LOCUS       NM_152902               2998 bp    mRNA    linear   PRI 15-OCT-2024
DEFINITION  Homo sapiens TOR signaling pathway regulator (TIPRL), transcript
            variant 1, mRNA.
ACCESSION   NM_152902
VERSION     NM_152902.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2998)
  AUTHORS   Gao,J., You,T., Liu,J., Yang,L., Liu,Y. and Wang,Y.
  TITLE     TIPRL, a Potential Double-edge Molecule to be Targeted and
            Re-targeted Toward Cancer
  JOURNAL   Cell Biochem Biophys 82 (3), 1681-1691 (2024)
   PUBMED   38888871
  REMARK    GeneRIF: TIPRL, a Potential Double-edge Molecule to be Targeted and
            Re-targeted Toward Cancer.
            Review article
REFERENCE   2  (bases 1 to 2998)
  AUTHORS   Jeon,S.J., Ahn,J.H., Halder,D., Cho,H.S., Lim,J.H., Jun,S.Y.,
            Lee,J.J., Yoon,J.Y., Choi,M.H., Jung,C.R., Kim,J.M. and Kim,N.S.
  TITLE     TIPRL potentiates survival of lung cancer by inducing autophagy
            through the eIF2alpha-ATF4 pathway
  JOURNAL   Cell Death Dis 10 (12), 959 (2019)
   PUBMED   31862913
  REMARK    GeneRIF: TIPRL potentiates survival of lung cancer by inducing
            autophagy through the eIF2alpha-ATF4 pathway.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2998)
  AUTHORS   Jun,S.Y., Jeon,S.J., Yoon,J.Y., Lee,J.J., Yoon,H.R., Choi,M.H.,
            Halder,D., Lee,K. and Kim,N.S.
  TITLE     The positive correlation of TIPRL with LC3 and CD133 contributes to
            cancer aggressiveness: potential biomarkers for early liver cancer
  JOURNAL   Sci Rep 9 (1), 16802 (2019)
   PUBMED   31727942
  REMARK    GeneRIF: The positive correlation of TIPRL with LC3 and CD133
            contributes to cancer aggressiveness: potential biomarkers for
            early liver cancer.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 2998)
  AUTHORS   Yang,Y., Wang,L., Li,L., Li,W., Zhang,Y., Chang,H., Xiao,X., Li,M.
            and Lv,L.
  TITLE     Genetic association and meta-analysis of a schizophrenia GWAS
            variant rs10489202 in East Asian populations
  JOURNAL   Transl Psychiatry 8 (1), 144 (2018)
   PUBMED   30087317
  REMARK    GeneRIF: MPC2 rs10489202 was genome-wide significantly associated
            with schizophrenia. The expression quantitative trait loci analysis
            in lymphoblastoid cell lines from East Asian donors revealed that
            MPC2 rs10489202 was specifically and significantly associated with
            the expression of TIPRL gene.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 2998)
  AUTHORS   St-Denis,N., Gupta,G.D., Lin,Z.Y., Gonzalez-Badillo,B., Veri,A.O.,
            Knight,J.D.R., Rajendran,D., Couzens,A.L., Currie,K.W., Tkach,J.M.,
            Cheung,S.W.T., Pelletier,L. and Gingras,A.C.
  TITLE     Phenotypic and Interaction Profiling of the Human Phosphatases
            Identifies Diverse Mitotic Regulators
  JOURNAL   Cell Rep 17 (9), 2488-2501 (2016)
   PUBMED   27880917
REFERENCE   6  (bases 1 to 2998)
  AUTHORS   Cheung,C.L., Chan,B.Y., Chan,V., Ikegawa,S., Kou,I., Ngai,H.,
            Smith,D., Luk,K.D., Huang,Q.Y., Mori,S., Sham,P.C. and Kung,A.W.
  TITLE     Pre-B-cell leukemia homeobox 1 (PBX1) shows functional and possible
            genetic association with bone mineral density variation
  JOURNAL   Hum Mol Genet 18 (4), 679-687 (2009)
   PUBMED   19064610
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 2998)
  AUTHORS   Chowdhury,D., Xu,X., Zhong,X., Ahmed,F., Zhong,J., Liao,J.,
            Dykxhoorn,D.M., Weinstock,D.M., Pfeifer,G.P. and Lieberman,J.
  TITLE     A PP4-phosphatase complex dephosphorylates gamma-H2AX generated
            during DNA replication
  JOURNAL   Mol Cell 31 (1), 33-46 (2008)
   PUBMED   18614045
REFERENCE   8  (bases 1 to 2998)
  AUTHORS   McConnell,J.L., Gomez,R.J., McCorvey,L.R., Law,B.K. and
            Wadzinski,B.E.
  TITLE     Identification of a PP2A-interacting protein that functions as a
            negative regulator of phosphatase activity in the ATM/ATR signaling
            pathway
  JOURNAL   Oncogene 26 (41), 6021-6030 (2007)
   PUBMED   17384681
REFERENCE   9  (bases 1 to 2998)
  AUTHORS   Gingras,A.C., Caballero,M., Zarske,M., Sanchez,A., Hazbun,T.R.,
            Fields,S., Sonenberg,N., Hafen,E., Raught,B. and Aebersold,R.
  TITLE     A novel, evolutionarily conserved protein phosphatase complex
            involved in cisplatin sensitivity
  JOURNAL   Mol Cell Proteomics 4 (11), 1725-1740 (2005)
   PUBMED   16085932
REFERENCE   10 (bases 1 to 2998)
  AUTHORS   Matsuda,A., Suzuki,Y., Honda,G., Muramatsu,S., Matsuzaki,O.,
            Nagano,Y., Doi,T., Shimotohno,K., Harada,T., Nishida,E., Hayashi,H.
            and Sugano,S.
  TITLE     Large-scale identification and characterization of human genes that
            activate NF-kappaB and MAPK signaling pathways
  JOURNAL   Oncogene 22 (21), 3307-3318 (2003)
   PUBMED   12761501
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AK313520.1 and AL021397.1.
            
            On Nov 22, 2018 this sequence version replaced NM_152902.4.
            
            Summary: TIPRL is an inhibitory regulator of protein phosphatase-2A
            (PP2A) (see PPP2CA; MIM 176915), PP4 (see PPP4C; MIM 602035), and
            PP6 (see PPP6C; MIM 612725) (McConnell et al., 2007 [PubMed
            17384681]).[supplied by OMIM, Nov 2010].
            
            Transcript Variant: This variant (1) represents the longer
            transcript and encodes the longer isoform (1).
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.980507.1,
                                           SRR3476690.906064.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000367833.7/ ENSP00000356807.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-935               AK313520.1         118-1052
            936-2998            AL021397.1         14502-16564         c
FEATURES             Location/Qualifiers
     source          1..2998
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q24.2"
     gene            1..2998
                     /gene="TIPRL"
                     /gene_synonym="TIP; TIP41; TIPRL1"
                     /note="TOR signaling pathway regulator"
                     /db_xref="GeneID:261726"
                     /db_xref="HGNC:HGNC:30231"
                     /db_xref="MIM:611807"
     exon            1..220
                     /gene="TIPRL"
                     /gene_synonym="TIP; TIP41; TIPRL1"
                     /inference="alignment:Splign:2.1.0"
     CDS             117..935
                     /gene="TIPRL"
                     /gene_synonym="TIP; TIP41; TIPRL1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     TIP41-like protein; putative MAPK-activating protein PM10;
                     type 2A-interacting protein; TIP41, TOR signaling pathway
                     regulator-like"
                     /codon_start=1
                     /product="TIP41-like protein isoform 1"
                     /protein_id="NP_690866.1"
                     /db_xref="CCDS:CCDS1270.1"
                     /db_xref="GeneID:261726"
                     /db_xref="HGNC:HGNC:30231"
                     /db_xref="MIM:611807"
                     /translation="MMIHGFQSSHRDFCFGPWKLTASKTHIMKSADVEKLADELHMPS
                     LPEMMFGDNVLRIQHGSGFGIEFNATDALRCVNNYQGMLKVACAEEWQESRTEGEHSK
                     EVIKPYDWTYTTDYKGTLLGESLKLKVVPTTDHIDTEKLKAREQIKFFEEVLLFEDEL
                     HDHGVSSLSVKIRVMPSSFFLLLRFFLRIDGVLIRMNDTRLYHEADKTYMLREYTSRE
                     SKISSLMHVPPSLFTEPNEISQYLPIKEAVCEKLIFPERIDPNPADSQKSTQVE"
     exon            221..400
                     /gene="TIPRL"
                     /gene_synonym="TIP; TIP41; TIPRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            401..500
                     /gene="TIPRL"
                     /gene_synonym="TIP; TIP41; TIPRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            501..632
                     /gene="TIPRL"
                     /gene_synonym="TIP; TIP41; TIPRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            633..728
                     /gene="TIPRL"
                     /gene_synonym="TIP; TIP41; TIPRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            729..791
                     /gene="TIPRL"
                     /gene_synonym="TIP; TIP41; TIPRL1"
                     /inference="alignment:Splign:2.1.0"
     exon            792..2998
                     /gene="TIPRL"
                     /gene_synonym="TIP; TIP41; TIPRL1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1066..1071
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIPRL"
                     /gene_synonym="TIP; TIP41; TIPRL1"
                     /note="hexamer: AATAAA"
     polyA_site      1097
                     /gene="TIPRL"
                     /gene_synonym="TIP; TIP41; TIPRL1"
                     /note="major polyA site"
     regulatory      2976..2981
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIPRL"
                     /gene_synonym="TIP; TIP41; TIPRL1"
                     /note="hexamer: AATAAA"
     polyA_site      2998
                     /gene="TIPRL"
                     /gene_synonym="TIP; TIP41; TIPRL1"
ORIGIN      
        1 atggtaacgg ctcggaagcc taggaggctg ggccggaggg aggcggagga accggtgttc
       61 gccgccgccg ctgcttcagc ttattccttg tggcctctgc gggtcctgcc tcagccatga
      121 tgatccacgg cttccagagc agccaccggg atttctgctt cgggccctgg aagctgacgg
      181 cgtccaagac ccacatcatg aagtcggcgg atgtggagaa attagccgat gaattacata
      241 tgccatctct ccctgaaatg atgtttggag acaacgtttt aagaatccag catgggtctg
      301 gctttggaat tgagttcaat gctacagatg cgttaagatg tgtaaacaac taccaaggaa
      361 tgcttaaagt ggcctgtgct gaagagtggc aagaaagcag gacggagggt gaacactcca
      421 aagaggttat taaaccatat gattggacct atacaacaga ttataaggga accttacttg
      481 gagaatctct taagttaaag gttgtaccta caacagatca tatagataca gaaaaattga
      541 aagccagaga acagattaag ttttttgaag aagttctcct ttttgaggat gaacttcatg
      601 atcatggagt ttcaagcctg agtgtgaaga ttagagtaat gccttctagc tttttcctgc
      661 tgttgcggtt tttcttgaga attgatgggg tgcttatcag aatgaatgac acgagacttt
      721 accatgaggc tgacaagacc tacatgttac gagaatatac gtcacgagaa agcaaaattt
      781 ctagtttgat gcatgttcca ccttccctct tcacggaacc taatgaaata tcccagtatt
      841 taccaataaa ggaagcagtt tgtgagaagc taatatttcc agaaagaatt gatcctaacc
      901 cagcagactc acaaaaaagt acacaagtgg aataaaatgt gatacaacat atactcacta
      961 tggaatctga ctggacacct tggctatttg taaggggtta tttttattat gagaattaat
     1021 tgccttgttt atgtacagat tttctgtagc cttaaaggaa aaaaaaataa agatcgttac
     1081 aggcaggttt cactcaactg ctgtttgtac tgtctgtctt cacattcata ttccagattt
     1141 atattttctg gagttaaatt tggatgattt ctaaattatc acaaagtggg acctcagcag
     1201 tagtgatgtg tgtgtctcat gagcagtgag cacagtctgc attcatcatg aaacactatc
     1261 ttctaccagg aggaggttaa tgtaaatcac caaatcccaa tgccttgtga ctttcatagg
     1321 attcctgatc atgcatgttg atgtactggc tcttcacttt gggctttctg atgtttattc
     1381 acacctttgg agagttgcaa cttgccacat acgaaattag tctcatagtg tagtgaactt
     1441 caaccccaaa attttaaaaa tgtatttccc cccagtttta aattgccttt gaaatttaaa
     1501 aaaaaaaaat ttagacttag taccagaacc aaaaatacct agatttttgg agaacttatt
     1561 acatacatag aaacatgaat atggtttacc actgtgtgtg tgtaggatgt tagaattatc
     1621 tgtcctccat ctttaggtgc tttttcttaa atgtggttct acttatactg atatttttaa
     1681 tttccatctt ccatgcaacc tcagagtgaa taaacccctt aaatttggtg ctggttcgaa
     1741 aaagtctaaa gggtttatta ggggttgttt ttcgcaaata ttacatcaat ccttaaagca
     1801 acaagattaa ttttctgctt aaaatatttg ggaagatagg taaggaggag ggggttttaa
     1861 aatataaaag caagtttttc tattttaagg tgcatatttg taacattaca ggggatgaag
     1921 taaaatgtaa ttaattagca caagacttag ggagtacaga aaatacacag aagtaaattt
     1981 caaatccatt tgattgtttt catagtgacc ccttagtcat tttatattct tgtctgcctt
     2041 tctagaaaaa tggttgtcat aaagtggaaa gtgattaaaa agcatcaaat aagaaattat
     2101 ttcaagtgga tttttaaaaa tatttttttg aagggcaggg ggaaaattca ccccttttct
     2161 gatttgaaat atgttgtaca tatttccatt tgatggataa atcattaagt aagaatattt
     2221 gatttaaagt attagccaac ctcttcaggt attagcctga agataaattt taacaaaaca
     2281 tatacacttg ggtatccgtc attgctcaaa ctctatagtg tattgctgga gccaataggc
     2341 agggtatatt ttattagcta aatttgatat ttgtcttctg ccttctgtat cacctccaag
     2401 ctataggaaa tcaggatttt gttggcttta agaaaacaca tggtatgttc actgtatatt
     2461 aaatatacct gtatttaatg ttttctctta ggacagaaaa gtagacacac acacacacac
     2521 acacacacat gttgtgttca gctttctgtt ttatattatt tgccattgag attagaatag
     2581 aacaggctct attcatgcaa actatatgaa atgaaaaact tttaagactc ttcattaatt
     2641 ggagcttctg ggcaacatcg tgtgtgtgtg tgtgtgtgtg tgtgtgtgtg tgtgtataca
     2701 gacatttttt ttttaacttg ttgattcaga tgtcttggtc cctgaatagt cctagattac
     2761 ttattttgag aattcattgt taaaaattac agggaattaa aataattgcc tttttttttt
     2821 ttagagggta agagatgggt agaagagtat gcctctgaaa attttattag tttattcttg
     2881 tggagaatac caagaaaatg tgtatttgcc cattgctaaa tatgatatat gccattttgt
     2941 atttatttgt cccaagtgtc tttttgtaag aggagaataa acaataagga attactga
//
