LOCUS       NM_014464               1758 bp    mRNA    linear   PRI 06-JUN-2024
DEFINITION  Homo sapiens tubulointerstitial nephritis antigen (TINAG), mRNA.
ACCESSION   NM_014464
VERSION     NM_014464.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1758)
  AUTHORS   Tong,X., Li,G. and Feng,Y.
  TITLE     TINAG mutation as a genetic cause of pectus excavatum
  JOURNAL   Med Hypotheses 137, 109557 (2020)
   PUBMED   31981812
  REMARK    GeneRIF: TINAG mutation as a genetic cause of pectus excavatum.
REFERENCE   2  (bases 1 to 1758)
  AUTHORS   Niu,N., Qin,Y., Fridley,B.L., Hou,J., Kalari,K.R., Zhu,M., Wu,T.Y.,
            Jenkins,G.D., Batzler,A. and Wang,L.
  TITLE     Radiation pharmacogenomics: a genome-wide association approach to
            identify radiation response biomarkers using human lymphoblastoid
            cell lines
  JOURNAL   Genome Res 20 (11), 1482-1492 (2010)
   PUBMED   20923822
REFERENCE   3  (bases 1 to 1758)
  AUTHORS   Takemura,Y., Koshimichi,M., Sugimoto,K., Yanagida,H., Fujita,S.,
            Miyazawa,T., Miyazaki,K., Okada,M. and Takemura,T.
  TITLE     A tubulointerstitial nephritis antigen gene defect causes
            childhood-onset chronic renal failure
  JOURNAL   Pediatr Nephrol 25 (7), 1349-1353 (2010)
   PUBMED   20157734
  REMARK    GeneRIF: An hTIN-ag defect may be a potent cause of end-stage renal
            failure in childhood.
REFERENCE   4  (bases 1 to 1758)
  AUTHORS   Zhou,B., Nelson,T.R., Kashtan,C., Gleason,B., Michael,A.F.,
            Vlassi,M. and Charonis,A.S.
  TITLE     Identification of two alternatively spliced forms of human
            tubulointerstitial nephritis antigen (TIN-Ag)
  JOURNAL   J Am Soc Nephrol 11 (4), 658-668 (2000)
   PUBMED   10752525
REFERENCE   5  (bases 1 to 1758)
  AUTHORS   Ikeda,M., Takemura,T., Hino,S. and Yoshioka,K.
  TITLE     Molecular cloning, expression, and chromosomal localization of a
            human tubulointerstitial nephritis antigen
  JOURNAL   Biochem Biophys Res Commun 268 (1), 225-230 (2000)
   PUBMED   10652240
REFERENCE   6  (bases 1 to 1758)
  AUTHORS   Nelson,T.R., Kim,Y., Michael,A.F., Butkowski,R.J. and Charonis,A.S.
  TITLE     Tubulointerstitial nephritis antigen (TIN-ag) is expressed in
            distinct segments of the developing human nephron
  JOURNAL   Connect Tissue Res 37 (1-2), 53-60 (1998)
   PUBMED   9643646
REFERENCE   7  (bases 1 to 1758)
  AUTHORS   Chen,Y., Krishnamurti,U., Wayner,E.A., Michael,A.F. and
            Charonis,A.S.
  TITLE     REceptors in proximal tubular epithelial cells for
            tubulointerstitial nephritis antigen
  JOURNAL   Kidney Int 49 (1), 153-157 (1996)
   PUBMED   8770961
REFERENCE   8  (bases 1 to 1758)
  AUTHORS   Katz,A., Fish,A.J., Santamaria,P., Nevins,T.E., Kim,Y. and
            Butkowski,R.J.
  TITLE     Role of antibodies to tubulointerstitial nephritis antigen in human
            anti-tubular basement membrane nephritis associated with membranous
            nephropathy
  JOURNAL   Am J Med 93 (6), 691-698 (1992)
   PUBMED   1466368
  REMARK    Review article
REFERENCE   9  (bases 1 to 1758)
  AUTHORS   Butkowski,R.J., Kleppel,M.M., Katz,A., Michael,A.F. and Fish,A.J.
  TITLE     Distribution of tubulointerstitial nephritis antigen and evidence
            for multiple forms
  JOURNAL   Kidney Int 40 (5), 838-846 (1991)
   PUBMED   1762287
REFERENCE   10 (bases 1 to 1758)
  AUTHORS   Fliger,F.D., Wieslander,J., Brentjens,J.R., Andres,G.A. and
            Butkowski,R.J.
  TITLE     Identification of a target antigen in human anti-tubular basement
            membrane nephritis
  JOURNAL   Kidney Int 31 (3), 800-807 (1987)
   PUBMED   3553704
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC070278.1, AK312918.1 and
            AW027949.1.
            
            On Nov 22, 2018 this sequence version replaced NM_014464.3.
            
            Summary: This gene encodes a glycoprotein that is restricted within
            the kidney to the basement membranes underlying the epithelium of
            Bowman's capsule and proximal and distal tubules. Autoantibodies
            against this protein are found in sera of patients with
            tubulointerstital nephritis, membranous nephropathy and
            anti-glomerular basement membrane nephritis. Ontogeny studies
            suggest that the expression of this antigen is developmentally
            regulated in a precise spatial and temporal pattern throughout
            nephrogenesis. [provided by RefSeq, Nov 2011].
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK312918.1, BC070278.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000259782.9/ ENSP00000259782.4
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-174               BC070278.1         37-210
            175-628             AK312918.1         175-628
            629-705             BC070278.1         665-741
            706-1541            AK312918.1         706-1541
            1542-1758           AW027949.1         11-227              c
FEATURES             Location/Qualifiers
     source          1..1758
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="6"
                     /map="6p12.1"
     gene            1..1758
                     /gene="TINAG"
                     /gene_synonym="TIN-AG"
                     /note="tubulointerstitial nephritis antigen"
                     /db_xref="GeneID:27283"
                     /db_xref="HGNC:HGNC:14599"
                     /db_xref="MIM:606749"
     exon            1..465
                     /gene="TINAG"
                     /gene_synonym="TIN-AG"
                     /inference="alignment:Splign:2.1.0"
     CDS             111..1541
                     /gene="TINAG"
                     /gene_synonym="TIN-AG"
                     /codon_start=1
                     /product="tubulointerstitial nephritis antigen"
                     /protein_id="NP_055279.3"
                     /db_xref="CCDS:CCDS4955.1"
                     /db_xref="GeneID:27283"
                     /db_xref="HGNC:HGNC:14599"
                     /db_xref="MIM:606749"
                     /translation="MWTGYKILIFSYLTTEIWMEKQYLSQREVDLEAYFTRNHTVLQG
                     TRFKRAIFQGQYCRNFGCCEDRDDGCVTEFYAANALCYCDKFCDRENSDCCPDYKSFC
                     REEKEWPPHTQPWYPEGCFKDGQHYEEGSVIKENCNSCTCSGQQWKCSQHVCLVRSEL
                     IEQVNKGDYGWTAQNYSQFWGMTLEDGFKFRLGTLPPSPMLLSMNEMTASLPATTDLP
                     EFFVASYKWPGWTHGPLDQKNCAASWAFSTASVAADRIAIQSKGRYTANLSPQNLISC
                     CAKNRHGCNSGSIDRAWWYLRKRGLVSHACYPLFKDQNATNNGCAMASRSDGRGKRHA
                     TKPCPNNVEKSNRIYQCSPPYRVSSNETEIMKEIMQNGPVQAIMQVREDFFHYKTGIY
                     RHVTSTNKESEKYRKLQTHAVKLTGWGTLRGAQGQKEKFWIAANSWGKSWGENGYFRI
                     LRGVNESDIEKLIIAAWGQLTSSDEP"
     exon            466..529
                     /gene="TINAG"
                     /gene_synonym="TIN-AG"
                     /inference="alignment:Splign:2.1.0"
     exon            530..619
                     /gene="TINAG"
                     /gene_synonym="TIN-AG"
                     /inference="alignment:Splign:2.1.0"
     exon            620..734
                     /gene="TINAG"
                     /gene_synonym="TIN-AG"
                     /inference="alignment:Splign:2.1.0"
     exon            735..858
                     /gene="TINAG"
                     /gene_synonym="TIN-AG"
                     /inference="alignment:Splign:2.1.0"
     exon            859..1009
                     /gene="TINAG"
                     /gene_synonym="TIN-AG"
                     /inference="alignment:Splign:2.1.0"
     exon            1010..1190
                     /gene="TINAG"
                     /gene_synonym="TIN-AG"
                     /inference="alignment:Splign:2.1.0"
     exon            1191..1236
                     /gene="TINAG"
                     /gene_synonym="TIN-AG"
                     /inference="alignment:Splign:2.1.0"
     exon            1237..1360
                     /gene="TINAG"
                     /gene_synonym="TIN-AG"
                     /inference="alignment:Splign:2.1.0"
     exon            1361..1406
                     /gene="TINAG"
                     /gene_synonym="TIN-AG"
                     /inference="alignment:Splign:2.1.0"
     exon            1407..1758
                     /gene="TINAG"
                     /gene_synonym="TIN-AG"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1730..1735
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TINAG"
                     /gene_synonym="TIN-AG"
                     /note="hexamer: AATAAA"
     polyA_site      1758
                     /gene="TINAG"
                     /gene_synonym="TIN-AG"
                     /note="major polyA site"
ORIGIN      
        1 gttcaggctg aagtgtctta atgactagaa ttcaggttcc aaggagaagc ccacaaggct
       61 aagggtattg gatataacgg aaagtggaag ctatacctga cttccagaga atgtggaccg
      121 gatataagat cttaatcttc tcttatctta ctacagaaat ctggatggag aagcagtatt
      181 tatctcaaag agaagtggac ctagaggctt atttcactag gaatcacacc gttttgcaag
      241 gtactcgatt caaaagagcc attttccaag ggcaatactg tagaaatttt ggctgttgtg
      301 aagacagaga tgatggctgt gtcactgagt tctatgcggc gaatgcgttg tgctactgtg
      361 ataaattctg tgacagagaa aattctgatt gctgtcctga ctacaagtcc ttttgccgtg
      421 aagagaaaga atggcctcct cacacacagc cttggtatcc agaaggttgc ttcaaagatg
      481 gtcaacatta tgaagaggga tcagtaatta aagaaaactg caactcctgc acatgctcag
      541 gacagcaatg gaaatgttcc cagcatgtat gccttgttcg ttcagaatta attgaacagg
      601 tcaataaagg agactatgga tggacagcac agaattacag ccaattttgg ggaatgactt
      661 tagaagatgg ttttaaattt cgccttggca ctttgccacc tagtcccatg ctcctgagca
      721 tgaatgaaat gacagcttct ttacctgcaa caactgatct tccagagttt tttgttgctt
      781 cttataaatg gcctggatgg actcatggcc cattggatca aaaaaattgt gctgcatcct
      841 gggcattttc cactgcaagt gtggctgctg accgaatagc aattcagtct aagggtcgat
      901 acacggccaa tctatcccct cagaatttga tctcttgctg tgccaagaac cgtcatggat
      961 gcaatagtgg aagcatcgat agggcttggt ggtacctgag aaaacgtgga ctggtatccc
     1021 acgcatgcta cccacttttc aaagaccaaa atgctaccaa caatggatgt gccatggcaa
     1081 gcaggtctga tgggcgagga aaacggcatg ccacgaagcc atgtcccaac aacgtagaaa
     1141 aatctaacag gatctatcaa tgttctcctc catacagagt ctcttccaac gaaactgaga
     1201 taatgaaaga aatcatgcaa aatggaccag ttcaagccat aatgcaagtc cgtgaagatt
     1261 tcttccatta taagacaggg atatacagac atgttaccag cacaaataaa gaatcagaaa
     1321 aatatcgaaa gcttcagaca catgcagtca aactcactgg atggggcaca ctgagaggag
     1381 cacaagggca gaaagaaaaa ttttggattg ctgccaattc ctggggaaag tcatggggag
     1441 agaatggcta tttcaggatt cttcgaggag taaatgagtc cgacattgaa aagttgatta
     1501 tcgcagcttg gggccaactg acgagttctg atgaaccata acatatcatt aaatttccat
     1561 aaggtcatgc ctttaagtaa ccccctaaat tgaagtttag caatatgaca ttcttggtga
     1621 cagtggaatc tttgtctctt caccgtgtta acataatcta tctattttct tattttcccc
     1681 tctggtctat gcttctgctt ccttcatatt actgagcatt aacaacacca ataaaggaca
     1741 gcagagtccc taaatgtc
//
