LOCUS       NM_012192               2788 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens translocase of inner mitochondrial membrane 10B
            (TIMM10B), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_012192
VERSION     NM_012192.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2788)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 2788)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 2788)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   4  (bases 1 to 2788)
  AUTHORS   Vukotic,M., Nolte,H., Konig,T., Saita,S., Ananjew,M., Kruger,M.,
            Tatsuta,T. and Langer,T.
  TITLE     Acylglycerol Kinase Mutated in Sengers Syndrome Is a Subunit of the
            TIM22 Protein Translocase in Mitochondria
  JOURNAL   Mol Cell 67 (3), 471-483 (2017)
   PUBMED   28712724
REFERENCE   5  (bases 1 to 2788)
  AUTHORS   Kang,Y., Baker,M.J., Liem,M., Louber,J., McKenzie,M., Atukorala,I.,
            Ang,C.S., Keerthikumar,S., Mathivanan,S. and Stojanovski,D.
  TITLE     Tim29 is a novel subunit of the human TIM22 translocase and is
            involved in complex assembly and stability
  JOURNAL   Elife 5, e17463 (2016)
   PUBMED   27554484
  REMARK    Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2788)
  AUTHORS   Muhlenbein,N., Hofmann,S., Rothbauer,U. and Bauer,M.F.
  TITLE     Organization and function of the small Tim complexes acting along
            the import pathway of metabolite carriers into mammalian
            mitochondria
  JOURNAL   J Biol Chem 279 (14), 13540-13546 (2004)
   PUBMED   14726512
REFERENCE   7  (bases 1 to 2788)
  AUTHORS   Rothbauer,U., Hofmann,S., Muhlenbein,N., Paschen,S.A.,
            Gerbitz,K.D., Neupert,W., Brunner,M. and Bauer,M.F.
  TITLE     Role of the deafness dystonia peptide 1 (DDP1) in import of human
            Tim23 into the inner membrane of mitochondria
  JOURNAL   J Biol Chem 276 (40), 37327-37334 (2001)
   PUBMED   11489896
REFERENCE   8  (bases 1 to 2788)
  AUTHORS   Bauer,M.F., Rothbauer,U., Muhlenbein,N., Smith,R.J., Gerbitz,K.,
            Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     The mitochondrial TIM22 preprotein translocase is highly conserved
            throughout the eukaryotic kingdom
  JOURNAL   FEBS Lett 464 (1-2), 41-47 (1999)
   PUBMED   10611480
REFERENCE   9  (bases 1 to 2788)
  AUTHORS   Jin,H., Kendall,E., Freeman,T.C., Roberts,R.G. and Vetrie,D.L.
  TITLE     The human family of Deafness/Dystonia peptide (DDP) related
            mitochondrial import proteins
  JOURNAL   Genomics 61 (3), 259-267 (1999)
   PUBMED   10552927
REFERENCE   10 (bases 1 to 2788)
  AUTHORS   Hadjiargyrou,M., Halsey,M.F., Ahrens,W., Rightmire,E.P.,
            McLeod,K.J. and Rubin,C.T.
  TITLE     Cloning of a novel cDNA expressed during the early stages of
            fracture healing
  JOURNAL   Biochem Biophys Res Commun 249 (3), 879-884 (1998)
   PUBMED   9731230
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            DA290694.1, BC011014.1, AC084337.7 and AI052126.1.
            
            On Nov 23, 2018 this sequence version replaced NM_012192.3.
            
            Summary: FXC1, or TIMM10B, belongs to a family of evolutionarily
            conserved proteins that are organized in heterooligomeric complexes
            in the mitochondrial intermembrane space. These proteins mediate
            the import and insertion of hydrophobic membrane proteins into the
            mitochondrial inner membrane.[supplied by OMIM, Apr 2004].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1660805.76223.1,
                                           SRR1660805.155022.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: PMID: 14726512; reported by
                                                  MitoCarta
            MANE Ensembl match                 :: ENST00000254616.11/
                                                  ENSP00000254616.6
            RefSeq Select criteria             :: based on single
                                                  protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-7                 DA290694.1         55-61
            8-283               BC011014.1         4-279
            284-2445            AC084337.7         70991-73152
            2446-2788           AI052126.1         20-362              c
FEATURES             Location/Qualifiers
     source          1..2788
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11p15.4"
     gene            1..2788
                     /gene="TIMM10B"
                     /gene_synonym="FXC1; TIM10B; Tim9b"
                     /note="translocase of inner mitochondrial membrane 10B"
                     /db_xref="GeneID:26515"
                     /db_xref="HGNC:HGNC:4022"
                     /db_xref="MIM:607388"
     exon            1..55
                     /gene="TIMM10B"
                     /gene_synonym="FXC1; TIM10B; Tim9b"
                     /inference="alignment:Splign:2.1.0"
     CDS             17..328
                     /gene="TIMM10B"
                     /gene_synonym="FXC1; TIM10B; Tim9b"
                     /note="fracture callus 1 homolog; mitochondrial import
                     inner membrane translocase subunit Tim9 B; fracture callus
                     protein 1; translocase of inner mitochondrial membrane 10
                     homolog B"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit Tim10 B"
                     /protein_id="NP_036324.1"
                     /db_xref="CCDS:CCDS7766.1"
                     /db_xref="GeneID:26515"
                     /db_xref="HGNC:HGNC:4022"
                     /db_xref="MIM:607388"
                     /translation="MERQQQQQQQLRNLRDFLLVYNRMTELCFQRCVPSLHHRALDAE
                     EEACLHSCAGKLIHSNHRLMAAYVQLMPALVQRRIADYEAASAVPGVAAEQPGVSPSG
                     S"
     exon            56..151
                     /gene="TIMM10B"
                     /gene_synonym="FXC1; TIM10B; Tim9b"
                     /inference="alignment:Splign:2.1.0"
     exon            152..2788
                     /gene="TIMM10B"
                     /gene_synonym="FXC1; TIM10B; Tim9b"
                     /inference="alignment:Splign:2.1.0"
     regulatory      1149..1154
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMM10B"
                     /gene_synonym="FXC1; TIM10B; Tim9b"
                     /note="hexamer: AGTAAA"
     polyA_site      1167
                     /gene="TIMM10B"
                     /gene_synonym="FXC1; TIM10B; Tim9b"
                     /note="major polyA site"
     regulatory      2767..2772
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMM10B"
                     /gene_synonym="FXC1; TIM10B; Tim9b"
                     /note="hexamer: AATAAA"
     polyA_site      2788
                     /gene="TIMM10B"
                     /gene_synonym="FXC1; TIM10B; Tim9b"
ORIGIN      
        1 atgcgccggt ggcgtgatgg agcggcagca gcagcagcaa cagcaactgc gaaacctgcg
       61 tgacttcctg ttggtctaca atcggatgac agaactctgc ttccagcgct gtgtgcccag
      121 cttgcaccac cgagctctgg acgctgagga ggaggcctgt ctgcacagct gtgctgggaa
      181 gctgatccat tccaaccacc gcctcatggc cgcttacgtg cagctcatgc ctgccctggt
      241 acagcgccgc atcgcagact acgaggctgc ctcggctgtg ccaggcgttg ctgctgaaca
      301 gcctggggtc tctccatcag gcagctagcc atacccaacc ccaggaagga aggccttgga
      361 tggaccctca gattgaagga cccggtggac cttggggttg gtgaatccta aacagagaga
      421 attcgaggtt gcctgaaagc tgggtgtcct tgctcctttt cctggagcca atatacccag
      481 tttttactca gtttgattta tattctgggc aaggaagctt tgcctacttt attggcacaa
      541 tccgttgttc tgtcgtttag tgcatatctg ctggcttcag ccctggcagc tgagaaattg
      601 ttttctatat gtagaaggaa aacctgagca tttgcaggca tctggttaaa gcagggtctg
      661 tgtgtacaat tttaaaacgg gtaatatgtc atgctcttag ttcatcttca caacaaaact
      721 atgagtaagc ggtattagcc tcacttaaca gatgaggaag caagattcca gaaagtacca
      781 gaaggtcatt ttatacaaca ggagattggt tcctgcccag atgacagaaa atgggagctc
      841 tgtctagttg tccttaagtc tgactgactt cagtggctca taaccgtgag ccaagtattt
      901 gttggttcat aactgttgtt ttgtgaacta tgtcttacat gtctagagtt ctgctggatc
      961 tagggaaagg aggagctatc gaagtacaac ggatcaaaaa accacagggc ttttgggcac
     1021 tgcctccttg ggaagttagt ggccacagaa gagagatgaa acctgtaaga agtctggagt
     1081 cttttggaac ttcagccatt tccccaggtt gttactttct tagtatgtac agtcttctca
     1141 ggatgagcag taaaaccttt gaacaaaggt ctgtgtggtt gtcttcacgg gcaatcagga
     1201 agggagagag ctggggacca tattctgcaa tgcagccaaa tccgaggaag agaaactgaa
     1261 gggagaagta gatggcaatg gttatgataa aaagggataa aactaaatct tcgggacttc
     1321 tttaatgcta cgttaatgtt tcactgctcg tctagaaact cctaaatcca gctttctatc
     1381 atctgcccca cattggtccc attgagtaca ttctgtgatt tctaattcca gcctctccat
     1441 tcttttctca ttattgcctc ccccgccccc caactttgtg taatttactt ctgtattcag
     1501 cagcctggat agcatatcat tccatcaccc cattttcttg ccaccattgg ccatcttttt
     1561 gtatcattcc acttattctg tcttttccat tccttcattc aaactgctag agaaaaacag
     1621 ttgtgtaatg aatgccacta aatattcaag gcctccaacc tcagccaagt cctcacacca
     1681 acacgcagtc acaccaacac acacctttat gggttcctgg tccatttcct tctctaatta
     1741 ccatggcagt tattttacac ctctactgct gtccttaatc ccatacccca ccctcatcag
     1801 gtgaccctgt ttcctttttt agagaaattg aagctcttag acattggttt ccacagtaat
     1861 aattttaaaa cttcttacaa ctacctacaa agcagatgtt ctatcctatc tacagagcag
     1921 aaaattgaaa ttctcaagta gcagacccgg tattaaagtg cagatctgac tttaaagtcc
     1981 atgttcattt tacacagcag gctgcctctt aagatagtat ttattgagca cacactttgt
     2041 gtaggttctg attttggtag atgtcatgct ttatattaat ctttacaaca actataagta
     2101 agaggtatta acctcactta acagatgagg aagcaagaat ccagaatgtg ccagaaggca
     2161 cattctgcag atttcgtgca aacatttata cacagcttct tttttttttt tttgagacag
     2221 agtctcgctc tgtcacccag gctggagtgc agtggagcga tctaggctca ctgcaacctc
     2281 cgccacccgg gttcaagcag ttctcctgcc tcagcctctc gagtagctgg gattacaggc
     2341 atgcgccacc acgcccagct aattttgttt ttgtatttta agtagagacg gggtttcact
     2401 gtattggtca ggctggtctt gaactcctga ccttgtgatc cgcccgcctc ggcctccaaa
     2461 agtgctggga ttacaggtgt gagccaccac ggccggccta tacaaagttt cttattgaga
     2521 aaagtggttc caatcatgtt ttttgccccc tttagctgct atctcttgaa cagaaaagtt
     2581 tgttaggaag gtaaaagttg ctgactagga ccttacccac agggtggcac tctgtccttg
     2641 ggaaatataa atgcaagtaa aacaggtttg aacttcttaa cttccagaag ataggaggat
     2701 gggacctgtg atactgtgct gctggtggga ggacccttcc acatcaacat ttgtgtgtat
     2761 ccttgcaata aacttccatt gtgaatta
//
