LOCUS       NM_001290117            2495 bp    mRNA    linear   PRI 21-SEP-2024
DEFINITION  Homo sapiens translocase of inner mitochondrial membrane 23 homolog
            B (TIMM23B), transcript variant 1, mRNA; nuclear gene for
            mitochondrial product.
ACCESSION   NM_001290117 XM_005278340
VERSION     NM_001290117.2
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2495)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2495)
  AUTHORS   Girard,A., Sachidanandam,R., Hannon,G.J. and Carmell,M.A.
  TITLE     A germline-specific class of small RNAs binds mammalian Piwi
            proteins
  JOURNAL   Nature 442 (7099), 199-202 (2006)
   PUBMED   16751776
REFERENCE   3  (bases 1 to 2495)
  AUTHORS   Guo,Y., Cheong,N., Zhang,Z., De Rose,R., Deng,Y., Farber,S.A.,
            Fernandes-Alnemri,T. and Alnemri,E.S.
  TITLE     Tim50, a component of the mitochondrial translocator, regulates
            mitochondrial integrity and cell death
  JOURNAL   J Biol Chem 279 (23), 24813-24825 (2004)
   PUBMED   15044455
REFERENCE   4  (bases 1 to 2495)
  AUTHORS   Yamamoto,H., Esaki,M., Kanamori,T., Tamura,Y., Nishikawa,Si. and
            Endo,T.
  TITLE     Tim50 is a subunit of the TIM23 complex that links protein
            translocation across the outer and inner mitochondrial membranes
  JOURNAL   Cell 111 (4), 519-528 (2002)
   PUBMED   12437925
REFERENCE   5  (bases 1 to 2495)
  AUTHORS   Moro,F., Sirrenberg,C., Schneider,H.C., Neupert,W. and Brunner,M.
  TITLE     The TIM17.23 preprotein translocase of mitochondria: composition
            and function in protein transport into the matrix
  JOURNAL   EMBO J 18 (13), 3667-3675 (1999)
   PUBMED   10393182
REFERENCE   6  (bases 1 to 2495)
  AUTHORS   Bauer,M.F., Gempel,K., Reichert,A.S., Rappold,G.A., Lichtner,P.,
            Gerbitz,K.D., Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     Genetic and structural characterization of the human mitochondrial
            inner membrane translocase
  JOURNAL   J Mol Biol 289 (1), 69-82 (1999)
   PUBMED   10339406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DC419977.1, AL542628.3, AK098044.1, AK293228.1, BU928648.1 and
            BU620107.1.
            
            On May 21, 2020 this sequence version replaced NM_001290117.1.
            
            Transcript Variant: This variant (1) encodes the longer isoform
            (1).
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR11853565.3417.1,
                                           SRR1803614.259933.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: inferred from homology
            MANE Ensembl match                 :: ENST00000651259.3/
                                                  ENSP00000502369.1
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-248               DC419977.1         22-269
            249-270             AL542628.3         380-401
            271-759             AK098044.1         400-888
            760-1324            AK293228.1         588-1152
            1325-1643           AK098044.1         1454-1772
            1644-2210           BU928648.1         59-625
            2211-2495           BU620107.1         19-303              c
FEATURES             Location/Qualifiers
     source          1..2495
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="10"
                     /map="10q11.23"
     gene            1..2495
                     /gene="TIMM23B"
                     /note="translocase of inner mitochondrial membrane 23
                     homolog B"
                     /db_xref="GeneID:100652748"
                     /db_xref="HGNC:HGNC:23581"
                     /db_xref="MIM:620758"
     exon            1..248
                     /gene="TIMM23B"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..709
                     /gene="TIMM23B"
                     /note="isoform 1 is encoded by transcript variant 1;
                     putative mitochondrial import inner membrane translocase
                     subunit Tim23B"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit Tim23B isoform 1"
                     /protein_id="NP_001277046.1"
                     /db_xref="CCDS:CCDS73131.1"
                     /db_xref="GeneID:100652748"
                     /db_xref="HGNC:HGNC:23581"
                     /db_xref="MIM:620758"
                     /translation="MEGGGGSGDKTTGVLAGFFGAGEAGYSHADLAGVPLTGMNPLCP
                     YLNVDPRYLVQDTDEFILPTGANKTWGRFELAFFTIGGCCMTGAAFGAMNGLRLGLKE
                     TQNMAWSKPGNVQILNMVTRQGALWANTLGSLALLYSAFGVIIEKTRGAEDDLNTVAA
                     GTMTGMLYKCTVSEMALDSPFCVLLSGS"
     exon            249..307
                     /gene="TIMM23B"
                     /inference="alignment:Splign:2.1.0"
     exon            308..401
                     /gene="TIMM23B"
                     /inference="alignment:Splign:2.1.0"
     exon            402..486
                     /gene="TIMM23B"
                     /inference="alignment:Splign:2.1.0"
     exon            487..545
                     /gene="TIMM23B"
                     /inference="alignment:Splign:2.1.0"
     exon            546..656
                     /gene="TIMM23B"
                     /inference="alignment:Splign:2.1.0"
     exon            657..2495
                     /gene="TIMM23B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1024..1029
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMM23B"
                     /note="hexamer: AATAAA"
     polyA_site      1047
                     /gene="TIMM23B"
                     /note="major polyA site"
     regulatory      2472..2477
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMM23B"
                     /note="hexamer: ATTAAA"
     polyA_site      2495
                     /gene="TIMM23B"
ORIGIN      
        1 aacgggaacc ggcgcccgga atgtcagcgt gtgaagtagg cgctggcaac gcggggttac
       61 ccgctgttat tgaggagtaa cggcccagcg gaccacccag gcttgaggca gcggcgggaa
      121 ccactcggtt tgctgcgata ccatggaagg aggcggggga agcggcgaca aaaccacagg
      181 ggtattggcc ggctttttcg gagccggcga agcaggttac tcgcacgcgg atttggctgg
      241 cgtcccgcta actggtatga accctctgtg tccttattta aatgtggatc cacgatacct
      301 cgtgcaggat acagatgagt tcattttacc taccggagct aataaaacct ggggcagatt
      361 tgagctggcc ttctttacga ttggagggtg ttgcatgaca ggggctgcgt ttggggcaat
      421 gaatggtctt cggctaggat tgaaggaaac ccagaacatg gcctggtcca aaccaggaaa
      481 tgtacagatt ttgaatatgg tgactaggca aggggcactt tgggctaata ctctaggttc
      541 tctggcgttg ctctatagtg catttggtgt catcattgag aaaacacgag gtgcagaaga
      601 tgaccttaac acagtagcag ctggaaccat gacaggcatg ttgtataaat gtacagtgtc
      661 agagatggct ttggattccc cgttctgtgt gctgctgtct ggctcctgaa cccagctgta
      721 gaggtgtgtg tcaatcccaa ctggtgaagt actgagaaga agctacacaa aaggcagcaa
      781 agtattagta agtgtacctc tgacatttta accacctctg acttttccat ggaatggaca
      841 agtagtagtc tctgtcagag ctacatttta aaggagaaaa agaaacgtga agtcatgaac
      901 tgtttattta tgctgttatt tttgtgttta ctcacctcat ttatattgac ttgtaaatta
      961 gtaatttctg aactattatt tatcaattca ttgcctacat gtcagcaaac aaattttctt
     1021 cttaataaag aatccagttg ctgggcacaa tggttcacac ctgtaatctc agcacgtttg
     1081 gagggcaagg caggaggatt ccttggggct aggagttcaa gaccagcctg ggcaatatag
     1141 caagatttca tctctacaaa aaaatgaaaa cattggctgg gcatggtggc tcattcctat
     1201 agttcaggct actgaggagc ctgatgtagg aggatcacgt gaccccagta gtttgaggct
     1261 gcagtgagct atgatcctaa cactgctctc cagcctgggt gacacaccaa gttgccatct
     1321 cttcaaaaaa ggaatctaga gacatcagtg tgtgcacaag catggtttgt gaatttggaa
     1381 gtgtgtatgt gcatagttgt gctcaagaat gtgttgatga ttataccttc tcagaatgaa
     1441 ggtaattttt tttttttctt tttttttgag atggagtctt gctctgttgc caggctggag
     1501 tgcagtggtg ctctcagctc actgcaacct ctgcctcccg gcttcaagca gttctcctgc
     1561 ctcagcctcc caagtagctg ggactacagg cacacaccac cactcccggc taattttttg
     1621 tgttttagta gagacggggt tttaccatgt tggccaggat ggtctcgatc ccccgacctt
     1681 gtgatccacc caccttggcc tcccaaagtg ttgggattac aggtgtgagc caccgtgcct
     1741 ggcctgaagg tcatttttat aaagatctct ccacgtctta gatttgattc ttcctttaaa
     1801 tatttttctc attgacattt gaaagcacct gaccttatat aaaatgaaca attttcataa
     1861 ctccataaaa ggagaattat ggcatcatct atttctttct cttgtctcat aaatctaaac
     1921 catcaacctg cttatttttg tatactgtca cactgtgtat tccctgcatt gaatgcctgt
     1981 ctgttgacat tatctgtaaa aattgtggga agttttctgc accctgaaat ttctgttatg
     2041 cggattaaat atccactatc catgtttttc caagtcttac agtagaaagg gtaaatgcag
     2101 ccctcacagc agcctgttgt tcgtcctgca aatgtgtttc catcacatta cacaaagcct
     2161 ctttgtcttc gtggttctac cctactaata agttttttaa aaaattatgt aatgtgtgta
     2221 tatacaaata cctatatgta tgtgtgtaca catacagctg atatctgctg agattatgta
     2281 tgcatgaact atagaattaa cttgtaattt taagaaaata aattattttg taaagataaa
     2341 tctcatgttt aagaagagga attacagttg aatcatttag ggatgcctca gcctaaacat
     2401 aatatggaaa aagccataac caaaagtcat tttagagtac tgctaggtta ctcaacctat
     2461 catcacattt aattaaaatg tcagtttgaa ccatg
//
