LOCUS       XM_011519207            4567 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens tight junction protein 2 (TJP2), transcript
            variant X1, mRNA.
ACCESSION   XM_011519207
VERSION     XM_011519207.3
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000009.12) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_011519207.2.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
FEATURES             Location/Qualifiers
     source          1..4567
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="9"
     gene            1..4567
                     /gene="TJP2"
                     /gene_synonym="C9DUPq21.11; DFNA51; DUP9q21.11; FHCA1;
                     PFIC4; X104; ZO2"
                     /note="tight junction protein 2; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 1
                     mRNA, 146 ESTs, 1126 long SRA reads, 8 Proteins, and 100%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 29 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:9414"
                     /db_xref="HGNC:HGNC:11828"
                     /db_xref="MIM:607709"
     CDS             230..3733
                     /gene="TJP2"
                     /gene_synonym="C9DUPq21.11; DFNA51; DUP9q21.11; FHCA1;
                     PFIC4; X104; ZO2"
                     /codon_start=1
                     /product="tight junction protein ZO-2 isoform X1"
                     /protein_id="XP_011517509.1"
                     /db_xref="GeneID:9414"
                     /db_xref="HGNC:HGNC:11828"
                     /db_xref="MIM:607709"
                     /translation="MEELIWEQYTVTLQKDSKRGFGIAVSGGRDNPHFENGETSIVIS
                     DVLPGGPADGLLQENDRVVMVNGTPMEDVLHSFAVQQLRKSGKVAAIVVKRPRKVQVA
                     ALQASPPLDQDDRAFEVMDEFDGRSFRSGYSERSRLNSHGGRSRSWEDSPERGRPHER
                     ARSRERDLSRDRSRGRSLERGLDQDHARTRDRSRGRSLERGLDHDFGPSRDRDRDRSR
                     GRSIDQDYERAYHRAYDPDYERAYSPEYRRGARHDARSRGPRSRSREHPHSRSPSPEP
                     RGRPGPIGVLLMKSRANEEYGLRLGSQIFVKEMTRTGLATKDGNLHEGDIILKINGTV
                     TENMSLTDARKLIEKSRGKLQLVVLRDSQQTLINIPSLNDSDSEIEDISEIESNRSFS
                     PEERRHQYSDYDYHSSSEKLKERPSSREDTPSRLSRMGATPTPFKSTGDIAGTVVPET
                     NKEPRYQEDPPAPQPKAAPRTFLRPSPEDEAIYGPNTKMVRFKKGDSVGLRLAGGNDV
                     GIFVAGIQEGTSAEQEGLQEGDQILKVNTQDFRGLVREDAVLYLLEIPKGEMVTILAQ
                     SRADVYRDILACGRGDSFFIRSHFECEKETPQSLAFTRGEVFRVVDTLYDGKLGNWLA
                     VRIGNELEKGLIPNKSRAEQMASVQNAQRDNAGDRADFWRMRGQRSGVKKNLRKSRED
                     LTAVVSVSTKFPAYERVLLREAGFKRPVVLFGPIADIAMEKLANELPDWFQTAKTEPK
                     DAGSEKSTGVVRLNTVRQIIEQDKHALLDVTPKAVDLLNYTQWFPIVIFFNPDSRQGV
                     KTMRQRLNPTSNKSSRKLFDQANKLKKTCAHLFTATINLNSANDSWFGSLKDTIQHQQ
                     GEAVWVSEGKMEGMDDDPEDRMSYLTAMGADYLSCDSRLISDFEDTDGEGGAYTDNEL
                     DEPAEEPLVSSITRSSEPVQHEESIRKPSPEPRAQMRRAASSDQLRDNSPPPAFKPEP
                     PKAKTQNKEESYDFSKSYEYKSNPSAVAGNETPGASTKGYPPPVAAKPTFGRSILKPS
                     TPIPPQEGEEVGESSEEQDNAPKSVLGKVKIFEKMDHKARLQRMQELQEAQNARIEIA
                     QKHPDIYAVPIKTHKPDPGTPQHTSSRPPEPQKAPSRPYQDTRGSYGSDAEEEEYRQQ
                     LSEHSKRGYYGQSARYRDTEL"
ORIGIN      
        1 cttttgaaat gcaggatctc aggccccacc cagatctgct gaatcaggat cacccaaggg
       61 atccgtttgc acattaacgt ctgagaagta ctggcctagg gtgcgaagta ccacattact
      121 gtcatctccc tgtgagtggg attggcaccc cggctgcagc tccaggagca agtactccag
      181 gaagcacaga gctgtaccag tacacggccc acgttgccag gccccaggca tggaagagct
      241 gatatgggaa cagtacactg tgaccctaca aaaggattcc aaaagaggat ttggaattgc
      301 agtgtccgga ggcagagaca acccccactt tgaaaatgga gaaacgtcaa ttgtcatttc
      361 tgatgtgctc ccgggtgggc ctgctgatgg gctgctccaa gaaaatgaca gagtggtcat
      421 ggtcaatggc acccccatgg aggatgtgct tcattcgttt gcagttcagc agctcagaaa
      481 aagtgggaag gtcgctgcta ttgtggtcaa gaggccccgg aaggtccagg tggccgcact
      541 tcaggccagc cctcccctgg atcaggatga ccgggctttt gaggtgatgg acgagtttga
      601 tggcagaagt ttccggagtg gctacagcga gaggagccgg ctgaacagcc atggggggcg
      661 cagccgcagc tgggaggaca gcccggaaag ggggcgtccc catgagcggg cccggagccg
      721 ggagcgggac ctcagccggg accggagccg tggccggagc ctggagcggg gcctggacca
      781 agaccatgcg cgcacccgag accgcagccg tggccggagc ctggagcggg gcctggacca
      841 cgactttggg ccatcccggg accgggaccg tgaccgcagc cgcggccgga gcattgacca
      901 ggactacgag cgagcctatc accgggccta cgacccagac tacgagcggg cctacagccc
      961 ggagtacagg cgcggggccc gccacgatgc ccgctctcgg ggaccccgaa gccgcagccg
     1021 cgagcacccg cactcacgga gccccagccc cgagcctagg gggcggccgg ggcccatcgg
     1081 ggtcctcctg atgaaaagca gagcgaacga agagtatggt ctccggcttg ggagtcagat
     1141 cttcgtaaag gaaatgaccc gaacgggtct ggcaactaaa gatggcaacc ttcacgaagg
     1201 agacataatt ctcaagatca atgggactgt aactgagaac atgtctttaa cggatgctcg
     1261 aaaattgata gaaaagtcaa gaggaaaact acagctagtg gtgttgagag acagccagca
     1321 gaccctcatc aacatcccgt cattaaatga cagtgactca gaaatagaag atatttcaga
     1381 aatagagtca aaccgatcat tttctccaga ggagagacgt catcagtatt ctgattatga
     1441 ttatcattcc tcaagtgaga agctgaagga aaggccaagt tccagagagg acacgccgag
     1501 cagattgtcc aggatgggtg cgacacccac tccctttaag tccacagggg atattgcagg
     1561 cacagttgtc ccagagacca acaaggaacc cagataccaa gaggaccccc cagctcctca
     1621 accaaaagca gccccgagaa cttttcttcg tcctagtcct gaagatgaag caatatatgg
     1681 ccctaatacc aaaatggtaa ggttcaagaa gggagacagc gtgggcctcc ggttggctgg
     1741 tggcaatgat gtcgggatat ttgttgctgg cattcaagaa gggacctcgg cggagcagga
     1801 gggccttcaa gaaggagacc agattctgaa ggtgaacaca caggatttca gaggattagt
     1861 gcgggaggat gccgttctct acctgttaga aatccctaaa ggtgaaatgg tgaccatttt
     1921 agctcagagc cgagccgatg tgtatagaga catcctggct tgtggcagag gggattcgtt
     1981 ttttataaga agccactttg aatgtgagaa ggaaactcca cagagcctgg ccttcaccag
     2041 aggggaggtc ttccgagtgg tagacacact gtatgacggc aagctgggca actggctggc
     2101 tgtgaggatt gggaacgagt tggagaaagg cttaatcccc aacaagagca gagctgaaca
     2161 aatggccagt gttcaaaatg cccagagaga caacgctggg gaccgggcag atttctggag
     2221 aatgcgtggc cagaggtctg gggtgaagaa gaacctgagg aaaagtcggg aagacctcac
     2281 agctgttgtg tctgtcagca ccaagttccc agcttatgag agggttttgc tgcgagaagc
     2341 tggtttcaag agacctgtgg tcttattcgg ccccatagct gatatagcaa tggaaaaatt
     2401 ggctaatgag ttacctgact ggtttcaaac tgctaaaacg gaaccaaaag atgcaggatc
     2461 tgagaaatcc actggagtgg tccggttaaa taccgtgagg caaattattg aacaggataa
     2521 gcatgcacta ctggatgtga ctccgaaagc tgtggacctg ttgaattaca cccagtggtt
     2581 cccaattgtg atttttttca acccagactc cagacaaggt gtcaaaacca tgagacaaag
     2641 gttaaatcca acgtccaaca aaagttctcg aaagttattt gatcaagcca acaagcttaa
     2701 aaaaacgtgt gcacaccttt ttacagctac aatcaaccta aattcagcca atgatagctg
     2761 gtttggcagc ttaaaggaca ctattcagca tcagcaagga gaagcggttt gggtctctga
     2821 aggaaagatg gaagggatgg atgatgaccc cgaagaccgc atgtcctact taaccgccat
     2881 gggcgcggac tatctgagtt gcgacagccg cctcatcagt gactttgaag acacggacgg
     2941 tgaaggaggc gcctacactg acaatgagct ggatgagcca gccgaggagc cgctggtgtc
     3001 gtccatcacc cgctcctcgg agccggtgca gcacgaggag agcataagga aacccagccc
     3061 agagccacga gctcagatga ggagggctgc tagcagcgat caacttaggg acaatagccc
     3121 gcccccagca ttcaagccag agccgcccaa ggccaaaacc cagaacaaag aagaatccta
     3181 tgacttctcc aaatcctatg aatataagtc aaacccctct gccgttgctg gtaatgaaac
     3241 tcctggggca tctaccaaag gttatcctcc tcctgttgca gcaaaaccta cctttgggcg
     3301 gtctatactg aagccctcca ctcccatccc tcctcaagag ggtgaggagg tgggagagag
     3361 cagtgaggag caagataatg ctcccaaatc agtcctgggc aaagtcaaaa tatttgagaa
     3421 gatggatcac aaggccaggt tacagagaat gcaggagctc caggaagcac agaatgcaag
     3481 gatcgaaatt gcccagaagc atcctgatat ctatgcagtt ccaatcaaaa cgcacaagcc
     3541 agaccctggc acgccccagc acacgagttc cagaccccct gagccacaga aagctccttc
     3601 cagaccttat caggatacca gaggaagtta tggcagtgat gccgaggagg aggagtaccg
     3661 ccagcagctg tcagaacact ccaagcgcgg ttactatggc cagtctgccc gataccggga
     3721 cacagaatta tagatgtctg agcacggact ctcccaggcc tgcctgcatg gcatcagact
     3781 agccactcct gccaggccgc cgggatggtt cttctccagt tagaatgcac catggagacg
     3841 tggtgggact ccagctcgtg tgtcctcatg gagaacccag gggacagctg gtgcaaattc
     3901 agaactgagg gctctgtttg tgggactggg ttagaggagt ctgtggcttt ttgttcagaa
     3961 ttaagcagaa cactgcagtc agatcctgtt acttgcttca gtggaccgaa atctgtattc
     4021 tgtttgcgta cttgtaatat gtatattaag aagcaataac tatttttcct cattaatagc
     4081 tgccttcaag gactgtttca gtgtgagtca gaatgtgaaa aaggaataaa aaatactgtt
     4141 gggctcaaac taaattcaaa gaagtacttt attgcaactc ttttaagtgc cttggatgag
     4201 aagtgtctta aattttcttc ctttgaagct ttaggcagag ccataatgga ctaaaacatt
     4261 ttgactaagt ttttatacca gcttaatagc tgtagttttc cctgcactgt gtcatctttt
     4321 caaggcattt gtctttgtaa tattttccat aaatttggac tgtctatatc ataactatac
     4381 ttgatagttt ggctataagt gctcaatagc ttgaagccca agaagttggt atcgaaattt
     4441 gttgtttgtt taaacccaag tgctgcacaa aagcagatac ttgaggaaaa cactatttcc
     4501 aaaagcacat gtattgacaa cagttttata atttaataaa aaggaataca ttgcaatccg
     4561 taatttt
//
