LOCUS       NM_001318777            2189 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens TIR domain containing adaptor protein (TIRAP),
            transcript variant 5, mRNA.
ACCESSION   NM_001318777 XM_011542582
VERSION     NM_001318777.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2189)
  AUTHORS   Rani,A., Nawaz,S.K., Arshad,M. and Arshad,N.
  TITLE     Role of MyD88-Adaptor-Like (MAL) Gene Polymorphism rs8177374 and
            Cytokine (IFN-gamma, TNF-alpha, IL-10, TGF-beta) Levels in Diverse
            Malaria Manifestations upon P. falciparum and P. vivax Infections
  JOURNAL   Jpn J Infect Dis 76 (6), 358-364 (2023)
   PUBMED   37648490
  REMARK    GeneRIF: Role of MyD88-Adaptor-Like (MAL) Gene Polymorphism
            rs8177374 and Cytokine (IFN-gamma, TNF-alpha, IL-10, TGF-beta)
            Levels in Diverse Malaria Manifestations upon P. falciparum and P.
            vivax Infections.
REFERENCE   2  (bases 1 to 2189)
  AUTHORS   Chen,Y., Zhou,P., Deng,Y., Cai,X., Sun,M., Sun,Y. and Wu,D.
  TITLE     ALKBH5-mediated m6 A demethylation of TIRAP mRNA promotes
            radiation-induced liver fibrosis and decreases radiosensitivity of
            hepatocellular carcinoma
  JOURNAL   Clin Transl Med 13 (2), e1198 (2023)
   PUBMED   36792369
  REMARK    GeneRIF: ALKBH5-mediated m[6] A demethylation of TIRAP mRNA
            promotes radiation-induced liver fibrosis and decreases
            radiosensitivity of hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 2189)
  AUTHORS   Bekampyte,J., Savukaityte,A., Bartnykaite,A., Ugenskiene,R.,
            Ziliene,E., Inciura,A. and Juozaityte,E.
  TITLE     TIRAP Rs8177376, Rs611953, Rs3802814, and Rs8177374 Polymorphisms
            and Their Association with Cervical Cancer Phenotype and Prognosis
  JOURNAL   Genes (Basel) 13 (8), 1365 (2022)
   PUBMED   36011276
  REMARK    GeneRIF: TIRAP Rs8177376, Rs611953, Rs3802814, and Rs8177374
            Polymorphisms and Their Association with Cervical Cancer Phenotype
            and Prognosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2189)
  AUTHORS   Traets,M.J.M., Nijhuis,R.H.T., Morre,S.A., Ouburg,S., Remijn,J.A.,
            Blok,B.A., de Laat,B., Jong,E., Herder,G.J.M., Fiolet,A.T.L. and
            Verweij,S.P.
  TITLE     Association of genetic variations in ACE2, TIRAP and factor X with
            outcomes in COVID-19
  JOURNAL   PLoS One 17 (1), e0260897 (2022)
   PUBMED   34995294
  REMARK    GeneRIF: Association of genetic variations in ACE2, TIRAP and
            factor X with outcomes in COVID-19.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2189)
  AUTHORS   Tayel,S.I., Muharram,N.M., Fotoh,D.S., Elbarbary,H.S.,
            Abd-Elhafiz,H.I., El-Masry,E.A., Taha,A.E. and Soliman,S.E.
  TITLE     Prognostic Impact of Genetic Variants of MECP2 and TIRAP on
            Clinical Outcomes of Systemic Lupus Erythematosus with and without
            Nephritis
  JOURNAL   Biomolecules 11 (9), 1378 (2021)
   PUBMED   34572591
  REMARK    GeneRIF: Prognostic Impact of Genetic Variants of MECP2 and TIRAP
            on Clinical Outcomes of Systemic Lupus Erythematosus with and
            without Nephritis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2189)
  AUTHORS   Yamamoto,M., Sato,S., Hemmi,H., Sanjo,H., Uematsu,S., Kaisho,T.,
            Hoshino,K., Takeuchi,O., Kobayashi,M., Fujita,T., Takeda,K. and
            Akira,S.
  TITLE     Essential role for TIRAP in activation of the signalling cascade
            shared by TLR2 and TLR4
  JOURNAL   Nature 420 (6913), 324-329 (2002)
   PUBMED   12447441
REFERENCE   7  (bases 1 to 2189)
  AUTHORS   Bannerman,D.D., Erwert,R.D., Winn,R.K. and Harlan,J.M.
  TITLE     TIRAP mediates endotoxin-induced NF-kappaB activation and apoptosis
            in endothelial cells
  JOURNAL   Biochem Biophys Res Commun 295 (1), 157-162 (2002)
   PUBMED   12083783
  REMARK    GeneRIF: a role for TIRAP in mediating LPS-induced NF-kappaB
            activation and apoptosis in human endothelial cells
REFERENCE   8  (bases 1 to 2189)
  AUTHORS   Shinobu,N., Iwamura,T., Yoneyama,M., Yamaguchi,K., Suhara,W.,
            Fukuhara,Y., Amano,F. and Fujita,T.
  TITLE     Involvement of TIRAP/MAL in signaling for the activation of
            interferon regulatory factor 3 by lipopolysaccharide
  JOURNAL   FEBS Lett 517 (1-3), 251-256 (2002)
   PUBMED   12062447
REFERENCE   9  (bases 1 to 2189)
  AUTHORS   Fitzgerald,K.A., Palsson-McDermott,E.M., Bowie,A.G.,
            Jefferies,C.A., Mansell,A.S., Brady,G., Brint,E., Dunne,A.,
            Gray,P., Harte,M.T., McMurray,D., Smith,D.E., Sims,J.E., Bird,T.A.
            and O'Neill,L.A.
  TITLE     Mal (MyD88-adapter-like) is required for Toll-like receptor-4
            signal transduction
  JOURNAL   Nature 413 (6851), 78-83 (2001)
   PUBMED   11544529
REFERENCE   10 (bases 1 to 2189)
  AUTHORS   Horng,T., Barton,G.M. and Medzhitov,R.
  TITLE     TIRAP: an adapter molecule in the Toll signaling pathway
  JOURNAL   Nat Immunol 2 (9), 835-841 (2001)
   PUBMED   11526399
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK124298.1, AY576785.1 and
            AP001318.6.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Aug 13, 2020 this sequence version replaced NM_001318777.1.
            
            Summary: The innate immune system recognizes microbial pathogens
            through Toll-like receptors (TLRs), which identify
            pathogen-associated molecular patterns. Different TLRs recognize
            different pathogen-associated molecular patterns and all TLRs have
            a Toll-interleukin 1 receptor (TIR) domain, which is responsible
            for signal transduction. The protein encoded by this gene is a TIR
            adaptor protein involved in the TLR4 signaling pathway of the
            immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which
            then results in cytokine secretion and the inflammatory response.
            Alternative splicing of this gene results in several transcript
            variants; however, not all variants have been fully described.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (5) differs in the 5' UTR compared
            to variant 3. Variants 3 and 5 both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK124298.1, SRR14372079.3944037.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1968189
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000392679.6/ ENSP00000376446.1
            RefSeq Select criteria :: based on conservation, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-440               AK124298.1         7-446
            441-1919            AY576785.1         203-1681
            1920-2166           AK124298.1         1926-2172
            2167-2189           AP001318.6         67183-67205
FEATURES             Location/Qualifiers
     source          1..2189
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..2189
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /note="TIR domain containing adaptor protein"
                     /db_xref="GeneID:114609"
                     /db_xref="HGNC:HGNC:17192"
                     /db_xref="MIM:606252"
     exon            1..61
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /inference="alignment:Splign:2.1.0"
     exon            62..185
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /inference="alignment:Splign:2.1.0"
     exon            186..344
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /inference="alignment:Splign:2.1.0"
     CDS             278..943
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /note="isoform a is encoded by transcript variant 5;
                     adapter protein wyatt; toll-interleukin 1 receptor (TIR)
                     domain containing adaptor protein; MyD88 adapter-like
                     protein; toll/interleukin-1 receptor domain-containing
                     adapter protein; Toll-like receptor adaptor protein;
                     adaptor protein Wyatt"
                     /codon_start=1
                     /product="toll/interleukin-1 receptor domain-containing
                     adapter protein isoform a"
                     /protein_id="NP_001305706.1"
                     /db_xref="CCDS:CCDS8472.1"
                     /db_xref="GeneID:114609"
                     /db_xref="HGNC:HGNC:17192"
                     /db_xref="MIM:606252"
                     /translation="MASSTSLPAPGSRPKKPLGKMADWFRQTLLKKPKKRPNSPESTS
                     SDASQPTSQDSPLPPSLSSVTSPSLPPTHASDSGSSRWSKDYDVCVCHSEEDLVAAQD
                     LVSYLEGSTASLRCFLQLRDATPGGAIVSELCQALSSSHCRVLLITPGFLQDPWCKYQ
                     MLQALTEAPGAEGCTIPLLSGLSRAAYPPELRFMYYVDGRGPDGGFRQVKEAVMRYLQ
                     TLS"
     exon            345..923
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /inference="alignment:Splign:2.1.0"
     exon            924..2189
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1917..1922
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /note="hexamer: AATGAA"
     polyA_site      1940
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /note="major polyA site"
     polyA_site      2020
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /note="major polyA site"
     polyA_site      2026
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
     regulatory      2058..2063
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /note="hexamer: TATAAA"
     polyA_site      2077
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
ORIGIN      
        1 ctcttccccg cggagcccgc gcagtccgcg cagccctcat cgcaactggg cccgcgcgca
       61 ggccttacat aggaagtcct tctaaagagc tgcctgccag ctgcccttcc ccagatcccg
      121 aatatcctcc tggccaggtg gagcagagaa cagttcctca gctggtcatg ctgagctcat
      181 accctgatgg ctgctccatg aggtcaagac tgggtctcct ccctcctccc ccttcaccaa
      241 tgcctggtct cacggggcta gttttgaccc ccacgctatg gcatcatcga cctccctccc
      301 agctcctggc tctcggccta agaagcctct aggcaagatg gctgactggt tcaggcagac
      361 cctgctgaag aagcccaaga agaggcccaa ctccccagaa agcacctcca gcgatgcttc
      421 acagcctacc tcacaggaca gcccactacc cccaagcctc agctcagtca cgtctcccag
      481 cctgccaccc acacatgcga gtgacagtgg cagtagtcgc tggagcaaag actatgacgt
      541 ctgcgtgtgc cacagtgagg aagacctggt ggccgcccag gacctggtct cctacttgga
      601 aggcagcact gccagcctgc gctgcttcct gcaactccgg gatgcaaccc caggcggcgc
      661 tatagtgtcc gagctgtgcc aggcactgag cagtagtcac tgccgggtgc tgctcatcac
      721 gccgggcttc cttcaggacc cctggtgcaa gtaccagatg ctgcaggccc tgaccgaggc
      781 tccaggggcc gagggctgca ccatccccct gctgtcgggc ctcagcagag ctgcctaccc
      841 acctgagctc cgattcatgt actacgtcga tggcaggggc cctgatggtg gctttcgtca
      901 agtcaaagaa gctgtcatgc gttatctgca gacactcagt tgacacttgt tatatcatgg
      961 gaccccggaa attggagtga agctagaaac agaaaaccca tgcagggcct cggattccca
     1021 caaatgtgac aagaggtata gggagtgagt cacagcgctt tgctcgtgac cctgggatca
     1081 gagcacccat caggcttcca ttactgtggg ctccctaaga agaccatgga gagcttgggg
     1141 actcccccag gaaggccgtg aagctgggga ttccccctag gaaagccatg aggaagctgg
     1201 ggactcccca agaaggccat gaggaagcca gaaattggag gtggtaggaa gtggtactga
     1261 tcaatgatgg ccagcaggac tcatctcctg cctaactgga caggaagcct ggcacccact
     1321 tctgtcttcc cctggaactg ggcactggcg tacactggta tccctcctaa agaagtgact
     1381 cacctgactg atcagcaaga agcctagatt gcaggcctca ccatggatgg tcttcctagt
     1441 tgcctgggga aaccctggaa tgggcatcag gagaaagcaa caagaatcca gtccttcaca
     1501 ctcacactac tctgttcctc ttcccagaga catcgattca cttcaaagag ctgtagggaa
     1561 gatgcagtca gcactgcact gtatttttta tttattgcct aggtgccatt aaagacacaa
     1621 acctagaagc ctagaggcca ttctgaatat gggggtgggg tggtggaggg agcaagtgaa
     1681 gagatgggaa tccagggctc agggttcaat gccttcacct gagatcacaa gcccatggat
     1741 gctgtgacat ctgggagctt catcagtggt ctggctaaag ctgatacttt cacagtcacc
     1801 atcttcacct ttggactggg aagaatcacc atttttcttc tggcagatga ctgtattcct
     1861 tataggacag gcaaggtttc attcatctgt tctcagtaag tttgttgttg aactgaaatg
     1921 aatttcatta tttcctccaa tgtgtacttt tgtgcccccc tctcacttct ccctatcatg
     1981 acccctcttt tgctgaaaaa aatttttatt attttttcta tctctagttc tagaaagaga
     2041 aaatttattt tttaaattat aaactatttt gccaggcgcc atggctcaca cctgtaatct
     2101 cagcactttg ggaggccgag gcaggtggat cacctgaggt caggagttca agactagcct
     2161 ggccaatatg gtgaaaccct gtctctact
//
