LOCUS       NM_003256               1194 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens TIMP metallopeptidase inhibitor 4 (TIMP4), mRNA.
ACCESSION   NM_003256
VERSION     NM_003256.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1194)
  AUTHORS   Jakel,L., De Kort,A.M., Stellingwerf,A., Hernandez Utrilla,C.,
            Kersten,I., Vervuurt,M., Vermeiren,Y., Kusters,B.,
            Schreuder,F.H.B.M., Klijn,C.J.M., Kuiperij,H.B. and Verbeek,M.M.
  TITLE     Altered brain expression and cerebrospinal fluid levels of TIMP4 in
            cerebral amyloid angiopathy
  JOURNAL   Acta Neuropathol Commun 12 (1), 103 (2024)
   PUBMED   38915119
  REMARK    GeneRIF: Altered brain expression and cerebrospinal fluid levels of
            TIMP4 in cerebral amyloid angiopathy.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1194)
  AUTHORS   Zhou,W., Jiang,Z., Yi,Z., Ouyang,J., Li,X., Zhang,Q. and Wang,P.
  TITLE     Defect of TIMP4 Is Associated with High Myopia and Participates in
            Rat Ocular Development in a Dose-Dependent Manner
  JOURNAL   Int J Mol Sci 24 (23), 16928 (2023)
   PUBMED   38069250
  REMARK    GeneRIF: Defect of TIMP4 Is Associated with High Myopia and
            Participates in Rat Ocular Development in a Dose-Dependent Manner.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1194)
  AUTHORS   Zheng,X., Jing,J., Yuan,M., Liu,N. and Song,Y.
  TITLE     Contribution of gene polymorphisms on 3p25 to salivary gland
            carcinoma, ameloblastoma, and odontogenic keratocyst in the Chinese
            Han population
  JOURNAL   Oral Surg Oral Med Oral Pathol Oral Radiol 136 (2), 220-230 (2023)
   PUBMED   37495273
  REMARK    GeneRIF: Contribution of gene polymorphisms on 3p25 to salivary
            gland carcinoma, ameloblastoma, and odontogenic keratocyst in the
            Chinese Han population.
REFERENCE   4  (bases 1 to 1194)
  AUTHORS   Fukutsu,K., Kase,S., Iwata,D., Suzuki,K., Namba,K. and Ishida,S.
  TITLE     The Expression of Matrix Metalloproteinases in Eyes with
            Intraocular Lymphoma
  JOURNAL   Ocul Immunol Inflamm 30 (7-8), 1798-1802 (2022)
   PUBMED   34379046
  REMARK    GeneRIF: The Expression of Matrix Metalloproteinases in Eyes with
            Intraocular Lymphoma.
REFERENCE   5  (bases 1 to 1194)
  AUTHORS   Han,J., Jing,Y., Han,F. and Sun,P.
  TITLE     Comprehensive analysis of expression, prognosis and immune
            infiltration for TIMPs in glioblastoma
  JOURNAL   BMC Neurol 21 (1), 447 (2021)
   PUBMED   34781885
  REMARK    GeneRIF: Comprehensive analysis of expression, prognosis and immune
            infiltration for TIMPs in glioblastoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1194)
  AUTHORS   Hernandez-Barrantes,S., Shimura,Y., Soloway,P.D., Sang,Q.A. and
            Fridman,R.
  TITLE     Differential roles of TIMP-4 and TIMP-2 in pro-MMP-2 activation by
            MT1-MMP
  JOURNAL   Biochem Biophys Res Commun 281 (1), 126-130 (2001)
   PUBMED   11178970
REFERENCE   7  (bases 1 to 1194)
  AUTHORS   Pohar,N., Godenschwege,T.A. and Buchner,E.
  TITLE     Invertebrate tissue inhibitor of metalloproteinase: structure and
            nested gene organization within the synapsin locus is conserved
            from Drosophila to human
  JOURNAL   Genomics 57 (2), 293-296 (1999)
   PUBMED   10198170
REFERENCE   8  (bases 1 to 1194)
  AUTHORS   Olson,T.M., Hirohata,S., Ye,J., Leco,K., Seldin,M.F. and Apte,S.S.
  TITLE     Cloning of the human tissue inhibitor of metalloproteinase-4 gene
            (TIMP4) and localization of the TIMP4 and Timp4 genes to human
            chromosome 3p25 and mouse chromosome 6, respectively
  JOURNAL   Genomics 51 (1), 148-151 (1998)
   PUBMED   9693046
REFERENCE   9  (bases 1 to 1194)
  AUTHORS   Bigg,H.F., Shi,Y.E., Liu,Y.E., Steffensen,B. and Overall,C.M.
  TITLE     Specific, high affinity binding of tissue inhibitor of
            metalloproteinases-4 (TIMP-4) to the COOH-terminal hemopexin-like
            domain of human gelatinase A. TIMP-4 binds progelatinase A and the
            COOH-terminal domain in a similar manner to TIMP-2
  JOURNAL   J Biol Chem 272 (24), 15496-15500 (1997)
   PUBMED   9182583
REFERENCE   10 (bases 1 to 1194)
  AUTHORS   Greene,J., Wang,M., Liu,Y.E., Raymond,L.A., Rosen,C. and Shi,Y.E.
  TITLE     Molecular cloning and characterization of human tissue inhibitor of
            metalloproteinase 4
  JOURNAL   J Biol Chem 271 (48), 30375-30380 (1996)
   PUBMED   8939999
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from BC010553.1.
            
            On Nov 23, 2018 this sequence version replaced NM_003256.3.
            
            Summary: This gene belongs to the TIMP gene family. The proteins
            encoded by this gene family are inhibitors of the matrix
            metalloproteinases, a group of peptidases involved in degradation
            of the extracellular matrix. The secreted, netrin domain-containing
            protein encoded by this gene is involved in regulation of platelet
            aggregation and recruitment and may play role in hormonal
            regulation and endometrial tissue remodeling. [provided by RefSeq,
            Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC010553.1, SRR3476690.294263.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000287814.5/ ENSP00000287814.4
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1194              BC010553.1         440-1633
FEATURES             Location/Qualifiers
     source          1..1194
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3p25.2"
     gene            1..1194
                     /gene="TIMP4"
                     /gene_synonym="TIMP-4"
                     /note="TIMP metallopeptidase inhibitor 4"
                     /db_xref="GeneID:7079"
                     /db_xref="HGNC:HGNC:11823"
                     /db_xref="MIM:601915"
     exon            1..211
                     /gene="TIMP4"
                     /gene_synonym="TIMP-4"
                     /inference="alignment:Splign:2.1.0"
     CDS             73..747
                     /gene="TIMP4"
                     /gene_synonym="TIMP-4"
                     /note="tissue inhibitor of metalloproteinase 4;
                     metalloproteinase inhibitor 4; tissue inhibitor of
                     metalloproteinases 4"
                     /codon_start=1
                     /product="metalloproteinase inhibitor 4 precursor"
                     /protein_id="NP_003247.1"
                     /db_xref="CCDS:CCDS2608.1"
                     /db_xref="GeneID:7079"
                     /db_xref="HGNC:HGNC:11823"
                     /db_xref="MIM:601915"
                     /translation="MPGSPRPAPSWVLLLRLLALLRPPGLGEACSCAPAHPQQHICHS
                     ALVIRAKISSEKVVPASADPADTEKMLRYEIKQIKMFKGFEKVKDVQYIYTPFDSSLC
                     GVKLEANSQKQYLLTGQVLSDGKVFIHLCNYIEPWEDLSLVQRESLNHHYHLNCGCQI
                     TTCYTVPCTISAPNECLWTDWLLERKLYGYQAQHYVCMKHVDGTCSWYRGHLPLRKEF
                     VDIVQP"
     exon            212..309
                     /gene="TIMP4"
                     /gene_synonym="TIMP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            310..424
                     /gene="TIMP4"
                     /gene_synonym="TIMP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            425..549
                     /gene="TIMP4"
                     /gene_synonym="TIMP-4"
                     /inference="alignment:Splign:2.1.0"
     exon            550..1194
                     /gene="TIMP4"
                     /gene_synonym="TIMP-4"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1181..1186
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMP4"
                     /gene_synonym="TIMP-4"
                     /note="hexamer: AATGAA"
     polyA_site      1194
                     /gene="TIMP4"
                     /gene_synonym="TIMP-4"
                     /note="major polyA site"
ORIGIN      
        1 cttgggaagg agccctgctg gggccgtcca gtcccccaga cctcacaggc tcagtcgcgg
       61 atctgcagtg tcatgcctgg gagccctcgg cccgcgccaa gctgggtgct gttgctgcgg
      121 ctgctggcgt tgctgcggcc cccggggctg ggtgaggcat gcagctgcgc cccggcgcac
      181 cctcagcagc acatctgcca ctcggcactt gtgattcggg ccaaaatctc cagtgagaag
      241 gtagttccgg ccagtgcaga ccctgctgac actgaaaaaa tgctccggta tgaaatcaaa
      301 cagataaaga tgttcaaagg gtttgagaaa gtcaaggatg ttcagtatat ctatacgcct
      361 tttgactctt ccctctgtgg tgtgaaacta gaagccaaca gccagaagca gtatctcttg
      421 actggtcagg tcctcagtga tggaaaagtc ttcatccatc tgtgcaacta catcgagccc
      481 tgggaggacc tgtccttggt gcagagggaa agtctgaatc atcactacca tctgaactgt
      541 ggctgccaaa tcaccacctg ctacacagta ccctgtacca tctcggcccc taacgagtgc
      601 ctctggacag actggctgtt ggaacgaaag ctctatggtt accaggctca gcattatgtc
      661 tgtatgaagc atgttgacgg cacctgcagc tggtaccggg gccacctgcc tctcaggaag
      721 gagtttgttg acatcgttca gccctagtag ggaccagtga ccatcacatc ccttcaagag
      781 tcctgaagat caagccagtt ctccttccct gcagagcttt ggccattacc acctgacctc
      841 ttgctgccag ctaataagaa gtgccaagtg gacagtctgg ccactgtcaa ggcagggaag
      901 gggccatgac ttttctgccc tgccctcagc ctgttgcccc tgcctcccaa accccattag
      961 tctagccttg tagctgttac tgcaagtgtt tcttctggct tagtctgttt tctaaagcca
     1021 ggactattcc ctttcctccc caggaatatg tgttttcctt tgtcttaatc gatctggtag
     1081 gggagaaatg gcgaatgtca tacacatgag atggtatatc cttgcgatgt acagtatcag
     1141 aaggtggttt gacagcatca taaacaggct gactggcagg aatgaaaaca agaa
//
