LOCUS       NM_001350562            2699 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens tight junction associated protein 1 (TJAP1),
            transcript variant 9, mRNA.
ACCESSION   NM_001350562 XM_006715249
VERSION     NM_001350562.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2699)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   2  (bases 1 to 2699)
  AUTHORS   Deng,X., Sabino,E.C., Cunha-Neto,E., Ribeiro,A.L., Ianni,B.,
            Mady,C., Busch,M.P. and Seielstad,M.
  CONSRTM   REDSII Chagas Study Group from the NHLBI Retrovirus Epidemiology
            Donor Study-II Component International
  TITLE     Genome wide association study (GWAS) of Chagas cardiomyopathy in
            Trypanosoma cruzi seropositive subjects
  JOURNAL   PLoS One 8 (11), e79629 (2013)
   PUBMED   24324551
  REMARK    Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2699)
  AUTHORS   Kawabe,H., Nakanishi,H., Asada,M., Fukuhara,A., Morimoto,K.,
            Takeuchi,M. and Takai,Y.
  TITLE     Pilt, a novel peripheral membrane protein at tight junctions in
            epithelial cells
  JOURNAL   J Biol Chem 276 (51), 48350-48355 (2001)
   PUBMED   11602598
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AL359813.23 and AL355802.13.
            
            On Jun 2, 2019 this sequence version replaced NM_001350562.1.
            
            Summary: This gene encodes a tight junction-associated protein.
            Incorporation of the encoded protein into tight junctions occurs at
            a late stage of formation of the junctions. The encoded protein
            localizes to the Golgi and may function in vesicle trafficking.
            Alternatively spliced transcript variants have been described. A
            related pseudogene exists on the X chromosome. [provided by RefSeq,
            Mar 2009].
            
            Transcript Variant: This variant (9), as well as variants 1, 2, 8,
            and 10-15, encodes isoform a.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.19611.1,
                                           SRR1803614.376581.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968968, SAMEA2142586
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000372449.6/ ENSP00000361527.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-59                AL359813.23        93119-93177
            60-205              AL359813.23        93636-93781
            206-302             AL355802.13        10638-10734
            303-425             AL355802.13        11735-11857
            426-454             AL355802.13        13501-13529
            455-616             AL355802.13        14283-14444
            617-683             AL355802.13        15040-15106
            684-713             AL355802.13        15345-15374
            714-821             AL355802.13        16158-16265
            822-905             AL355802.13        16380-16463
            906-2699            AL355802.13        17518-19311
FEATURES             Location/Qualifiers
     source          1..2699
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p21.1"
     gene            1..2699
                     /gene="TJAP1"
                     /gene_synonym="PILT; TJP4"
                     /note="tight junction associated protein 1"
                     /db_xref="GeneID:93643"
                     /db_xref="HGNC:HGNC:17949"
                     /db_xref="MIM:612658"
     exon            1..59
                     /gene="TJAP1"
                     /gene_synonym="PILT; TJP4"
                     /inference="alignment:Splign:2.1.0"
     exon            60..205
                     /gene="TJAP1"
                     /gene_synonym="PILT; TJP4"
                     /inference="alignment:Splign:2.1.0"
     exon            206..302
                     /gene="TJAP1"
                     /gene_synonym="PILT; TJP4"
                     /inference="alignment:Splign:2.1.0"
     exon            303..425
                     /gene="TJAP1"
                     /gene_synonym="PILT; TJP4"
                     /inference="alignment:Splign:2.1.0"
     CDS             327..2000
                     /gene="TJAP1"
                     /gene_synonym="PILT; TJP4"
                     /note="isoform a is encoded by transcript variant 9;
                     protein incorporated later into tight junctions; tight
                     junction protein 4 (peripheral); tight junction associated
                     protein 1 (peripheral)"
                     /codon_start=1
                     /product="tight junction-associated protein 1 isoform a"
                     /protein_id="NP_001337491.1"
                     /db_xref="CCDS:CCDS55004.1"
                     /db_xref="GeneID:93643"
                     /db_xref="HGNC:HGNC:17949"
                     /db_xref="MIM:612658"
                     /translation="MTSAAPAKKPYRKAPPEHRELRLEIPGSRLEQEEPLTDAERMKL
                     LQEENEELRRRLASATRRTEALERELEIGQDCLELELGQSREELDKFKDKFRRLQNSY
                     TASQRTNQELEDKLHTLASLSHSWIFAIKKAEMDRKTLDWEIVELTNKLLDAKNTINK
                     LEELNERYRLDCNLAVQLLKCNKSHFRNHKFADLPCELQDMVRKHLHSGQEAASPGPA
                     PSLAPGAVVPTSVIARVLEKPESLLLNSAQSGSAGRPLAEDVFVHVDMSEGVPGDPAS
                     PPAPGSPTPQPNGECHSLGTARGSPEEELPLPAFEKLNPYPTPSPPHPLYPGRRVIEF
                     SEDKVRIPRNSPLPNCTYATRQAISLSLVEEGSERARPSPVPSTPASAQASPHHQPSP
                     APLTLSAPASSASSEEDLLVSWQRAFVDRTPPPAAVAQRTAFGRDALPELQRHFAHSP
                     ADRDEVVQAPSARPEESELLLPTEPDSGFPREEEELNLPISPEEERQSLLPINRGTEE
                     GPGTSHTEGRAWPLPSSSRPQRSPKRMGVHHLHRKDSLTQAQEQGNLLN"
     exon            426..454
                     /gene="TJAP1"
                     /gene_synonym="PILT; TJP4"
                     /inference="alignment:Splign:2.1.0"
     exon            455..616
                     /gene="TJAP1"
                     /gene_synonym="PILT; TJP4"
                     /inference="alignment:Splign:2.1.0"
     exon            617..683
                     /gene="TJAP1"
                     /gene_synonym="PILT; TJP4"
                     /inference="alignment:Splign:2.1.0"
     exon            684..713
                     /gene="TJAP1"
                     /gene_synonym="PILT; TJP4"
                     /inference="alignment:Splign:2.1.0"
     exon            714..821
                     /gene="TJAP1"
                     /gene_synonym="PILT; TJP4"
                     /inference="alignment:Splign:2.1.0"
     exon            822..905
                     /gene="TJAP1"
                     /gene_synonym="PILT; TJP4"
                     /inference="alignment:Splign:2.1.0"
     exon            906..2699
                     /gene="TJAP1"
                     /gene_synonym="PILT; TJP4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2679..2684
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TJAP1"
                     /gene_synonym="PILT; TJP4"
                     /note="hexamer: AATAAA"
     polyA_site      2699
                     /gene="TJAP1"
                     /gene_synonym="PILT; TJP4"
                     /note="major polyA site"
ORIGIN      
        1 actacccggc ctgccccgcg gcaagatggc ggcctgaacg cagctggcag cggcggaaag
       61 cttagatcag cctttccaca gctgttagca gcatctgccc caatttcagc tgaagattca
      121 ggtgccccag ggactggaag aaattacagt gcctacttgg aaagaagaag agatagcgac
      181 ttgccccagt ccaaccccag agcgggagct gtggctaaag gaagtggagg ggccgtggga
      241 tgcggagagc cgagggctaa ctcccggaca gcggaacaga gagagctgcc gacaaacaga
      301 cggcggagga gccgtcacct cccagaatga ctagtgccgc ccctgctaag aaaccctacc
      361 gtaaggcacc accagagcat cgggagctgc gtttggaaat tcctggatcc cggcttgagc
      421 aggaggaacc cctgactgat gcagaaagga tgaagctctt acaggaggag aatgaagagc
      481 ttcgccggcg cctggcctcc gccaccagac gcactgaggc cctggaacgt gagctggaaa
      541 ttgggcagga ctgcctggag ctggagctgg gccagagccg cgaggagctg gacaaattta
      601 aggataagtt ccgcaggctg cagaacagct acacggcttc ccagcggacc aaccaggagt
      661 tggaggacaa gctgcacaca ctggcctctc ttagccacag ctggattttt gcaatcaaga
      721 aggctgagat ggataggaag acgctggact gggagattgt ggagctgacc aacaagctgc
      781 tggatgccaa gaacaccatc aacaagctgg aagagctcaa tgagcggtac cggctggact
      841 gcaacctggc tgtacagctc ctcaagtgca acaagtccca cttccgaaac cacaagtttg
      901 ccgatctgcc ctgtgagcta caggacatgg ttcggaaaca tttgcacagt ggtcaagagg
      961 ccgccagccc aggtcctgct cccagcctag ccccaggggc tgtggtgcct acctcagtca
     1021 ttgcccgagt gttagagaag ccggagtctc tactgctcaa ttcagcccag tcaggcagcg
     1081 ccgggcgccc cttggctgag gatgtctttg tgcatgtgga catgagtgag ggtgtcccag
     1141 gtgatccagc cagtcccccg gcccctggca gccccacccc acaacccaat ggggagtgcc
     1201 actctctggg tactgccagg ggctccccgg aggaagagct gcccctgcca gcctttgaga
     1261 agctgaaccc ctacccaacc ccgtctccac cacacccact gtatcctggc cgcagggtaa
     1321 tagagttctc tgaggataag gttcggatcc cccgcaacag ccccctgccc aactgcactt
     1381 acgctacccg ccaggccatt tccctgagcc tggtagagga ggggagtgag cgggcccgcc
     1441 ccagcccagt gcccagcacc cctgcctcag cccaggcctc accccaccac cagcccagcc
     1501 cagcacccct aacactcagt gccccagcta gctctgccag ctctgaagag gacctgctgg
     1561 tcagctggca gcgggcattt gtggaccgta ctccaccacc tgctgctgtg gcccagcgca
     1621 cagcctttgg acgcgatgcc ctccctgagc tgcagcgcca ttttgcccat agccccgctg
     1681 acagagatga ggtggtccag gcaccttctg cccgacccga agagagtgag cttttgctac
     1741 ccacagaacc tgactctggc tttcccaggg aggaagaaga gctgaacctg cctatcagtc
     1801 ctgaggaaga gcgccagagc ctgctgccca ttaacagggg cacagaggag gggccaggca
     1861 cttcccacac cgagggcagg gcctggccac tccccagctc cagtcgcccc cagcgcagcc
     1921 ccaagaggat gggggttcac cacctgcacc gcaaggacag cctgacccag gcccaggagc
     1981 agggcaacct gctcaactag ggcccctgct ggccttcctg ccattgctgc accaggactg
     2041 caaggagtcc ccacaccttg gcagctcagg gtccccagtc caagcccttg acctctcctc
     2101 tatccagacc cgcacagctg tttcctgtgt ggatggggtc aggttgtggg ccatgccagg
     2161 cctgtcagct gcgttgactg actgcagcag cttgcctcat ggttttccct ttttcttaga
     2221 atatttattc ttcagaggta acatgcagtt gggtctcaag acctttcctc caatcagccc
     2281 aacccagccc agactgggct tttctgggga gctgaggagt ttatcagtat tcatcttcca
     2341 tcctttcata gtcacaagtt ttgttatttt gttttttttt gggggtgatg gtgtaattgt
     2401 taacctcatt tccgtttcct acctgtttgc ttcccccccc agtcctccgc atgagctgtt
     2461 gccctccagg ggcctggcac agctggcctt ggggacgagg gagaggactg attcagggcc
     2521 ccctcagctg tctcctccct ccctctggaa aggagggtgg ggctcagggg cctcaagctg
     2581 ggctctgtgt gaggcctggc ccccactccc aaccttggct ctagactgtt actcttaagc
     2641 tttgagaaat tttcacattg atgactattt taaaatcaaa taaaactatt ttactggta
//
