LOCUS       NM_001164407            5884 bp    mRNA    linear   PRI 27-SEP-2024
DEFINITION  Homo sapiens TLC domain containing 2 (TLCD2), mRNA.
ACCESSION   NM_001164407 XM_001126126
VERSION     NM_001164407.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5884)
  AUTHORS   Petkevicius,K., Palmgren,H., Glover,M.S., Ahnmark,A.,
            Andreasson,A.C., Madeyski-Bengtson,K., Kawana,H., Allman,E.L.,
            Kaper,D., Uhrbom,M., Andersson,L., Aasehaug,L., Forsstrom,J.,
            Wallin,S., Ahlstedt,I., Leke,R., Karlsson,D., Gonzalez-King,H.,
            Lofgren,L., Nilsson,R., Pellegrini,G., Kono,N., Aoki,J., Hess,S.,
            Sienski,G., Pilon,M., Bohlooly-Y,M., Maresca,M. and Peng,X.R.
  TITLE     TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine
            composition and promote the progression of non-alcoholic
            steatohepatitis
  JOURNAL   Nat Commun 13 (1), 6020 (2022)
   PUBMED   36241646
  REMARK    GeneRIF: TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine
            composition and promote the progression of non-alcoholic
            steatohepatitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 5884)
  AUTHORS   Ruiz,M., Bodhicharla,R., Svensk,E., Devkota,R., Busayavalasa,K.,
            Palmgren,H., Stahlman,M., Boren,J. and Pilon,M.
  TITLE     Membrane fluidity is regulated by the C. elegans transmembrane
            protein FLD-1 and its human homologs TLCD1/2
  JOURNAL   Elife 7, e40686 (2018)
   PUBMED   30509349
  REMARK    GeneRIF: inhibition of FLD-1 or TLCD1/2 prevents lipotoxicity by
            allowing increased levels of membrane phospholipids that contain
            fluidizing long-chain polyunsaturated fatty acids.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 5884)
  AUTHORS   Pewzner-Jung,Y., Ben-Dor,S. and Futerman,A.H.
  TITLE     When do Lasses (longevity assurance genes) become CerS (ceramide
            synthases)?: Insights into the regulation of ceramide synthesis
  JOURNAL   J Biol Chem 281 (35), 25001-25005 (2006)
   PUBMED   16793762
  REMARK    Review article
REFERENCE   4  (bases 1 to 5884)
  AUTHORS   Zody,M.C., Garber,M., Adams,D.J., Sharpe,T., Harrow,J.,
            Lupski,J.R., Nicholson,C., Searle,S.M., Wilming,L., Young,S.K.,
            Abouelleil,A., Allen,N.R., Bi,W., Bloom,T., Borowsky,M.L.,
            Bugalter,B.E., Butler,J., Chang,J.L., Chen,C.K., Cook,A., Corum,B.,
            Cuomo,C.A., de Jong,P.J., DeCaprio,D., Dewar,K., FitzGerald,M.,
            Gilbert,J., Gibson,R., Gnerre,S., Goldstein,S., Grafham,D.V.,
            Grocock,R., Hafez,N., Hagopian,D.S., Hart,E., Norman,C.H.,
            Humphray,S., Jaffe,D.B., Jones,M., Kamal,M., Khodiyar,V.K.,
            LaButti,K., Laird,G., Lehoczky,J., Liu,X., Lokyitsang,T.,
            Loveland,J., Lui,A., Macdonald,P., Major,J.E., Matthews,L.,
            Mauceli,E., McCarroll,S.A., Mihalev,A.H., Mudge,J., Nguyen,C.,
            Nicol,R., O'Leary,S.B., Osoegawa,K., Schwartz,D.C., Shaw-Smith,C.,
            Stankiewicz,P., Steward,C., Swarbreck,D., Venkataraman,V.,
            Whittaker,C.A., Yang,X., Zimmer,A.R., Bradley,A., Hubbard,T.,
            Birren,B.W., Rogers,J., Lander,E.S. and Nusbaum,C.
  TITLE     DNA sequence of human chromosome 17 and analysis of rearrangement
            in the human lineage
  JOURNAL   Nature 440 (7087), 1045-1049 (2006)
   PUBMED   16625196
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC130343.7.
            
            On Nov 23, 2018 this sequence version replaced NM_001164407.1.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803612.448205.1,
                                           ERR279844.3714.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMN04284274 [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000330676.8/ ENSP00000331965.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-311               AC130343.7         159581-159891       c
            312-394             AC130343.7         159318-159400       c
            395-477             AC130343.7         159013-159095       c
            478-5884            AC130343.7         152330-157736       c
FEATURES             Location/Qualifiers
     source          1..5884
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17p13.3"
     gene            1..5884
                     /gene="TLCD2"
                     /note="TLC domain containing 2"
                     /db_xref="GeneID:727910"
                     /db_xref="HGNC:HGNC:33522"
                     /db_xref="MIM:620967"
     exon            1..311
                     /gene="TLCD2"
                     /inference="alignment:Splign:2.1.0"
     CDS             136..930
                     /gene="TLCD2"
                     /codon_start=1
                     /product="TLC domain-containing protein 2"
                     /protein_id="NP_001157879.1"
                     /db_xref="CCDS:CCDS45567.1"
                     /db_xref="GeneID:727910"
                     /db_xref="HGNC:HGNC:33522"
                     /db_xref="MIM:620967"
                     /translation="MAPTGLLVAGASFLAFRGLHWGLRRLPTPESAARDRWQWWNLCV
                     SLAHSLLSGTGALLGLSLYPQMAADPIHGHPRWALVLVAVSVGYFLADGADLLWNQTL
                     GKTWDLLCHHLVVVSCLSTAVLSGHYVGFSMVSLLLELNSACLHLRKLLLLSRQAPSL
                     AFSVTSWASLATLALFRLVPLGWMSLWLFRQHHQVPLALVTLGGIGLVTVGIMSIILG
                     IRILVNDVLQSRPHPPSPGHEKTRGTRTRRDNGPVTSNSSTLSLKD"
     exon            312..394
                     /gene="TLCD2"
                     /inference="alignment:Splign:2.1.0"
     exon            395..477
                     /gene="TLCD2"
                     /inference="alignment:Splign:2.1.0"
     exon            478..5884
                     /gene="TLCD2"
                     /inference="alignment:Splign:2.1.0"
     regulatory      5864..5869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLCD2"
                     /note="hexamer: AATAAA"
     polyA_site      5884
                     /gene="TLCD2"
                     /note="major polyA site"
ORIGIN      
        1 gctgatccca aaggcgcggc ggggagggga gccggggccc cagccctgcc gggaaacggg
       61 ttcccagtcc cggccgagag cgcgggcgcc gaggggaccg acccggactc cccgcaaccc
      121 cccaaccgcc aggccatggc gcccacgggg ctcctggtgg ccggcgcctc cttcctcgcg
      181 ttccgggggc tgcactgggg gttgcggcgg ctgcccacgc cggaatcggc cgctcgggac
      241 cgctggcagt ggtggaacct ctgcgtctcc ctggcgcaca gcctgctctc ggggaccggg
      301 gcgctgctcg gcctgtcact gtaccctcag atggccgccg accccatcca tggccacccg
      361 cgctgggctc tggtgctggt ggctgtgtct gtgggttact tcctggcaga cggagctgac
      421 ctgctgtgga accagacctt gggcaagacc tgggatcttc tctgtcatca tttggtggtg
      481 gtgagctgcc tcagcaccgc tgttctgtct ggccactacg tgggcttctc catggtgtct
      541 ctgctcctgg aactgaactc tgcctgcttg cacctgcgga agctgctgtt gctttctcgc
      601 caggccccat ccctggcctt cagcgtgacc agctgggcct ccttggccac cttggccctc
      661 ttccgcctgg tcccgctggg gtggatgagt ctgtggctgt tccggcagca ccaccaggtt
      721 cctcttgctc tggtcaccct gggtggaatt gggctggtca ctgtgggcat catgagcatc
      781 atattgggga tccgtattct ggtcaatgat gtcctacagt ctcgacccca tccacccagc
      841 cctggccatg agaaaaccag ggggaccagg acacgtcgtg acaatggacc tgtcaccagc
      901 aacagttcga ctctcagcct gaaagactag agagaagcca tgggcccctc gctgggggag
      961 gtggggccag gacaaggaga tgagggtctt ccatgcacag tcccccatca gggtgagggc
     1021 cagacttgct catcagaatc tcagtttctc ttccagctaa ctcacatccc ttccccttcc
     1081 tcggatctaa gaagaaatgc tgatgttgga tgggtgggaa cctgggtttc tgttcactga
     1141 aatccgtcat cagatgagca tcctttccag caaataaact caagaggtac agctagagct
     1201 atcagtaaag ggtggcagga ggcatgcagc tggaagaaac tgccagtgga gacagaagct
     1261 ctttgcttta acccagggac agatggggga aggtgaagtc ccactaggat cagagagatc
     1321 tggtatgggg cgggtgggga cagagagaaa agagatctca cctataacca aattctggca
     1381 gtgggaggaa ggtagaggag gtgctatctg tagcagcaga gatggacgtg atagttgcca
     1441 agagacagaa cctgggccac agcaattgct gctgatgttt ctggttctca aagccacact
     1501 cctgtttttc tttttctttt tctttttttt tatgagacgg aatcttactc tgtcacccag
     1561 gctggagtgt agtggcacga tttcggctca ctgcaacctc agcctcctgg gttcaagtga
     1621 ttgtcctgcc ttagcctccc gagtagctgt gacttcaggc atgcaccacc aagcccagct
     1681 aatttttgta ttttttggtg gagaggaggt ttcaccatgt tgcccaggct ggtctcgaac
     1741 tcctgacctc aagtaatcca cctgcctcgg cctcccagag tgctgggatt acagacgtga
     1801 gaacaggcgc acactcctgt ttttctcctt aaccctggtc ctgctgtgtc tagcctttta
     1861 tttttatttt tatttttagt atcttttgac ttttcttttt tcttttcttt tttttttttt
     1921 ttttttgaga caagttcttg ctctgttgcc caggatggag tgcagtggct tgatcttggc
     1981 tcactgcaat ctctgcctcc caggctcaag caattctcct gcctcccacc tcagcctccc
     2041 aagtagctgg gactacaggt gcacgccact gcaccaggct aatttttgta tttttttgta
     2101 gagaccaggt tttgccatgt tgcccaggct ggtctcaaac ttttgcactc aagtgatcca
     2161 cccacctcag cctcccaaag tgctgggatt acagacgtga gccaccgtac ccgacccctt
     2221 ttgacttttc aaagacaatt cggattctta gaggaatgaa cacagggctg gtttgtcttc
     2281 ttaggacggc actgaagtct agaattacag aaggaaaggt gcccagtaca gagttttccc
     2341 aggcccaggc tttcatggaa gaacaagggc agaggtagac tgtgtgagag aaggctgcag
     2401 gaggataaag gaatagctgg ccctctggct gggcgcagca gctcacgcct gtaatcccag
     2461 cactttggga ggccgaggcg ggaggatcac ctgaggtcag gagttcaaga ccagcctggt
     2521 caacatggtg aaaccctgtc tctactaaaa atacaaaatt agccgggcat ggtggtgcat
     2581 gcctgtaatc ccagctactc aggaggctga ggcaggagaa tcgcttgaac ccaggaggca
     2641 gaggttgcag tgagccgagg tcgtgccact gcactccagc ctgggcaaac agagtgagac
     2701 tcttgtctct aaagaaaaaa aaaaaaggaa gagctgggac ttttctgaga tacattcata
     2761 aagtcttctt cctccctgct gcttctgctg cgtttttttc tgttgaacaa gaccccttcc
     2821 ttcccagaac atcgaggtga cgggaagtgc ccagcagatt aagtctgctg ttccactaaa
     2881 caatggactg agagaggcaa cccttagcca tccacagaaa agctacatga gcaaaagcaa
     2941 gagacaggaa gattgtcttc aaaaaaaaac aaaacaaaac aaaaaccttg ctaagaagcg
     3001 gaggtacaga aagatacgaa gaatgacaga gacagacata catagattga gtgatagata
     3061 gaaagagaga aggattattc acatagaggt gacagaggca aagaaggatg gagggcaaaa
     3121 gagacaggcc ctagcagaaa tatggagaaa ggctgtcata gatcctgaga gacaccaaag
     3181 tcacagaact gataaaaggg ttataaacaa aaaggaccag aaaaatagaa atgaaggccg
     3241 acaagaagag accccaaggc tgaaaggcac agagagtcta gacagtgaaa tagagtgagt
     3301 gacaaggaga aacacccagg ctcaggagtg atggaggaaa tactggcaga tagagagatc
     3361 agaagagcaa gaggagaggt gggaacagag aagagcgggg acgagtccgg ggagctgaga
     3421 agcagaaggc ggaggaggca gtcagtggga agattcactg acagaagaga ccaggagata
     3481 tggggacttg gaggcaggca gaaagacaaa ggacaaacag ctgcagcgca aaccctaaag
     3541 acaggctgac agtaaccggt cggcagagac tggtaggaag ataaggacaa gtcagaatca
     3601 ggggtgtcaa ctgagatgca aatataggca aaggagctga caaagagaat cacagagaga
     3661 aaaaaaagga ggagagcaca gaacaattta aatatccagg ctgggcatgg tgggtcacgc
     3721 ctgtaatccc agcattttgg gaggccgagg caggcggatc acgaggtcag gagatgacca
     3781 tcctggctaa catggtgaaa caccatctct actaaaaata caaaaaattg gccgggcgtg
     3841 gtggcaggcg cccgtaatcc cggctactga ggaggctgag gcaggagaat cgtttgaacc
     3901 tgggaggccg aggttgttat aatgagccga gatagtgcca ctgcagtcca gcaggggtga
     3961 cagagtgaga ctccgtctca aaaaaaaaaa ttgaatatcc aaagaacaaa gaagaggcag
     4021 gaacccagaa atgaaaagag gaggaaaaat acaggtgtga aaaaaaaatg agagggattg
     4081 tgagaagtct ccatcataga gtcataaaaa caggcgcaaa ggatgaaaat acatcgagac
     4141 tgaggaaaac acagttggaa ggagctaaac acaagcagaa aataagagca gagcatttaa
     4201 atgtaattag ataaaaaccc aagaggcaaa ggtatagata gtgagctaga gaaacaatgc
     4261 agaattttgt cagagtctgt acttctagaa gtcatgtttg ctggctgggc atggtggctc
     4321 acgcctgtaa tcccagcact ttgggaggcc gaggtaggag gagtggttga gctcaggagt
     4381 tcaagaccag tctgggcaac atattgagac ctcctctcta caaaaaaaaa aaattttctt
     4441 ttttctttct tttcttcttt tttttttttt ttttttgaga cagtttcatt cttgctgccc
     4501 aggctggaat gcagtggcac aatcttggct cactgcaacc tccacctcct ggactcaagt
     4561 gattctcctg cctcagcctc cctagtagct gggattacag gtacccacca ccacactcgg
     4621 ctaatttttg tgtttttagt agagacagga tttcaccata ttggccaggc tggtctcaaa
     4681 ctcctgacct caggtgatcc gcccaccttg ggctcccaaa ctactgggat tatatgcgtg
     4741 agccaacaca cccggccaaa aaaaaatttt taattaaaaa aaaaagtcat atctgcaaaa
     4801 ctcaatttgc catcttaact gaatgccttg attaacaaaa atgttgtctg ccttgagttt
     4861 ttaaagaaaa agaaatatga caaactcatg tgaggaatct attccttaaa tatctgttga
     4921 ggttgatatg aattgattct aagtcataca ccttttcttt ggccactggt atacattcat
     4981 gatggtttga gtgagtgtcc cttttggtaa tacttgatag tgtctatgag gccgggcgtg
     5041 gtggctcacg cctgtaatcc cagcactttg ggggaccgag gcaggtgaaa tcccatctct
     5101 actaaaaata aaaaaaatta gccgggcgtg gtggcgggcg cctgtagtcc cagctactca
     5161 ggaggctgag gcaggagaat ggcatgaacc cgggaggcgg agcttgcagt gagccaagat
     5221 cgtgccactg cactccagcc tgggtgacag agcaagactc cgtcttaaaa aataaataaa
     5281 taaataaata gacagataga tagatagata gtgtctatga aggctgccca agaacttgac
     5341 cattagggaa acatggctgt ttctgtggat taactagtca agcccataca ggaagagtga
     5401 ggtcagctcc caggtggggc aggatgtagt ggacgcttgg aagaatttgg gaccacacac
     5461 gaattgctac catggtgagc cagtgaaact tgaggaaggc aggactggat tgtgattaca
     5521 actgagtaag taggcagaga attggagtgt gggcaacata aagatgatgt gaatcaaaga
     5581 agaatggtca attaagaccc taaaaaaagg acgttcaaaa atgcagaggt taaaaaaaaa
     5641 aaaagcagag attgccagat gctccatttg gtaggagtct gcttagcaca gtggtgcttc
     5701 gccagacttt accgtggccc agggaaatgg tcctcaagac ggactccatg tctaccaagc
     5761 tacttgctaa tgatttcttt gtcctccagg acagggaagg ggcttttctg gatgggatac
     5821 attgatattt tatggccttg aaacactatc ctgattataa attaataaat tgctatgcaa
     5881 ataa
//
