LOCUS       NM_014177               3084 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens translocase of inner mitochondrial membrane 21
            (TIMM21), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_014177
VERSION     NM_014177.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3084)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 3084)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 3084)
  AUTHORS   Richter,F., Dennerlein,S., Nikolov,M., Jans,D.C., Naumenko,N.,
            Aich,A., MacVicar,T., Linden,A., Jakobs,S., Urlaub,H., Langer,T.
            and Rehling,P.
  TITLE     ROMO1 is a constituent of the human presequence translocase
            required for YME1L protease import
  JOURNAL   J Cell Biol 218 (2), 598-614 (2019)
   PUBMED   30598479
REFERENCE   4  (bases 1 to 3084)
  AUTHORS   Dennerlein,S., Oeljeklaus,S., Jans,D., Hellwig,C., Bareth,B.,
            Jakobs,S., Deckers,M., Warscheid,B. and Rehling,P.
  TITLE     MITRAC7 Acts as a COX1-Specific Chaperone and Reveals a Checkpoint
            during Cytochrome c Oxidase Assembly
  JOURNAL   Cell Rep 12 (10), 1644-1655 (2015)
   PUBMED   26321642
REFERENCE   5  (bases 1 to 3084)
  AUTHORS   Mick,D.U., Dennerlein,S., Wiese,H., Reinhold,R., Pacheu-Grau,D.,
            Lorenzi,I., Sasarman,F., Weraarpachai,W., Shoubridge,E.A.,
            Warscheid,B. and Rehling,P.
  TITLE     MITRAC links mitochondrial protein translocation to
            respiratory-chain assembly and translational regulation
  JOURNAL   Cell 151 (7), 1528-1541 (2012)
   PUBMED   23260140
  REMARK    GeneRIF: TIM21 is dispensable for protein import but required for
            integration of early-assembling, presequence-containing subunits
            into respiratory-chain intermediates.
REFERENCE   6  (bases 1 to 3084)
  AUTHORS   Hendrickson,S.L., Lautenberger,J.A., Chinn,L.W., Malasky,M.,
            Sezgin,E., Kingsley,L.A., Goedert,J.J., Kirk,G.D., Gomperts,E.D.,
            Buchbinder,S.P., Troyer,J.L. and O'Brien,S.J.
  TITLE     Genetic variants in nuclear-encoded mitochondrial genes influence
            AIDS progression
  JOURNAL   PLoS One 5 (9), e12862 (2010)
   PUBMED   20877624
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
            Publication Status: Online-Only
REFERENCE   7  (bases 1 to 3084)
  AUTHORS   Bauer,M.F., Gempel,K., Reichert,A.S., Rappold,G.A., Lichtner,P.,
            Gerbitz,K.D., Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     Genetic and structural characterization of the human mitochondrial
            inner membrane translocase
  JOURNAL   J Mol Biol 289 (1), 69-82 (1999)
   PUBMED   10339406
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            BG431414.1, BC000892.1, BG820086.1 and AC084702.4.
            
            On Nov 22, 2018 this sequence version replaced NM_014177.2.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.163252.1,
                                           SRR1803613.114660.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000169551.11/
                                                  ENSP00000169551.6
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-28                BG431414.1         40-67
            29-1036             BC000892.1         1-1008
            1037-1522           BG820086.1         28-513
            1523-3084           AC084702.4         89560-91121
FEATURES             Location/Qualifiers
     source          1..3084
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="18"
                     /map="18q22.3"
     gene            1..3084
                     /gene="TIMM21"
                     /gene_synonym="C18orf55; HSPC154; TIM21"
                     /note="translocase of inner mitochondrial membrane 21"
                     /db_xref="GeneID:29090"
                     /db_xref="HGNC:HGNC:25010"
                     /db_xref="MIM:615180"
     exon            1..587
                     /gene="TIMM21"
                     /gene_synonym="C18orf55; HSPC154; TIM21"
                     /inference="alignment:Splign:2.1.0"
     CDS             287..1033
                     /gene="TIMM21"
                     /gene_synonym="C18orf55; HSPC154; TIM21"
                     /note="TIM21-like protein, mitochondrial; mitochondrial
                     import inner membrane translocase subunit Tim21;
                     translocase of inner mitochondrial membrane 21 homolog"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit Tim21 precursor"
                     /protein_id="NP_054896.2"
                     /db_xref="CCDS:CCDS12003.1"
                     /db_xref="GeneID:29090"
                     /db_xref="HGNC:HGNC:25010"
                     /db_xref="MIM:615180"
                     /translation="MICTFLRAVQYTEKLHRSSAKRLLLPYIVLNKACLKTEPSLRCG
                     LQYQKKTLRPRCILGVTQKTIWTQGPSPRKAKEDGSKQVSVHRSQRGGTAVPTSQKVK
                     EAGRDFTYLIVVLFGISITGGLFYTIFKELFSSSSPSKIYGRALEKCRSHPEVIGVFG
                     ESVKGYGEVTRRGRRQHVRFTEYVKDGLKHTCVKFYIEGSEPGKQGTVYAQVKENPGS
                     GEYDFRYIFVEIESYPRRTIIIEDNRSQDD"
     exon            588..650
                     /gene="TIMM21"
                     /gene_synonym="C18orf55; HSPC154; TIM21"
                     /inference="alignment:Splign:2.1.0"
     exon            651..748
                     /gene="TIMM21"
                     /gene_synonym="C18orf55; HSPC154; TIM21"
                     /inference="alignment:Splign:2.1.0"
     exon            749..822
                     /gene="TIMM21"
                     /gene_synonym="C18orf55; HSPC154; TIM21"
                     /inference="alignment:Splign:2.1.0"
     exon            823..928
                     /gene="TIMM21"
                     /gene_synonym="C18orf55; HSPC154; TIM21"
                     /inference="alignment:Splign:2.1.0"
     exon            929..3084
                     /gene="TIMM21"
                     /gene_synonym="C18orf55; HSPC154; TIM21"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1320..1325
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMM21"
                     /gene_synonym="C18orf55; HSPC154; TIM21"
                     /note="hexamer: AATAAA"
     polyA_site      1339
                     /gene="TIMM21"
                     /gene_synonym="C18orf55; HSPC154; TIM21"
                     /note="major polyA site"
     regulatory      1384..1389
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMM21"
                     /gene_synonym="C18orf55; HSPC154; TIM21"
                     /note="hexamer: AATAAA"
     polyA_site      1406
                     /gene="TIMM21"
                     /gene_synonym="C18orf55; HSPC154; TIM21"
     regulatory      1497..1502
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMM21"
                     /gene_synonym="C18orf55; HSPC154; TIM21"
                     /note="hexamer: AATACA"
     polyA_site      1515
                     /gene="TIMM21"
                     /gene_synonym="C18orf55; HSPC154; TIM21"
     regulatory      3041..3046
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMM21"
                     /gene_synonym="C18orf55; HSPC154; TIM21"
                     /note="hexamer: ACTAAA"
     polyA_site      3084
                     /gene="TIMM21"
                     /gene_synonym="C18orf55; HSPC154; TIM21"
ORIGIN      
        1 aggtgacttt gcgaaggcat ggcggggaca ctgtgaatgt cagcccagaa ggtgatcaga
       61 gcctgttaat taaaatggaa agaagacaga agggaaggta gacatcaggt tctccctgga
      121 gacttttcgt tttcatttac gctgcggaaa ctgacgtttt tgcctaacac cccatgtaat
      181 gtaaacgtat aggcttgagt acgtgtccgg ccgcatgtgt agtgaaccct aaagctttcc
      241 taattgtagt tagcatcgtc cctaagcgga acgattttcc gtgaacatga tttgtacttt
      301 tctacgagcc gtacagtata cggagaagct gcacaggtcc tcggcaaagc gattgctttt
      361 gccatacatc gtgcttaaca aagcgtgctt gaagactgag cccagtttga gatgtgggct
      421 tcaatatcaa aagaaaacgc tgcgacctag atgtattctt ggagtcaccc agaaaaccat
      481 ctggacgcag ggaccgagcc cccgaaaagc aaaggaggat ggcagcaaac aagtgtctgt
      541 gcacaggagt cagagagggg gaaccgccgt cccaacatca caaaaagtga aagaagccgg
      601 aagagatttt acctatttaa tagtggtgct ttttggaatc agcattacag gtggcttgtt
      661 ttacacgatt ttcaaagaac ttttttcttc atccagtcct agcaagatat atgggagagc
      721 cttagaaaaa tgcagatcac atcctgaggt gatcggtgtc tttggtgagt ctgttaaagg
      781 ctatggggag gtgacaaggc ggggtcgccg gcagcatgtc aggttcactg aatatgtaaa
      841 agatgggctg aaacacacgt gtgtgaaatt ctacattgag ggctctgagc cagggaagca
      901 aggaacggtg tatgcgcaag tgaaagagaa cccaggaagt ggtgaatatg attttcgata
      961 tatatttgta gaaattgaat cttatcctag aagaactatt atcattgaag ataatcgatc
     1021 ccaagatgat taaaataggg tttctgatgg atgttgaatg gcgtggactc gctactccgt
     1081 tcttcacagc tgccttccag aatgtgttca aaagaaagac aagaaggagt gtatggctta
     1141 taaagtgaat ctaatacagt atttgttgca tttaaacaaa ctagacattt tcttacggaa
     1201 aaattatgaa atacagcata ttttatgttc tcccattgac tcaatcatga caatatttct
     1261 gctttaacac catctttcat gattagaaat gtttgttatt ggaaatgtta caccatgtaa
     1321 ataaaggaaa tagattttag tattgtattc attttatatt atagaactgc ataatgtctg
     1381 cagaataaaa ttaaaactaa caaatatgtc attagcagct gccctccgca tactttggaa
     1441 tctgacttga gataagcatg tgaaaatggt tgagggccat agggaaccag atggtaaata
     1501 cattcttcaa aattgtgtga gttttaggaa tctgtctcat atttcgcgct tcatgaatta
     1561 agggcctagt acatagcggg aaaagtacac actcccaagt tgggtagacc tgggcaccca
     1621 ccccaccttt tctagcaggt gcgtggtcaa gtgtccctgt tgtgtgggtt gttaggatgg
     1681 cagtgtgatg agaggtacaa gcctggacca tagaaggcag ccatgaagtg ccctcatccc
     1741 ctttagaact tacttgcact gatacttctg actgccaaaa gaacatggga gtgaatgaga
     1801 gacattcaaa tacgtgtgtg aggcccctta aagaaaaaaa aaaaaaaaaa ggaaattcta
     1861 ttttatttga aatatttgct ggggatttgg aaaaaagtga ccttcactta caagatcctg
     1921 attccatatc tatgtaagtg ctatgtgcat tgggaggggt ctagaaccat gtttatctgc
     1981 ggtggcttca gtgtgaggta tcccctctga tgtgtttgtt ccttctcccc gagaactgtc
     2041 tgtagaggaa tttctgatgt gttcttgaaa ttttgggata ttcaggatag agagacctcc
     2101 aggcaatcta tctccccttt ttactttatc tccctgctta atttagttag tttcttggtt
     2161 tgactgcttg ttttagatgt ttttaattat aaaaatttcc aacatttaag gagtatagaa
     2221 aatataacag acactcgtct ccctgacgta acacactttg actgaatgag gccttaactt
     2281 aggctttctc tcctaatcgt tttttccttt gctatagaat gttcagtttc aggattcact
     2341 gaaatgtcaa catttaacag gctgagaagt tccacttgct atcctaaact caaaaaagca
     2401 gccctgctct tcaaacaacc tgctcaaact gtagcttgct gaagaagccc ggcatctgag
     2461 ctcaggtggg gatttagcca ccctccatgg ccctgtcatt tgacttaaga ctgtttgctt
     2521 tttctgtatt catttttatg cacctgccat tttacaatat gctcatgccc ctttaagatc
     2581 tgagcttttg gccaggcgag gtggctcatg cctataatcc cagcactttg ggaggctgag
     2641 gcaggtcaat cactggaggt caggagttca agaccagcct ggccaacatg gtgaaaccct
     2701 atctactaaa aattcaaaaa aaaaaaaatt aaccaggcac gttgacacac tcctgtaatc
     2761 tcatctactc aggagacagg agaagcgctt gaacccagga ggcagaggtt gcagtgagcc
     2821 aagatcatgt cactgcactc cagcatgagt gacggagtgt gacttcgtct caaaaaaaaa
     2881 aaacaaaaaa cagatctgag cttttataat tagaaataaa actaaattac tttttcaaaa
     2941 ggaaaaactc tgtaccaata agagattctt ctgtatagcc acaggaaaat gtgatgtgta
     3001 actctctaga tctctgtttt cattccctct gatgtaccct actaaatgtt aaaatttctg
     3061 tgttttaaga ccctctttaa tcca
//
