LOCUS       XM_047432987            7883 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens tight junction protein 1 (TJP1), transcript
            variant X17, mRNA.
ACCESSION   XM_047432987
VERSION     XM_047432987.1
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 6% of CDS bases
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..7883
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     gene            1..7883
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /note="tight junction protein 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 4
                     mRNAs, 83 ESTs, 743 long SRA reads, 16 Proteins, and 95%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 24 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
     CDS             577..5655
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /codon_start=1
                     /product="tight junction protein ZO-1 isoform X17"
                     /protein_id="XP_047288943.1"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
                     /translation="MERNTFSMDCHSKSTAMEETAIWEQHTVTLHRAPGFGFGIAISG
                     GRDNPHFQSGETSIVISDVLKGGPAEGQLQENDRVAMVNGVSMDNVEHAFAVQQLRKS
                     GKNAKITIRRKKKVQIPVSRPDPEPVSDNEEDSYDEEIHDPRSGRSGVVNRRSEKIWP
                     RDRSASRERSLSPRSDRRSVASSQPAKPTKVTLVKSRKNEEYGLRLASHIFVKEISQD
                     SLAARDGNIQEGDVVLKINGTVTENMSLTDAKTLIERSKGKLKMVVQRDERATLLNVP
                     DLSDSIHSANASERDDISEIQSLASDHSGRSHDRPPRRSRSRSPDQRSEPSDHSRHSP
                     QQPSNGSLRSRDEERISKPGAVSTPVKHADDHTPKTVEEVTVERNEKQTPSLPEPKPV
                     YAQVGQPDVDLPVSPSDGVLPNSTHEDGILRPSMKLVKFRKGDSVGLRLAGGNDVGIF
                     VAGVLEDSPAAKEGLEEGDQILRVNNVDFTNIIREEAVLFLLDLPKGEEVTILAQKKK
                     DVYRRIVESDVGDSFYIRTHFEYEKESPYGLSFNKGEVFRVVDTLYNGKLGSWLAIRI
                     GKNHKEVERGIIPNKNRAEQLASVQYTLPKTAGGDRADFWRFRGLRSSKRNLRKSRED
                     LSAQPVQTKFPAYERVVLREAGFLRPVTIFGPIADVAREKLAREEPDIYQIAKSEPRD
                     AGTDQRSSGIIRLHTIKQIIDQDKHALLDVTPNAVDRLNYAQWYPIVVFLNPDSKQGV
                     KTMRMRLCPESRKSARKLYERSHKLRKNNHHLFTTTINLNSMNDGWYGALKEAIQQQQ
                     NQLVWVSEGKADGATSDDLDLHDDRLSYLSAPGSEYSMYSTDSRHTSDYEDTDTEGGA
                     YTDQELDETLNDEVGTPPESAITRSSEPVREDSSGMHHENQTYPPYSPQAQPQPIHRI
                     DSPGFKPASQQVYRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEK
                     QASRDLEQPTYRYESSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPF
                     DNQHSQDLDSRQHPEESSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPG
                     YDTHGRLRPEAQPHPSAGPKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAA
                     VPPLIPSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLE
                     TKKDVNDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPE
                     DIVRSNHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFS
                     SYSSKGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPVTSASLHIHSKGA
                     HGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYPQKSFPDKAPVNG
                     TEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETAHKPDLSSKTPTS
                     PKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPVSPSAVEEDEDED
                     GHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLD
                     KEKGETLLSPLVMCGPHGLKFLKPVELRLPHCASMTPDGWSFALKSSDSSSGDPKTWQ
                     NKCLPGDPNYLVGANCVSVLIDHF"
ORIGIN      
        1 gtggccgctg agttgccggc gccggctgag ccagcggacg ccgcgttcct tggcggccgc
       61 cggttcccgg gaagttacgt ggcgaagccg gcttccgagg agacgccggg aggccacggg
      121 tgctgctgac gggcgggcga ccgggcgagg ccgacgtggc cgggctgcga aagctgcggg
      181 aggccgagtg ggtggccgcg ctcggaggga ggtgccggtc gggcgcgccc cgtggagaag
      241 acccgggcgg ggcgggcgct tcccggactt ttgtccgagt tgaattccct ccccctgggc
      301 cgggcccttc cggccgcccc cgcccgtgcc ccgctcgctc tcgggagatg tttatttggg
      361 ctgtggcgtg aggagcgggc gggccagcgc cgcggagttt cgggtccgag gagcctcgcg
      421 cggcgctgga gagagacaag atgtccgcca gagctgcggc cgccaaggag gaaaggcttt
      481 gtttccgtat tacacagaat gtcactttgt tcctgaagtg tgatctctgg tacttaatat
      541 gcaagacaac acacttttta agaggttatt tcaagtatgg agagaaatac gttttcaatg
      601 gattgccaca gtaagagcac agcaatggag gaaacagcta tatgggaaca acatacagtg
      661 acgcttcaca gggctcctgg atttggattt ggaattgcaa tatctggtgg acgagataat
      721 cctcattttc agagtgggga aacgtcaata gtgatttcag atgtgctgaa aggaggacca
      781 gctgaaggac agctacagga aaatgaccga gttgcaatgg ttaacggagt ttcaatggat
      841 aatgttgaac atgcttttgc tgttcagcaa ctaaggaaaa gtgggaaaaa tgcaaaaatt
      901 acaattagaa ggaagaagaa agttcaaata ccagtaagtc gtcctgatcc tgaaccagta
      961 tctgataatg aagaagatag ttatgatgag gaaatacatg atccaagaag tggccggagt
     1021 ggtgtggtta acagaaggag tgagaagatt tggccgaggg atagaagtgc aagtagagag
     1081 aggagcttgt ccccgcggtc agacaggcgg tcagtggctt ccagccagcc tgctaaacct
     1141 actaaagtca cactggtgaa atcccggaaa aatgaagaat atggtcttcg attggcaagc
     1201 catatatttg ttaaggaaat ttcacaagat agtttggcag caagagatgg caatattcaa
     1261 gaaggtgatg ttgtattgaa gataaatggt actgtgacag aaaatatgtc attgacagat
     1321 gcaaagacat tgatagaaag gtctaaaggc aaattaaaaa tggtagttca aagagatgaa
     1381 cgggctacgc tattgaatgt ccctgatctt tctgacagca tccactctgc taatgcctct
     1441 gagagagacg acatttcaga aattcagtca ctggcatcag atcattctgg tcgatcacac
     1501 gataggcctc cccgccgcag ccggtcacga tctcctgacc agcggtcaga gccttctgat
     1561 cattccaggc actcgccgca gcagccaagc aatggcagtc tccggagtag agatgaagag
     1621 agaatttcta aacctggggc tgtctcaact cctgtaaagc atgctgatga tcacacacct
     1681 aaaacagtgg aagaagttac agttgaaaga aatgagaaac aaacaccttc tcttccagaa
     1741 ccaaagcctg tgtatgccca agttgggcaa ccagatgtgg atttacctgt cagtccatct
     1801 gatggtgtcc tacctaattc aactcatgaa gatgggattc ttcggcccag catgaaattg
     1861 gtaaaattca gaaaaggaga tagtgtgggt ttgcggctgg ctggtggaaa tgatgttgga
     1921 atatttgtag ctggcgttct agaagatagc cctgcagcca aggaaggctt agaggaaggt
     1981 gatcaaattc tcagggtaaa caacgtagat tttacaaata tcataagaga agaagccgtc
     2041 cttttcctgc ttgacctccc taaaggagaa gaagtgacca tattggctca gaagaagaag
     2101 gatgtttatc gtcgcattgt agaatcagat gtaggagatt ctttctatat tagaacccat
     2161 tttgaatatg aaaaggaatc tccctatgga cttagtttta acaaaggaga ggtgttccgt
     2221 gttgtggata ccttgtacaa tggaaaactg ggctcttggc ttgctattcg aattggtaaa
     2281 aatcataagg aggtagaacg aggcatcatc cctaataaga acagagctga gcagctagcc
     2341 agtgtacagt atacacttcc aaaaacagca ggcggagacc gtgctgactt ctggagattc
     2401 agaggtcttc gcagctccaa gagaaatctt cgaaaaagca gagaggattt gtccgctcag
     2461 cctgttcaaa caaagtttcc agcttatgaa agagtggttc ttcgagaagc tggatttctg
     2521 aggcctgtaa ccatttttgg accaatagct gatgttgcca gagaaaagct ggcaagagaa
     2581 gaaccagata tttatcaaat tgcaaagagt gaaccacgag acgctggaac tgaccaacgt
     2641 agctctggca ttattcgcct gcatacaata aagcaaatca tagatcaaga caaacatgct
     2701 ttattagatg taacaccaaa tgcagttgat cgtcttaact atgcccagtg gtatccaatt
     2761 gttgtatttc ttaaccctga ttctaagcaa ggagtaaaaa caatgagaat gaggttatgt
     2821 ccagaatctc ggaaaagtgc caggaagtta tacgagcgat ctcataaact tcgtaaaaat
     2881 aatcaccatc tttttacaac tacaattaac ttaaattcaa tgaatgatgg ttggtatggt
     2941 gcgctgaaag aagcaattca acaacagcaa aaccagctgg tatgggtttc cgagggaaag
     3001 gcggatggtg ctacaagtga tgaccttgat ttgcatgatg atcgtctgtc ctacctgtca
     3061 gctccaggta gtgaatactc aatgtatagc acggacagta gacacacttc tgactatgaa
     3121 gacacagaca cagaaggcgg ggcctacact gatcaagaac tagatgaaac tcttaatgat
     3181 gaggttggga ctccaccgga gtctgccatt acacggtcct ctgagcctgt aagagaggac
     3241 tcctctggaa tgcatcatga aaaccaaaca tatcctcctt actcaccaca agcgcagcca
     3301 caaccaattc atagaataga ctcccctgga tttaagccag cctctcaaca ggtgtataga
     3361 aaggatccat atcccgagga aatgatgagg cagaaccatg ttttgaaaca gccagccgtt
     3421 agtcacccag ggcacaggcc agacaaagag cctaatctga cctatgaacc ccaactccca
     3481 tacgtagaga aacaagccag cagagacctc gagcagccca catacagata cgagtcctca
     3541 agctatacgg accagttttc tcgaaactat gaacatcgtc tgcgatacga agatcgcgtc
     3601 cccatgtatg aagaacagtg gtcatattat gatgacaaac agccctaccc atctcggcca
     3661 ccttttgata atcagcactc tcaagacctt gactccagac agcatcccga agagtcctca
     3721 gaacgagggt actttccacg ttttgaagag ccagcccctc tgtcttacga cagcagacca
     3781 cgttacgaac aggcacctag agcatccgcc ctgcggcacg aagagcagcc agctcctggg
     3841 tatgacacac atggtagact cagaccggaa gcccagcccc acccttcagc agggcccaag
     3901 cctgcagagt ccaagcagta ttttgagcaa tattcacgca gttacgagca agtaccaccc
     3961 caaggattta cctctagagc aggtcatttt gagcctctcc atggtgctgc agctgtccct
     4021 ccgctgatac cttcatctca gcataagcca gaagctctgc cttcaaacac caaaccactg
     4081 cctccacccc caactcaaac cgaagaagag gaagatccag caatgaagcc acagtctgta
     4141 ctcaccagag ttaagatgtt tgaaaacaaa agatctgcat ccttagagac caagaaggat
     4201 gtaaatgaca ctggcagttt taagcctcca gaagtagcat ctaaaccttc aggtgctccc
     4261 atcattggtc ccaaacccac ttctcagaat caattcagtg aacatgacaa aactctgtac
     4321 aggatcccag aacctcaaaa acctcaactg aagccacctg aagatattgt tcggtccaat
     4381 cattatgacc ctgaagaaga tgaagaatat tatcgaaaac agctgtcata ctttgaccga
     4441 agaagttttg agaataagcc tcctgcacac attgccgcca gccatctctc cgagcctgca
     4501 aagccagcgc attctcagaa tcaatcaaat ttttctagtt attcttcaaa gggaaagcct
     4561 cctgaagctg atggtgtgga tagatcattt ggcgagaaac gctatgaacc catccaggcc
     4621 actccccctc ctcctccatt gccctcgcag tatgcccagc catctcagcc tgtcaccagc
     4681 gcgtctctcc acatacattc taagggagca catggtgaag gtaattcagt gtcattggat
     4741 tttcagaatt ccttagtgtc caaaccagac ccacctccat ctcagaataa gccagcaact
     4801 ttcagaccac caaaccgaga agatactgct caggcagctt tctatcccca gaaaagtttt
     4861 ccagataaag ccccagttaa tggaactgaa cagactcaga aaacagtcac tccagcatac
     4921 aatcgattca caccaaaacc atatacaagt tctgcccgac catttgaacg caagtttgaa
     4981 agtcctaaat tcaatcacaa tcttctgcca agtgaaactg cacataaacc tgacttgtct
     5041 tcaaaaactc ccacttctcc aaaaactctt gtgaaatcgc acagtttggc acagcctcct
     5101 gagtttgaca gtggagttga aactttctct atccatgcag agaagcctaa atatcaaata
     5161 aataatatca gcacagtgcc taaagctatt cctgtgagtc cttcagctgt ggaagaggat
     5221 gaagatgaag atggtcatac tgtggtggcc acagcccgag gcatatttaa cagcaatggg
     5281 ggcgtgctga gttccataga aactggtgtt agtataatta tccctcaagg agccattccc
     5341 gaaggagttg agcaggaaat ctatttcaag gtctgccggg acaacagcat ccttccacct
     5401 ttagataaag agaaaggtga aacactgctg agtcctttgg tgatgtgtgg tccccatggc
     5461 ctcaagttcc tgaagcctgt ggagctgcgc ttaccacact gtgcgtccat gactcctgac
     5521 ggttggtctt ttgctctaaa atcatccgac tcctcgtcgg gtgatcctaa aacctggcaa
     5581 aacaagtgtc ttcccggaga tccaaattat ctcgttggag caaactgtgt ttctgtcctt
     5641 attgaccact tttaactctt gaaatatagg aacttaaata atgtgaaact ggattaaact
     5701 taatctaaat ggaaccactc tatcaagtat tatacctttt ttagagttga tactacagtt
     5761 tgttagtatg aggcatttgt ttgaactgat aaagatgagt gagcatgccc ctgaaccatg
     5821 gtcggaaaac atgctacaca ctgcatgttt gtgattgacg ggactgttgg tattggctag
     5881 aggttcaaag atattttgct ttgtgatttt tgtaattttt ttatcgtcac tgcttaactt
     5941 cacatattga tttccgttaa aataccagcc agtaaatggg ggtgcatttg aggtctgttc
     6001 tttccaaagt acactgtttc aaactttact atggccctgg cctagcatac gtacacattt
     6061 tattttatta tgcatgaagt aatatgcaca cattttttaa atgcacctgg aatatataac
     6121 cagtgttgtg gatttaacag aaatgtacag caaggagatt tacaactggg ggagggtgaa
     6181 gtgaagacaa tgacttactg tacatgaaaa cacatttttc ttagggaagg atacaaaagc
     6241 atgtgagact ggttccatgg cctcttcaga tctctaactt caccatatta ccacagacat
     6301 actaaccagc agaaatgcct taccctcatg ttcttaattc ttagctcatt ctccttgtgt
     6361 tactaagttt ttatggcttt tgtgcattat ctagatactg tatcatgaca aagactgagt
     6421 acgttgtgca tttggtggtt tcagaaatgt gttatcaccc agaagaaaat agtggtgtga
     6481 tttggggata tttttttctt ttcttttctt ttcttttttt ttttttttga caaggggcag
     6541 tggtggtttt ctgttctttc tggctatgca tttgaaaatt ttgatgtttt aaggatgctt
     6601 gtacataatg cgtgcatacc acttttgttc ttggtttgta aattaacttt tataaacttt
     6661 acctttttta tacataaaca agaccacgtt tctaaaggct acctttgtat tctctcctgt
     6721 acctcttgag ccttgaactt tgacctctgc agcaataaag cagcgtttct atgacacatg
     6781 caaggtcatt ttttttaaga aaaaggatgc acagagttgt tacattttta agtgctgcat
     6841 ttaaaagata cagttactca gaattctcta gtttgattaa attcttgcaa agtatcccta
     6901 ctgtaatttg tgatacaatg ctgtgcccta aagtgtattt ttttactaat agacaattta
     6961 ttatggcaca tcagcacgat ttctgtttag ataatacacc actacattct gttaatcatt
     7021 aggtgtgact gaatttcttt tgccgttatt aaaaatctca aatttctaaa tctccaaaat
     7081 aaaacttttt aaaataaagt gctggcttgg tctgtttgcc cactgttttc tagtttcatg
     7141 cagctttata atcctgtttt aaaatcctgc acacaaatcc ctatcaccca gcgtcaccta
     7201 ccacctcgtc gtctggtgtt gcatgcagaa tttctcccct tggccagcat gtacagatgg
     7261 gtgggcagtg ctcatctgaa gggctcagac tgaagtgggg cagaaggacc tggagacaga
     7321 gtgggagaag gcagcaggcc gacttccccc tgtgggtaaa cacacacccc tgcgtggaga
     7381 aacacccctg catggggaca cacgtgcgtt tgtgtgtgtg cgtgtaacca tttgtatatg
     7441 gttttattcc ccagataaat agcacgggca ttgtttaatg tcacccacat ttgggggaag
     7501 aaaatgggtt tagtgagcat aaatattcca ttgtggacat cctacttact taactgccac
     7561 ccctgttgac atttggatta ttgctatagt gtttcagtaa acacctttgt ggactgaatc
     7621 catctatgtg gattttattt ttttcatctt tgttaaggta taatttacat agagtaagtt
     7681 actgttttta aaatgtatag ttcaaatttt gacaaacaca tactgtttat ttaccacggt
     7741 taatacatac aacagtttct ttatcttctc taatcatttg taccccttta tactcaaccc
     7801 ttcttccagc ccctggcagg atgatctctt ctgtttctat agttgccttt ttgacagtgt
     7861 catataaatg gaatcataca ata
//
