LOCUS       NM_006335               1650 bp    mRNA    linear   PRI 09-FEB-2025
DEFINITION  Homo sapiens translocase of inner mitochondrial membrane 17A
            (TIMM17A), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_006335
VERSION     NM_006335.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1650)
  AUTHORS   Miao,L., Wu,D., Zhao,H. and Xie,A.
  TITLE     TIMM17A overexpression in lung adenocarcinoma and its association
            with prognosis
  JOURNAL   Sci Rep 14 (1), 8840 (2024)
   PUBMED   38632467
  REMARK    GeneRIF: TIMM17A overexpression in lung adenocarcinoma and its
            association with prognosis.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 1650)
  AUTHORS   Fielden,L.F., Busch,J.D., Merkt,S.G., Ganesan,I., Steiert,C.,
            Hasselblatt,H.B., Busto,J.V., Wirth,C., Zufall,N., Jungbluth,S.,
            Noll,K., Dung,J.M., Butenko,L., von der Malsburg,K., Koch,H.G.,
            Hunte,C., van der Laan,M. and Wiedemann,N.
  TITLE     Central role of Tim17 in mitochondrial presequence protein
            translocation
  JOURNAL   Nature 621 (7979), 627-634 (2023)
   PUBMED   37527780
  REMARK    GeneRIF: Central role of Tim17 in mitochondrial presequence protein
            translocation.
REFERENCE   3  (bases 1 to 1650)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   4  (bases 1 to 1650)
  AUTHORS   Chaudhuri,M., Darden,C., Gonzalez,F.S., Singha,U.K., Quinones,L.
            and Tripathi,A.
  TITLE     Tim17 Updates: A Comprehensive Review of an Ancient Mitochondrial
            Protein Translocator
  JOURNAL   Biomolecules 10 (12), 1643 (2020)
   PUBMED   33297490
  REMARK    GeneRIF: Tim17 Updates: A Comprehensive Review of an Ancient
            Mitochondrial Protein Translocator.
            Review article
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 1650)
  AUTHORS   Li,X., Deng,S., Pang,X., Song,Y., Luo,S., Jin,L. and Pan,Y.
  TITLE     LncRNA NEAT1 Silenced miR-133b Promotes Migration and Invasion of
            Breast Cancer Cells
  JOURNAL   Int J Mol Sci 20 (15), 3616 (2019)
   PUBMED   31344855
  REMARK    GeneRIF: We also confirmed that lncRNA NEAT1 was up-regulated in
            breast cancer and inhibited the expression of miR-133b, and
            identified the mitochondrial protein translocase of inner
            mitochondrial membrane 17 homolog A (TIMM17A) that serves as the
            target of miR-133b.
            Erratum:[Int J Mol Sci. 2020 Jul 30;21(15):E5414. doi:
            10.3390/ijms21155414.. PMID: 32825207]
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 1650)
  AUTHORS   Iacovino,M., Granycome,C., Sembongi,H., Bokori-Brown,M.,
            Butow,R.A., Holt,I.J. and Bateman,J.M.
  TITLE     The conserved translocase Tim17 prevents mitochondrial DNA loss
  JOURNAL   Hum Mol Genet 18 (1), 65-74 (2009)
   PUBMED   18826960
  REMARK    GeneRIF: Tim17 is a conserved suppressor of mtDNA instability.
REFERENCE   7  (bases 1 to 1650)
  AUTHORS   Piesse,C., Tymms,M., Garrafa,E., Gouzy,C., Lacasa,M., Cadel,S.,
            Cohen,P. and Foulon,T.
  TITLE     Human aminopeptidase B (rnpep) on chromosome 1q32.2: complementary
            DNA, genomic structure and expression
  JOURNAL   Gene 292 (1-2), 129-140 (2002)
   PUBMED   12119107
REFERENCE   8  (bases 1 to 1650)
  AUTHORS   Moro,F., Sirrenberg,C., Schneider,H.C., Neupert,W. and Brunner,M.
  TITLE     The TIM17.23 preprotein translocase of mitochondria: composition
            and function in protein transport into the matrix
  JOURNAL   EMBO J 18 (13), 3667-3675 (1999)
   PUBMED   10393182
REFERENCE   9  (bases 1 to 1650)
  AUTHORS   Bauer,M.F., Gempel,K., Reichert,A.S., Rappold,G.A., Lichtner,P.,
            Gerbitz,K.D., Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     Genetic and structural characterization of the human mitochondrial
            inner membrane translocase
  JOURNAL   J Mol Biol 289 (1), 69-82 (1999)
   PUBMED   10339406
REFERENCE   10 (bases 1 to 1650)
  AUTHORS   Bomer,U., Rassow,J., Zufall,N., Pfanner,N., Meijer,M. and
            Maarse,A.C.
  TITLE     The preprotein translocase of the inner mitochondrial membrane:
            evolutionary conservation of targeting and assembly of Tim17
  JOURNAL   J Mol Biol 262 (4), 389-395 (1996)
   PUBMED   8893850
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            AU123184.1, BC020833.1, AF106622.1 and AC099676.2.
            
            On Nov 22, 2018 this sequence version replaced NM_006335.2.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.327682.1,
                                           SRR1803611.156774.1 [ECO:0000332]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000367287.5/
                                                  ENSP00000356256.4
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-10                AU123184.1         13-22
            11-1342             BC020833.1         1-1332
            1343-1647           AF106622.1         1325-1629
            1648-1650           AC099676.2         71308-71310
FEATURES             Location/Qualifiers
     source          1..1650
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="1"
                     /map="1q32.1"
     gene            1..1650
                     /gene="TIMM17A"
                     /gene_synonym="TIM17; TIM17A"
                     /note="translocase of inner mitochondrial membrane 17A"
                     /db_xref="GeneID:10440"
                     /db_xref="HGNC:HGNC:17315"
                     /db_xref="MIM:605057"
     exon            1..50
                     /gene="TIMM17A"
                     /gene_synonym="TIM17; TIM17A"
                     /inference="alignment:Splign:2.1.0"
     CDS             25..540
                     /gene="TIMM17A"
                     /gene_synonym="TIM17; TIM17A"
                     /note="preprotein translocase; translocase of inner
                     mitochondrial membrane 17 homolog A; mitochondrial inner
                     membrane translocase; inner membrane preprotein
                     translocase Tim17a"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit Tim17-A"
                     /protein_id="NP_006326.1"
                     /db_xref="CCDS:CCDS1417.1"
                     /db_xref="GeneID:10440"
                     /db_xref="HGNC:HGNC:17315"
                     /db_xref="MIM:605057"
                     /translation="MEEYAREPCPWRIVDDCGGAFTMGTIGGGIFQAIKGFRNSPVGV
                     NHRLRGSLTAIKTRAPQLGGSFAVWGGLFSMIDCSMVQVRGKEDPWNSITSGALTGAI
                     LAARNGPVAMVGSAAMGGILLALIEGAGILLTRFASAQFPNGPQFAEDPSQLPSTQLP
                     SSPFGDYRQYQ"
     exon            51..150
                     /gene="TIMM17A"
                     /gene_synonym="TIM17; TIM17A"
                     /inference="alignment:Splign:2.1.0"
     exon            151..214
                     /gene="TIMM17A"
                     /gene_synonym="TIM17; TIM17A"
                     /inference="alignment:Splign:2.1.0"
     exon            215..343
                     /gene="TIMM17A"
                     /gene_synonym="TIM17; TIM17A"
                     /inference="alignment:Splign:2.1.0"
     exon            344..454
                     /gene="TIMM17A"
                     /gene_synonym="TIM17; TIM17A"
                     /inference="alignment:Splign:2.1.0"
     exon            455..1650
                     /gene="TIMM17A"
                     /gene_synonym="TIM17; TIM17A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      901..906
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMM17A"
                     /gene_synonym="TIM17; TIM17A"
                     /note="hexamer: AATAAA"
     polyA_site      922
                     /gene="TIMM17A"
                     /gene_synonym="TIM17; TIM17A"
     regulatory      1310..1315
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMM17A"
                     /gene_synonym="TIM17; TIM17A"
                     /note="hexamer: AATAAA"
     polyA_site      1336
                     /gene="TIMM17A"
                     /gene_synonym="TIM17; TIM17A"
                     /note="major polyA site"
     regulatory      1628..1633
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMM17A"
                     /gene_synonym="TIM17; TIM17A"
                     /note="hexamer: CATAAA"
     regulatory      1633..1638
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMM17A"
                     /gene_synonym="TIM17; TIM17A"
                     /note="hexamer: AATAAT"
     polyA_site      1647
                     /gene="TIMM17A"
                     /gene_synonym="TIM17; TIM17A"
     polyA_site      1650
                     /gene="TIMM17A"
                     /gene_synonym="TIM17; TIM17A"
ORIGIN      
        1 atcactcgcg gcattggagt caagatggag gagtacgcgc gagagccttg cccatggcga
       61 attgtggatg actgtggtgg ggcctttacg atgggtacca ttggtggtgg tatctttcaa
      121 gcaatcaaag gttttcgcaa ttctccagtg ggagtaaacc acagactacg agggagtttg
      181 acagctatta aaaccagggc tccacagtta ggaggtagct ttgcagtttg gggagggctg
      241 ttttccatga ttgactgtag tatggttcaa gtcagaggaa aggaagatcc ctggaactcc
      301 atcacaagtg gtgccttaac gggagccata ctggcagcaa gaaatggacc agtggccatg
      361 gttgggtcag ccgcaatggg tggcattctc ctagctttaa ttgaaggagc tggtatcttg
      421 ttgacaagat ttgcctctgc acagtttccc aatggtcctc agtttgcaga agacccctcc
      481 cagttgcctt caactcagtt accttcctca ccttttggag actatcgaca atatcagtag
      541 gacttctttc ctaggatttc tttaacagaa cgagttgtgg ttcgagaagg atttcagaag
      601 atcaagttac agtctgtttt taaaaccata ggtgggacag ctatggccaa taggctataa
      661 agagacattt agcacttttt tctatttaaa ggaacaagcg gggaagggtg ctaaaagata
      721 atacgtttat ttattcacac ttgaattgca tttgtgatca aaataaatgt ttaaatcgct
      781 aaaggaaaat acagtaagtg cttgaaagat gaaggaccaa aaggccaaaa aacagtgaaa
      841 tatgatcatc atctccttgc ggacttctct gcctggtttt gtgtgttctg ttattcaaac
      901 aataaaaagc tggtggaact tactctttct tttaagataa gttgtagact tcgatgtttc
      961 atgctcatgt acttcaaata atgcatgttt tatagttagt ccctcatcac ttgaagtgac
     1021 ttctgagaat tatgcagagt caacatggat catttcacag tgagatgctt tatggattga
     1081 aggatatggt aaaatgttta tagtttactt tgaaagtaaa atatactatg tcttggtttt
     1141 gaggatattg gatacaaaac tctcttcctt tagggctact gagtcttgat tcctgatcat
     1201 cagaaatttc accagaaaca acttgcttcc aatataccca attctatatg aagaattcat
     1261 ggagagtgta ctggcactgg aagagtttag tgtttcttgt atgcttgaaa ataaagtatg
     1321 tactgttttg aatgtgttcc aagtcctctg cataaacgat gtattttggg gtctggttgg
     1381 gcctggaaaa tggatgagca cttcagaaca ggtcattttc ctgatattgg aagtgacatg
     1441 tggccctata ggaggcatga tgttagttaa ttacacattt gcctacatct gtgggaaatg
     1501 gagaacaaag ccatgtgggt actgtaaaca cacgtttatc ttttggccca atgccataca
     1561 tatggtaggc atttaattac tgattgtgtt tggataattt gggaattttc gactgtggta
     1621 aaatatacat aaaataatac ttattaacca
//
