LOCUS       NM_001396408            3652 bp    mRNA    linear   PRI 08-APR-2024
DEFINITION  Homo sapiens TINCR ubiquitin domain containing (TINCR), transcript
            variant 1, mRNA.
ACCESSION   NM_001396408 NR_027064 XR_040439 XR_040440 XR_040441
VERSION     NM_001396408.1
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3652)
  AUTHORS   Wei,Y. and Zhu,P.
  TITLE     Long non-coding RNA TINCR suppresses growth and
            epithelial-mesenchymal transition by inhibiting Wnt/beta-catenin
            signaling pathway in human pancreatic cancer PANC-1 cells: Insights
            from in vitro and in vivo studies
  JOURNAL   Acta Pharm 74 (1), 131-147 (2024)
   PUBMED   38554384
  REMARK    GeneRIF: Long non-coding RNA TINCR suppresses growth and
            epithelial-mesenchymal transition by inhibiting Wnt/beta-catenin
            signaling pathway in human pancreatic cancer PANC-1 cells: Insights
            from in vitro and in vivo studies.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3652)
  AUTHORS   Azman,A.A., Siok-Fong,C., Rajab,N.F., Md Zin,R.R., Ahmad Daud,N.N.
            and Mohamad Hanif,E.A.
  TITLE     The potential roles of lncRNA TINCR in triple negative breast
            cancer
  JOURNAL   Mol Biol Rep 50 (9), 7909-7917 (2023)
   PUBMED   37442895
  REMARK    GeneRIF: The potential roles of lncRNA TINCR in triple negative
            breast cancer.
            Review article
REFERENCE   3  (bases 1 to 3652)
  AUTHORS   Wang,Q., Li,G., Ma,X., Liu,L., Liu,J., Yin,Y., Li,H., Chen,Y.,
            Zhang,X., Zhang,L., Sun,L., Ai,J. and Xu,S.
  TITLE     LncRNA TINCR impairs the efficacy of immunotherapy against breast
            cancer by recruiting DNMT1 and downregulating MiR-199a-5p via the
            STAT1-TINCR-USP20-PD-L1 axis
  JOURNAL   Cell Death Dis 14 (2), 76 (2023)
   PUBMED   36725842
  REMARK    GeneRIF: LncRNA TINCR impairs the efficacy of immunotherapy against
            breast cancer by recruiting DNMT1 and downregulating MiR-199a-5p
            via the STAT1-TINCR-USP20-PD-L1 axis.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 3652)
  AUTHORS   Shi,J., Guo,C., Li,Y. and Ma,J.
  TITLE     The long noncoding RNA TINCR promotes self-renewal of human liver
            cancer stem cells through autophagy activation
  JOURNAL   Cell Death Dis 13 (11), 961 (2022)
   PUBMED   36385098
  REMARK    GeneRIF: The long noncoding RNA TINCR promotes self-renewal of
            human liver cancer stem cells through autophagy activation.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3652)
  AUTHORS   Nita,A., Matsumoto,A., Tang,R., Shiraishi,C., Ichihara,K.,
            Saito,D., Suyama,M., Yasuda,T., Tsuji,G., Furue,M., Katayama,B.,
            Ozawa,T., Murata,T., Dainichi,T., Kabashima,K., Hatano,A.,
            Matsumoto,M. and Nakayama,K.I.
  TITLE     A ubiquitin-like protein encoded by the 'noncoding' RNA TINCR
            promotes keratinocyte proliferation and wound healing
  JOURNAL   PLoS Genet 17 (8), e1009686 (2021)
   PUBMED   34351912
  REMARK    GeneRIF: A ubiquitin-like protein encoded by the ''noncoding'' RNA
            TINCR promotes keratinocyte proliferation and wound healing.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 3652)
  AUTHORS   Eckhart,L., Lachner,J., Tschachler,E. and Rice,R.H.
  TITLE     TINCR is not a non-coding RNA but encodes a protein component of
            cornified epidermal keratinocytes
  JOURNAL   Exp Dermatol 29 (4), 376-379 (2020)
   PUBMED   32012357
  REMARK    GeneRIF: TINCR is not a non-coding RNA but encodes a protein
            component of cornified epidermal keratinocytes.
REFERENCE   7  (bases 1 to 3652)
  AUTHORS   Xu,T.P., Liu,X.X., Xia,R., Yin,L., Kong,R., Chen,W.M., Huang,M.D.
            and Shu,Y.Q.
  TITLE     SP1-induced upregulation of the long noncoding RNA TINCR regulates
            cell proliferation and apoptosis by affecting KLF2 mRNA stability
            in gastric cancer
  JOURNAL   Oncogene 34 (45), 5648-5661 (2015)
   PUBMED   25728677
  REMARK    GeneRIF: findings suggest that TINCR contributes to the oncogenic
            potential of GC and may constitute a potential therapeutic target
            in this disease.
REFERENCE   8  (bases 1 to 3652)
  AUTHORS   Li,B., Tsoi,L.C., Swindell,W.R., Gudjonsson,J.E., Tejasvi,T.,
            Johnston,A., Ding,J., Stuart,P.E., Xing,X., Kochkodan,J.J.,
            Voorhees,J.J., Kang,H.M., Nair,R.P., Abecasis,G.R. and Elder,J.T.
  TITLE     Transcriptome analysis of psoriasis in a large case-control sample:
            RNA-seq provides insights into disease mechanisms
  JOURNAL   J Invest Dermatol 134 (7), 1828-1838 (2014)
   PUBMED   24441097
REFERENCE   9  (bases 1 to 3652)
  AUTHORS   Kretz,M.
  TITLE     TINCR, staufen1, and cellular differentiation
  JOURNAL   RNA Biol 10 (10), 1597-1601 (2013)
   PUBMED   24019000
  REMARK    GeneRIF: TINCR, together with Staufen1, seems to stabilize a subset
            of mRNAs required for epidermal differentiation.
REFERENCE   10 (bases 1 to 3652)
  AUTHORS   Kretz,M., Siprashvili,Z., Chu,C., Webster,D.E., Zehnder,A., Qu,K.,
            Lee,C.S., Flockhart,R.J., Groff,A.F., Chow,J., Johnston,D.,
            Kim,G.E., Spitale,R.C., Flynn,R.A., Zheng,G.X., Aiyer,S., Raj,A.,
            Rinn,J.L., Chang,H.Y. and Khavari,P.A.
  TITLE     Control of somatic tissue differentiation by the long non-coding
            RNA TINCR
  JOURNAL   Nature 493 (7431), 231-235 (2013)
   PUBMED   23201690
  REMARK    GeneRIF: a 3.7-kilobase lncRNA, terminal differentiation-induced
            ncRNA (TINCR), controls human epidermal differentiation by a
            post-transcriptional mechanism
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011533.6.
            
            On Oct 14, 2021 this sequence version replaced NR_027064.3.
            
            Summary: This gene produces a spliced long non-coding RNA that
            binds RNAs. This transcript interacts with staufen-1 protein to
            regulate the stability of mRNAs for genes involved in the
            differentiation of epidermal tissue. Variation in this gene may be
            associated with cancer progression. [provided by RefSeq, Aug 2017].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC036545.1, SRR14038192.948761.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1968968
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000448587.6/ ENSP00000490584.1
            NMD candidate          :: PMID: 32012357, 34351912
            RefSeq Select criteria :: based on manual assertion, expression
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-289               AC011533.6         30144-30432         c
            290-419             AC011533.6         24561-24690         c
            420-3652            AC011533.6         20646-23878         c
FEATURES             Location/Qualifiers
     source          1..3652
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..3652
                     /gene="TINCR"
                     /gene_synonym="LINC00036; NCRNA00036; onco-lncRNA-16;
                     PLAC2; TUBL"
                     /note="TINCR ubiquitin domain containing"
                     /db_xref="GeneID:257000"
                     /db_xref="HGNC:HGNC:14607"
                     /db_xref="MIM:615241"
     exon            1..289
                     /gene="TINCR"
                     /gene_synonym="LINC00036; NCRNA00036; onco-lncRNA-16;
                     PLAC2; TUBL"
                     /inference="alignment:Splign:2.1.0"
     CDS             30..293
                     /gene="TINCR"
                     /gene_synonym="LINC00036; NCRNA00036; onco-lncRNA-16;
                     PLAC2; TUBL"
                     /note="isoform 1 is encoded by transcript variant 1; long
                     intergenic non-protein coding RNA 36; placenta-specific 2
                     (non-protein coding); terminal differentiation-induced
                     ncRNA; tissue differentiation-inducing non-protein coding
                     RNA; TINCR-encoded ubiquitin-like protein"
                     /codon_start=1
                     /product="TINCR ubiquitin domain containing isoform 1"
                     /protein_id="NP_001383337.1"
                     /db_xref="CCDS:CCDS92495.1"
                     /db_xref="GeneID:257000"
                     /db_xref="HGNC:HGNC:14607"
                     /db_xref="MIM:615241"
                     /translation="MEGLRRGLSRWKRYHIKVHLADEALLLPLTVRPRDTLSDLRAQL
                     VGQGVSSWKRAFYYNARRLDDHQTVRDARLQDGSVLLLVSDPR"
     exon            290..419
                     /gene="TINCR"
                     /gene_synonym="LINC00036; NCRNA00036; onco-lncRNA-16;
                     PLAC2; TUBL"
                     /inference="alignment:Splign:2.1.0"
     exon            420..3652
                     /gene="TINCR"
                     /gene_synonym="LINC00036; NCRNA00036; onco-lncRNA-16;
                     PLAC2; TUBL"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3634..3639
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TINCR"
                     /gene_synonym="LINC00036; NCRNA00036; onco-lncRNA-16;
                     PLAC2; TUBL"
                     /note="hexamer: ATTACA"
     polyA_site      3652
                     /gene="TINCR"
                     /gene_synonym="LINC00036; NCRNA00036; onco-lncRNA-16;
                     PLAC2; TUBL"
                     /note="major polyA site"
ORIGIN      
        1 agagctggag ccggagccgg gcgggcgcca tggaggggct gcggcggggg ctgtcgcgct
       61 ggaagcgcta ccacatcaag gtgcacctgg cggacgaggc gctgctgcta ccgctgaccg
      121 tgcggccgcg ggacacgctc agcgacctgc gcgcccagct ggtgggccag ggcgtgagct
      181 cctggaagcg cgccttctac tacaacgcgc ggcggctgga cgaccaccag acggtgcgcg
      241 acgcgcgcct gcaggacggc tcggtgctgc tgctcgtcag cgaccccagg tagtctgggt
      301 tggaggaggc agagccatga ccaaggggac ctgggtactg gctgaaggaa taggctgggg
      361 tagagggcac ttttggaagg cacttctcct gcctcccggg agcctagatc tcactccagg
      421 gtctgggctc ccaggtggac catgaaaccc tggcctgacc agctgatgca cactgcttca
      481 gacactcctg ctggagcccc agtccctgac aaggacctag gacatttttg ctcctgccca
      541 gcctatcggg agggagcctt gagcctttca gctctgctgt gtgactttga ggttgttgct
      601 cccctcttgg ggccctgggt gccctgtctt cagtggaaag cactgtgcca ccttggaaag
      661 ctcccatggg cagccagagg gcatcgcaag aagagaagca cagaaggggc aggagagaca
      721 ctcagaggca cttccgctct tgcccaggac attttcccag ccacaccttt gcccaagccg
      781 tgccccctgc ctggagcact tttcaacctc ttctctgcag ctccaataca cctgggattg
      841 cagtctcctc caggaagtct tctcagattc cctccttccc agccagagag cacctagcct
      901 tctttggggc ccccacaggc cctttgtgca gtgaacagcc ctggctgggg gtgcagccag
      961 tcgtgtccga actctccaat gactaagcgg ggagatgcgg acatcctagc tccttctcag
     1021 gcctccaact gtgccccatt tccaccccca aatacctccc caggaggcac ctgtgcccac
     1081 cccctgggct gtttccccct tccccttaaa tccggatgcc tcgtcttgca tagggtcttg
     1141 gggcagcggg gaaggggttc tgaagaactc tggccaagag gacgaggatc tgggggtggg
     1201 gaactgggcc tagctgtggg aggtcatcgc ggggcattgc agggagtgcg ttgtgggaat
     1261 tccgggtgga gaccctcagg gcagtgtgcc gggcctccgt tgcacctctg acctgcagcc
     1321 acgtcatcgt tgcgcagccc ctggggaggg tctttgggga gggggtgccg aggctacgca
     1381 tgtcctcgag ggccgtgtac actctccagg caccatgggc ggaggcgcca gaggctggga
     1441 agaaataatg ttttagttaa gagtcctgtt ggctgcagga ctcagagcat ggacaggtgg
     1501 atagtaaatc accaccacgg ggacagccgt gcccagactg tgcgtttgct tagctcgggg
     1561 acagcacttg gcccggggtc tcctgctcgc ctcccttcag agcatctgcc aaacttcggg
     1621 catctaccct gcaattcccg cttggctgag aggaggggga gaaggagggg aagagagagg
     1681 agccccactt cactccggca ggcagacctg ctggagctgc tttgcagaat gacttgggtc
     1741 ttgctggccc ctgggtgtgc ctggaggggg gtcttcctat ccccctccac ctctcccctt
     1801 ggtgcctaac ccaggacttt gtccccagag acccactgtg tgccccctgg agctcctcct
     1861 agagcagagt ctgctgctgt ctgttctgca gagggtagcc tgaggcccaa ggaggttgtc
     1921 agggacacac agcaggggga ggcagcccag atccctgctc atgcgtggtt tgggcctctg
     1981 ctaacagctg ggccacatgc gtgtatctag agcctgggtc ccctctgtcc tcatttccct
     2041 gtgcatattc agggacatgc ctcgtcaggg tttggcaaga aaatggggca tttaataatc
     2101 tccccagttt cattccttgg tccttactcc atgccaggac ttgtgcacat ctttttggag
     2161 ccctgtctca cttgattgac agccggccag gcgcggtggc tcacgcctgt aatcccagca
     2221 ctttgggagg acgaggcagg cggatcatga ggtcaggaga tggagaccat cctggctaac
     2281 acggtgaaac cccgtctcta ctaaaagtac aaaaaaaata gccgggcctg gtggcgggcg
     2341 cctgtagtcc cagctacttg gtaggctgag gcaggagaat ggcgggaacc cgggaggcag
     2401 aggttgcagt gagctgagat cacgccactg cactccagcc tgggcgacag agcgagactc
     2461 cgtctcaaaa aaaaaaaaaa aaaagattga cagcctcact gctcaggggc caggataaca
     2521 gcccatttta cagatggctt ttggcttgcc caaggtcacc accctctgaa ctgaggcgtc
     2581 cccaacccat gccgggagct ggtggaggaa gtggggaagg gtttcccgct tctccactgg
     2641 gggtggaggt gggagaaagc attttcaggg tgttttgaca tttaacaaac agtatgcaaa
     2701 tcacatgcaa atcgcatgca aatcaccacc catttcttaa gcctcgacag cgctggcatg
     2761 ttctgaaata ataatgttgg acctgtccct tgatgatgac ctgggtcggg aggtgcacgg
     2821 ccttttcctt cctccgtctt cccttccctt cccttccctt cccatctgtt ctcccttcct
     2881 tcgccccctt cctttcctct ccctccctat cttccatttt tctcttcttc cttcacatca
     2941 tttgtccaag acctccctgg cctgagataa acataagttg caaaagtggc ttcctgcagc
     3001 ccattttcca ggttgggaaa ctgaggcatg ggcctaaggt cccacagcca caccgaggaa
     3061 agcagccccc actgaatgtc accatgcacc aaagtgcatg gtcctcgtga cacaaagagg
     3121 ggagatgaca gtggctggag ttgtcagagc tgctttgagg aagctccagg cctgataggc
     3181 ttgacagggc caaggggaac tattgtggaa tgtcttggcc ttgaatgaca ggctgctgat
     3241 tttggatctg gagaaagctc acactgactc ttcctgctcc cccagtctgt ttttctcctg
     3301 ctactccatc catgtatccc tgagtttggg ccacagtccc tccacttggt ttgcatgtcc
     3361 caccttcttt gtttggcaag ctcctattca tccttcaaag ccctagcttc aatacctgct
     3421 acttcatgca gccattgctt atccttcaag gagagcctac ttccctcaag gaccctgctg
     3481 cttccagtct caccttctga ctcactcggg atccactgaa ctgggaggtc tgtgtctcct
     3541 cccagcagag tcatcactac ctttggggcc gcaggatcac ccagcttgga actagataca
     3601 gaaatgctgt tttgagagtg tactgaataa aagattacat gtttgaaaac aa
//
