LOCUS       NM_138463               1042 bp    mRNA    linear   PRI 27-SEP-2024
DEFINITION  Homo sapiens TLC domain containing 1 (TLCD1), transcript variant 1,
            mRNA.
ACCESSION   NM_138463
VERSION     NM_138463.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1042)
  AUTHORS   Petkevicius,K., Palmgren,H., Glover,M.S., Ahnmark,A.,
            Andreasson,A.C., Madeyski-Bengtson,K., Kawana,H., Allman,E.L.,
            Kaper,D., Uhrbom,M., Andersson,L., Aasehaug,L., Forsstrom,J.,
            Wallin,S., Ahlstedt,I., Leke,R., Karlsson,D., Gonzalez-King,H.,
            Lofgren,L., Nilsson,R., Pellegrini,G., Kono,N., Aoki,J., Hess,S.,
            Sienski,G., Pilon,M., Bohlooly-Y,M., Maresca,M. and Peng,X.R.
  TITLE     TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine
            composition and promote the progression of non-alcoholic
            steatohepatitis
  JOURNAL   Nat Commun 13 (1), 6020 (2022)
   PUBMED   36241646
  REMARK    GeneRIF: TLCD1 and TLCD2 regulate cellular phosphatidylethanolamine
            composition and promote the progression of non-alcoholic
            steatohepatitis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1042)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 1042)
  AUTHORS   Ruiz,M., Bodhicharla,R., Svensk,E., Devkota,R., Busayavalasa,K.,
            Palmgren,H., Stahlman,M., Boren,J. and Pilon,M.
  TITLE     Membrane fluidity is regulated by the C. elegans transmembrane
            protein FLD-1 and its human homologs TLCD1/2
  JOURNAL   Elife 7, e40686 (2018)
   PUBMED   30509349
  REMARK    GeneRIF: inhibition of FLD-1 or TLCD1/2 prevents lipotoxicity by
            allowing increased levels of membrane phospholipids that contain
            fluidizing long-chain polyunsaturated fatty acids.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1042)
  AUTHORS   Papanayotou,C., De Almeida,I., Liao,P., Oliveira,N.M., Lu,S.Q.,
            Kougioumtzidou,E., Zhu,L., Shaw,A., Sheng,G., Streit,A., Yu,D., Wah
            Soong,T. and Stern,C.D.
  TITLE     Calfacilitin is a calcium channel modulator essential for
            initiation of neural plate development
  JOURNAL   Nat Commun 4, 1837 (2013)
   PUBMED   23673622
REFERENCE   5  (bases 1 to 1042)
  AUTHORS   Winter,E. and Ponting,C.P.
  TITLE     TRAM, LAG1 and CLN8: members of a novel family of lipid-sensing
            domains?
  JOURNAL   Trends Biochem Sci 27 (8), 381-383 (2002)
   PUBMED   12151215
  REMARK    Review article
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC010761.10, CA453962.1, BC014072.2 and BF478215.1.
            
            On Nov 23, 2018 this sequence version replaced NM_138463.3.
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC014072.2, SRR1163655.510489.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000292090.8/ ENSP00000292090.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-21                AC010761.10        78365-78385         c
            22-25               CA453962.1         7-10
            26-1032             BC014072.2         1-1007
            1033-1042           BF478215.1         17-26               c
FEATURES             Location/Qualifiers
     source          1..1042
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q11.2"
     gene            1..1042
                     /gene="TLCD1"
                     /note="TLC domain containing 1"
                     /db_xref="GeneID:116238"
                     /db_xref="HGNC:HGNC:25177"
                     /db_xref="MIM:620966"
     exon            1..330
                     /gene="TLCD1"
                     /inference="alignment:Splign:2.1.0"
     CDS             137..880
                     /gene="TLCD1"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; TLC domain-containing protein 1; calfacilitin"
                     /codon_start=1
                     /product="TLC domain-containing protein 1 isoform 1
                     precursor"
                     /protein_id="NP_612472.1"
                     /db_xref="CCDS:CCDS11242.1"
                     /db_xref="GeneID:116238"
                     /db_xref="HGNC:HGNC:25177"
                     /db_xref="MIM:620966"
                     /translation="MPRLLHPALPLLLGATLTFRALRRALCRLPLPVHVRADPLRTWR
                     WHNLLVSFAHSIVSGIWALLCVWQTPDMLVEIETAWSLSGYLLVCFSAGYFIHDTVDI
                     VASGQTRASWEYLVHHVMAMGAFFSGIFWSSFVGGGVLTLLVEVSNIFLTIRMMMKIS
                     NAQDHLLYRVNKYVNLVMYFLFRLAPQAYLTHFFLRYVNQRTLGTFLLGILLMLDVMI
                     IIYFSRLLRSDFCPEHVPKKQHKDKFLTE"
     exon            331..413
                     /gene="TLCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            414..496
                     /gene="TLCD1"
                     /inference="alignment:Splign:2.1.0"
     exon            497..1042
                     /gene="TLCD1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1023..1028
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TLCD1"
                     /note="hexamer: AATGAA"
     polyA_site      1042
                     /gene="TLCD1"
                     /note="major polyA site"
ORIGIN      
        1 ctagagggct tcgccaactg tgtggggctg gcggccggcg ggagaggcgg ccggcctgga
       61 ctggcccgag agggatcccg gttcccagaa cagacctagg aggcggcctc gagggcggac
      121 ggcagggagg gccagcatgc cccgactgct gcaccccgcc ctgccgctgc tcctgggcgc
      181 cacgctgacc ttccgggcgc tccggcgcgc gctctgtcgc ctgcccctac ccgtgcacgt
      241 gcgcgccgac cccctgcgca cctggcgctg gcacaacctg ctcgtctcct tcgctcactc
      301 cattgtgtcg gggatctggg cactgctgtg tgtatggcag actcctgaca tgttagtgga
      361 gattgagacg gcgtggtcac tttctggcta tttgctcgtt tgcttctctg cggggtattt
      421 catccacgat acggtggaca tcgtggctag cggacagacg cgagcctctt gggaatacct
      481 tgtccatcac gtcatggcca tgggtgcctt cttctccggc atcttttgga gcagctttgt
      541 cggtgggggt gtcttaacac tactggtgga agtcagcaac atcttcctca ccattcgcat
      601 gatgatgaaa atcagtaatg cccaggatca tctcctctac cgggttaaca agtatgtgaa
      661 cctggtcatg tactttctct tccgcctggc ccctcaggcc tacctcaccc atttcttctt
      721 gcgttatgtg aaccagagga ccctgggcac cttcctgctg ggtatcctgc tcatgctgga
      781 cgtgatgatc ataatctact tttcccgcct cctccgctct gacttctgcc ctgagcatgt
      841 ccccaagaag caacacaaag acaagttctt gactgagtga ggggcacaga gcctgggaca
      901 acaaaaacgg acaaggccag aaacagcttc atatggacac tgggacttag ccccaagcct
      961 gggtgtcctc tgaggccagc ctctccacct tctgagcctg cgcccacact attgaaaaca
     1021 ctaatgaaag tactcctctg aa
//
