LOCUS       NM_001267560            3076 bp    mRNA    linear   PRI 11-FEB-2025
DEFINITION  Homo sapiens tight junction protein 3 (TJP3), transcript variant 1,
            mRNA.
ACCESSION   NM_001267560
VERSION     NM_001267560.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3076)
  AUTHORS   Chaojun,L., Pengping,L., Yanjun,L., Fangyuan,Z., Yaning,H.,
            Yingbo,S., Qi,C. and Hui,L.
  TITLE     TJP3 promotes T cell immunity escape and chemoresistance in breast
            cancer: a comprehensive analysis of anoikis-based prognosis
            prediction and drug sensitivity stratification
  JOURNAL   Aging (Albany NY) 15 (22), 12890-12906 (2023)
   PUBMED   37950731
  REMARK    GeneRIF: TJP3 promotes T cell immunity escape and chemoresistance
            in breast cancer: a comprehensive analysis of anoikis-based
            prognosis prediction and drug sensitivity stratification.
REFERENCE   2  (bases 1 to 3076)
  AUTHORS   Caillet-Saguy,C., Durbesson,F., Rezelj,V.V., Gogl,G., Tran,Q.D.,
            Twizere,J.C., Vignuzzi,M., Vincentelli,R. and Wolff,N.
  TITLE     Host PDZ-containing proteins targeted by SARS-CoV-2
  JOURNAL   FEBS J 288 (17), 5148-5162 (2021)
   PUBMED   33864728
REFERENCE   3  (bases 1 to 3076)
  AUTHORS   Luo,M., Zhang,L., Yang,H., Luo,K. and Qing,C.
  TITLE     Long non-coding RNA NEAT1 promotes ovarian cancer cell invasion and
            migration by interacting with miR-1321 and regulating tight
            junction protein 3 expression
  JOURNAL   Mol Med Rep 22 (4), 3429-3439 (2020)
   PUBMED   32945443
  REMARK    GeneRIF: Long noncoding RNA NEAT1 promotes ovarian cancer cell
            invasion and migration by interacting with miR1321 and regulating
            tight junction protein 3 expression.
            Erratum:[Mol Med Rep. 2024 Jun;29(6):91. doi:
            10.3892/mmr.2024.13215.. PMID: 38577942]
REFERENCE   4  (bases 1 to 3076)
  AUTHORS   Sweeney,M.D., Zhao,Z., Montagne,A., Nelson,A.R. and Zlokovic,B.V.
  TITLE     Blood-Brain Barrier: From Physiology to Disease and Back
  JOURNAL   Physiol Rev 99 (1), 21-78 (2019)
   PUBMED   30280653
  REMARK    Review article
REFERENCE   5  (bases 1 to 3076)
  AUTHORS   Capaldo,C.T., Koch,S., Kwon,M., Laur,O., Parkos,C.A. and Nusrat,A.
  TITLE     Tight function zonula occludens-3 regulates cyclin D1-dependent
            cell proliferation
  JOURNAL   Mol Biol Cell 22 (10), 1677-1685 (2011)
   PUBMED   21411630
  REMARK    GeneRIF: Tight function zonula occludens-3 regulates cyclin
            D1-dependent cell proliferation
REFERENCE   6  (bases 1 to 3076)
  AUTHORS   Voss,M., Lettau,M. and Janssen,O.
  TITLE     Identification of SH3 domain interaction partners of human FasL
            (CD178) by phage display screening
  JOURNAL   BMC Immunol 10, 53 (2009)
   PUBMED   19807924
  REMARK    Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3076)
  AUTHORS   Aho,S., Lupo,J., Coly,P.A., Sabine,A., Castellazzi,M., Morand,P.,
            Sergeant,A., Manet,E., Boyer,V. and Gruffat,H.
  TITLE     Characterization of the ubinuclein protein as a new member of the
            nuclear and adhesion complex components (NACos)
  JOURNAL   Biol Cell 101 (6), 319-334 (2009)
   PUBMED   18823282
REFERENCE   8  (bases 1 to 3076)
  AUTHORS   Roh,M.H., Liu,C.J., Laurinec,S. and Margolis,B.
  TITLE     The carboxyl terminus of zona occludens-3 binds and recruits a
            mammalian homologue of discs lost to tight junctions
  JOURNAL   J Biol Chem 277 (30), 27501-27509 (2002)
   PUBMED   12021270
REFERENCE   9  (bases 1 to 3076)
  AUTHORS   Wittchen,E.S., Haskins,J. and Stevenson,B.R.
  TITLE     Protein interactions at the tight junction. Actin has multiple
            binding partners, and ZO-1 forms independent complexes with ZO-2
            and ZO-3
  JOURNAL   J Biol Chem 274 (49), 35179-35185 (1999)
   PUBMED   10575001
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL555606.3, AK091118.1,
            DB079164.1, AK128237.1 and BM981999.1.
            
            On Nov 22, 2018 this sequence version replaced NM_001267560.1.
            
            Summary: The protein encoded by this gene is a member of the
            membrane-associated guanylate kinase-like (MAGUK) protein family
            which is characterized by members having multiple PDZ domains, a
            single SH3 domain, and a single guanylate kinase-like (GUK)-domain.
            In addition, members of the zonula occludens protein subfamily have
            an acidic domain, a basic arginine-rich region, and a proline-rich
            domain. The protein encoded by this gene plays a role in the
            linkage between the actin cytoskeleton and tight-junctions and also
            sequesters cyclin D1 at tight junctions during mitosis. Alternative
            splicing results in multiple transcript variants encoding distinct
            isoforms. This gene has a partial pseudogene on chromosome 1.
            [provided by RefSeq, May 2012].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes isoform 1.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK091118.1, DRR138524.787348.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968832
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000541714.7/ ENSP00000439278.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-16                AL555606.3         48-63
            17-360              AK091118.1         17-360
            361-474             DB079164.1         208-321
            475-2591            AK091118.1         475-2591
            2592-3072           AK128237.1         2588-3068
            3073-3076           BM981999.1         18-21               c
FEATURES             Location/Qualifiers
     source          1..3076
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3076
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /note="tight junction protein 3"
                     /db_xref="GeneID:27134"
                     /db_xref="HGNC:HGNC:11829"
                     /db_xref="MIM:612689"
     exon            1..178
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            179..235
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     CDS             188..2947
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /note="isoform 1 is encoded by transcript variant 1; tight
                     junction protein ZO-3; zona occludens protein 3; zonula
                     occludens protein 3; tight junction protein 3 (zona
                     occludens 3)"
                     /codon_start=1
                     /product="tight junction protein ZO-3 isoform 1"
                     /protein_id="NP_001254489.1"
                     /db_xref="CCDS:CCDS32873.2"
                     /db_xref="GeneID:27134"
                     /db_xref="HGNC:HGNC:11829"
                     /db_xref="MIM:612689"
                     /translation="MEELTIWEQHTATLSKDPRRGFGIAISGGRDRPGGSMVVSDVVP
                     GGPAEGRLQTGDHIVMVNGVSMENATSAFAIQILKTCTKMANITVKRPRRIHLPATKA
                     SPSSPGRQDSDEDDGPQRVEEVDQGRGYDGDSSSGSGRSWDERSRRPRPGRRGRAGSH
                     GRRSPGGGSEANGLALVSGFKRLPRQDVQMKPVKSVLVKRRDSEEFGVKLGSQIFIKH
                     ITDSGLAARHRGLQEGDLILQINGVSSQNLSLNDTRRLIEKSEGKLSLLVLRDRGQFL
                     VNIPPAVSDSDSSPLEDISDLASELSQAPPSHIPPPPRHAQRSPEASQTDSPVESPRL
                     RRESSVDSRTISEPDEQRSELPRESSYDIYRVPSSQSMEDRGYSPDTRVVRFLKGKSI
                     GLRLAGGNDVGIFVSGVQAGSPADGQGIQEGDQILQVNDVPFQNLTREEAVQFLLGLP
                     PGEEMELVTQRKQDIFWKMVQSRVGDSFYIRTHFELEPSPPSGLGFTRGDVFHVLDTL
                     HPGPGQSHARGGHWLAVRMGRDLREQERGIIPNQSRAEQLASLEAAQRAVGVGPGSSA
                     GSNARAEFWRLRGLRRGAKKTTQRSREDLSALTRQGRYPPYERVVLREASFKRPVVIL
                     GPVADIAMQKLTAEMPDQFEIAETVSRTDSPSKIIKLDTVRVIAEKDKHALLDVTPSA
                     IERLNYVQYYPIVVFFIPESRPALKALRQWLAPASRRSTRRLYAQAQKLRKHSSHLFT
                     ATIPLNGTSDTWYQELKAIIREQQTRPIWTAEDQLDGSLEDNLDLPHHGLADSSADLS
                     CDSRVNSDYETDGEGGAYTDGEGYTDGEGGPYTDVDDEPPAPALARSSEPVQADESQS
                     PRDRGRISAHQGAQVDSRHPQGQWRQDSMRTYEREALKKKFMRVHDAESSDEDGYDWG
                     PATDL"
     exon            236..345
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            346..448
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            449..800
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            801..904
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            905..1064
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1065..1173
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1174..1247
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1248..1314
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1315..1471
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1472..1580
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1581..1818
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            1819..2030
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2031..2126
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2127..2197
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2198..2408
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2409..2509
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2510..2797
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2798..2844
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     exon            2845..3076
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3053..3058
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /note="hexamer: AATAAA"
     polyA_site      3076
                     /gene="TJP3"
                     /gene_synonym="ZO-3; ZO3"
                     /note="major polyA site"
ORIGIN      
        1 agttccactg gcaggggacc tgcctccctg ttgccaccac aagagaggaa aagttggtca
       61 aacaggtggg gaggccagag ctacaagcct cgggttccct ccccaccacc cgtgccaggc
      121 aggcacccgg gccctggcac ctgctgcctg cccagaggcc acccagcctc ctagacaggt
      181 ggctgacatg gaggagctga ccatctggga acagcacacg gccacactgt ccaaggaccc
      241 ccgccggggc tttggcattg cgatctctgg aggccgagac cggcccggtg gatccatggt
      301 tgtatctgac gtggtacctg gagggccggc ggagggcagg ctacagacag gcgaccacat
      361 cgtcatggtg aacggggttt ccatggagaa tgccacctcc gcgtttgcca ttcagatact
      421 caagacctgc accaagatgg ccaacatcac agtgaaacgt ccccggagga tccacctgcc
      481 cgccaccaaa gccagcccct ccagcccagg gcgccaggac tcggatgaag acgatgggcc
      541 ccagcgggtg gaggaggtgg accagggccg gggctatgac ggcgactcat ccagtggctc
      601 cggccgctcc tgggacgagc gctcccgccg gccgaggcct ggtcgccggg gccgggccgg
      661 cagccatggg cgtaggagcc caggtggtgg ctctgaggcc aacgggctgg ccctggtgtc
      721 cggctttaag cggctgccac ggcaggacgt gcagatgaag cctgtgaagt cagtgctggt
      781 gaagaggaga gacagcgaag agtttggcgt caagctgggc agtcagatct tcatcaagca
      841 cattacagat tcgggcctgg ctgcccggca ccgtgggctg caggaaggag atctcattct
      901 acagatcaac ggggtgtcta gccagaacct gtcactgaac gacacccggc gactgattga
      961 gaagtcagaa gggaagctaa gcctgctggt gctgagagat cgtgggcagt tcctggtgaa
     1021 cattccgcct gctgtcagtg acagcgacag ctcgccattg gaggacatct cggacctcgc
     1081 ctcggagcta tcgcaggcac caccatccca catcccacca ccaccccggc atgctcagcg
     1141 gagccccgag gccagccaga ccgactctcc cgtggagagt ccccggcttc ggcgggaaag
     1201 ttcagtagat tccagaacca tctcggaacc agatgagcaa cggtcagagt tgcccaggga
     1261 aagcagctat gacatctaca gagtgcccag cagtcagagc atggaggatc gtgggtacag
     1321 ccccgacacg cgtgtggtcc gcttcctcaa gggcaagagc atcgggctgc ggctggcagg
     1381 gggcaatgac gtgggcatct tcgtgtccgg ggtgcaggcg ggcagcccgg ccgacgggca
     1441 gggcatccag gagggagatc agattctgca ggtgaatgac gtgccattcc agaacctgac
     1501 acgggaggag gcagtgcagt tcctgctggg gctgccacca ggcgaggaga tggagctggt
     1561 gacgcagagg aagcaggaca ttttctggaa aatggtgcag tcccgcgtgg gtgactcctt
     1621 ctacatccgc actcactttg agctggagcc cagtccaccg tctggcctgg gcttcacccg
     1681 tggcgacgtc ttccacgtgc tggacacgct gcaccccggc cccgggcaga gccacgcacg
     1741 aggaggccac tggctggcgg tgcgcatggg tcgtgacctg cgggagcaag agcggggcat
     1801 cattcccaac cagagcaggg cggagcagct ggccagcctg gaagctgccc agagggccgt
     1861 gggagtcggg cccggctcct ccgcgggctc caatgctcgg gccgagttct ggcggctgcg
     1921 gggtcttcgt cgaggagcca agaagaccac tcagcggagc cgtgaggacc tctcagctct
     1981 gacccgacag ggccgctacc cgccctacga acgagtggtg ttgcgagaag ccagtttcaa
     2041 gcgcccggta gtgatcctgg gacccgtggc cgacattgct atgcagaagt tgactgctga
     2101 gatgcctgac cagtttgaaa tcgcagagac tgtgtccagg accgacagcc cctccaagat
     2161 catcaaacta gacaccgtgc gggtgattgc agaaaaagac aagcatgcgc tcctggatgt
     2221 gaccccctcc gccatcgagc gcctcaacta tgtgcagtac taccccattg tggtcttctt
     2281 catccccgag agccggccgg ccctcaaggc actgcgccag tggctggcgc ctgcctcccg
     2341 ccgcagcacc cgtcgcctct acgcacaagc ccagaagctg cgaaaacaca gcagccacct
     2401 cttcacagcc accatccctc tgaatggcac gagtgacacc tggtaccagg agctcaaggc
     2461 catcattcga gagcagcaga cgcggcccat ctggacggcg gaagatcagc tggatggctc
     2521 cttggaggac aacctagacc tccctcacca cggcctggcc gacagctccg ctgacctcag
     2581 ctgcgacagc cgcgttaaca gcgactacga gacggacggc gagggcggcg cgtacacgga
     2641 tggcgagggc tacacagacg gcgagggggg gccctacacg gatgtggatg atgagccccc
     2701 ggctccagcc ctggcccggt cctcggagcc cgtgcaggca gatgagtccc agagcccgag
     2761 ggatcgtggg agaatctcgg ctcatcaggg ggcccaggtg gacagccgcc acccccaggg
     2821 acagtggcga caggacagca tgcgaaccta tgaacgggaa gccctgaaga aaaagtttat
     2881 gcgagtacat gatgcggagt cctccgatga agacggctat gactggggtc cggccactga
     2941 cctgtgacct ctcgaaggct gccagctggt ccgtcctcct tctccctccc tggggctggg
     3001 actcagtttc ccatacagaa cccacaacct tacctccctc cgcctggtct ttaataaaca
     3061 gagtattttc acagca
//
