LOCUS       XM_011519208            4570 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens tight junction protein 2 (TJP2), transcript
            variant X2, mRNA.
ACCESSION   XM_011519208
VERSION     XM_011519208.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000009.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011519208.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4570
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
     gene            1..4570
                     /gene="TJP2"
                     /gene_synonym="C9DUPq21.11; DFNA51; DUP9q21.11; FHCA1;
                     PFIC4; X104; ZO2"
                     /note="tight junction protein 2; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 146 ESTs, 1126 long SRA reads, 8 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 5 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:9414"
                     /db_xref="HGNC:HGNC:11828"
                     /db_xref="MIM:607709"
     CDS             233..3736
                     /gene="TJP2"
                     /gene_synonym="C9DUPq21.11; DFNA51; DUP9q21.11; FHCA1;
                     PFIC4; X104; ZO2"
                     /codon_start=1
                     /product="tight junction protein ZO-2 isoform X1"
                     /protein_id="XP_011517510.1"
                     /db_xref="GeneID:9414"
                     /db_xref="HGNC:HGNC:11828"
                     /db_xref="MIM:607709"
                     /translation="MEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVIS
                     DVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVA
                     ALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHER
                     ARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRSR
                     GRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEP
                     RGRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTV
                     TENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFS
                     PEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPET
                     NKEPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDV
                     GIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQ
                     SRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLA
                     VRIGNELEKGLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSRED
                     LTAVVSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPK
                     DAGSEKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGV
                     KTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQ
                     GEAVWVSEGKMEGMDDDPEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNEL
                     DEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEP
                     PKAKTQNKEESYDFSKSYEYKSNPSAVAGNETPGASTKGYPPPVAAKPTFGRSILKPS
                     TPIPPQEGEEVGESSEEQDNAPKSVLGKVKIFEKMDHKARLQRMQELQEAQNARIEIA
                     QKHPDIYAVPIKTHKPDPGTPQHTSSRPPEPQKAPSRPYQDTRGSYGSDAEEEEYRQQ
                     LSEHSKRGYYGQSARYRDTEL"
ORIGIN      
        1 caccctctcc gcctttcccg acaccccaaa gtagcgctgc gagcagctgc gtctccctcc
       61 cggggctcgc gcgcccagaa ccctccggtc tcaaggaagc agggtgcgaa gtaccacatt
      121 actgtcatct ccctgtgagt gggattggca ccccggctgc agctccagga gcaagtactc
      181 caggaagcac agagctgtac cagtacacgg cccacgttgc caggccccag gcatggaaga
      241 gctgatatgg gaacagtaca ctgtgaccct acaaaaggat tccaaaagag gatttggaat
      301 tgcagtgtcc ggaggcagag acaaccccca ctttgaaaat ggagaaacgt caattgtcat
      361 ttctgatgtg ctcccgggtg ggcctgctga tgggctgctc caagaaaatg acagagtggt
      421 catggtcaat ggcaccccca tggaggatgt gcttcattcg tttgcagttc agcagctcag
      481 aaaaagtggg aaggtcgctg ctattgtggt caagaggccc cggaaggtcc aggtggccgc
      541 acttcaggcc agccctcccc tggatcagga tgaccgggct tttgaggtga tggacgagtt
      601 tgatggcaga agtttccgga gtggctacag cgagaggagc cggctgaaca gccatggggg
      661 gcgcagccgc agctgggagg acagcccgga aagggggcgt ccccatgagc gggcccggag
      721 ccgggagcgg gacctcagcc gggaccggag ccgtggccgg agcctggagc ggggcctgga
      781 ccaagaccat gcgcgcaccc gagaccgcag ccgtggccgg agcctggagc ggggcctgga
      841 ccacgacttt gggccatccc gggaccggga ccgtgaccgc agccgcggcc ggagcattga
      901 ccaggactac gagcgagcct atcaccgggc ctacgaccca gactacgagc gggcctacag
      961 cccggagtac aggcgcgggg cccgccacga tgcccgctct cggggacccc gaagccgcag
     1021 ccgcgagcac ccgcactcac ggagccccag ccccgagcct agggggcggc cggggcccat
     1081 cggggtcctc ctgatgaaaa gcagagcgaa cgaagagtat ggtctccggc ttgggagtca
     1141 gatcttcgta aaggaaatga cccgaacggg tctggcaact aaagatggca accttcacga
     1201 aggagacata attctcaaga tcaatgggac tgtaactgag aacatgtctt taacggatgc
     1261 tcgaaaattg atagaaaagt caagaggaaa actacagcta gtggtgttga gagacagcca
     1321 gcagaccctc atcaacatcc cgtcattaaa tgacagtgac tcagaaatag aagatatttc
     1381 agaaatagag tcaaaccgat cattttctcc agaggagaga cgtcatcagt attctgatta
     1441 tgattatcat tcctcaagtg agaagctgaa ggaaaggcca agttccagag aggacacgcc
     1501 gagcagattg tccaggatgg gtgcgacacc cactcccttt aagtccacag gggatattgc
     1561 aggcacagtt gtcccagaga ccaacaagga acccagatac caagaggacc ccccagctcc
     1621 tcaaccaaaa gcagccccga gaacttttct tcgtcctagt cctgaagatg aagcaatata
     1681 tggccctaat accaaaatgg taaggttcaa gaagggagac agcgtgggcc tccggttggc
     1741 tggtggcaat gatgtcggga tatttgttgc tggcattcaa gaagggacct cggcggagca
     1801 ggagggcctt caagaaggag accagattct gaaggtgaac acacaggatt tcagaggatt
     1861 agtgcgggag gatgccgttc tctacctgtt agaaatccct aaaggtgaaa tggtgaccat
     1921 tttagctcag agccgagccg atgtgtatag agacatcctg gcttgtggca gaggggattc
     1981 gttttttata agaagccact ttgaatgtga gaaggaaact ccacagagcc tggccttcac
     2041 cagaggggag gtcttccgag tggtagacac actgtatgac ggcaagctgg gcaactggct
     2101 ggctgtgagg attgggaacg agttggagaa aggcttaatc cccaacaaga gcagagctga
     2161 acaaatggcc agtgttcaaa atgcccagag agacaacgct ggggaccggg cagatttctg
     2221 gagaatgcgt ggccagaggt ctggggtgaa gaagaacctg aggaaaagtc gggaagacct
     2281 cacagctgtt gtgtctgtca gcaccaagtt cccagcttat gagagggttt tgctgcgaga
     2341 agctggtttc aagagacctg tggtcttatt cggccccata gctgatatag caatggaaaa
     2401 attggctaat gagttacctg actggtttca aactgctaaa acggaaccaa aagatgcagg
     2461 atctgagaaa tccactggag tggtccggtt aaataccgtg aggcaaatta ttgaacagga
     2521 taagcatgca ctactggatg tgactccgaa agctgtggac ctgttgaatt acacccagtg
     2581 gttcccaatt gtgatttttt tcaacccaga ctccagacaa ggtgtcaaaa ccatgagaca
     2641 aaggttaaat ccaacgtcca acaaaagttc tcgaaagtta tttgatcaag ccaacaagct
     2701 taaaaaaacg tgtgcacacc tttttacagc tacaatcaac ctaaattcag ccaatgatag
     2761 ctggtttggc agcttaaagg acactattca gcatcagcaa ggagaagcgg tttgggtctc
     2821 tgaaggaaag atggaaggga tggatgatga ccccgaagac cgcatgtcct acttaaccgc
     2881 catgggcgcg gactatctga gttgcgacag ccgcctcatc agtgactttg aagacacgga
     2941 cggtgaagga ggcgcctaca ctgacaatga gctggatgag ccagccgagg agccgctggt
     3001 gtcgtccatc acccgctcct cggagccggt gcagcacgag gagagcataa ggaaacccag
     3061 cccagagcca cgagctcaga tgaggagggc tgctagcagc gatcaactta gggacaatag
     3121 cccgccccca gcattcaagc cagagccgcc caaggccaaa acccagaaca aagaagaatc
     3181 ctatgacttc tccaaatcct atgaatataa gtcaaacccc tctgccgttg ctggtaatga
     3241 aactcctggg gcatctacca aaggttatcc tcctcctgtt gcagcaaaac ctacctttgg
     3301 gcggtctata ctgaagccct ccactcccat ccctcctcaa gagggtgagg aggtgggaga
     3361 gagcagtgag gagcaagata atgctcccaa atcagtcctg ggcaaagtca aaatatttga
     3421 gaagatggat cacaaggcca ggttacagag aatgcaggag ctccaggaag cacagaatgc
     3481 aaggatcgaa attgcccaga agcatcctga tatctatgca gttccaatca aaacgcacaa
     3541 gccagaccct ggcacgcccc agcacacgag ttccagaccc cctgagccac agaaagctcc
     3601 ttccagacct tatcaggata ccagaggaag ttatggcagt gatgccgagg aggaggagta
     3661 ccgccagcag ctgtcagaac actccaagcg cggttactat ggccagtctg cccgataccg
     3721 ggacacagaa ttatagatgt ctgagcacgg actctcccag gcctgcctgc atggcatcag
     3781 actagccact cctgccaggc cgccgggatg gttcttctcc agttagaatg caccatggag
     3841 acgtggtggg actccagctc gtgtgtcctc atggagaacc caggggacag ctggtgcaaa
     3901 ttcagaactg agggctctgt ttgtgggact gggttagagg agtctgtggc tttttgttca
     3961 gaattaagca gaacactgca gtcagatcct gttacttgct tcagtggacc gaaatctgta
     4021 ttctgtttgc gtacttgtaa tatgtatatt aagaagcaat aactattttt cctcattaat
     4081 agctgccttc aaggactgtt tcagtgtgag tcagaatgtg aaaaaggaat aaaaaatact
     4141 gttgggctca aactaaattc aaagaagtac tttattgcaa ctcttttaag tgccttggat
     4201 gagaagtgtc ttaaattttc ttcctttgaa gctttaggca gagccataat ggactaaaac
     4261 attttgacta agtttttata ccagcttaat agctgtagtt ttccctgcac tgtgtcatct
     4321 tttcaaggca tttgtctttg taatattttc cataaatttg gactgtctat atcataacta
     4381 tacttgatag tttggctata agtgctcaat agcttgaagc ccaagaagtt ggtatcgaaa
     4441 tttgttgttt gtttaaaccc aagtgctgca caaaagcaga tacttgagga aaacactatt
     4501 tccaaaagca catgtattga caacagtttt ataatttaat aaaaaggaat acattgcaat
     4561 ccgtaatttt
//
