.1.0"
     exon            259..460
                     /gene="TLCD3A"
                     /gene_synonym="CT120; FAM57A"
                     /inference="alignment:Splign:2.1.0"
     exon            461..556
                     /gene="TLCD3A"
                     /gene_synonym="CT120; FAM57A"
                     /inference="alignment:Splign:2.1.0"
     exon            557..2224
                     /gene="TLCD3A"
                     /gene_synonym="CT120; FAM57A"
                     /inference="alignment:Splign:2.1.0"
     polyA_site      2091
                     /gene="TLCD3A"
                     /gene_synonym="CT120; FAM57A"
                     /note="major polyA site"
     regulatory      2129..2134
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLCD3A"
                     /gene_synonym="CT120; FAM57A"
                     /note="hexamer: AACAAA"
     polyA_site      2140
                     /gene="TLCD3A"
                     /gene_synonym="CT120; FAM57A"
                     /note="major polyA site"
     regulatory      2201..2206
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLCD3A"
                     /gene_synonym="CT120; FAM57A"
                     /note="hexamer: ATTAAA"
     polyA_site      2224
                     /gene="TLCD3A"
                     /gene_synonym="CT120; FAM57A"
                     /note="major polyA site"
ORIGIN      
        1 gagccgaacc cagccacgcg gcgccagcga ggcggccgga cccgcagccc cgatgctgct
       61 gacgctggcc gggggcgcgc tcttcttccc ggggctcttc gcgctctgca cctgggcgct
      121 gcgccgctcc cagcccggat ggagccgcac cgactgcgtg atgatcagca ccaggctggt
      181 ttcctcggtg cacgccgtgc tggccaccgg ctcggggatc gtcatcattc gctcctgcga
      241 cgacgtgatc accggcaggc actggcttgc ccgggaatat gtgtggtttc tgattccata
      301 catgatctat gactcgtacg ccatgtacct ctgtgaatgg tgccgaacca gagaccagaa
      361 ccgtgcgccc tccctcactc ttcgaaactt cctaagtcga aaccgcctca tgatcacaca
      421 tcatgcggtc attctctttg tccttgtgcc agtcgcacag aggctccggg gagaccttgg
      481 ggacttcttt gtcggctgca tcttcacggc agaactgagc actccgtttg tgtcgctggg
      541 cagggttctg attcagctaa agcagcagca cacccttctg tacaaggtga atggaatcct
      601 cacgctggcc accttccttt cctgccggat ccttctcttc cccttcatgt actggtccta
      661 tggccgccag cagggactaa gcctgctcca agtacccttc agcatcccat tctactgcaa
      721 cgtggccaat gccttcctcg tagctcctca gatctactgg ttctgtctgc tgtgcaggaa
      781 ggcagtccgg ctctttgaca ctccccaagc caaaaaggat ggctaaatgc tcctgggagt
      841 caggcgcagc ctcacaccag ctgcctcctc cactcagcat tccatggacc aaattgtgcc
      901 ctgggtagcc tcagactttg ggtattgata agccgatgga tttgagtttt tctaaagaat
      961 attcatatta cctccttctt ctaacttgcc ctatttgcaa aagcactttt gtagtaacaa
     1021 ctattgggtc ctgtcagacc tccacggaca gcaaagtggt tttaatgcaa gcccaaggat
     1081 ccttcttaag gtcttatctc aagagctctg ggaggtggaa gcatggggtg ggatcggtgg
     1141 accagggtgg taagtgtctg cacatctgcc tgtccctgta tcagcggcta cccaccttcc
     1201 aaaccactca ggacagtacc cgtggcactg ggcccgcaga agcaagggat gacttggttc
     1261 ttggaagtaa tgtcgtcttg tgacattggc ctgggacaat cattgtgggt aggtagttat
     1321 tgatcgttta ctagataacc cattggttct ttgcctcatc ctctcatcca tgggtcagag
     1381 ttgaattctt atgtctatag acttccaatc agaagtctca ctggtggggc tgggggtggg
     1441 ggcaggcagg aggcatggat gggaacctga gtaggtagtg tggccaagag atcagcacaa
     1501 cctttgcagg ctgacttgct aagtctgaca gtgacaaact tgtgagctta ctgcagtcag
     1561 tcacagaggc tgttcttttt cacacacccc ttcatgcccg gctttcccca tatccacatg
     1621 cagagggcga gctcataaaa ctacagggaa gcgtgaaatg atggctttgg tagctgttta
     1681 ctgggtaacc ccactgtgac actgtccttt tcatgtgatg tggaaaccta cttctgtcct
     1741 ccaaaccatg aaatgtgtca tctagactgc agagtacttg agtgctttgc ctcccgatat
     1801 gccagagctt gtggtccaaa gcccattcct gtgtgtccgt cctgccattt agccacagaa
     1861 ggctgcggag tgaggcggca gctagcctgg ccagtggctg tcccgtggac cgacacctgc
     1921 gcccccttct gcaagcagga ttttctggtg ccaacactca ttcatcattc ccgatcaact
     1981 aggatgaatt taagactgtg ctaccatgtg ttctcaagtg gtagtttaaa aagtggattt
     2041 ttaaagtgcc tttcaattgt ctgtgaacgt ctaaaggact gatttgtctc attttgactg
     2101 ttgagtcttt aatgggtgcc atttaaaaaa caaaatgcta ttttttaatt gtcttttttt
     2161 tttaactatc agtgtatctt taaaagtcac ccttacggtg attaaattgc actaacattc
     2221 ccaa
//
