LOCUS       NM_022164               2207 bp    mRNA    linear   PRI 03-SEP-2024
DEFINITION  Homo sapiens tubulointerstitial nephritis antigen like 1 (TINAGL1),
            transcript variant 1, mRNA.
ACCESSION   NM_022164
VERSION     NM_022164.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2207)
  AUTHORS   Zhang,L., Cai,E., Xu,Y., Liu,Z., Zheng,M., Sun,Z., Pei,D. and
            Wang,Q.
  TITLE     YTHDF1 facilitates esophageal cancer progression via augmenting
            m6A-dependent TINAGL1 translation
  JOURNAL   Cell Signal 122, 111332 (2024)
   PUBMED   39098703
  REMARK    GeneRIF: YTHDF1 facilitates esophageal cancer progression via
            augmenting m6A-dependent TINAGL1 translation.
REFERENCE   2  (bases 1 to 2207)
  AUTHORS   Lee,D., Ham,I.H., Oh,H.J., Lee,D.M., Yoon,J.H., Son,S.Y., Kim,T.M.,
            Kim,J.Y., Han,S.U. and Hur,H.
  TITLE     Tubulointerstitial nephritis antigen-like 1 from cancer-associated
            fibroblasts contribute to the progression of diffuse-type gastric
            cancers through the interaction with integrin beta1
  JOURNAL   J Transl Med 22 (1), 154 (2024)
   PUBMED   38355577
  REMARK    GeneRIF: Tubulointerstitial nephritis antigen-like 1 from
            cancer-associated fibroblasts contribute to the progression of
            diffuse-type gastric cancers through the interaction with integrin
            beta1.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2207)
  AUTHORS   Teng,Y., Xie,R., Xu,J., Wang,P., Chen,W., Shan,Z., Yan,Z., Mao,F.,
            Cheng,P., Peng,L., Zhang,J., Tian,W., Yang,S., Zhao,Y., Chen,W.,
            Zou,Q. and Zhuang,Y.
  TITLE     Tubulointerstitial nephritis antigen-like 1 is a novel
            matricellular protein that promotes gastric bacterial colonization
            and gastritis in the setting of Helicobacter pylori infection
  JOURNAL   Cell Mol Immunol 20 (8), 924-940 (2023)
   PUBMED   37336990
  REMARK    GeneRIF: Tubulointerstitial nephritis antigen-like 1 is a novel
            matricellular protein that promotes gastric bacterial colonization
            and gastritis in the setting of Helicobacter pylori infection.
REFERENCE   4  (bases 1 to 2207)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 2207)
  AUTHORS   Shen,M., Jiang,Y.Z., Wei,Y., Ell,B., Sheng,X., Esposito,M.,
            Kang,J., Hang,X., Zheng,H., Rowicki,M., Zhang,L., Shih,W.J.,
            Celia-Terrassa,T., Liu,Y., Cristea,I., Shao,Z.M. and Kang,Y.
  TITLE     Tinagl1 Suppresses Triple-Negative Breast Cancer Progression and
            Metastasis by Simultaneously Inhibiting Integrin/FAK and EGFR
            Signaling
  JOURNAL   Cancer Cell 35 (1), 64-80 (2019)
   PUBMED   30612941
  REMARK    GeneRIF: Results show that lower TINAGL1 expression correlates with
            advanced triple-negative breast cancer (TNBC) tumor stages, reduced
            disease-free survival (DFS) and distant metastasis-free survival.
            Consistent with higher risk of metastatic relapse in breast tumors
            with lower expression of TINAGL1, highly metastatic human breast
            cancer cell lines express lower TINAGL1 levels than weakly
            metastatic cells.
REFERENCE   6  (bases 1 to 2207)
  AUTHORS   Gornemann,J., Hofmann,T.G., Will,H. and Muller,M.
  TITLE     Interaction of human papillomavirus type 16 L2 with cellular
            proteins: identification of novel nuclear body-associated proteins
  JOURNAL   Virology 303 (1), 69-78 (2002)
   PUBMED   12482659
REFERENCE   7  (bases 1 to 2207)
  AUTHORS   Jiang,L.Q., Wen,S.J., Wang,H.Y. and Chen,L.Y.
  TITLE     Screening the proteins that interact with calpain in a human heart
            cDNA library using a yeast two-hybrid system
  JOURNAL   Hypertens Res 25 (4), 647-652 (2002)
   PUBMED   12358155
REFERENCE   8  (bases 1 to 2207)
  AUTHORS   Kobayashi,M., Kinouchi,T., Hakamata,Y., Kamiakito,T., Kuriki,K.,
            Suzuki,K., Tokue,A., Fukayama,M. and Tanaka,A.
  TITLE     Isolation of an androgen-inducible novel lipocalin gene, Arg1, from
            androgen-dependent mouse mammary Shionogi carcinoma cells
  JOURNAL   J Steroid Biochem Mol Biol 77 (2-3), 109-115 (2001)
   PUBMED   11377975
REFERENCE   9  (bases 1 to 2207)
  AUTHORS   Wex,T., Lipyansky,A., Bromme,N.C., Wex,H., Guan,X.Q. and Bromme,D.
  TITLE     TIN-ag-RP, a novel catalytically inactive cathepsin B-related
            protein with EGF domains, is predominantly expressed in vascular
            smooth muscle cells
  JOURNAL   Biochemistry 40 (5), 1350-1357 (2001)
   PUBMED   11170462
REFERENCE   10 (bases 1 to 2207)
  AUTHORS   Bromme,N.C., Wex,T., Wex,H., Levy,B., Lipyansky,A. and Bromme,D.
  TITLE     Cloning, characterization, and expression of the human TIN-ag-RP
            gene encoding a novel putative extracellular matrix protein
  JOURNAL   Biochem Biophys Res Commun 271 (2), 474-480 (2000)
   PUBMED   10799322
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from DA656570.1 and BC064633.1.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_022164.2.
            
            Summary: The protein encoded by this gene is similar in sequence to
            tubulointerstitial nephritis antigen, a secreted glycoprotein that
            is recognized by antibodies in some types of immune-related
            tubulointerstitial nephritis. Three transcript variants encoding
            different isoforms have been found for this gene. [provided by
            RefSeq, Feb 2011].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longest isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AY358421.1, AB050716.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000271064.12/ ENSP00000271064.7
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-12                DA656570.1         32-43
            13-2207             BC064633.1         1-2195
FEATURES             Location/Qualifiers
     source          1..2207
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1p35.2"
     gene            1..2207
                     /gene="TINAGL1"
                     /gene_synonym="ARG1; LCN7; LIECG3; TINAGRP"
                     /note="tubulointerstitial nephritis antigen like 1"
                     /db_xref="GeneID:64129"
                     /db_xref="HGNC:HGNC:19168"
                     /db_xref="MIM:616064"
     exon            1..81
                     /gene="TINAGL1"
                     /gene_synonym="ARG1; LCN7; LIECG3; TINAGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            82..406
                     /gene="TINAGL1"
                     /gene_synonym="ARG1; LCN7; LIECG3; TINAGRP"
                     /inference="alignment:Splign:2.1.0"
     CDS             97..1500
                     /gene="TINAGL1"
                     /gene_synonym="ARG1; LCN7; LIECG3; TINAGRP"
                     /note="isoform 1 precursor is encoded by transcript
                     variant 1; androgen-regulated gene 1; P3ECSL; TINAG-like
                     1; lipocalin 7; oxidized-LDL responsive gene 2;
                     tubulointerstitial nephritis antigen-related protein;
                     tubulointerstitial nephritis antigen-like; OLRG-2;
                     TIN-Ag-RP; TIN Ag-related protein;
                     glucocorticoid-inducible protein 5"
                     /codon_start=1
                     /product="tubulointerstitial nephritis antigen-like
                     isoform 1 precursor"
                     /protein_id="NP_071447.1"
                     /db_xref="CCDS:CCDS343.1"
                     /db_xref="GeneID:64129"
                     /db_xref="HGNC:HGNC:19168"
                     /db_xref="MIM:616064"
                     /translation="MWRCPLGLLLLLPLAGHLALGAQQGRGRRELAPGLHLRGIRDAG
                     GRYCQEQDLCCRGRADDCALPYLGAICYCDLFCNRTVSDCCPDFWDFCLGVPPPFPPI
                     QGCMHGGRIYPVLGTYWDNCNRCTCQENRQWQCDQEPCLVDPDMIKAINQGNYGWQAG
                     NHSAFWGMTLDEGIRYRLGTIRPSSSVMNMHEIYTVLNPGEVLPTAFEASEKWPNLIH
                     EPLDQGNCAGSWAFSTAAVASDRVSIHSLGHMTPVLSPQNLLSCDTHQQQGCRGGRLD
                     GAWWFLRRRGVVSDHCYPFSGRERDEAGPAPPCMMHSRAMGRGKRQATAHCPNSYVNN
                     NDIYQVTPVYRLGSNDKEIMKELMENGPVQALMEVHEDFFLYKGGIYSHTPVSLGRPE
                     RYRRHGTHSVKITGWGEETLPDGRTLKYWTAANSWGPAWGERGHFRIVRGVNECDIES
                     FVLGVWGRVGMEDMGHH"
     exon            407..470
                     /gene="TINAGL1"
                     /gene_synonym="ARG1; LCN7; LIECG3; TINAGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            471..563
                     /gene="TINAGL1"
                     /gene_synonym="ARG1; LCN7; LIECG3; TINAGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            564..678
                     /gene="TINAGL1"
                     /gene_synonym="ARG1; LCN7; LIECG3; TINAGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            679..802
                     /gene="TINAGL1"
                     /gene_synonym="ARG1; LCN7; LIECG3; TINAGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            803..953
                     /gene="TINAGL1"
                     /gene_synonym="ARG1; LCN7; LIECG3; TINAGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            954..1143
                     /gene="TINAGL1"
                     /gene_synonym="ARG1; LCN7; LIECG3; TINAGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1189
                     /gene="TINAGL1"
                     /gene_synonym="ARG1; LCN7; LIECG3; TINAGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1190..1313
                     /gene="TINAGL1"
                     /gene_synonym="ARG1; LCN7; LIECG3; TINAGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1314..1359
                     /gene="TINAGL1"
                     /gene_synonym="ARG1; LCN7; LIECG3; TINAGRP"
                     /inference="alignment:Splign:2.1.0"
     exon            1360..2207
                     /gene="TINAGL1"
                     /gene_synonym="ARG1; LCN7; LIECG3; TINAGRP"
                     /inference="alignment:Splign:2.1.0"
     regulatory      2186..2191
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TINAGL1"
                     /gene_synonym="ARG1; LCN7; LIECG3; TINAGRP"
                     /note="hexamer: AATAAA"
     polyA_site      2207
                     /gene="TINAGL1"
                     /gene_synonym="ARG1; LCN7; LIECG3; TINAGRP"
                     /note="major polyA site"
ORIGIN      
        1 gactttgagc gtccggcggt cgcagagcca ggaggcggag gcgcgcgggc cagcctgggc
       61 cccagcccac accttcacca gggcccagga gccaccatgt ggcgatgtcc actggggcta
      121 ctgctgttgc tgccgctggc tggccacttg gctctgggtg cccagcaggg tcgtgggcgc
      181 cgggagctag caccgggtct gcacctgcgg ggcatccggg acgcgggagg ccggtactgc
      241 caggagcagg acctgtgctg ccgcggccgt gccgacgact gtgccctgcc ctacctgggc
      301 gccatctgtt actgtgacct cttctgcaac cgcacggtct ccgactgctg ccctgacttc
      361 tgggacttct gcctcggcgt gccaccccct tttcccccga tccaaggatg tatgcatgga
      421 ggtcgtatct atccagtctt gggaacgtac tgggacaact gtaaccgttg cacctgccag
      481 gagaacaggc agtggcagtg tgaccaagaa ccatgcctgg tggatccaga catgatcaaa
      541 gccatcaacc agggcaacta tggctggcag gctgggaacc acagcgcctt ctggggcatg
      601 accctggatg agggcattcg ctaccgcctg ggcaccatcc gcccatcttc ctcggtcatg
      661 aacatgcatg aaatttatac agtgctgaac ccaggggagg tgcttcccac agccttcgag
      721 gcctctgaga agtggcccaa cctgattcat gagcctcttg accaaggcaa ctgtgcaggc
      781 tcctgggcct tctccacagc agctgtggca tccgatcgtg tctcaatcca ttctctggga
      841 cacatgacgc ctgtcctgtc gccccagaac ctgctgtctt gtgacaccca ccagcagcag
      901 ggctgccgcg gtgggcgtct cgatggtgcc tggtggttcc tgcgtcgccg aggggtggtg
      961 tctgaccact gctacccctt ctcgggccgt gaacgagacg aggctggccc tgcgcccccc
     1021 tgtatgatgc acagccgagc catgggtcgg ggcaagcgcc aggccactgc ccactgcccc
     1081 aacagctatg ttaataacaa tgacatctac caggtcactc ctgtctaccg cctcggctcc
     1141 aacgacaagg agatcatgaa ggagctgatg gagaatggcc ctgtccaagc cctcatggag
     1201 gtgcatgagg acttcttcct atacaaggga ggcatctaca gccacacgcc agtgagcctt
     1261 gggaggccag agagataccg ccggcatggg acccactcag tcaagatcac aggatgggga
     1321 gaggagacgc tgccagatgg aaggacgctc aaatactgga ctgcggccaa ctcctggggc
     1381 ccagcctggg gcgagagggg ccacttccgc atcgtgcgcg gcgtcaatga gtgcgacatc
     1441 gagagcttcg tgctgggcgt ctggggccgc gtgggcatgg aggacatggg tcatcactga
     1501 ggctgcgggc accacgcggg gtccggcctg ggatccaggc taagggccgg cggaagaggc
     1561 cccaatgggg cggtgacccc agcctcgccc gacagagccc ggggcgcagg cgggcgccag
     1621 ggcgctaatc ccggcgcggg ttccgctgac gcagcgcccc gcctgggagc cgcgggcagg
     1681 cgagactggc ggagccccca gacctcccag tggggacggg gcagggcctg gcctgggaag
     1741 agcacagctg cagatcccag gcctctggcg cccccactca agactaccaa agccaggaca
     1801 cctcaagtct ccagccccac taccccaccc cactcctgta ttcttttttt ttttttttta
     1861 gacagggtct tgctccgttg cccaggttgg agtgcagtgg cccatcaggg ctcactgtaa
     1921 cctccgactc ctgggttcaa gtgaccctcc cacctcagcc tctcaagtag ctgggactac
     1981 aggtgcacca ccacacctgg ctaatttttg tattttttgt aaagaggggg gtctcactgt
     2041 gttgcccagg ctggtctcga actcctgggc tcaagcggtc cacctgcctc cgcctcccaa
     2101 agtgctggga ttgcaggcat gagccactgc acccagccct gtattcttat tcttcagata
     2161 tttatttttc ttttcactgt tttaaaataa aaccaaagta ttgataa
//
