LOCUS       NM_138358               1347 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens translocase of inner mitochondrial membrane 29
            (TIMM29), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_138358
VERSION     NM_138358.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1347)
  AUTHORS   Guo,L., Liu,J.J., Long,S.Y., Wang,P.Y., Li,S., Wang,J.L., Wei,X.F.,
            Li,J., Lei,L., Huang,A.L. and Hu,J.L.
  TITLE     TIM22 and TIM29 inhibit HBV replication by up-regulating SRSF1
            expression
  JOURNAL   J Med Virol 96 (2), e29439 (2024)
   PUBMED   38294104
  REMARK    GeneRIF: TIM22 and TIM29 inhibit HBV replication by up-regulating
            SRSF1 expression.
REFERENCE   2  (bases 1 to 1347)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   3  (bases 1 to 1347)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   4  (bases 1 to 1347)
  AUTHORS   Valpadashi,A., Callegari,S., Linden,A., Neumann,P., Ficner,R.,
            Urlaub,H., Deckers,M. and Rehling,P.
  TITLE     Defining the architecture of the human TIM22 complex by chemical
            crosslinking
  JOURNAL   FEBS Lett 595 (2), 157-168 (2021)
   PUBMED   33125709
  REMARK    GeneRIF: Defining the architecture of the human TIM22 complex by
            chemical crosslinking.
REFERENCE   5  (bases 1 to 1347)
  AUTHORS   Muriungi,N.G. and Ueda,K.
  TITLE     TIMM29 interacts with hepatitis B virus preS1 to modulate the HBV
            life cycle
  JOURNAL   Microbiol Immunol 64 (12), 792-809 (2020)
   PUBMED   32970362
  REMARK    GeneRIF: TIMM29 interacts with hepatitis B virus preS1 to modulate
            the HBV life cycle.
REFERENCE   6  (bases 1 to 1347)
  AUTHORS   Kang,Y., Stroud,D.A., Baker,M.J., De Souza,D.P., Frazier,A.E.,
            Liem,M., Tull,D., Mathivanan,S., McConville,M.J., Thorburn,D.R.,
            Ryan,M.T. and Stojanovski,D.
  TITLE     Sengers Syndrome-Associated Mitochondrial Acylglycerol Kinase Is a
            Subunit of the Human TIM22 Protein Import Complex
  JOURNAL   Mol Cell 67 (3), 457-470 (2017)
   PUBMED   28712726
REFERENCE   7  (bases 1 to 1347)
  AUTHORS   Vukotic,M., Nolte,H., Konig,T., Saita,S., Ananjew,M., Kruger,M.,
            Tatsuta,T. and Langer,T.
  TITLE     Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the
            TIM22 Protein Translocase in Mitochondria
  JOURNAL   Mol Cell 67 (3), 471-483 (2017)
   PUBMED   28712724
REFERENCE   8  (bases 1 to 1347)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
REFERENCE   9  (bases 1 to 1347)
  AUTHORS   Callegari,S., Richter,F., Chojnacka,K., Jans,D.C., Lorenzi,I.,
            Pacheu-Grau,D., Jakobs,S., Lenz,C., Urlaub,H., Dudek,J.,
            Chacinska,A. and Rehling,P.
  TITLE     TIM29 is a subunit of the human carrier translocase required for
            protein transport
  JOURNAL   FEBS Lett 590 (23), 4147-4158 (2016)
   PUBMED   27718247
  REMARK    GeneRIF: TIM29 is required for the structural integrity of the
            TIM22 complex and for import of substrate proteins by the carrier
            translocase
REFERENCE   10 (bases 1 to 1347)
  AUTHORS   Kang,Y., Baker,M.J., Liem,M., Louber,J., McKenzie,M., Atukorala,I.,
            Ang,C.S., Keerthikumar,S., Mathivanan,S. and Stojanovski,D.
  TITLE     Tim29 is a novel subunit of the human TIM22 translocase and is
            involved in complex assembly and stability
  JOURNAL   Elife 5, e17463 (2016)
   PUBMED   27554484
  REMARK    GeneRIF: Here, the authors identify Tim29 (C19orf52) as a novel,
            metazoan-specific subunit of the human TIM22 complex. The protein
            is integrated into the mitochondrial inner membrane with it's
            C-terminus exposed to the intermembrane space.
            Publication Status: Online-Only
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AC011442.5.
            
            On Nov 22, 2018 this sequence version replaced NM_138358.3.
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC007244.1, SRR3476690.518010.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA1970526
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000270502.7/
                                                  ENSP00000270502.5
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-106               AC011442.5         50506-50611
            107-1347            AC011442.5         50709-51949
FEATURES             Location/Qualifiers
     source          1..1347
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.2"
     gene            1..1347
                     /gene="TIMM29"
                     /gene_synonym="C19orf52; TIM29"
                     /note="translocase of inner mitochondrial membrane 29"
                     /db_xref="GeneID:90580"
                     /db_xref="HGNC:HGNC:25152"
                     /db_xref="MIM:617380"
     exon            1..106
                     /gene="TIMM29"
                     /gene_synonym="C19orf52; TIM29"
                     /inference="alignment:Splign:2.1.0"
     CDS             13..795
                     /gene="TIMM29"
                     /gene_synonym="C19orf52; TIM29"
                     /note="uncharacterized protein C19orf52"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit Tim29"
                     /protein_id="NP_612367.1"
                     /db_xref="CCDS:CCDS12252.1"
                     /db_xref="GeneID:90580"
                     /db_xref="HGNC:HGNC:25152"
                     /db_xref="MIM:617380"
                     /translation="MAAAALRRFWSRRRAEAGDAVVAKPGVWARLGSWARALLRDYAE
                     ACRDASAEARARPGRAAVYVGLLGGAAACFTLAPSEGAFEEALLEASGTLLLLAPATR
                     NRESEAFVQRLLWLRGRGRLRYVNLGLCSLVYEAPFDAQASLYQARCRYLQPRWTDFP
                     GRVLDVGFVGRWWVLGAWMRDCDINDDEFLHLPAHLRVVGPQQLHSETNERLFDEKYK
                     PVVLTDDQVDQALWEEQVLQKEKKDRLALSQAHSLVQAEAPR"
     exon            107..1347
                     /gene="TIMM29"
                     /gene_synonym="C19orf52; TIM29"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1316..1321
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMM29"
                     /gene_synonym="C19orf52; TIM29"
                     /note="hexamer: AATAAA"
     polyA_site      1347
                     /gene="TIMM29"
                     /gene_synonym="C19orf52; TIM29"
                     /note="major polyA site"
ORIGIN      
        1 agacggaaga ggatggccgc ggcggctctg aggagatttt ggtcccggcg ccgcgcagag
       61 gcgggcgacg cggtagtggc gaagccggga gtgtgggcgc ggctggggtc ctgggcccgc
      121 gcgctgctcc gggactacgc cgaggcctgc agggacgctt cggcggaggc tagggcccgg
      181 ccggggcgcg ccgctgtgta tgtgggtctg ctgggcggcg cggcggcctg cttcacgctg
      241 gcgcccagcg agggtgcctt cgaggaggcg ctgctggagg cgtcggggac cctcctgctg
      301 ctggcgccgg ccacccgcaa ccgcgagtcc gaagccttcg tgcagaggct gctctggctg
      361 cggggccgtg gccgcctgcg ctacgtcaac ctggggctct gctcgctggt gtacgaggcg
      421 cccttcgacg cccaggccag cctctaccag gcgcgttgcc gctacctgca gccccgctgg
      481 accgacttcc ccggccgggt cctggacgtg ggcttcgtgg gtcgctggtg ggtgctgggg
      541 gcctggatgc gcgactgcga catcaacgac gacgaattcc tgcacctgcc ggcgcatttg
      601 cgggtggtcg ggccccagca gctgcattcc gagaccaacg agcggctctt cgatgagaag
      661 tacaagcctg tcgtgctcac cgacgatcag gtggaccagg cgctgtggga ggagcaggtc
      721 ttgcagaagg agaagaagga caggctcgcc ctgagccagg cccactcgct ggtgcaggcg
      781 gaggccccga gatgaaaccc tgaggccccc gagtcctggc aaactgcttg cctggggtgg
      841 tgcagttctg agtgtgcctc acctgcagaa cagctgagac agatgatgtg caaagtgttt
      901 tctcactgga tttgcacaag tttggggagc ctttctgccc cccgtctttg ttctttatta
      961 gctgaagcta attcagagcc acctgggtcc gggagttggg gacagcagaa cgacttgaca
     1021 catgttcatc actggcagag ctggtcatga gccttttata taagcctttt tcatcgggcc
     1081 tcagaggccc tccttaagga ggtaccacat tggtcagctg acttgcaaac tcttctaagg
     1141 ccacttagat tttctttttc aagtttgggt tgtggcctgg catggtgatg tctgtaatcc
     1201 cagcagtttg caaactgagg caagagaatc gcttgaggcc aggagtttga ggccagctag
     1261 agtgacatag caagactccg atgctacaaa aaagaataat aatagtaatt aactaaataa
     1321 aatttgagct gaaatgtttt tattcta
//
