LOCUS       NM_012458               1664 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens translocase of inner mitochondrial membrane 13
            (TIMM13), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_012458
VERSION     NM_012458.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 1664)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 1664)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 1664)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 1664)
  AUTHORS   Wang,Z., Fan,M., Candas,D., Zhang,T.Q., Qin,L., Eldridge,A.,
            Wachsmann-Hogiu,S., Ahmed,K.M., Chromy,B.A., Nantajit,D., Duru,N.,
            He,F., Chen,M., Finkel,T., Weinstein,L.S. and Li,J.J.
  TITLE     Cyclin B1/Cdk1 coordinates mitochondrial respiration for cell-cycle
            G2/M progression
  JOURNAL   Dev Cell 29 (2), 217-232 (2014)
   PUBMED   24746669
REFERENCE   5  (bases 1 to 1664)
  AUTHORS   Gentle,I.E., Perry,A.J., Alcock,F.H., Likic,V.A., Dolezal,P.,
            Ng,E.T., Purcell,A.W., McConnville,M., Naderer,T., Chanez,A.L.,
            Charriere,F., Aschinger,C., Schneider,A., Tokatlidis,K. and
            Lithgow,T.
  TITLE     Conserved motifs reveal details of ancestry and structure in the
            small TIM chaperones of the mitochondrial intermembrane space
  JOURNAL   Mol Biol Evol 24 (5), 1149-1160 (2007)
   PUBMED   17329230
REFERENCE   6  (bases 1 to 1664)
  AUTHORS   Rothbauer,U., Hofmann,S., Muhlenbein,N., Paschen,S.A.,
            Gerbitz,K.D., Neupert,W., Brunner,M. and Bauer,M.F.
  TITLE     Role of the deafness dystonia peptide 1 (DDP1) in import of human
            Tim23 into the inner membrane of mitochondria
  JOURNAL   J Biol Chem 276 (40), 37327-37334 (2001)
   PUBMED   11489896
REFERENCE   7  (bases 1 to 1664)
  AUTHORS   Rehling,P., Wiedemann,N., Pfanner,N. and Truscott,K.N.
  TITLE     The mitochondrial import machinery for preproteins
  JOURNAL   Crit Rev Biochem Mol Biol 36 (3), 291-336 (2001)
   PUBMED   11450972
  REMARK    Review article
REFERENCE   8  (bases 1 to 1664)
  AUTHORS   Paschen,S.A., Rothbauer,U., Kaldi,K., Bauer,M.F., Neupert,W. and
            Brunner,M.
  TITLE     The role of the TIM8-13 complex in the import of Tim23 into
            mitochondria
  JOURNAL   EMBO J 19 (23), 6392-6400 (2000)
   PUBMED   11101512
REFERENCE   9  (bases 1 to 1664)
  AUTHORS   Bauer,M.F., Rothbauer,U., Muhlenbein,N., Smith,R.J., Gerbitz,K.,
            Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     The mitochondrial TIM22 preprotein translocase is highly conserved
            throughout the eukaryotic kingdom
  JOURNAL   FEBS Lett 464 (1-2), 41-47 (1999)
   PUBMED   10611480
REFERENCE   10 (bases 1 to 1664)
  AUTHORS   Jin,H., Kendall,E., Freeman,T.C., Roberts,R.G. and Vetrie,D.L.
  TITLE     The human family of Deafness/Dystonia peptide (DDP) related
            mitochondrial import proteins
  JOURNAL   Genomics 61 (3), 259-267 (1999)
   PUBMED   10552927
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from HY098076.1, AK024764.1 and
            AC011522.8.
            
            On Nov 22, 2018 this sequence version replaced NM_012458.3.
            
            Summary: This gene encodes a member of the evolutionarily conserved
            TIMM (translocase of inner mitochondrial membrane) family of
            proteins that function as chaperones in the import of proteins from
            the cytoplasm into the mitochondrial inner membrane. Proteins of
            this family play a role in collecting substrate proteins from the
            translocase of the outer mitochondrial membrane (TOM) complex and
            delivering them to either the sorting and assembly machinery in the
            outer mitochondrial membrane (SAM) complex or the TIMM22 complex in
            the inner mitochondrial membrane. The encoded protein and the
            translocase of mitochondrial inner membrane 8a protein form a 70
            kDa complex in the intermembrane space. [provided by RefSeq, Jul
            2013].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR3476690.773314.1,
                                           SRR3476690.880947.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2148874, SAMEA2163105
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000215570.8/
                                                  ENSP00000215570.2
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-35                HY098076.1         328-362
            36-899              AK024764.1         1-864
            900-1223            AK024764.1         866-1189
            1224-1224           AC011522.8         17313-17313         c
            1225-1664           AK024764.1         1191-1630
FEATURES             Location/Qualifiers
     source          1..1664
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="19"
                     /map="19p13.3"
     gene            1..1664
                     /gene="TIMM13"
                     /gene_synonym="ppv1; TIM13; TIM13B; TIMM13A; TIMM13B"
                     /note="translocase of inner mitochondrial membrane 13"
                     /db_xref="GeneID:26517"
                     /db_xref="HGNC:HGNC:11816"
                     /db_xref="MIM:607383"
     exon            1..173
                     /gene="TIMM13"
                     /gene_synonym="ppv1; TIM13; TIM13B; TIMM13A; TIMM13B"
                     /inference="alignment:Splign:2.1.0"
     CDS             54..341
                     /gene="TIMM13"
                     /gene_synonym="ppv1; TIM13; TIM13B; TIMM13A; TIMM13B"
                     /note="mitochondrial import inner membrane translocase
                     subunit Tim13B; translocase of inner mitochondrial
                     membrane 13 homolog"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit Tim13"
                     /protein_id="NP_036590.1"
                     /db_xref="CCDS:CCDS12089.1"
                     /db_xref="GeneID:26517"
                     /db_xref="HGNC:HGNC:11816"
                     /db_xref="MIM:607383"
                     /translation="MEGGFGSDFGGSGSGKLDPGLIMEQVKVQIAVANAQELLQRMTD
                     KCFRKCIGKPGGSLDNSEQKCIAMCMDRYMDAWNTVSRAYNSRLQRERANM"
     exon            174..242
                     /gene="TIMM13"
                     /gene_synonym="ppv1; TIM13; TIM13B; TIMM13A; TIMM13B"
                     /inference="alignment:Splign:2.1.0"
     exon            243..1664
                     /gene="TIMM13"
                     /gene_synonym="ppv1; TIM13; TIM13B; TIMM13A; TIMM13B"
                     /inference="alignment:Splign:2.1.0"
     regulatory      704..709
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMM13"
                     /gene_synonym="ppv1; TIM13; TIM13B; TIMM13A; TIMM13B"
                     /note="hexamer: AATAAA"
     polyA_site      724
                     /gene="TIMM13"
                     /gene_synonym="ppv1; TIM13; TIM13B; TIMM13A; TIMM13B"
                     /note="major polyA site"
     regulatory      1622..1627
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMM13"
                     /gene_synonym="ppv1; TIM13; TIM13B; TIMM13A; TIMM13B"
                     /note="hexamer: AATAAA"
     polyA_site      1664
                     /gene="TIMM13"
                     /gene_synonym="ppv1; TIM13; TIM13B; TIMM13A; TIMM13B"
ORIGIN      
        1 agttagttac gagtcggcgc acgcggcctc ggtccggttg actttgcgga gccatggagg
       61 gcggcttcgg ctccgatttc gggggctccg gcagcgggaa gctggaccca gggctcataa
      121 tggagcaggt gaaagtgcag atcgccgtgg ccaacgcgca ggagctgctg cagaggatga
      181 cggacaagtg tttccggaag tgtataggga aacctggggg ctccctggac aactccgagc
      241 agaagtgcat cgccatgtgc atggaccgct acatggacgc ctggaacacc gtgtctcgcg
      301 cctacaactc gcggctgcag cgggaacgag ccaacatgtg accggcgagc gcgggccacc
      361 ccaccctgtt catttccata aacgtgcttt gagaggcggg gtccgcatgt acgtactgcc
      421 tgcccggggc ttaggagggt ggcaccggtg ctgggacaca cgggactgtg tcctcgccac
      481 cccccgccct gccccctgcc agccagtgca gcttggatct cgggggtgtg gggccctgtg
      541 ccttcctgaa gtgctggcag cccagtggca cctccttcag gcctttgggg tattccccta
      601 gtgtgcccaa gtcagcctca tattctgggc ggacagcttg tctggacttc ggagttgggg
      661 gtggtcagac accacaggag ctgtcacctc ctgcggatgg gcaaataaat tggtggagga
      721 cggagagaaa cctctttatt tccctcctga ggggtctctg ggaagaggtg acgcgtgtcc
      781 ctggaacccc agctcggagg gtctcagcct cccctgggtt gggagaagtc catctttccc
      841 cttagtgcca ccgggctgct gagtcacgag gaatgtgttg ctgctgccac ccctgcccca
      901 aaggctaagg gggacagcct tccccttgtc agggcttgct ttgaccctgc ttcgttccac
      961 cccgggtcct ggtggagcac caggcaggtg gtcctcgctg tgacactgag gtgctgagcc
     1021 agtgagctag ggtggagggg ctgtgtttat tggaacaaag ggtggtacca aaatgcatcc
     1081 ccatgaccca cagccccccc acacccgtcc ttgggtaggg tacggtgggg tggggtgttg
     1141 ggtggcctgc tgctcctgtt gctttcacgt agagtctcgg cctgggcagt cacgtggtgg
     1201 tcactcctgg atgtgctgtc ctatccagcc tctcacagct gccacccggg tatagacacc
     1261 tgggaagtgg ggccggccac agccatagcc ccagctagtg accccagtta gcacccaccg
     1321 tccagagggc tccctgcagg ccaggggtcc cccagcgtca ccctgttggg gagagaagaa
     1381 agggggttca gaggccggta cctcccctac agcagccctt gggtcattgg cccctctagg
     1441 agtgacccta gtgacttccc ctgggagccg cattttcact atctggaaaa tgggctcaat
     1501 gcaaaggtgg cagacattta tggacacccg ccacgtggtc ccggagtgga acggtgcctc
     1561 ccactgcagc ctctgcctgc tctgccgccg aggcccgggg atgggatgcg gtgggttgcc
     1621 caataaacgg ctgtggagtg gaaattcctc cagagccaaa aagg
//
