LOCUS       NM_003255               3652 bp    mRNA    linear   PRI 15-JUL-2024
DEFINITION  Homo sapiens TIMP metallopeptidase inhibitor 2 (TIMP2), mRNA.
ACCESSION   NM_003255 XM_941104
VERSION     NM_003255.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3652)
  AUTHORS   Zhang,F., Li,J., Xu,J., Jiang,X., Chen,S. and Nasser,Q.A.
  TITLE     Circular RNA circLIFR suppresses papillary thyroid cancer
            progression by modulating the miR-429/TIMP2 axis
  JOURNAL   J Cancer Res Clin Oncol 150 (6), 323 (2024)
   PUBMED   38914806
  REMARK    GeneRIF: Circular RNA circLIFR suppresses papillary thyroid cancer
            progression by modulating the miR-429/TIMP2 axis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 3652)
  AUTHORS   Yang,Y., Huang,F., Wu,X., Huang,C. and Li,Y.
  TITLE     Demethylation of TIMP2 and TIMP3 Inhibits Cell Proliferation,
            Migration, and Invasion in Pituitary Adenomas
  JOURNAL   Discov Med 36 (184), 971-980 (2024)
   PUBMED   38798256
  REMARK    GeneRIF: Demethylation of TIMP2 and TIMP3 Inhibits Cell
            Proliferation, Migration, and Invasion in Pituitary Adenomas.
REFERENCE   3  (bases 1 to 3652)
  AUTHORS   Gowtham,P., Girigoswami,K., Thirumalai,A., Harini,K., Pallavi,P.
            and Girigoswami,A.
  TITLE     Association of TIMP2 418 G/C and MMP Gene Polymorphism with Risk of
            Urinary Cancers: Systematic Review and Meta-analysis
  JOURNAL   Genet Test Mol Biomarkers 28 (3), 83-90 (2024)
   PUBMED   38478803
  REMARK    GeneRIF: Association of TIMP2 418 G/C and MMP Gene Polymorphism
            with Risk of Urinary Cancers: Systematic Review and Meta-analysis.
            Review article
REFERENCE   4  (bases 1 to 3652)
  AUTHORS   Tang,J., Kang,Y., Zhou,Y., Shang,N., Li,X., Wang,H., Lan,J.,
            Wang,S., Wu,L. and Peng,Y.
  TITLE     TIMP2 ameliorates blood-brain barrier disruption in traumatic brain
            injury by inhibiting Src-dependent VE-cadherin internalization
  JOURNAL   J Clin Invest 134 (3), e164199 (2023)
   PUBMED   38015626
  REMARK    GeneRIF: TIMP2 ameliorates blood-brain barrier disruption in
            traumatic brain injury by inhibiting Src-dependent VE-cadherin
            internalization.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 3652)
  AUTHORS   Ferreira,A.C., Hemmer,B.M., Philippi,S.M., Grau-Perales,A.B.,
            Rosenstadt,J.L., Liu,H., Zhu,J.D., Kareva,T., Ahfeldt,T.,
            Varghese,M., Hof,P.R. and Castellano,J.M.
  TITLE     Neuronal TIMP2 regulates hippocampus-dependent plasticity and
            extracellular matrix complexity
  JOURNAL   Mol Psychiatry 28 (9), 3943-3954 (2023)
   PUBMED   37914840
  REMARK    GeneRIF: Neuronal TIMP2 regulates hippocampus-dependent plasticity
            and extracellular matrix complexity.
REFERENCE   6  (bases 1 to 3652)
  AUTHORS   De Clerck,Y., Szpirer,C., Aly,M.S., Cassiman,J.J., Eeckhout,Y. and
            Rousseau,G.
  TITLE     The gene for tissue inhibitor of metalloproteinases-2 is localized
            on human chromosome arm 17q25
  JOURNAL   Genomics 14 (3), 782-784 (1992)
   PUBMED   1427908
REFERENCE   7  (bases 1 to 3652)
  AUTHORS   Osthues,A., Knauper,V., Oberhoff,R., Reinke,H. and Tschesche,H.
  TITLE     Isolation and characterization of tissue inhibitors of
            metalloproteinases (TIMP-1 and TIMP-2) from human rheumatoid
            synovial fluid
  JOURNAL   FEBS Lett 296 (1), 16-20 (1992)
   PUBMED   1730286
REFERENCE   8  (bases 1 to 3652)
  AUTHORS   Stetler-Stevenson,W.G., Krutzsch,H.C. and Liotta,L.A.
  TITLE     TIMP-2: identification and characterization of a new member of the
            metalloproteinase inhibitor family
  JOURNAL   Matrix Suppl 1, 299-306 (1992)
   PUBMED   1480041
REFERENCE   9  (bases 1 to 3652)
  AUTHORS   Liotta,L.A., Stetler-Stevenson,W. and Steeg,P.S.
  TITLE     Metastasis suppressor genes
  JOURNAL   Important Adv Oncol, 85-100 (1991)
   PUBMED   1869284
  REMARK    Review article
REFERENCE   10 (bases 1 to 3652)
  AUTHORS   Boone,T.C., Johnson,M.J., De Clerck,Y.A. and Langley,K.E.
  TITLE     cDNA cloning and expression of a metalloproteinase inhibitor
            related to tissue inhibitor of metalloproteinases
  JOURNAL   Proc Natl Acad Sci U S A 87 (7), 2800-2804 (1990)
   PUBMED   2157214
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC100788.8, BC052605.1,
            AC022966.13 and AL110197.1.
            
            On Nov 22, 2018 this sequence version replaced NM_003255.4.
            
            Summary: This gene is a member of the TIMP gene family. The
            proteins encoded by this gene family are natural inhibitors of the
            matrix metalloproteinases, a group of peptidases involved in
            degradation of the extracellular matrix. In addition to an
            inhibitory role against metalloproteinases, the encoded protein has
            a unique role among TIMP family members in its ability to directly
            suppress the proliferation of endothelial cells. As a result, the
            encoded protein may be critical to the maintenance of tissue
            homeostasis by suppressing the proliferation of quiescent tissues
            in response to angiogenic factors, and by inhibiting protease
            activity in tissues undergoing remodelling of the extracellular
            matrix. [provided by RefSeq, Jul 2008].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC071586.1, HM005597.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2145245
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000262768.11/ ENSP00000262768.6
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-20                AC100788.8         49774-49793         c
            21-1077             BC052605.1         1-1057
            1078-1840           AC022966.13        161661-162423       c
            1841-3652           AL110197.1         1-1812
FEATURES             Location/Qualifiers
     source          1..3652
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="17"
                     /map="17q25.3"
     gene            1..3652
                     /gene="TIMP2"
                     /gene_synonym="CSC-21K; DDC8"
                     /note="TIMP metallopeptidase inhibitor 2"
                     /db_xref="GeneID:7077"
                     /db_xref="HGNC:HGNC:11821"
                     /db_xref="MIM:188825"
     exon            1..429
                     /gene="TIMP2"
                     /gene_synonym="CSC-21K; DDC8"
                     /inference="alignment:Splign:2.1.0"
     CDS             300..962
                     /gene="TIMP2"
                     /gene_synonym="CSC-21K; DDC8"
                     /note="tissue inhibitor of metalloproteinases 2;
                     metalloproteinase inhibitor 2; testicular secretory
                     protein Li 57"
                     /codon_start=1
                     /product="metalloproteinase inhibitor 2 precursor"
                     /protein_id="NP_003246.1"
                     /db_xref="CCDS:CCDS11758.1"
                     /db_xref="GeneID:7077"
                     /db_xref="HGNC:HGNC:11821"
                     /db_xref="MIM:188825"
                     /translation="MGAAARTLRLALGLLLLATLLRPADACSCSPVHPQQAFCNADVV
                     IRAKAVSEKEVDSGNDIYGNPIKRIQYEIKQIKMFKGPEKDIEFIYTAPSSAVCGVSL
                     DVGGKKEYLIAGKAEGDGKMHITLCDFIVPWDTLSTTQKKSLNHRYQMGCECKITRCP
                     MIPCYISSPDECLWMDWVTEKNINGHQAKFFACIKRSDGSCAWYRGAAPPKQEFLDIE
                     DP"
     exon            430..530
                     /gene="TIMP2"
                     /gene_synonym="CSC-21K; DDC8"
                     /inference="alignment:Splign:2.1.0"
     exon            531..639
                     /gene="TIMP2"
                     /gene_synonym="CSC-21K; DDC8"
                     /inference="alignment:Splign:2.1.0"
     exon            640..764
                     /gene="TIMP2"
                     /gene_synonym="CSC-21K; DDC8"
                     /inference="alignment:Splign:2.1.0"
     exon            765..3652
                     /gene="TIMP2"
                     /gene_synonym="CSC-21K; DDC8"
                     /inference="alignment:Splign:2.1.0"
     regulatory      3629..3634
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMP2"
                     /gene_synonym="CSC-21K; DDC8"
                     /note="hexamer: AATAAA"
     polyA_site      3652
                     /gene="TIMP2"
                     /gene_synonym="CSC-21K; DDC8"
                     /note="major polyA site"
ORIGIN      
        1 agcaaacaca tccgtagaag gcagcgcggc cgccgagaac cgcagcgccg ctcgcccgcc
       61 gccccccacc ccgccgcccc gcccggcgaa ttgcgccccg cgcccctccc ctcgcgcccc
      121 cgagacaaag aggagagaaa gtttgcgcgg ccgagcgggg caggtgagga gggtgagccg
      181 cgcgggaggg gcccgcctcg gccccggctc agcccccgcc cgcgccccca gcccgccgcc
      241 gcgagcagcg cccggacccc ccagcggcgg cccccgcccg cccagccccc cggcccgcca
      301 tgggcgccgc ggcccgcacc ctgcggctgg cgctcggcct cctgctgctg gcgacgctgc
      361 ttcgcccggc cgacgcctgc agctgctccc cggtgcaccc gcaacaggcg ttttgcaatg
      421 cagatgtagt gatcagggcc aaagcggtca gtgagaagga agtggactct ggaaacgaca
      481 tttatggcaa ccctatcaag aggatccagt atgagatcaa gcagataaag atgttcaaag
      541 ggcctgagaa ggatatagag tttatctaca cggccccctc ctcggcagtg tgtggggtct
      601 cgctggacgt tggaggaaag aaggaatatc tcattgcagg aaaggccgag ggggacggca
      661 agatgcacat caccctctgt gacttcatcg tgccctggga caccctgagc accacccaga
      721 agaagagcct gaaccacagg taccagatgg gctgcgagtg caagatcacg cgctgcccca
      781 tgatcccgtg ctacatctcc tccccggacg agtgcctctg gatggactgg gtcacagaga
      841 agaacatcaa cgggcaccag gccaagttct tcgcctgcat caagagaagt gacggctcct
      901 gtgcgtggta ccgcggcgcg gcgcccccca agcaggagtt tctcgacatc gaggacccat
      961 aagcaggcct ccaacgcccc tgtggccaac tgcaaaaaaa gcctccaagg gtttcgactg
     1021 gtccagctct gacatccctt cctggaaaca gcatgaataa aacactcatc ccatgggtcc
     1081 aaattaatat gattctgctc cccccttctc cttttagaca tggttgtggg tctggaggga
     1141 gacgtgggtc caaggtcctc atcccatcct ccctctgcca ggcactatgt gtctggggct
     1201 tcgatccttg ggtgcaggca gggctgggac acgcggcttc cctcccagtc cctgccttgg
     1261 caccgtcaca gatgccaagc aggcagcact tagggatctc ccagctgggt tagggcaggg
     1321 cctggaaatg tgcattttgc agaaactttt gagggtcgtt gcaagactgt gtagcaggcc
     1381 taccaggtcc ctttcatctt gagagggaca tggcccttgt tttctgcagc ttccacgcct
     1441 ctgcactccc tgcccctggc aagtgctccc atcgccccgg tgcccaccat gagctcccag
     1501 cacctgactc cccccacatc caagggcagc ctggaaccag tggctagttc ttgaaggagc
     1561 cccatcaatc ctattaatcc tcagaattcc agtgggagcc tccctctgag ccttgtagaa
     1621 atgggagcga gaaaccccag ctgagctgcg ttccagcctc agctgagtct ttttggtctg
     1681 cacccacccc cccacccccc cccccccgcc cacatgctcc ccagcttgca ggaggaatcg
     1741 gtgaggtcct gtcctgaggc tgctgtccgg ggccggtggc tgccctcaag gtcccttccc
     1801 tagctgctgc ggttgccatt gcttcttgcc tgttctggca tcaggcacct ggattgagtt
     1861 gcacagcttt gctttatccg ggcttgtgtg cagggcccgg ctgggctccc catctgcaca
     1921 tcctgaggac agaaaaagct gggtcttgct gtgccctccc aggcttagtg ttccctccct
     1981 caaagactga cagccatcgt tctgcacggg gctttctgca tgtgacgcca gctaagcata
     2041 gtaagaagtc cagcctagga agggaaggat tttggaggta ggtggctttg gtgacacact
     2101 cacttctttc tcagcctcca ggacactatg gcctgtttta agagacatct tatttttcta
     2161 aaggtgaatt ctcagatgat aggtgaacct gagttgcaga tataccaact tctgcttgta
     2221 tttcttaaat gacaaagatt acctagctaa gaaacttcct agggaactag ggaacctatg
     2281 tgttccctca gtgtggtttc ctgaagccag tgatatgggg gttaggatag gaagaacttt
     2341 ctcggtaatg ataaggagaa tctcttgttt cctcccacct gtgttgtaaa gataaactga
     2401 cgatatacag gcacattatg taaacataca cacgcaatga aaccgaagct tggcggcctg
     2461 ggcgtggtct tgcaaaatgc ttccaaagcc accttagcct gttctattca gcggcaaccc
     2521 caaagcacct gttaagactc ctgaccccca agtggcatgc agcccccatg cccaccggga
     2581 cctggtcagc acagatcttg atgacttccc tttctagggc agactgggag ggtatccagg
     2641 aatcggcccc tgccccacgg gcgttttcat gctgtacagt gacctaaagt tggtaagatg
     2701 tcataatgga ccagtccatg tgatttcagt atatacaact ccaccagacc cctccaaccc
     2761 atataacacc ccacccctgt tcgcttcctg tatggtgata tcatatgtaa catttactcc
     2821 tgtttctgct gattgttttt ttaatgtttt ggtttgtttt tgacatcagc tgtaatcatt
     2881 cctgtgctgt gttttttatt acccttggta ggtattagac ttgcactttt ttaaaaaaag
     2941 gtttctgcat cgtggaagca tttgacccag agtggaacgc gtggcctatg caggtggatt
     3001 ccttcaggtc tttcctttgg ttctttgagc atctttgctt tcattcgtct cccgtctttg
     3061 gttctccagt tcaaattatt gcaaagtaaa ggatctttga gtaggttcgg tctgaaaggt
     3121 gtggccttta tatttgatcc acacacgttg gtcttttaac cgtgctgagc agaaaacaaa
     3181 acaggttaag aagagccggg tggcagctga cagaggaagc cgctcaaata ccttcacaat
     3241 aaatagtggc aatatatata tagtttaaga aggctctcca tttggcatcg tttaatttat
     3301 atgttatgtt ctaagcacag ctctcttctc ctattttcat cctgcaagca actcaaaata
     3361 tttaaaataa agtttacatt gtagttattt tcaaatcttt gcttgataag tattaagaaa
     3421 tattggactt gctgccgtaa tttaaagctc tgttgatttt gtttccgttt ggatttttgg
     3481 gggaggggag cactgtgttt atgctggaat atgaagtctg agaccttccg gtgctgggaa
     3541 cacacaagag ttgttgaaag ttgacaagca gactgcgcat gtctctgatg ctttgtatca
     3601 ttcttgagca atcgctcggt ccgtggacaa taaacagtat tatcaaagag aa
//
