LOCUS       NM_017858               1728 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens TIMELESS interacting protein (TIPIN), transcript
            variant 1, mRNA.
ACCESSION   NM_017858
VERSION     NM_017858.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1728)
  AUTHORS   Arai,H., Xiao,Y., Millstein,J., Wang,J., Battaglin,F.,
            Kawanishi,N., Jayachandran,P., Soni,S., Zhang,W., Mancao,C.,
            Salhia,B., Mumenthaler,S.M., Parikh,A.R. and Lenz,H.J.
  TITLE     Germline polymorphisms in genes maintaining the replication fork
            predict the efficacy of oxaliplatin and irinotecan in patients with
            metastatic colorectal cancer
  JOURNAL   Br J Cancer 126 (1), 72-78 (2022)
   PUBMED   34689170
  REMARK    GeneRIF: Germline polymorphisms in genes maintaining the
            replication fork predict the efficacy of oxaliplatin and irinotecan
            in patients with metastatic colorectal cancer.
REFERENCE   2  (bases 1 to 1728)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1728)
  AUTHORS   Lerner,L.K., Holzer,S., Kilkenny,M.L., Svikovic,S., Murat,P.,
            Schiavone,D., Eldridge,C.B., Bittleston,A., Maman,J.D., Branzei,D.,
            Stott,K., Pellegrini,L. and Sale,J.E.
  TITLE     Timeless couples G-quadruplex detection with processing by DDX11
            helicase during DNA replication
  JOURNAL   EMBO J 39 (18), e104185 (2020)
   PUBMED   32705708
REFERENCE   4  (bases 1 to 1728)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
REFERENCE   5  (bases 1 to 1728)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   6  (bases 1 to 1728)
  AUTHORS   Gotter,A.L., Suppa,C. and Emanuel,B.S.
  TITLE     Mammalian TIMELESS and Tipin are evolutionarily conserved
            replication fork-associated factors
  JOURNAL   J Mol Biol 366 (1), 36-52 (2007)
   PUBMED   17141802
  REMARK    GeneRIF: TIM and Tipin are functional orthologs of their
            replisome-associated yeast counterparts capable of coordinating
            replication with genotoxic stress responses, and distinguishes
            mammalian TIM from the circadian-specific paralogs.
REFERENCE   7  (bases 1 to 1728)
  AUTHORS   Yoshizawa-Sugata,N. and Masai,H.
  TITLE     Human Tim/Timeless-interacting protein, Tipin, is required for
            efficient progression of S phase and DNA replication checkpoint
  JOURNAL   J Biol Chem 282 (4), 2729-2740 (2007)
   PUBMED   17102137
  REMARK    GeneRIF: Tipin is a checkpoint mediator that cooperates with Tim
            and may regulate the nuclear relocation of Claspin in response to
            replication checkpoint
REFERENCE   8  (bases 1 to 1728)
  AUTHORS   Chou,D.M. and Elledge,S.J.
  TITLE     Tipin and Timeless form a mutually protective complex required for
            genotoxic stress resistance and checkpoint function
  JOURNAL   Proc Natl Acad Sci U S A 103 (48), 18143-18147 (2006)
   PUBMED   17116885
  REMARK    GeneRIF: observation explains the similar checkpoint phenotypes
            observed in both Tipin- and Timeless-depleted cells
REFERENCE   9  (bases 1 to 1728)
  AUTHORS   Gotter,A.L.
  TITLE     Tipin, a novel timeless-interacting protein, is developmentally
            co-expressed with timeless and disrupts its self-association
  JOURNAL   J Mol Biol 331 (1), 167-176 (2003)
   PUBMED   12875843
REFERENCE   10 (bases 1 to 1728)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC055855.9.
            
            On Nov 23, 2018 this sequence version replaced NM_017858.2.
            
            Summary: The protein encoded by this gene is part of the replisome
            complex, a group of proteins that support DNA replication. It binds
            TIM, which is involved in circadian rhythm regulation, and aids in
            protecting cells against DNA damage and stress. Two pseudogenes and
            two transcript variants encoding different isoforms have been found
            for this gene. [provided by RefSeq, Jul 2014].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR12921934.2502533.1,
                                           SRR14038197.56315.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000261881.9/ ENSP00000261881.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-47                AC055855.9         120033-120079       c
            48-188              AC055855.9         116209-116349       c
            189-267             AC055855.9         115523-115601       c
            268-343             AC055855.9         114919-114994       c
            344-466             AC055855.9         112709-112831       c
            467-530             AC055855.9         112454-112517       c
            531-737             AC055855.9         104544-104750       c
            738-1728            AC055855.9         99585-100575        c
FEATURES             Location/Qualifiers
     source          1..1728
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="15"
                     /map="15q22.31"
     gene            1..1728
                     /gene="TIPIN"
                     /note="TIMELESS interacting protein"
                     /db_xref="GeneID:54962"
                     /db_xref="HGNC:HGNC:30750"
                     /db_xref="MIM:610716"
     exon            1..47
                     /gene="TIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            48..188
                     /gene="TIPIN"
                     /inference="alignment:Splign:2.1.0"
     CDS             56..961
                     /gene="TIPIN"
                     /note="isoform 1 is encoded by transcript variant 1;
                     timeless-interacting protein; CSM3 homolog"
                     /codon_start=1
                     /product="TIMELESS-interacting protein isoform 1"
                     /protein_id="NP_060328.3"
                     /db_xref="CCDS:CCDS10215.1"
                     /db_xref="GeneID:54962"
                     /db_xref="HGNC:HGNC:30750"
                     /db_xref="MIM:610716"
                     /translation="MLEPQENGVIDLPDYEHVEDETFPPFPPPASPERQDGEGTEPDE
                     ESGNGAPVRVPPKRTVKRNIPKLDAQRLISERGLPALRHVFDKAKFKGKGHEAEDLKM
                     LIRHMEHWAHRLFPKLQFEDFIDRVEYLGSKKEVQTCLKRIRLDLPILHEDFVSNNDE
                     VAENNEHDVTSTELDPFLTNLSESEMFASELSRSLTEEQQQRIERNKQLALERRQAKL
                     LSNSQTLGNDMLMNTPRAHTVEEVNTDEDQKEESNGLNEDILDNPCNDAIANTLNEEE
                     TLLDQSFKNVQQQLDATSRNITEAR"
     exon            189..267
                     /gene="TIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            268..343
                     /gene="TIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            344..466
                     /gene="TIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            467..530
                     /gene="TIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            531..737
                     /gene="TIPIN"
                     /inference="alignment:Splign:2.1.0"
     exon            738..1728
                     /gene="TIPIN"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1056..1061
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIPIN"
                     /note="hexamer: AGTAAA"
     polyA_site      1085
                     /gene="TIPIN"
                     /note="major polyA site"
     regulatory      1179..1184
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIPIN"
                     /note="hexamer: CATAAA"
     polyA_site      1199
                     /gene="TIPIN"
     regulatory      1706..1711
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIPIN"
                     /note="hexamer: AGTAAA"
     polyA_site      1728
                     /gene="TIPIN"
ORIGIN      
        1 agtctgcacg ccgaggtccg cgctgtgtcc cgtgttttct gcgtgagagg aaaagatgct
       61 agaaccacag gagaatggcg tgattgacct accagattat gagcatgtag aagatgaaac
      121 ttttcctcct ttcccacctc cagcctctcc agagagacaa gatggtgaag gaactgagcc
      181 tgatgaagag tcaggaaatg gagcacctgt tcgtgtacct ccaaagagaa cagttaaaag
      241 aaatataccc aagctggatg ctcagagatt aatttcagag agaggacttc cagccttaag
      301 gcatgtattt gataaggcaa aattcaaagg taaaggtcat gaggctgaag acttgaagat
      361 gctaatcaga cacatggagc actgggcaca taggctattc cctaaactgc agtttgagga
      421 ttttattgac agagttgaat acctgggaag taaaaaggaa gttcagacct gtttaaaacg
      481 aattcgactt gatctcccta ttttacatga agattttgtt agcaataatg atgaagttgc
      541 ggagaataat gaacatgatg tcacttctac tgaattagat ccctttctga caaacttatc
      601 tgaaagtgag atgtttgctt ctgagttaag tagaagccta acagaagagc aacaacaaag
      661 aattgagaga aataaacaac tggccttgga aagaaggcag gcaaagctgc tgagtaatag
      721 tcagacccta ggaaatgata tgttaatgaa tacacccagg gcacacacgg ttgaagaggt
      781 taatactgat gaggatcaaa aggaggagtc aaatggatta aacgaagaca ttctggacaa
      841 tccatgtaat gatgctattg ccaatacttt aaatgaagag gaaacactgc tggaccagtc
      901 ttttaaaaat gtgcaacagc aacttgatgc tacatccaga aatattactg aagctagata
      961 agtttccatt aagagaaaat gtatctgtta agtcatcgtc ctgcaagctt ggcgttacta
     1021 tgtatttttt cttcttggag tgaaaatcct tagatagtaa aactgttata gattattgtt
     1081 taaaatctga taatctggta tttatttata attatgcttg tcactttagt taaatctatt
     1141 tgttctcttt agtgtttgtt tttatatagg tatttcttca taaaatgatt aggaggtaat
     1201 aagcagtttc tgctgctggt ctgtcattga atgccttgtt ttcactaagt tgggaggttt
     1261 tgtttctgtt ttttactgct ccttgcaaag cagggctaat ccatggacag tgtgcccaga
     1321 gtagtctagt tgaagttttt tgttttgttt tgttttgttt tttttgacac agagtctcac
     1381 tctgttggcc aggctggagt gcagtggcac agtcttggct cactgcaacc tctgcctcct
     1441 gggctcaagc aattctcctg ccttagcctc ccgagtagct gggactacag gcgtgtgcca
     1501 ccacgcttgg ctaatttttg tacttttagt agagatgagg tttcaccatg ttggccaggc
     1561 tggtctcaaa ctcctaacct caggtaatcc gcccccctcg gcctcccaaa gtgctgggat
     1621 tacaggtgtg agccaccgcg cccagcctgg gtgaagtttt gagatgtaca tatatactga
     1681 atattaatgt caatttttta aaagaagtaa aaattatctt aaaaacta
//
