LOCUS       XM_017022523            8015 bp    mRNA    linear   PRI 25-AUG-2024
DEFINITION  PREDICTED: Homo sapiens tight junction protein 1 (TJP1), transcript
            variant X3, mRNA.
ACCESSION   XM_017022523
VERSION     XM_017022523.2
DBLINK      BioProject: PRJNA168
KEYWORDS    RefSeq; includes ab initio.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
COMMENT     MODEL REFSEQ:  This record is predicted by automated computational
            analysis. This record is derived from a genomic sequence
            (NC_000015.10) annotated using gene prediction method: Gnomon,
            supported by mRNA and EST evidence.
            Also see:
                Documentation of NCBI's Annotation Process
            
            On Apr 5, 2022 this sequence version replaced XM_017022523.1.
            
            ##Genome-Annotation-Data-START##
            Annotation Provider         :: NCBI RefSeq
            Annotation Status           :: Updated annotation
            Annotation Name             :: GCF_000001405.40-RS_2024_08
            Annotation Pipeline         :: NCBI eukaryotic genome annotation
                                           pipeline
            Annotation Software Version :: 10.3
            Annotation Method           :: Best-placed RefSeq; Gnomon;
                                           RefSeqFE; cmsearch; tRNAscan-SE
            Features Annotated          :: Gene; mRNA; CDS; ncRNA
            Annotation Date             :: 08/23/2024
            ##Genome-Annotation-Data-END##
            
            ##RefSeq-Attributes-START##
            ab initio :: 2% of CDS bases
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..8015
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
     gene            1..8015
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /note="tight junction protein 1; Derived by automated
                     computational analysis using gene prediction method:
                     Gnomon. Supporting evidence includes similarity to: 2
                     mRNAs, 82 ESTs, 426 long SRA reads, 13 Proteins, and 97%
                     coverage of the annotated genomic feature by RNAseq
                     alignments, including 9 samples with support for all
                     annotated introns"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
     CDS             211..5787
                     /gene="TJP1"
                     /gene_synonym="ZO-1"
                     /codon_start=1
                     /product="tight junction protein ZO-1 isoform X3"
                     /protein_id="XP_016878012.1"
                     /db_xref="GeneID:7082"
                     /db_xref="HGNC:HGNC:11827"
                     /db_xref="MIM:601009"
                     /translation="MRRLEGLCLRRRRRRRGPARERSGDKMKYQKYLTVLQMAIGVTP
                     SNRGSLLPLKRKLWVTPSSENPNGATSSVSQGKPSLRRIKGRLHRSKSLDSMDFCELT
                     STAMEETAIWEQHTVTLHRAPGFGFGIAISGGRDNPHFQSGETSIVISDVLKGGPAEG
                     QLQENDRVAMVNGVSMDNVEHAFAVQQLRKSGKNAKITIRRKKKVQIPVSRPDPEPVS
                     DNEEDSYDEEIHDPRSGRSGVVNRRSEKIWPRDRSASRERSLSPRSDRRSVASSQPAK
                     PTKVTLVKSRKNEEYGLRLASHIFVKEISQDSLAARDGNIQEGDVVLKINGTVTENMS
                     LTDAKTLIERSKGKLKMVVQRDERATLLNVPDLSDSIHSANASERDDISEIQSLASDH
                     SGRSHDRPPRRSRSRSPDQRSEPSDHSRHSPQQPSNGSLRSRDEERISKPGAVSTPVK
                     HADDHTPKTVEEVTVERNEKQTPSLPEPKPVYAQVGQPDVDLPVSPSDGVLPNSTHED
                     GILRPSMKLVKFRKGDSVGLRLAGGNDVGIFVAGVLEDSPAAKEGLEEGDQILRVNNV
                     DFTNIIREEAVLFLLDLPKGEEVTILAQKKKDVYRRIVESDVGDSFYIRTHFEYEKES
                     PYGLSFNKGEVFRVVDTLYNGKLGSWLAIRIGKNHKEVERGIIPNKNRAEQLASVQYT
                     LPKTAGGDRADFWRFRGLRSSKRNLRKSREDLSAQPVQTKFPAYERVVLREAGFLRPV
                     TIFGPIADVAREKLAREEPDIYQIAKSEPRDAGTDQRSSGIIRLHTIKQIIDQDKHAL
                     LDVTPNAVDRLNYAQWYPIVVFLNPDSKQGVKTMRMRLCPESRKSARKLYERSHKLRK
                     NNHHLFTTTINLNSMNDGWYGALKEAIQQQQNQLVWVSEGKADGATSDDLDLHDDRLS
                     YLSAPGSEYSMYSTDSRHTSDYEDTDTEGGAYTDQELDETLNDEVGTPPESAITRSSE
                     PVREDSSGMHHENQTYPPYSPQAQPQPIHRIDSPGFKPASQQKAEASSPVPYLSPETN
                     PASSTSAVNHNVNLTNVRLEEPTPAPSTSYSPQADSLRTPSTEAAHIMLRDQEPSLSS
                     HVDPTKVYRKDPYPEEMMRQNHVLKQPAVSHPGHRPDKEPNLTYEPQLPYVEKQASRD
                     LEQPTYRYESSSYTDQFSRNYEHRLRYEDRVPMYEEQWSYYDDKQPYPSRPPFDNQHS
                     QDLDSRQHPEESSERGYFPRFEEPAPLSYDSRPRYEQAPRASALRHEEQPAPGYDTHG
                     RLRPEAQPHPSAGPKPAESKQYFEQYSRSYEQVPPQGFTSRAGHFEPLHGAAAVPPLI
                     PSSQHKPEALPSNTKPLPPPPTQTEEEEDPAMKPQSVLTRVKMFENKRSASLETKKDV
                     NDTGSFKPPEVASKPSGAPIIGPKPTSQNQFSEHDKTLYRIPEPQKPQLKPPEDIVRS
                     NHYDPEEDEEYYRKQLSYFDRRSFENKPPAHIAASHLSEPAKPAHSQNQSNFSSYSSK
                     FLGSYTSYDYLKRNVKWGKPPEADGVDRSFGEKRYEPIQATPPPPPLPSQYAQPSQPV
                     TSASLHIHSKGAHGEGNSVSLDFQNSLVSKPDPPPSQNKPATFRPPNREDTAQAAFYP
                     QKSFPDKAPVNGTEQTQKTVTPAYNRFTPKPYTSSARPFERKFESPKFNHNLLPSETA
                     HKPDLSSKTPTSPKTLVKSHSLAQPPEFDSGVETFSIHAEKPKYQINNISTVPKAIPV
                     SPSAVEEDEDEDGHTVVATARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFK
                     VCRDNSILPPLDKEKGETLLSPLVMCGPHGLKFLKPVELRLPHCDPKTWQNKCLPGDP
                     NYLVGANCVSVLIDHF"
ORIGIN      
        1 gccgccgggc cacggcctgc aggggtggaa ggggcggcgg cggcgggagc tgcgggccac
       61 gcacggcggc ggcggcggga gcggccgggc acgcacggcg acggcggcgg cgggagcggg
      121 agcccgggcc acgcacggcc gcagctgcgg gtgcggcggg cgcgggagcg gtgggagctg
      181 tggtggcggc ggatggccca gagctgatct atgcggcgcc tggaggggct gtgtctgcgg
      241 cggcggcgga ggcggcgggg ccctgcccgc gagcggagcg gggacaagat gaagtaccag
      301 aaatacctga cggtgctgca gatggccatc ggcgtcaccc cctccaaccg cggcagcctc
      361 ctgccgctca agaggaagct gtgggtaacg ccatcctctg aaaatcctaa tggtgctact
      421 tctagtgtca gccaaggaaa accctcttta agacgaatta aagggagatt acacagaagc
      481 aaaagccttg atagcatgga tttctgtgag ctcactagca cagcaatgga ggaaacagct
      541 atatgggaac aacatacagt gacgcttcac agggctcctg gatttggatt tggaattgca
      601 atatctggtg gacgagataa tcctcatttt cagagtgggg aaacgtcaat agtgatttca
      661 gatgtgctga aaggaggacc agctgaagga cagctacagg aaaatgaccg agttgcaatg
      721 gttaacggag tttcaatgga taatgttgaa catgcttttg ctgttcagca actaaggaaa
      781 agtgggaaaa atgcaaaaat tacaattaga aggaagaaga aagttcaaat accagtaagt
      841 cgtcctgatc ctgaaccagt atctgataat gaagaagata gttatgatga ggaaatacat
      901 gatccaagaa gtggccggag tggtgtggtt aacagaagga gtgagaagat ttggccgagg
      961 gatagaagtg caagtagaga gaggagcttg tccccgcggt cagacaggcg gtcagtggct
     1021 tccagccagc ctgctaaacc tactaaagtc acactggtga aatcccggaa aaatgaagaa
     1081 tatggtcttc gattggcaag ccatatattt gttaaggaaa tttcacaaga tagtttggca
     1141 gcaagagatg gcaatattca agaaggtgat gttgtattga agataaatgg tactgtgaca
     1201 gaaaatatgt cattgacaga tgcaaagaca ttgatagaaa ggtctaaagg caaattaaaa
     1261 atggtagttc aaagagatga acgggctacg ctattgaatg tccctgatct ttctgacagc
     1321 atccactctg ctaatgcctc tgagagagac gacatttcag aaattcagtc actggcatca
     1381 gatcattctg gtcgatcaca cgataggcct ccccgccgca gccggtcacg atctcctgac
     1441 cagcggtcag agccttctga tcattccagg cactcgccgc agcagccaag caatggcagt
     1501 ctccggagta gagatgaaga gagaatttct aaacctgggg ctgtctcaac tcctgtaaag
     1561 catgctgatg atcacacacc taaaacagtg gaagaagtta cagttgaaag aaatgagaaa
     1621 caaacacctt ctcttccaga accaaagcct gtgtatgccc aagttgggca accagatgtg
     1681 gatttacctg tcagtccatc tgatggtgtc ctacctaatt caactcatga agatgggatt
     1741 cttcggccca gcatgaaatt ggtaaaattc agaaaaggag atagtgtggg tttgcggctg
     1801 gctggtggaa atgatgttgg aatatttgta gctggcgttc tagaagatag ccctgcagcc
     1861 aaggaaggct tagaggaagg tgatcaaatt ctcagggtaa acaacgtaga ttttacaaat
     1921 atcataagag aagaagccgt ccttttcctg cttgacctcc ctaaaggaga agaagtgacc
     1981 atattggctc agaagaagaa ggatgtttat cgtcgcattg tagaatcaga tgtaggagat
     2041 tctttctata ttagaaccca ttttgaatat gaaaaggaat ctccctatgg acttagtttt
     2101 aacaaaggag aggtgttccg tgttgtggat accttgtaca atggaaaact gggctcttgg
     2161 cttgctattc gaattggtaa aaatcataag gaggtagaac gaggcatcat ccctaataag
     2221 aacagagctg agcagctagc cagtgtacag tatacacttc caaaaacagc aggcggagac
     2281 cgtgctgact tctggagatt cagaggtctt cgcagctcca agagaaatct tcgaaaaagc
     2341 agagaggatt tgtccgctca gcctgttcaa acaaagtttc cagcttatga aagagtggtt
     2401 cttcgagaag ctggatttct gaggcctgta accatttttg gaccaatagc tgatgttgcc
     2461 agagaaaagc tggcaagaga agaaccagat atttatcaaa ttgcaaagag tgaaccacga
     2521 gacgctggaa ctgaccaacg tagctctggc attattcgcc tgcatacaat aaagcaaatc
     2581 atagatcaag acaaacatgc tttattagat gtaacaccaa atgcagttga tcgtcttaac
     2641 tatgcccagt ggtatccaat tgttgtattt cttaaccctg attctaagca aggagtaaaa
     2701 acaatgagaa tgaggttatg tccagaatct cggaaaagtg ccaggaagtt atacgagcga
     2761 tctcataaac ttcgtaaaaa taatcaccat ctttttacaa ctacaattaa cttaaattca
     2821 atgaatgatg gttggtatgg tgcgctgaaa gaagcaattc aacaacagca aaaccagctg
     2881 gtatgggttt ccgagggaaa ggcggatggt gctacaagtg atgaccttga tttgcatgat
     2941 gatcgtctgt cctacctgtc agctccaggt agtgaatact caatgtatag cacggacagt
     3001 agacacactt ctgactatga agacacagac acagaaggcg gggcctacac tgatcaagaa
     3061 ctagatgaaa ctcttaatga tgaggttggg actccaccgg agtctgccat tacacggtcc
     3121 tctgagcctg taagagagga ctcctctgga atgcatcatg aaaaccaaac atatcctcct
     3181 tactcaccac aagcgcagcc acaaccaatt catagaatag actcccctgg atttaagcca
     3241 gcctctcaac agaaagcaga agcttcatct ccagtccctt acctttcgcc tgaaacaaac
     3301 ccagcatcat caacctctgc tgttaatcat aatgtaaatt taactaatgt cagactggag
     3361 gagcccaccc cagctccttc cacctcttac tcaccacaag ctgattcttt aagaacacca
     3421 agtactgagg cagctcacat aatgctaaga gatcaagaac catcattgtc gtcgcatgta
     3481 gatccaacaa aggtgtatag aaaggatcca tatcccgagg aaatgatgag gcagaaccat
     3541 gttttgaaac agccagccgt tagtcaccca gggcacaggc cagacaaaga gcctaatctg
     3601 acctatgaac cccaactccc atacgtagag aaacaagcca gcagagacct cgagcagccc
     3661 acatacagat acgagtcctc aagctatacg gaccagtttt ctcgaaacta tgaacatcgt
     3721 ctgcgatacg aagatcgcgt ccccatgtat gaagaacagt ggtcatatta tgatgacaaa
     3781 cagccctacc catctcggcc accttttgat aatcagcact ctcaagacct tgactccaga
     3841 cagcatcccg aagagtcctc agaacgaggg tactttccac gttttgaaga gccagcccct
     3901 ctgtcttacg acagcagacc acgttacgaa caggcaccta gagcatccgc cctgcggcac
     3961 gaagagcagc cagctcctgg gtatgacaca catggtagac tcagaccgga agcccagccc
     4021 cacccttcag cagggcccaa gcctgcagag tccaagcagt attttgagca atattcacgc
     4081 agttacgagc aagtaccacc ccaaggattt acctctagag caggtcattt tgagcctctc
     4141 catggtgctg cagctgtccc tccgctgata ccttcatctc agcataagcc agaagctctg
     4201 ccttcaaaca ccaaaccact gcctccaccc ccaactcaaa ccgaagaaga ggaagatcca
     4261 gcaatgaagc cacagtctgt actcaccaga gttaagatgt ttgaaaacaa aagatctgca
     4321 tccttagaga ccaagaagga tgtaaatgac actggcagtt ttaagcctcc agaagtagca
     4381 tctaaacctt caggtgctcc catcattggt cccaaaccca cttctcagaa tcaattcagt
     4441 gaacatgaca aaactctgta caggatccca gaacctcaaa aacctcaact gaagccacct
     4501 gaagatattg ttcggtccaa tcattatgac cctgaagaag atgaagaata ttatcgaaaa
     4561 cagctgtcat actttgaccg aagaagtttt gagaataagc ctcctgcaca cattgccgcc
     4621 agccatctct ccgagcctgc aaagccagcg cattctcaga atcaatcaaa tttttctagt
     4681 tattcttcaa aatttcttgg ctcttacact agctatgact acttgaaaag gaacgtcaag
     4741 tggggaaagc ctcctgaagc tgatggtgtg gatagatcat ttggcgagaa acgctatgaa
     4801 cccatccagg ccactccccc tcctcctcca ttgccctcgc agtatgccca gccatctcag
     4861 cctgtcacca gcgcgtctct ccacatacat tctaagggag cacatggtga aggtaattca
     4921 gtgtcattgg attttcagaa ttccttagtg tccaaaccag acccacctcc atctcagaat
     4981 aagccagcaa ctttcagacc accaaaccga gaagatactg ctcaggcagc tttctatccc
     5041 cagaaaagtt ttccagataa agccccagtt aatggaactg aacagactca gaaaacagtc
     5101 actccagcat acaatcgatt cacaccaaaa ccatatacaa gttctgcccg accatttgaa
     5161 cgcaagtttg aaagtcctaa attcaatcac aatcttctgc caagtgaaac tgcacataaa
     5221 cctgacttgt cttcaaaaac tcccacttct ccaaaaactc ttgtgaaatc gcacagtttg
     5281 gcacagcctc ctgagtttga cagtggagtt gaaactttct ctatccatgc agagaagcct
     5341 aaatatcaaa taaataatat cagcacagtg cctaaagcta ttcctgtgag tccttcagct
     5401 gtggaagagg atgaagatga agatggtcat actgtggtgg ccacagcccg aggcatattt
     5461 aacagcaatg ggggcgtgct gagttccata gaaactggtg ttagtataat tatccctcaa
     5521 ggagccattc ccgaaggagt tgagcaggaa atctatttca aggtctgccg ggacaacagc
     5581 atccttccac ctttagataa agagaaaggt gaaacactgc tgagtccttt ggtgatgtgt
     5641 ggtccccatg gcctcaagtt cctgaagcct gtggagctgc gcttaccaca ctgtgatcct
     5701 aaaacctggc aaaacaagtg tcttcccgga gatccaaatt atctcgttgg agcaaactgt
     5761 gtttctgtcc ttattgacca cttttaactc ttgaaatata ggaacttaaa taatgtgaaa
     5821 ctggattaaa cttaatctaa atggaaccac tctatcaagt attatacctt ttttagagtt
     5881 gatactacag tttgttagta tgaggcattt gtttgaactg ataaagatga gtgagcatgc
     5941 ccctgaacca tggtcggaaa acatgctaca cactgcatgt ttgtgattga cgggactgtt
     6001 ggtattggct agaggttcaa agatattttg ctttgtgatt tttgtaattt ttttatcgtc
     6061 actgcttaac ttcacatatt gatttccgtt aaaataccag ccagtaaatg ggggtgcatt
     6121 tgaggtctgt tctttccaaa gtacactgtt tcaaacttta ctatggccct ggcctagcat
     6181 acgtacacat tttattttat tatgcatgaa gtaatatgca cacatttttt aaatgcacct
     6241 ggaatatata accagtgttg tggatttaac agaaatgtac agcaaggaga tttacaactg
     6301 ggggagggtg aagtgaagac aatgacttac tgtacatgaa aacacatttt tcttagggaa
     6361 ggatacaaaa gcatgtgaga ctggttccat ggcctcttca gatctctaac ttcaccatat
     6421 taccacagac atactaacca gcagaaatgc cttaccctca tgttcttaat tcttagctca
     6481 ttctccttgt gttactaagt ttttatggct tttgtgcatt atctagatac tgtatcatga
     6541 caaagactga gtacgttgtg catttggtgg tttcagaaat gtgttatcac ccagaagaaa
     6601 atagtggtgt gatttgggga tatttttttc ttttcttttc ttttcttttt tttttttttt
     6661 gacaaggggc agtggtggtt ttctgttctt tctggctatg catttgaaaa ttttgatgtt
     6721 ttaaggatgc ttgtacataa tgcgtgcata ccacttttgt tcttggtttg taaattaact
     6781 tttataaact ttaccttttt tatacataaa caagaccacg tttctaaagg ctacctttgt
     6841 attctctcct gtacctcttg agccttgaac tttgacctct gcagcaataa agcagcgttt
     6901 ctatgacaca tgcaaggtca ttttttttaa gaaaaaggat gcacagagtt gttacatttt
     6961 taagtgctgc atttaaaaga tacagttact cagaattctc tagtttgatt aaattcttgc
     7021 aaagtatccc tactgtaatt tgtgatacaa tgctgtgccc taaagtgtat ttttttacta
     7081 atagacaatt tattatggca catcagcacg atttctgttt agataataca ccactacatt
     7141 ctgttaatca ttaggtgtga ctgaatttct tttgccgtta ttaaaaatct caaatttcta
     7201 aatctccaaa ataaaacttt ttaaaataaa gtgctggctt ggtctgtttg cccactgttt
     7261 tctagtttca tgcagcttta taatcctgtt ttaaaatcct gcacacaaat ccctatcacc
     7321 cagcgtcacc taccacctcg tcgtctggtg ttgcatgcag aatttctccc cttggccagc
     7381 atgtacagat gggtgggcag tgctcatctg aagggctcag actgaagtgg ggcagaagga
     7441 cctggagaca gagtgggaga aggcagcagg ccgacttccc cctgtgggta aacacacacc
     7501 cctgcgtgga gaaacacccc tgcatgggga cacacgtgcg tttgtgtgtg tgcgtgtaac
     7561 catttgtata tggttttatt ccccagataa atagcacggg cattgtttaa tgtcacccac
     7621 atttggggga agaaaatggg tttagtgagc ataaatattc cattgtggac atcctactta
     7681 cttaactgcc acccctgttg acatttggat tattgctata gtgtttcagt aaacaccttt
     7741 gtggactgaa tccatctatg tggattttat ttttttcatc tttgttaagg tataatttac
     7801 atagagtaag ttactgtttt taaaatgtat agttcaaatt ttgacaaaca catactgttt
     7861 atttaccacg gttaatacat acaacagttt ctttatcttc tctaatcatt tgtacccctt
     7921 tatactcaac ccttcttcca gcccctggca ggatgatctc ttctgtttct atagttgcct
     7981 ttttgacagt gtcatataaa tggaatcata caata
//
