LOCUS       NM_015508               3861 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens TCDD inducible poly(ADP-ribose) polymerase (TIPARP),
            transcript variant 2, mRNA.
ACCESSION   NM_015508
VERSION     NM_015508.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3861)
  AUTHORS   Manetsch,P., Bohi,F., Nowak,K., Leslie Pedrioli,D.M. and
            Hottiger,M.O.
  TITLE     PARP7-mediated ADP-ribosylation of FRA1 promotes cancer cell growth
            by repressing IRF1- and IRF3-dependent apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 120 (49), e2309047120 (2023)
   PUBMED   38011562
  REMARK    GeneRIF: PARP7-mediated ADP-ribosylation of FRA1 promotes cancer
            cell growth by repressing IRF1- and IRF3-dependent apoptosis.
REFERENCE   2  (bases 1 to 3861)
  AUTHORS   Jiao,H., Yan,Z., Zhai,X., Yang,Y., Wang,N., Li,X., Jiang,Z. and
            Su,S.
  TITLE     Transcriptome screening identifies TIPARP as an antiviral host
            factor against the Getah virus
  JOURNAL   J Virol 97 (10), e0059123 (2023)
   PUBMED   37768084
  REMARK    GeneRIF: Transcriptome screening identifies TIPARP as an antiviral
            host factor against the Getah virus.
REFERENCE   3  (bases 1 to 3861)
  AUTHORS   Yang,C., Wierbilowicz,K., Dworak,N.M., Bae,S.Y., Tengse,S.B.,
            Abianeh,N., Drake,J.M., Abbas,T., Ratan,A., Wotton,D. and
            Paschal,B.M.
  TITLE     Induction of PARP7 Creates a Vulnerability for Growth Inhibition by
            RBN2397 in Prostate Cancer Cells
  JOURNAL   Cancer Res Commun 3 (4), 592-606 (2023)
   PUBMED   37077937
  REMARK    GeneRIF: Induction of PARP7 Creates a Vulnerability for Growth
            Inhibition by RBN2397 in Prostate Cancer Cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3861)
  AUTHORS   Zhang,Y., Song,M., Bi,Y., Lei,Y., Sun,X. and Chen,Y.
  TITLE     TIPARP is involved in the regulation of intraocular pressure
  JOURNAL   Commun Biol 5 (1), 1386 (2022)
   PUBMED   36536086
  REMARK    GeneRIF: TIPARP is involved in the regulation of intraocular
            pressure.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3861)
  AUTHORS   Gozgit,J.M., Vasbinder,M.M., Abo,R.P., Kunii,K., Kuplast-Barr,K.G.,
            Gui,B., Lu,A.Z., Molina,J.R., Minissale,E., Swinger,K.K.,
            Wigle,T.J., Blackwell,D.J., Majer,C.R., Ren,Y., Niepel,M.,
            Varsamis,Z.A., Nayak,S.P., Bamberg,E., Mo,J.R., Church,W.D.,
            Mady,A.S.A., Song,J., Utley,L., Rao,P.E., Mitchison,T.J.,
            Kuntz,K.W., Richon,V.M. and Keilhack,H.
  TITLE     PARP7 negatively regulates the type I interferon response in cancer
            cells and its inhibition triggers antitumor immunity
  JOURNAL   Cancer Cell 39 (9), 1214-1226 (2021)
   PUBMED   34375612
  REMARK    GeneRIF: PARP7 negatively regulates the type I interferon response
            in cancer cells and its inhibition triggers antitumor immunity.
REFERENCE   6  (bases 1 to 3861)
  AUTHORS   Goode,E.L., Chenevix-Trench,G., Song,H., Ramus,S.J., Notaridou,M.,
            Lawrenson,K., Widschwendter,M., Vierkant,R.A., Larson,M.C.,
            Kjaer,S.K., Birrer,M.J., Berchuck,A., Schildkraut,J., Tomlinson,I.,
            Kiemeney,L.A., Cook,L.S., Gronwald,J., Garcia-Closas,M., Gore,M.E.,
            Campbell,I., Whittemore,A.S., Sutphen,R., Phelan,C.,
            Anton-Culver,H., Pearce,C.L., Lambrechts,D., Rossing,M.A.,
            Chang-Claude,J., Moysich,K.B., Goodman,M.T., Dork,T.,
            Nevanlinna,H., Ness,R.B., Rafnar,T., Hogdall,C., Hogdall,E.,
            Fridley,B.L., Cunningham,J.M., Sieh,W., McGuire,V., Godwin,A.K.,
            Cramer,D.W., Hernandez,D., Levine,D., Lu,K., Iversen,E.S.,
            Palmieri,R.T., Houlston,R., van Altena,A.M., Aben,K.K.,
            Massuger,L.F., Brooks-Wilson,A., Kelemen,L.E., Le,N.D.,
            Jakubowska,A., Lubinski,J., Medrek,K., Stafford,A., Easton,D.F.,
            Tyrer,J., Bolton,K.L., Harrington,P., Eccles,D., Chen,A.,
            Molina,A.N., Davila,B.N., Arango,H., Tsai,Y.Y., Chen,Z.,
            Risch,H.A., McLaughlin,J., Narod,S.A., Ziogas,A., Brewster,W.,
            Gentry-Maharaj,A., Menon,U., Wu,A.H., Stram,D.O., Pike,M.C.,
            Beesley,J., Webb,P.M., Chen,X., Ekici,A.B., Thiel,F.C.,
            Beckmann,M.W., Yang,H., Wentzensen,N., Lissowska,J., Fasching,P.A.,
            Despierre,E., Amant,F., Vergote,I., Doherty,J., Hein,R.,
            Wang-Gohrke,S., Lurie,G., Carney,M.E., Thompson,P.J., Runnebaum,I.,
            Hillemanns,P., Durst,M., Antonenkova,N., Bogdanova,N., Leminen,A.,
            Butzow,R., Heikkinen,T., Stefansson,K., Sulem,P., Besenbacher,S.,
            Sellers,T.A., Gayther,S.A. and Pharoah,P.D.
  CONSRTM   Wellcome Trust Case-Control Consortium; Australian Cancer Study
            (Ovarian Cancer); Australian Ovarian Cancer Study Group; Ovarian
            Cancer Association Consortium (OCAC); Ovarian Cancer Association
            Consortium (OCAC)
  TITLE     A genome-wide association study identifies susceptibility loci for
            ovarian cancer at 2q31 and 8q24
  JOURNAL   Nat Genet 42 (10), 874-879 (2010)
   PUBMED   20852632
  REMARK    GeneRIF: Single nucleotide polymorphism in TIPARP is associated
            with ovarian cancer.
            GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (bases 1 to 3861)
  AUTHORS   de Waard,P.W., Peijnenburg,A.A., Baykus,H., Aarts,J.M.,
            Hoogenboom,R.L., van Schooten,F.J. and de Kok,T.M.
  TITLE     A human intervention study with foods containing natural
            Ah-receptor agonists does not significantly show AhR-mediated
            effects as measured in blood cells and urine
  JOURNAL   Chem Biol Interact 176 (1), 19-29 (2008)
   PUBMED   18762178
REFERENCE   8  (bases 1 to 3861)
  AUTHORS   Otto,H., Reche,P.A., Bazan,F., Dittmar,K., Haag,F. and
            Koch-Nolte,F.
  TITLE     In silico characterization of the family of PARP-like
            poly(ADP-ribosyl)transferases (pARTs)
  JOURNAL   BMC Genomics 6, 139 (2005)
   PUBMED   16202152
  REMARK    Publication Status: Online-Only
REFERENCE   9  (bases 1 to 3861)
  AUTHORS   Ame,J.C., Spenlehauer,C. and de Murcia,G.
  TITLE     The PARP superfamily
  JOURNAL   Bioessays 26 (8), 882-893 (2004)
   PUBMED   15273990
  REMARK    Review article
REFERENCE   10 (bases 1 to 3861)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human TIPARP gene within the
            CCNL amplicon at human chromosome 3q25.31
  JOURNAL   Int J Oncol 23 (2), 541-547 (2003)
   PUBMED   12851707
  REMARK    GeneRIF: TIPARP (DKFZp434J214) gene is amplified in HNSCC.  TIPARP,
            FLJ22693 and ZAP proteins with TPH, WW and PARP-like domains
            constitute the TIPARP family.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX537965.1, AC092927.5 and
            BC050350.1.
            
            On Nov 23, 2018 this sequence version replaced NM_015508.4.
            
            Summary: This gene encodes a member of the poly(ADP-ribose)
            polymerase superfamily. Studies of the mouse ortholog have shown
            that the encoded protein catalyzes histone poly(ADP-ribosyl)ation
            and may be involved in T-cell function. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, May
            2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.73394.1,
                                           SRR1660803.174701.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295924.12/ ENSP00000295924.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-3112              BX537965.1         2-3113
            3113-3113           AC092927.5         331-331             c
            3114-3836           BX537965.1         3115-3837
            3837-3861           BC050350.1         3814-3838
FEATURES             Location/Qualifiers
     source          1..3861
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.31"
     gene            1..3861
                     /gene="TIPARP"
                     /gene_synonym="ARTD14; PARP7; pART14"
                     /note="TCDD inducible poly(ADP-ribose) polymerase"
                     /db_xref="GeneID:25976"
                     /db_xref="HGNC:HGNC:23696"
                     /db_xref="MIM:612480"
     exon            1..207
                     /gene="TIPARP"
                     /gene_synonym="ARTD14; PARP7; pART14"
                     /inference="alignment:Splign:2.1.0"
     exon            208..1165
                     /gene="TIPARP"
                     /gene_synonym="ARTD14; PARP7; pART14"
                     /inference="alignment:Splign:2.1.0"
     CDS             249..2222
                     /gene="TIPARP"
                     /gene_synonym="ARTD14; PARP7; pART14"
                     /EC_number="2.4.2.30"
                     /note="poly [ADP-ribose] polymerase 7;
                     ADP-ribosyltransferase diphtheria toxin-like 14"
                     /codon_start=1
                     /product="protein mono-ADP-ribosyltransferase TIPARP"
                     /protein_id="NP_056323.2"
                     /db_xref="CCDS:CCDS3177.1"
                     /db_xref="GeneID:25976"
                     /db_xref="HGNC:HGNC:23696"
                     /db_xref="MIM:612480"
                     /translation="MEMETTEPEPDCVVQPPSPPDDFSCQMRLSEKITPLKTCFKKKD
                     QKRLGTGTLRSLRPILNTLLESGSLDGVFRSRNQSTDENSLHEPMMKKAMEINSSCPP
                     AENNMSVLIPDRTNVGDQIPEAHPSTEAPERVVPIQDHSFPSETLSGTVADSTPAHFQ
                     TDLLHPVSSDVPTSPDCLDKVIDYVPGIFQENSFTIQYILDTSDKLSTELFQDKSEEA
                     SLDLVFELVNQLQYHTHQENGIEICMDFLQGTCIYGRDCLKHHTVLPYHWQIKRTTTQ
                     KWQSVFNDSQEHLERFYCNPENDRMRMKYGGQEFWADLNAMNVYETTEFDQLRRLSTP
                     PSSNVNSIYHTVWKFFCRDHFGWREYPESVIRLIEEANSRGLKEVRFMMWNNHYILHN
                     SFFRREIKRRPLFRSCFILLPYLQTLGGVPTQAPPPLEATSSSQIICPDGVTSANFYP
                     ETWVYMHPSQDFIQVPVSAEDKSYRIIYNLFHKTVPEFKYRILQILRVQNQFLWEKYK
                     RKKEYMNRKMFGRDRIINERHLFHGTSQDVVDGICKHNFDPRVCGKHATMFGQGSYFA
                     KKASYSHNFSKKSSKGVHFMFLAKVLTGRYTMGSHGMRRPPPVNPGSVTSDLYDSCVD
                     NFFEPQIFVIFNDDQSYPYFVIQYEEVSNTVSI"
     exon            1166..1334
                     /gene="TIPARP"
                     /gene_synonym="ARTD14; PARP7; pART14"
                     /inference="alignment:Splign:2.1.0"
     exon            1335..1495
                     /gene="TIPARP"
                     /gene_synonym="ARTD14; PARP7; pART14"
                     /inference="alignment:Splign:2.1.0"
     exon            1496..1774
                     /gene="TIPARP"
                     /gene_synonym="ARTD14; PARP7; pART14"
                     /inference="alignment:Splign:2.1.0"
     exon            1775..3861
                     /gene="TIPARP"
                     /gene_synonym="ARTD14; PARP7; pART14"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3819..3824
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIPARP"
                     /gene_synonym="ARTD14; PARP7; pART14"
                     /note="hexamer: AATAAA"
     regulatory      3835..3840
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIPARP"
                     /gene_synonym="ARTD14; PARP7; pART14"
                     /note="hexamer: AATAAA"
     polyA_site      3841
                     /gene="TIPARP"
                     /gene_synonym="ARTD14; PARP7; pART14"
     polyA_site      3861
                     /gene="TIPARP"
                     /gene_synonym="ARTD14; PARP7; pART14"
                     /note="major polyA site"
ORIGIN      
        1 agagatcgag gtgacaggcg agctggctgg actcggagcg cggtcgaggc tttctgcgtt
       61 cgcggcggcg gaatggcccg tgcgcggctc gccgcgtcgc ggctctgtgg tccctagacg
      121 tcggctcccg ccctcggcgc tgatctccgg cgcgggcact gctttccact cggctcctgt
      181 cgtccgttct ctcaggctcc cgttcaggat ttttagactc tgaggagcag ttggagctaa
      241 tccacattat ggaaatggaa accaccgaac ctgagccaga ctgtgtagtg cagcctccct
      301 ctcctcctga tgacttttca tgccaaatga gactctctga gaagatcact ccattgaaga
      361 cttgttttaa gaaaaaggat cagaaaagat tgggaactgg aaccctgagg tctttgaggc
      421 caatattaaa cactcttcta gaatctggct cacttgatgg ggtttttaga tctaggaacc
      481 agagtacaga tgagaacagc ttacatgaac ctatgatgaa gaaagccatg gaaatcaatt
      541 catcatgccc accagcagaa aataatatgt ctgttctgat tcctgatagg acaaatgttg
      601 gggaccagat accggaagcc catccttcca ctgaagctcc agaacgagtg gttccaatcc
      661 aagatcacag ctttccatca gaaaccctca gtgggacggt ggcagattcc acaccagctc
      721 acttccagac tgatcttttg cacccagttt caagtgatgt tcctactagt cctgactgct
      781 tagacaaagt catagattat gttccaggca ttttccaaga aaacagtttt acaatccaat
      841 acattctgga caccagtgat aagctgagta ctgagctctt tcaggacaaa agtgaagagg
      901 cttcccttga cctcgtgttt gagctggtga accagttgca gtaccacact caccaagaga
      961 acggaattga aatttgcatg gactttctgc aaggcacttg tatttatggc agggattgtt
     1021 tgaagcacca cactgtcttg ccatatcatt ggcagatcaa aaggacaact actcaaaagt
     1081 ggcagagtgt attcaatgat tctcaggagc acttggaaag attttactgt aacccagaaa
     1141 atgatagaat gagaatgaag tatggaggac aagaattttg ggcagatttg aatgccatga
     1201 acgtgtatga aacaactgaa tttgaccaac tacgaaggct gtccacacca ccctctagca
     1261 atgtcaactc tatttaccac acagtctgga aattcttctg tagggaccac tttggatgga
     1321 gagagtatcc cgagtctgtc attcgattga ttgaagaagc caactctcgg ggtctgaaag
     1381 aggttcgatt tatgatgtgg aataaccact acatcctcca caattcattc ttcaggagag
     1441 agataaaaag gagacccctc ttccgctcct gttttatact gcttccatat ttacagacac
     1501 ttggtggggt tcccacacaa gctcctccac ctcttgaagc aacttcatca tcacaaatta
     1561 tctgcccaga tggggtcact tcagcaaact tttaccctga aacttgggtt tatatgcatc
     1621 catctcagga cttcatccaa gtccctgttt ctgcagagga taaaagttat cggatcattt
     1681 acaatctttt tcataagact gtgcctgagt ttaaatacag aattttgcag atattgagag
     1741 tccaaaacca gtttctttgg gagaaatata aaaggaaaaa ggaatatatg aacaggaaaa
     1801 tgtttggccg tgacaggata ataaatgaga gacatttatt tcatggaaca tcccaggatg
     1861 tggtagatgg aatctgcaaa cacaactttg accctcgagt ctgtggaaag catgctacaa
     1921 tgtttggaca aggcagttat tttgcaaaga aggcaagcta ctctcataac ttttctaaga
     1981 agtcctccaa aggagtccac ttcatgtttc tggccaaagt gctgacgggc agatacacaa
     2041 tgggcagtca tggcatgaga aggcccccgc cagtcaatcc tggcagtgtc accagtgacc
     2101 tttatgactc ttgtgtggat aatttctttg agcctcagat ttttgtcatt tttaatgatg
     2161 accagagtta cccttatttt gttatccaat atgaagaagt cagtaacact gtttccattt
     2221 gaaaaatctt ggtactgcta aattatttga tatgaactca atccagcatt tgtagcaggt
     2281 tttgaatggg tgggactggg tggggaacag cattggacat taatagggca cttttcagac
     2341 ccatttttta aagtgctaga aaatgctttt tttaaaaaaa aaatacaagt tttaaaatga
     2401 ccacttactc tttaattatt tactaattgc tagtgtactc agtgtggaaa agactacaga
     2461 ttacacactc ttttcattca cacttgtaca tatagacagc aatgttatta ggagcattaa
     2521 attaaaaaac tgaacagcct aatttaaatg tggcttgggc ctggtagaag tttgaccaaa
     2581 tggaatggag gctgtgagca atgtgaggat tctatttatt tatttacgtt tgataaaact
     2641 tactggaact agtactacca tgcgtattcc ctgtccaaag catcactgct ttggtatagt
     2701 ataagttcat gaaattctgg tgggtagaaa gaaattttta tttctatcag cagtactaaa
     2761 atgtatcagc caaccagaga acatcagtga ctttaacttc tgcagagttt gccccagaat
     2821 tcagagttct atttagagga agttaaaaca acaacaaaaa acaaccattt gaaaaatttt
     2881 tgtcaccagc aaaacttttc actaattagt gatatgaaat gtgatttttg tgttgttaaa
     2941 cttcagcttt ggaaaactca gtctctttca ttatcatcca ttccaatttg aaggagttgg
     3001 gcagctaatt tggttaaagg cagtcttgag ggttagaagt attacttcct tttcgggttc
     3061 cagacctagc ttgtgactga aagttttaga aaaaggaagt acatctatag ccaaattgat
     3121 aaggttatta ctgtgttttg cacaaagtat attagcaaaa gtatttgctg gaattattgg
     3181 tagatggcag tcccactcct acacctgctt tgtcagatac agctgggttc cctggctgac
     3241 tctgtacctt acttacacta cttacttaat agaaacacaa acttggaaat tgtgccagtg
     3301 gtccagctgg agcacaacgt ttggtgaata tgctgtttcc tcagttcaga gaggtagcaa
     3361 ctaggtaaac tccttataaa aagcaaatac ctggatttac aaaagtgaaa gtagttgttc
     3421 acaaaagaat tcgccatgga attctttcag ttaccaagct ctcctggtaa tgtttgtggt
     3481 tatatcattt acacaaaact tttcaggaac ttctgtgttg tttaagcaag atgtatctgt
     3541 actgatgtct cagtgaatca gtctgtttat taagcactta tcagggcttc cacacactta
     3601 tttattttgc cctagttaat cctgttgttt gctgccattg gcatgaaatg gccaactgtg
     3661 gctgttacag ttctttcatt caattataac ttgtaaacca gtgactccta atctttttca
     3721 agttaagaca ccttaccatt gcttatttgg ttttatgaga cttgttcctt tttttctccc
     3781 taaggaaaaa gaaagcttta tgacatattt atttttttaa taaaactaag caaaaataaa
     3841 acttatggta attctttaaa a
//
