LOCUS       NM_001039661            2342 bp    mRNA    linear   PRI 07-APR-2024
DEFINITION  Homo sapiens TIR domain containing adaptor protein (TIRAP),
            transcript variant 3, mRNA.
ACCESSION   NM_001039661
VERSION     NM_001039661.2
KEYWORDS    RefSeq.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2342)
  AUTHORS   Rani,A., Nawaz,S.K., Arshad,M. and Arshad,N.
  TITLE     Role of MyD88-Adaptor-Like (MAL) Gene Polymorphism rs8177374 and
            Cytokine (IFN-gamma, TNF-alpha, IL-10, TGF-beta) Levels in Diverse
            Malaria Manifestations upon P. falciparum and P. vivax Infections
  JOURNAL   Jpn J Infect Dis 76 (6), 358-364 (2023)
   PUBMED   37648490
  REMARK    GeneRIF: Role of MyD88-Adaptor-Like (MAL) Gene Polymorphism
            rs8177374 and Cytokine (IFN-gamma, TNF-alpha, IL-10, TGF-beta)
            Levels in Diverse Malaria Manifestations upon P. falciparum and P.
            vivax Infections.
REFERENCE   2  (bases 1 to 2342)
  AUTHORS   Chen,Y., Zhou,P., Deng,Y., Cai,X., Sun,M., Sun,Y. and Wu,D.
  TITLE     ALKBH5-mediated m6 A demethylation of TIRAP mRNA promotes
            radiation-induced liver fibrosis and decreases radiosensitivity of
            hepatocellular carcinoma
  JOURNAL   Clin Transl Med 13 (2), e1198 (2023)
   PUBMED   36792369
  REMARK    GeneRIF: ALKBH5-mediated m[6] A demethylation of TIRAP mRNA
            promotes radiation-induced liver fibrosis and decreases
            radiosensitivity of hepatocellular carcinoma.
REFERENCE   3  (bases 1 to 2342)
  AUTHORS   Bekampyte,J., Savukaityte,A., Bartnykaite,A., Ugenskiene,R.,
            Ziliene,E., Inciura,A. and Juozaityte,E.
  TITLE     TIRAP Rs8177376, Rs611953, Rs3802814, and Rs8177374 Polymorphisms
            and Their Association with Cervical Cancer Phenotype and Prognosis
  JOURNAL   Genes (Basel) 13 (8), 1365 (2022)
   PUBMED   36011276
  REMARK    GeneRIF: TIRAP Rs8177376, Rs611953, Rs3802814, and Rs8177374
            Polymorphisms and Their Association with Cervical Cancer Phenotype
            and Prognosis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2342)
  AUTHORS   Traets,M.J.M., Nijhuis,R.H.T., Morre,S.A., Ouburg,S., Remijn,J.A.,
            Blok,B.A., de Laat,B., Jong,E., Herder,G.J.M., Fiolet,A.T.L. and
            Verweij,S.P.
  TITLE     Association of genetic variations in ACE2, TIRAP and factor X with
            outcomes in COVID-19
  JOURNAL   PLoS One 17 (1), e0260897 (2022)
   PUBMED   34995294
  REMARK    GeneRIF: Association of genetic variations in ACE2, TIRAP and
            factor X with outcomes in COVID-19.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2342)
  AUTHORS   Tayel,S.I., Muharram,N.M., Fotoh,D.S., Elbarbary,H.S.,
            Abd-Elhafiz,H.I., El-Masry,E.A., Taha,A.E. and Soliman,S.E.
  TITLE     Prognostic Impact of Genetic Variants of MECP2 and TIRAP on
            Clinical Outcomes of Systemic Lupus Erythematosus with and without
            Nephritis
  JOURNAL   Biomolecules 11 (9), 1378 (2021)
   PUBMED   34572591
  REMARK    GeneRIF: Prognostic Impact of Genetic Variants of MECP2 and TIRAP
            on Clinical Outcomes of Systemic Lupus Erythematosus with and
            without Nephritis.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2342)
  AUTHORS   Yamamoto,M., Sato,S., Hemmi,H., Sanjo,H., Uematsu,S., Kaisho,T.,
            Hoshino,K., Takeuchi,O., Kobayashi,M., Fujita,T., Takeda,K. and
            Akira,S.
  TITLE     Essential role for TIRAP in activation of the signalling cascade
            shared by TLR2 and TLR4
  JOURNAL   Nature 420 (6913), 324-329 (2002)
   PUBMED   12447441
REFERENCE   7  (bases 1 to 2342)
  AUTHORS   Bannerman,D.D., Erwert,R.D., Winn,R.K. and Harlan,J.M.
  TITLE     TIRAP mediates endotoxin-induced NF-kappaB activation and apoptosis
            in endothelial cells
  JOURNAL   Biochem Biophys Res Commun 295 (1), 157-162 (2002)
   PUBMED   12083783
  REMARK    GeneRIF: a role for TIRAP in mediating LPS-induced NF-kappaB
            activation and apoptosis in human endothelial cells
REFERENCE   8  (bases 1 to 2342)
  AUTHORS   Shinobu,N., Iwamura,T., Yoneyama,M., Yamaguchi,K., Suhara,W.,
            Fukuhara,Y., Amano,F. and Fujita,T.
  TITLE     Involvement of TIRAP/MAL in signaling for the activation of
            interferon regulatory factor 3 by lipopolysaccharide
  JOURNAL   FEBS Lett 517 (1-3), 251-256 (2002)
   PUBMED   12062447
REFERENCE   9  (bases 1 to 2342)
  AUTHORS   Fitzgerald,K.A., Palsson-McDermott,E.M., Bowie,A.G.,
            Jefferies,C.A., Mansell,A.S., Brady,G., Brint,E., Dunne,A.,
            Gray,P., Harte,M.T., McMurray,D., Smith,D.E., Sims,J.E., Bird,T.A.
            and O'Neill,L.A.
  TITLE     Mal (MyD88-adapter-like) is required for Toll-like receptor-4
            signal transduction
  JOURNAL   Nature 413 (6851), 78-83 (2001)
   PUBMED   11544529
REFERENCE   10 (bases 1 to 2342)
  AUTHORS   Horng,T., Barton,G.M. and Medzhitov,R.
  TITLE     TIRAP: an adapter molecule in the Toll signaling pathway
  JOURNAL   Nat Immunol 2 (9), 835-841 (2001)
   PUBMED   11526399
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK124298.1, BC032474.1 and
            AP001318.6.
            
            On Aug 13, 2020 this sequence version replaced NM_001039661.1.
            
            Summary: The innate immune system recognizes microbial pathogens
            through Toll-like receptors (TLRs), which identify
            pathogen-associated molecular patterns. Different TLRs recognize
            different pathogen-associated molecular patterns and all TLRs have
            a Toll-interleukin 1 receptor (TIR) domain, which is responsible
            for signal transduction. The protein encoded by this gene is a TIR
            adaptor protein involved in the TLR4 signaling pathway of the
            immune system. It activates NF-kappa-B, MAPK1, MAPK3 and JNK, which
            then results in cytokine secretion and the inflammatory response.
            Alternative splicing of this gene results in several transcript
            variants; however, not all variants have been fully described.
            [provided by RefSeq, Jul 2008].
            
            Transcript Variant: This variant (3) represents the longer
            transcript but encodes the shorter isoform (a). Variants 3 and 5
            both encode the same isoform (a).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC032474.1, SRR11853562.6667.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-25                AK124298.1         7-31
            26-1095             BC032474.1         1-1070
            1096-2342           AP001318.6         65959-67205
FEATURES             Location/Qualifiers
     source          1..2342
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q24.2"
     gene            1..2342
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /note="TIR domain containing adaptor protein"
                     /db_xref="GeneID:114609"
                     /db_xref="HGNC:HGNC:17192"
                     /db_xref="MIM:606252"
     exon            1..61
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /inference="alignment:Splign:2.1.0"
     exon            62..214
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /inference="alignment:Splign:2.1.0"
     exon            215..338
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /inference="alignment:Splign:2.1.0"
     exon            339..497
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /inference="alignment:Splign:2.1.0"
     CDS             431..1096
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /note="isoform a is encoded by transcript variant 3;
                     adapter protein wyatt; toll-interleukin 1 receptor (TIR)
                     domain containing adaptor protein; MyD88 adapter-like
                     protein; toll/interleukin-1 receptor domain-containing
                     adapter protein; Toll-like receptor adaptor protein;
                     adaptor protein Wyatt"
                     /codon_start=1
                     /product="toll/interleukin-1 receptor domain-containing
                     adapter protein isoform a"
                     /protein_id="NP_001034750.1"
                     /db_xref="CCDS:CCDS8472.1"
                     /db_xref="GeneID:114609"
                     /db_xref="HGNC:HGNC:17192"
                     /db_xref="MIM:606252"
                     /translation="MASSTSLPAPGSRPKKPLGKMADWFRQTLLKKPKKRPNSPESTS
                     SDASQPTSQDSPLPPSLSSVTSPSLPPTHASDSGSSRWSKDYDVCVCHSEEDLVAAQD
                     LVSYLEGSTASLRCFLQLRDATPGGAIVSELCQALSSSHCRVLLITPGFLQDPWCKYQ
                     MLQALTEAPGAEGCTIPLLSGLSRAAYPPELRFMYYVDGRGPDGGFRQVKEAVMRYLQ
                     TLS"
     exon            498..1076
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /inference="alignment:Splign:2.1.0"
     exon            1077..2342
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2070..2075
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /note="hexamer: AATGAA"
     polyA_site      2093
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /note="major polyA site"
     polyA_site      2173
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /note="major polyA site"
     polyA_site      2179
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
     regulatory      2211..2216
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
                     /note="hexamer: TATAAA"
     polyA_site      2230
                     /gene="TIRAP"
                     /gene_synonym="BACTS1; Mal; MyD88-2; wyatt"
ORIGIN      
        1 ctcttccccg cggagcccgc gcagtccgcg cagccctcat cgcaactggg cccgcgcgca
       61 gatccaccaa agagaaagca gccctgtgcc agttgctctg ccagcctttc acaggagaag
      121 tgtcactaga atactacagc ccccacaggc tctgctccac agaaacttaa ggctgaaaga
      181 gtgtccgcca tcagggacat cctctgtcac tacggcctta cataggaagt ccttctaaag
      241 agctgcctgc cagctgccct tccccagatc ccgaatatcc tcctggccag gtggagcaga
      301 gaacagttcc tcagctggtc atgctgagct cataccctga tggctgctcc atgaggtcaa
      361 gactgggtct cctccctcct cccccttcac caatgcctgg tctcacgggg ctagttttga
      421 cccccacgct atggcatcat cgacctccct cccagctcct ggctctcggc ctaagaagcc
      481 tctaggcaag atggctgact ggttcaggca gaccctgctg aagaagccca agaagaggcc
      541 caactcccca gaaagcacct ccagcgatgc ttcacagcct acctcacagg acagcccact
      601 acccccaagc ctcagctcag tcacgtctcc cagcctgcca cccacacatg cgagtgacag
      661 tggcagtagt cgctggagca aagactatga cgtctgcgtg tgccacagtg aggaagacct
      721 ggtggccgcc caggacctgg tctcctactt ggaaggcagc actgccagcc tgcgctgctt
      781 cctgcaactc cgggatgcaa ccccaggcgg cgctatagtg tccgagctgt gccaggcact
      841 gagcagtagt cactgccggg tgctgctcat cacgccgggc ttccttcagg acccctggtg
      901 caagtaccag atgctgcagg ccctgaccga ggctccaggg gccgagggct gcaccatccc
      961 cctgctgtcg ggcctcagca gagctgccta cccacctgag ctccgattca tgtactacgt
     1021 cgatggcagg ggccctgatg gtggctttcg tcaagtcaaa gaagctgtca tgcgttatct
     1081 gcagacactc agttgacact tgttatatca tgggaccccg gaaattggag tgaagctaga
     1141 aacagaaaac ccatgcaggg cctcggattc ccacaaatgt gacaagaggt atagggagtg
     1201 agtcacagcg ctttgctcgt gaccctggga tcagagcacc catcaggctt ccattactgt
     1261 gggctcccta agaagaccat ggagagcttg gggactcccc caggaaggcc gtgaagctgg
     1321 ggattccccc taggaaagcc atgaggaagc tggggactcc ccaagaaggc catgaggaag
     1381 ccagaaattg gaggtggtag gaagtggtac tgatcaatga tggccagcag gactcatctc
     1441 ctgcctaact ggacaggaag cctggcaccc acttctgtct tcccctggaa ctgggcactg
     1501 gcgtacactg gtatccctcc taaagaagtg actcacctga ctgatcagca agaagcctag
     1561 attgcaggcc tcaccatgga tggtcttcct agttgcctgg ggaaaccctg gaatgggcat
     1621 caggagaaag caacaagaat ccagtccttc acactcacac tactctgttc ctcttcccag
     1681 agacatcgat tcacttcaaa gagctgtagg gaagatgcag tcagcactgc actgtatttt
     1741 ttatttattg cctaggtgcc attaaagaca caaacctaga agcctagagg ccattctgaa
     1801 tatgggggtg gggtggtgga gggagcaagt gaagagatgg gaatccaggg ctcagggttc
     1861 aatgccttca cctgagatca caagcccatg gatgctgtga catctgggag cttcatcagt
     1921 ggtctggcta aagctgatac tttcacagtc accatcttca cctttggact gggaagaatc
     1981 accatttttc ttctggcaga tgactgtatt ccttatagga caggcaaggt ttcattcatc
     2041 tgttctcagt aagtttgttg ttgaactgaa atgaatttca ttatttcctc caatgtgtac
     2101 ttttgtgccc ccctctcact tctccctatc atgacccctc ttttgctgaa aaaaattttt
     2161 attatttttt ctatctctag ttctagaaag agaaaattta ttttttaaat tataaactat
     2221 tttgccaggc gccatggctc acacctgtaa tctcagcact ttgggaggcc gaggcaggtg
     2281 gatcacctga ggtcaggagt tcaagactag cctggccaat atggtgaaac cctgtctcta
     2341 ct
//
