LOCUS       NM_006351               1843 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens translocase of inner mitochondrial membrane 44
            (TIMM44), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_006351
VERSION     NM_006351.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1843)
  AUTHORS   Zhang,L., Shi,X., Zhang,L., Mi,Y., Zuo,L. and Gao,S.
  TITLE     A first-in-class TIMM44 blocker inhibits bladder cancer cell growth
  JOURNAL   Cell Death Dis 15 (3), 204 (2024)
   PUBMED   38467612
  REMARK    GeneRIF: A first-in-class TIMM44 blocker inhibits bladder cancer
            cell growth.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1843)
  AUTHORS   Ma,Z.R., Li,H.P., Cai,S.Z., Du,S.Y., Chen,X., Yao,J., Cao,X.,
            Zhen,Y.F. and Wang,Q.
  TITLE     The mitochondrial protein TIMM44 is required for angiogenesis in
            vitro and in vivo
  JOURNAL   Cell Death Dis 14 (5), 307 (2023)
   PUBMED   37147302
  REMARK    GeneRIF: The mitochondrial protein TIMM44 is required for
            angiogenesis in vitro and in vivo.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 1843)
  AUTHORS   Guo,Y.Z., Chen,G., Huang,M., Wang,Y., Liu,Y.Y., Jiang,Q., Cao,C.
            and Liu,F.
  TITLE     TIMM44 is a potential therapeutic target of human glioma
  JOURNAL   Theranostics 12 (17), 7586-7602 (2022)
   PUBMED   36438483
  REMARK    GeneRIF: TIMM44 is a potential therapeutic target of human glioma.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 1843)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   5  (bases 1 to 1843)
  AUTHORS   Yu,X., Li,Y., Ding,Y., Zhang,H., Ding,N. and Lu,M.
  TITLE     HuR Promotes Ovarian Cancer Cell Proliferation by Regulating TIMM44
            mRNA Stability
  JOURNAL   Cell Biochem Biophys 78 (4), 447-453 (2020)
   PUBMED   32901414
  REMARK    GeneRIF: HuR Promotes Ovarian Cancer Cell Proliferation by
            Regulating TIMM44 mRNA Stability.
REFERENCE   6  (bases 1 to 1843)
  AUTHORS   Yuryev,A. and Wennogle,L.P.
  TITLE     Novel raf kinase protein-protein interactions found by an
            exhaustive yeast two-hybrid analysis
  JOURNAL   Genomics 81 (2), 112-125 (2003)
   PUBMED   12620389
REFERENCE   7  (bases 1 to 1843)
  AUTHORS   Yuryev,A., Ono,M., Goff,S.A., Macaluso,F. and Wennogle,L.P.
  TITLE     Isoform-specific localization of A-RAF in mitochondria
  JOURNAL   Mol Cell Biol 20 (13), 4870-4878 (2000)
   PUBMED   10848612
REFERENCE   8  (bases 1 to 1843)
  AUTHORS   Moro,F., Sirrenberg,C., Schneider,H.C., Neupert,W. and Brunner,M.
  TITLE     The TIM17.23 preprotein translocase of mitochondria: composition
            and function in protein transport into the matrix
  JOURNAL   EMBO J 18 (13), 3667-3675 (1999)
   PUBMED   10393182
REFERENCE   9  (bases 1 to 1843)
  AUTHORS   Bauer,M.F., Gempel,K., Reichert,A.S., Rappold,G.A., Lichtner,P.,
            Gerbitz,K.D., Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     Genetic and structural characterization of the human mitochondrial
            inner membrane translocase
  JOURNAL   J Mol Biol 289 (1), 69-82 (1999)
   PUBMED   10339406
REFERENCE   10 (bases 1 to 1843)
  AUTHORS   Abbott,W.M., Mellor,A., Edwards,Y. and Feizi,T.
  TITLE     Soluble bovine galactose-binding lectin. cDNA cloning reveals the
            complete amino acid sequence and an antigenic relationship with the
            major encephalitogenic domain of myelin basic protein
  JOURNAL   Biochem J 259 (1), 283-290 (1989)
   PUBMED   2470348
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AK289634.1, BC033628.1 and
            AC010336.8.
            This sequence is a reference standard in the RefSeqGene project.
            
            On Nov 22, 2018 this sequence version replaced NM_006351.3.
            
            Summary: This gene encodes a peripheral membrane protein associated
            with the mitochondrial inner membrane translocase, which functions
            in the import of proteins across the mitochondrial inner membrane
            and into the mitochondrial matrix. The encoded protein mediates
            binding of mitochondrial heat shock protein 70 to the translocase
            of inner mitochondrial membrane 23 (TIM23) complex. Expression of
            this gene is upregulated in kidney in a mouse model of diabetes. A
            mutation in this gene is associated with familial oncocytic thyroid
            carcinoma. [provided by RefSeq, Jul 2016].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.259519.1,
                                           SRR3476690.415820.1 [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000270538.8/
                                                  ENSP00000270538.2
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                AK289634.1         158-170
            14-1766             BC033628.1         1-1753
            1767-1767           AC010336.8         108005-108005       c
            1768-1843           BC033628.1         1755-1830
FEATURES             Location/Qualifiers
     source          1..1843
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1843
                     /gene="TIMM44"
                     /gene_synonym="TIM44"
                     /note="translocase of inner mitochondrial membrane 44"
                     /db_xref="GeneID:10469"
                     /db_xref="HGNC:HGNC:17316"
                     /db_xref="MIM:605058"
     exon            1..60
                     /gene="TIMM44"
                     /gene_synonym="TIM44"
                     /inference="alignment:Splign:2.1.0"
     CDS             16..1374
                     /gene="TIMM44"
                     /gene_synonym="TIM44"
                     /note="translocase of inner mitochondrial membrane 44
                     homolog"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit TIM44"
                     /protein_id="NP_006342.2"
                     /db_xref="CCDS:CCDS12192.1"
                     /db_xref="GeneID:10469"
                     /db_xref="HGNC:HGNC:17316"
                     /db_xref="MIM:605058"
                     /translation="MAAAALRSGWCRCPRRCLGSGIQFLSSHNLPHGSTYQMRRPGGE
                     LPLSKSYSSGNRKGFLSGLLDNVKQELAKNKEMKESIKKFRDEARRLEESDVLQEARR
                     KYKTIESETVRTSEVLRKKLGELTGTVKESLHEVSKSDLGRKIKEGVEEAAKTAKQSA
                     ESVSKGGEKLGRTAAFRALSQGVESVKKEIDDSVLGQTGPYRRPQRLRKRTEFAGDKF
                     KEEKVFEPNEEALGVVLHKDSKWYQQWKDFKENNVVFNRFFEMKMKYDESDNAFIRAS
                     RALTDKVTDLLGGLFSKTEMSEVLTEILRVDPAFDKDRFLKQCENDIIPNVLEAMISG
                     ELDILKDWCYEATYSQLAHPIQQAKALGLQFHSRILDIDNVDLAMGKMMEQGPVLIIT
                     FQAQLVMVVRNPKGEVVEGDPDKVLRMLYVWALCRDQDELNPYAAWRLLDISASSTEQ
                     IL"
     exon            61..156
                     /gene="TIMM44"
                     /gene_synonym="TIM44"
                     /inference="alignment:Splign:2.1.0"
     exon            157..327
                     /gene="TIMM44"
                     /gene_synonym="TIM44"
                     /inference="alignment:Splign:2.1.0"
     exon            328..408
                     /gene="TIMM44"
                     /gene_synonym="TIM44"
                     /inference="alignment:Splign:2.1.0"
     exon            409..558
                     /gene="TIMM44"
                     /gene_synonym="TIM44"
                     /inference="alignment:Splign:2.1.0"
     exon            559..698
                     /gene="TIMM44"
                     /gene_synonym="TIM44"
                     /inference="alignment:Splign:2.1.0"
     exon            699..784
                     /gene="TIMM44"
                     /gene_synonym="TIM44"
                     /inference="alignment:Splign:2.1.0"
     exon            785..877
                     /gene="TIMM44"
                     /gene_synonym="TIM44"
                     /inference="alignment:Splign:2.1.0"
     exon            878..1002
                     /gene="TIMM44"
                     /gene_synonym="TIM44"
                     /inference="alignment:Splign:2.1.0"
     exon            1003..1053
                     /gene="TIMM44"
                     /gene_synonym="TIM44"
                     /inference="alignment:Splign:2.1.0"
     exon            1054..1143
                     /gene="TIMM44"
                     /gene_synonym="TIM44"
                     /inference="alignment:Splign:2.1.0"
     exon            1144..1254
                     /gene="TIMM44"
                     /gene_synonym="TIM44"
                     /inference="alignment:Splign:2.1.0"
     exon            1255..1843
                     /gene="TIMM44"
                     /gene_synonym="TIM44"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1817..1822
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMM44"
                     /gene_synonym="TIM44"
                     /note="hexamer: AATAAA"
     polyA_site      1843
                     /gene="TIMM44"
                     /gene_synonym="TIM44"
                     /note="major polyA site"
ORIGIN      
        1 acacgattct ccaacatggc ggcggcggcc ctgcggagtg gctggtgccg ctgtccacgg
       61 agatgcctcg gcagtggaat ccaatttctt tccagccaca acctacccca tgggtcgacc
      121 tatcagatgc gccggccggg cggagagctg ccactgtcca aatcatattc ttctggaaac
      181 agaaaaggct ttctgtccgg cttgctagat aatgtcaaac aagaattagc caaaaacaaa
      241 gaaatgaaag aaagtataaa aaaattccgt gacgaggcca gaaggctaga agaatcagac
      301 gtgctccagg aggccagaag gaaatacaaa accatcgagt cagaaaccgt gcggacgagc
      361 gaggtgctac ggaagaagct tggggagctg acgggcaccg tgaaggagag ccttcacgaa
      421 gtcagtaaaa gtgatctcgg ccggaaaatc aaggagggcg tggaggaagc agccaagacg
      481 gccaagcagt cggccgagtc ggtatccaaa ggcggggaga agctgggcag gacagcggcc
      541 ttcagagccc tctcccaggg ggtggagtcc gtgaagaagg aaattgacga cagcgtcctg
      601 ggacagaccg ggccctaccg gaggccccag cgactccgga agagaacgga gtttgcggga
      661 gataagttca aggaggagaa agtgtttgag ccaaacgagg aggccctggg ggtcgtgctg
      721 cacaaggact ccaagtggta ccagcagtgg aaggacttca aggagaacaa cgtggtgttt
      781 aaccggttct tcgagatgaa gatgaagtat gacgaaagcg acaacgcgtt catccgggca
      841 tcccgggccc ttacggacaa ggtcaccgac ttgctggggg gcctgttctc caagacagag
      901 atgtcggagg tgctcacgga gatcctccgg gtggacccgg cctttgacaa ggaccggttt
      961 ctgaaacagt gcgagaacga catcatcccc aatgtcctgg aggccatgat ttctggagag
     1021 cttgacattc tcaaagactg gtgctatgaa gctacttaca gccagctggc ccaccccatc
     1081 cagcaggcca aggcactggg tctccagttc cattctcgca tcctagacat tgacaacgtc
     1141 gacctggcca tgggcaagat gatggagcag gggccggtgc tgatcatcac cttccaggca
     1201 cagctggtga tggtggtcag gaaccccaaa ggcgaggtgg tggagggtga cccggacaag
     1261 gtgctgcgga tgctgtacgt gtgggcgctc tgccgagacc aggacgagct caacccctac
     1321 gcggcctggc ggctcctgga catctcggcc tccagcaccg agcagattct ctgagtgtgg
     1381 tgccggagcc aggtagcccc ggcctgggtc atcaggcaca gaggcaccgc aacaccacct
     1441 gcggcaactc cagacctctg ggaacaagac tgcgggctct gcccccagct ctgccaggac
     1501 ggctgcaaga ccagctggcc cgggagggga caacgggctg ttgcgggtgc gcggcagctg
     1561 gagacactcc cccgcagggc caacccctgc cctgttgctc tgccctgcag gggtcccggc
     1621 gcctggtcac ctggggtgca cacaggtcac acagtgccaa gaggccccag ggcccaggga
     1681 ctccccccac agcagggtgg gacccgggac ccgcggctca gtggcccgct agccacgtca
     1741 gccaagccac tttaggtcca ttttttaatt ttaacagtgc tcttccatct tgtgcataag
     1801 cctgagattt ggaaagaata aaacaccgaa ttgcagaaga gca
//
