LOCUS       NP_056323                657 aa            linear   PRI 06-JUN-2024
DEFINITION  protein mono-ADP-ribosyltransferase TIPARP [Homo sapiens].
ACCESSION   NP_056323
VERSION     NP_056323.2
DBSOURCE    REFSEQ: accession NM_015508.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (residues 1 to 657)
  AUTHORS   Manetsch,P., Bohi,F., Nowak,K., Leslie Pedrioli,D.M. and
            Hottiger,M.O.
  TITLE     PARP7-mediated ADP-ribosylation of FRA1 promotes cancer cell growth
            by repressing IRF1- and IRF3-dependent apoptosis
  JOURNAL   Proc Natl Acad Sci U S A 120 (49), e2309047120 (2023)
   PUBMED   38011562
  REMARK    GeneRIF: PARP7-mediated ADP-ribosylation of FRA1 promotes cancer
            cell growth by repressing IRF1- and IRF3-dependent apoptosis.
REFERENCE   2  (residues 1 to 657)
  AUTHORS   Jiao,H., Yan,Z., Zhai,X., Yang,Y., Wang,N., Li,X., Jiang,Z. and
            Su,S.
  TITLE     Transcriptome screening identifies TIPARP as an antiviral host
            factor against the Getah virus
  JOURNAL   J Virol 97 (10), e0059123 (2023)
   PUBMED   37768084
  REMARK    GeneRIF: Transcriptome screening identifies TIPARP as an antiviral
            host factor against the Getah virus.
REFERENCE   3  (residues 1 to 657)
  AUTHORS   Yang,C., Wierbilowicz,K., Dworak,N.M., Bae,S.Y., Tengse,S.B.,
            Abianeh,N., Drake,J.M., Abbas,T., Ratan,A., Wotton,D. and
            Paschal,B.M.
  TITLE     Induction of PARP7 Creates a Vulnerability for Growth Inhibition by
            RBN2397 in Prostate Cancer Cells
  JOURNAL   Cancer Res Commun 3 (4), 592-606 (2023)
   PUBMED   37077937
  REMARK    GeneRIF: Induction of PARP7 Creates a Vulnerability for Growth
            Inhibition by RBN2397 in Prostate Cancer Cells.
            Publication Status: Online-Only
REFERENCE   4  (residues 1 to 657)
  AUTHORS   Zhang,Y., Song,M., Bi,Y., Lei,Y., Sun,X. and Chen,Y.
  TITLE     TIPARP is involved in the regulation of intraocular pressure
  JOURNAL   Commun Biol 5 (1), 1386 (2022)
   PUBMED   36536086
  REMARK    GeneRIF: TIPARP is involved in the regulation of intraocular
            pressure.
            Publication Status: Online-Only
REFERENCE   5  (residues 1 to 657)
  AUTHORS   Gozgit,J.M., Vasbinder,M.M., Abo,R.P., Kunii,K., Kuplast-Barr,K.G.,
            Gui,B., Lu,A.Z., Molina,J.R., Minissale,E., Swinger,K.K.,
            Wigle,T.J., Blackwell,D.J., Majer,C.R., Ren,Y., Niepel,M.,
            Varsamis,Z.A., Nayak,S.P., Bamberg,E., Mo,J.R., Church,W.D.,
            Mady,A.S.A., Song,J., Utley,L., Rao,P.E., Mitchison,T.J.,
            Kuntz,K.W., Richon,V.M. and Keilhack,H.
  TITLE     PARP7 negatively regulates the type I interferon response in cancer
            cells and its inhibition triggers antitumor immunity
  JOURNAL   Cancer Cell 39 (9), 1214-1226 (2021)
   PUBMED   34375612
  REMARK    GeneRIF: PARP7 negatively regulates the type I interferon response
            in cancer cells and its inhibition triggers antitumor immunity.
REFERENCE   6  (residues 1 to 657)
  AUTHORS   Goode,E.L., Chenevix-Trench,G., Song,H., Ramus,S.J., Notaridou,M.,
            Lawrenson,K., Widschwendter,M., Vierkant,R.A., Larson,M.C.,
            Kjaer,S.K., Birrer,M.J., Berchuck,A., Schildkraut,J., Tomlinson,I.,
            Kiemeney,L.A., Cook,L.S., Gronwald,J., Garcia-Closas,M., Gore,M.E.,
            Campbell,I., Whittemore,A.S., Sutphen,R., Phelan,C.,
            Anton-Culver,H., Pearce,C.L., Lambrechts,D., Rossing,M.A.,
            Chang-Claude,J., Moysich,K.B., Goodman,M.T., Dork,T.,
            Nevanlinna,H., Ness,R.B., Rafnar,T., Hogdall,C., Hogdall,E.,
            Fridley,B.L., Cunningham,J.M., Sieh,W., McGuire,V., Godwin,A.K.,
            Cramer,D.W., Hernandez,D., Levine,D., Lu,K., Iversen,E.S.,
            Palmieri,R.T., Houlston,R., van Altena,A.M., Aben,K.K.,
            Massuger,L.F., Brooks-Wilson,A., Kelemen,L.E., Le,N.D.,
            Jakubowska,A., Lubinski,J., Medrek,K., Stafford,A., Easton,D.F.,
            Tyrer,J., Bolton,K.L., Harrington,P., Eccles,D., Chen,A.,
            Molina,A.N., Davila,B.N., Arango,H., Tsai,Y.Y., Chen,Z.,
            Risch,H.A., McLaughlin,J., Narod,S.A., Ziogas,A., Brewster,W.,
            Gentry-Maharaj,A., Menon,U., Wu,A.H., Stram,D.O., Pike,M.C.,
            Beesley,J., Webb,P.M., Chen,X., Ekici,A.B., Thiel,F.C.,
            Beckmann,M.W., Yang,H., Wentzensen,N., Lissowska,J., Fasching,P.A.,
            Despierre,E., Amant,F., Vergote,I., Doherty,J., Hein,R.,
            Wang-Gohrke,S., Lurie,G., Carney,M.E., Thompson,P.J., Runnebaum,I.,
            Hillemanns,P., Durst,M., Antonenkova,N., Bogdanova,N., Leminen,A.,
            Butzow,R., Heikkinen,T., Stefansson,K., Sulem,P., Besenbacher,S.,
            Sellers,T.A., Gayther,S.A. and Pharoah,P.D.
  CONSRTM   Wellcome Trust Case-Control Consortium; Australian Cancer Study
            (Ovarian Cancer); Australian Ovarian Cancer Study Group; Ovarian
            Cancer Association Consortium (OCAC); Ovarian Cancer Association
            Consortium (OCAC)
  TITLE     A genome-wide association study identifies susceptibility loci for
            ovarian cancer at 2q31 and 8q24
  JOURNAL   Nat Genet 42 (10), 874-879 (2010)
   PUBMED   20852632
  REMARK    GeneRIF: Single nucleotide polymorphism in TIPARP is associated
            with ovarian cancer.
            GeneRIF: Observational study and genome-wide association study of
            gene-disease association. (HuGE Navigator)
REFERENCE   7  (residues 1 to 657)
  AUTHORS   de Waard,P.W., Peijnenburg,A.A., Baykus,H., Aarts,J.M.,
            Hoogenboom,R.L., van Schooten,F.J. and de Kok,T.M.
  TITLE     A human intervention study with foods containing natural
            Ah-receptor agonists does not significantly show AhR-mediated
            effects as measured in blood cells and urine
  JOURNAL   Chem Biol Interact 176 (1), 19-29 (2008)
   PUBMED   18762178
REFERENCE   8  (residues 1 to 657)
  AUTHORS   Otto,H., Reche,P.A., Bazan,F., Dittmar,K., Haag,F. and
            Koch-Nolte,F.
  TITLE     In silico characterization of the family of PARP-like
            poly(ADP-ribosyl)transferases (pARTs)
  JOURNAL   BMC Genomics 6, 139 (2005)
   PUBMED   16202152
  REMARK    Publication Status: Online-Only
REFERENCE   9  (residues 1 to 657)
  AUTHORS   Ame,J.C., Spenlehauer,C. and de Murcia,G.
  TITLE     The PARP superfamily
  JOURNAL   Bioessays 26 (8), 882-893 (2004)
   PUBMED   15273990
  REMARK    Review article
REFERENCE   10 (residues 1 to 657)
  AUTHORS   Katoh,M. and Katoh,M.
  TITLE     Identification and characterization of human TIPARP gene within the
            CCNL amplicon at human chromosome 3q25.31
  JOURNAL   Int J Oncol 23 (2), 541-547 (2003)
   PUBMED   12851707
  REMARK    GeneRIF: TIPARP (DKFZp434J214) gene is amplified in HNSCC.  TIPARP,
            FLJ22693 and ZAP proteins with TPH, WW and PARP-like domains
            constitute the TIPARP family.
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BX537965.1, AC092927.5 and
            BC050350.1.
            
            On Nov 26, 2003 this sequence version replaced NP_056323.1.
            
            Summary: This gene encodes a member of the poly(ADP-ribose)
            polymerase superfamily. Studies of the mouse ortholog have shown
            that the encoded protein catalyzes histone poly(ADP-ribosyl)ation
            and may be involved in T-cell function. Alternative splicing
            results in multiple transcript variants. [provided by RefSeq, May
            2010].
            
            Transcript Variant: This variant (2) differs in the 5' UTR compared
            to variant 1. Variants 1, 2 and 3 encode the same protein.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660809.73394.1,
                                           SRR1660803.174701.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000295924.12/ ENSP00000295924.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
FEATURES             Location/Qualifiers
     source          1..657
                     /organism="Homo sapiens"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q25.31"
     Protein         1..657
                     /product="protein mono-ADP-ribosyltransferase TIPARP"
                     /EC_number="2.4.2.30"
                     /note="poly [ADP-ribose] polymerase 7;
                     ADP-ribosyltransferase diphtheria toxin-like 14"
                     /calculated_mol_wt=76097
     Region          1..21
                     /region_name="Disordered.
                     /evidence=ECO:0000256|SAM:MobiDB-lite"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7Z3E1.1)"
     Region          41..47
                     /region_name="Nuclear localization signal.
                     /evidence=ECO:0000269|PubMed:30373764"
                     /note="propagated from UniProtKB/Swiss-Prot (Q7Z3E1.1)"
     Region          346..401
                     /region_name="WWE"
                     /note="WWE domain; pfam02825"
                     /db_xref="CDD:460715"
     Region          529..648
                     /region_name="TCCD_inducible_PARP_like"
                     /note="Poly(ADP-ribose) polymerases catalyse the covalent
                     attachment of ADP-ribose units from NAD+ to itself and to
                     a limited number of other DNA binding proteins, which
                     decreases their affinity for DNA. Poly(ADP-ribose)
                     polymerase is a regulatory component...; cd01439"
                     /db_xref="CDD:238719"
     Site            order(531..535,538,542,546..548,550,563..565,575,631)
                     /site_type="other"
                     /note="nad+ binding pocket [chemical binding]"
                     /db_xref="CDD:238719"
     CDS             1..657
                     /gene="TIPARP"
                     /gene_synonym="ARTD14; PARP7; pART14"
                     /coded_by="NM_015508.5:249..2222"
                     /db_xref="CCDS:CCDS3177.1"
                     /db_xref="GeneID:25976"
                     /db_xref="HGNC:HGNC:23696"
                     /db_xref="MIM:612480"
ORIGIN      
        1 memettepep dcvvqppspp ddfscqmrls ekitplktcf kkkdqkrlgt gtlrslrpil
       61 ntllesgsld gvfrsrnqst denslhepmm kkameinssc ppaennmsvl ipdrtnvgdq
      121 ipeahpstea pervvpiqdh sfpsetlsgt vadstpahfq tdllhpvssd vptspdcldk
      181 vidyvpgifq ensftiqyil dtsdklstel fqdkseeasl dlvfelvnql qyhthqengi
      241 eicmdflqgt ciygrdclkh htvlpyhwqi krtttqkwqs vfndsqehle rfycnpendr
      301 mrmkyggqef wadlnamnvy ettefdqlrr lstppssnvn siyhtvwkff crdhfgwrey
      361 pesvirliee ansrglkevr fmmwnnhyil hnsffrreik rrplfrscfi llpylqtlgg
      421 vptqappple atsssqiicp dgvtsanfyp etwvymhpsq dfiqvpvsae dksyriiynl
      481 fhktvpefky rilqilrvqn qflwekykrk keymnrkmfg rdriinerhl fhgtsqdvvd
      541 gickhnfdpr vcgkhatmfg qgsyfakkas yshnfskkss kgvhfmflak vltgrytmgs
      601 hgmrrpppvn pgsvtsdlyd scvdnffepq ifvifnddqs ypyfviqyee vsntvsi
//
