LOCUS       NM_032136               2660 bp    mRNA    linear   PRI 05-APR-2024
DEFINITION  Homo sapiens transketolase like 2 (TKTL2), mRNA.
ACCESSION   NM_032136
VERSION     NM_032136.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2660)
  AUTHORS   Deshpande,G.P., Patterton,H.G. and Faadiel Essop,M.
  TITLE     The human transketolase-like proteins TKTL1 and TKTL2 are bona fide
            transketolases
  JOURNAL   BMC Struct Biol 19 (1), 2 (2019)
   PUBMED   30646877
  REMARK    GeneRIF: Homology modelling of TKTL1 and TKTL2 using transketolase
            (TKT) as template, revealed that both could assume a folded
            structure like TKT. TKTL1/2 presented a cleft of suitable
            dimensions between the homodimer surfaces that could accommodate
            the co-factor-substrate. An appropriate cavity and a hydrophobic
            nodule were also present in TKTL1/2 and implicated in
            aminopyrimidine and thiazole ring binding in TKT, respectively.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2660)
  AUTHORS   Flachsbart,F., Franke,A., Kleindorp,R., Caliebe,A., Blanche,H.,
            Schreiber,S. and Nebel,A.
  TITLE     Investigation of genetic susceptibility factors for human longevity
            - a targeted nonsynonymous SNP study
  JOURNAL   Mutat Res 694 (1-2), 13-19 (2010)
   PUBMED   20800603
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   3  (bases 1 to 2660)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DB095901.1 and AL136779.1.
            
            On May 17, 2019 this sequence version replaced NM_032136.4.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AL136779.1, BC142943.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000280605.5/ ENSP00000280605.3
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-362               DB095901.1         142-503
            363-2660            AL136779.1         355-2652
FEATURES             Location/Qualifiers
     source          1..2660
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q32.2"
     gene            1..2660
                     /gene="TKTL2"
                     /note="transketolase like 2"
                     /db_xref="GeneID:84076"
                     /db_xref="HGNC:HGNC:25313"
     exon            1..2660
                     /gene="TKTL2"
                     /inference="alignment:Splign:2.1.0"
     CDS             21..1901
                     /gene="TKTL2"
                     /EC_number="2.2.1.1"
                     /note="testis tissue sperm-binding protein Li 39a"
                     /codon_start=1
                     /product="transketolase-like protein 2"
                     /protein_id="NP_115512.3"
                     /db_xref="CCDS:CCDS3805.1"
                     /db_xref="GeneID:84076"
                     /db_xref="HGNC:HGNC:25313"
                     /translation="MMANDAKPDVKTVQVLRDTANRLRIHSIRATCASGSGQLTSCCS
                     AAEVVSVLFFHTMKYKQTDPEHPDNDRFILSRGHAAPILYAAWVEVGDISESDLLNLR
                     KLHSDLERHPTPRLPFVDVATGSLGQGLGTACGMAYTGKYLDKASYRVFCLMGDGESS
                     EGSVWEAFAFASHYNLDNLVAVFDVNRLGQSGPAPLEHGADIYQNCCEAFGWNTYLVD
                     GHDVEALCQAFWQASQVKNKPTAIVAKTFKGRGIPNIEDAENWHGKPVPKERADAIVK
                     LIESQIQTNENLIPKSPVEDSPQISITDIKMTSPPAYKVGDKIATQKTYGLALAKLGR
                     ANERVIVLSGDTMNSTFSEIFRKEHPERFIECIIAEQNMVSVALGCATRGRTIAFAGA
                     FAAFFTRAFDQLRMGAISQANINLIGSHCGVSTGEDGVSQMALEDLAMFRSIPNCTVF
                     YPSDAISTEHAIYLAANTKGMCFIRTSQPETAVIYTPQENFEIGQAKVVRHGVNDKVT
                     VIGAGVTLHEALEAADHLSQQGISVRVIDPFTIKPLDAATIISSAKATGGRVITVEDH
                     YREGGIGEAVCAAVSREPDILVHQLAVSGVPQRGKTSELLDMFGISTRHIIAAVTLTL
                     MK"
     regulatory      2639..2644
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TKTL2"
                     /note="hexamer: AATAAA"
     polyA_site      2660
                     /gene="TKTL2"
                     /note="major polyA site"
ORIGIN      
        1 gccaaaccga caaaagagag atgatggcca acgacgccaa gcccgacgtg aagaccgtgc
       61 aggtgctgcg ggacacagcc aaccgcctgc ggatccattc catcagggcc acgtgtgcct
      121 ctggttctgg ccagctcacg tcgtgctgca gtgcagcgga ggtcgtgtct gtcctcttct
      181 tccacacgat gaagtataaa cagacagacc cagaacaccc ggacaacgac cggttcatcc
      241 tctccagggg acatgctgct cctatcctct atgctgcttg ggtggaggtg ggtgacatca
      301 gtgaatctga cttgctgaac ctgaggaaac ttcacagcga cttggagaga caccctaccc
      361 cccgattgcc gtttgttgac gtggcaacag ggtccctagg tcagggatta ggtactgcat
      421 gtggaatggc ttatactggc aagtaccttg acaaggccag ctaccgggtg ttctgcctta
      481 tgggagatgg cgaatcctca gaaggctctg tgtgggaggc ttttgctttt gcctcccact
      541 acaacttgga caatctcgtg gcggtcttcg acgtgaaccg cttgggacaa agtggccctg
      601 caccccttga gcatggcgca gacatctacc agaattgctg tgaagccttt ggatggaata
      661 cttacttagt ggatggccat gatgtggagg ccttgtgcca agcattttgg caagcaagtc
      721 aagtgaagaa caagcctact gctatagttg ccaagacctt caaaggtcgg ggtattccaa
      781 atattgagga tgcagaaaat tggcatggaa agccagtgcc aaaagaaaga gcagatgcaa
      841 ttgtcaaatt aattgagagt cagatacaga ccaatgagaa tctcatacca aaatcgcctg
      901 tggaagactc acctcaaata agcatcacag atataaaaat gacctcccca cctgcttaca
      961 aagttggtga caagatagct actcagaaaa catatggttt ggctctggct aaactgggcc
     1021 gtgcaaatga aagagttatt gttctgagtg gtgacacgat gaactccacc ttttctgaga
     1081 tattcaggaa agaacaccct gagcgtttca tagagtgtat tattgctgaa caaaacatgg
     1141 taagtgtggc actaggctgt gctacacgtg gtcgaaccat tgcttttgct ggtgcttttg
     1201 ctgccttttt tactagagca ttcgatcagc tccgaatggg agccatttct caagccaata
     1261 tcaaccttat tggttcccac tgtggggtat ccactggaga agatggagtc tcccagatgg
     1321 ccctggagga tctagccatg ttccgaagca ttcccaattg tactgttttc tatccaagtg
     1381 atgccatctc gacagagcat gctatttatc tagccgccaa taccaaggga atgtgcttca
     1441 ttcgaaccag ccaaccagaa actgcagtta tttatacccc acaagaaaat tttgagattg
     1501 gccaggccaa ggtggtccgc cacggtgtca atgataaagt cacagtaatt ggagctggag
     1561 ttactctcca tgaagcctta gaagctgctg accatctttc tcaacaaggt atttctgtcc
     1621 gtgtcatcga cccatttacc attaaacccc tggatgccgc caccatcatc tccagtgcaa
     1681 aagccacagg cggccgagtt atcacagtgg aggatcacta cagggaaggt ggcattggag
     1741 aagctgtttg tgcagctgtc tccagggagc ctgatatcct tgttcatcaa ctggcagtgt
     1801 caggagtgcc tcaacgtggg aaaactagtg aattgctgga tatgtttgga atcagtacca
     1861 gacacattat agcagccgta acacttactt taatgaagta aactaggctt atttctaaaa
     1921 agtcaagtct attggctttg gcccaaaagc actggtatct ttgtattaaa ttcatgttta
     1981 ttgtcacaaa accattattt atacctatac agttgtactg tttcttttaa agcaaagcca
     2041 tttaacatct ttcttcattc ctaatttgga aattaaagtt tacctttctg ttaatctatg
     2101 tataaatgtt actctgagtt attaatgtgg attttaaaat tgtaagcaat agaataggaa
     2161 ataaaacaac tacctaatac aaatatttct gataagacta caaatatctg actgagctgg
     2221 ggattaaagt agaggtaact gtatcttaaa tgagtatgat ttccttgtaa gttaaaaaaa
     2281 ttgaaattta attgtagact tcaatagtcc aagttttgaa ggatgtttga gcttttgtat
     2341 aatgccattt atacctgcag ttttacagat aatgtttgac tgcagttgcc ttggaaattc
     2401 ctccaaagtt tgccttcatc tctcctctac agtttggagg tgatggtgca gcagtggaac
     2461 atctcttgat gcaccacact acttgtgttc tgtgaagtga tgaaagtata actggttcta
     2521 gtttgcacac tacacacata gttttgtgaa gcttcagaaa tgttttttct tttccttgtg
     2581 gccaaaccag tttgttaatc tgattatatt catctgctaa tgatactaaa gttaatgtaa
     2641 taaagcattt aaaaatcaga
//
