LOCUS       NM_012456                668 bp    mRNA    linear   PRI 19-SEP-2024
DEFINITION  Homo sapiens translocase of inner mitochondrial membrane 10
            (TIMM10), mRNA; nuclear gene for mitochondrial product.
ACCESSION   NM_012456
VERSION     NM_012456.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 668)
  AUTHORS   Morgenstern,M., Peikert,C.D., Lubbert,P., Suppanz,I., Klemm,C.,
            Alka,O., Steiert,C., Naumenko,N., Schendzielorz,A., Melchionda,L.,
            Muhlhauser,W.W.D., Knapp,B., Busch,J.D., Stiller,S.B.,
            Dannenmaier,S., Lindau,C., Licheva,M., Eickhorst,C., Galbusera,R.,
            Zerbes,R.M., Ryan,M.T., Kraft,C., Kozjak-Pavlovic,V., Drepper,F.,
            Dennerlein,S., Oeljeklaus,S., Pfanner,N., Wiedemann,N. and
            Warscheid,B.
  TITLE     Quantitative high-confidence human mitochondrial proteome and its
            dynamics in cellular context
  JOURNAL   Cell Metab 33 (12), 2464-2483 (2021)
   PUBMED   34800366
REFERENCE   2  (bases 1 to 668)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   3  (bases 1 to 668)
  AUTHORS   Qi,L., Wang,Q., Guan,Z., Wu,Y., Shen,C., Hong,S., Cao,J., Zhang,X.,
            Yan,C. and Yin,P.
  TITLE     Cryo-EM structure of the human mitochondrial translocase TIM22
            complex
  JOURNAL   Cell Res 31 (3), 369-372 (2021)
   PUBMED   32901109
REFERENCE   4  (bases 1 to 668)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   5  (bases 1 to 668)
  AUTHORS   Fasci,D., van Ingen,H., Scheltema,R.A. and Heck,A.J.R.
  TITLE     Histone Interaction Landscapes Visualized by Crosslinking Mass
            Spectrometry in Intact Cell Nuclei
  JOURNAL   Mol Cell Proteomics 17 (10), 2018-2033 (2018)
   PUBMED   30021884
REFERENCE   6  (bases 1 to 668)
  AUTHORS   Vial,S., Lu,H., Allen,S., Savory,P., Thornton,D., Sheehan,J. and
            Tokatlidis,K.
  TITLE     Assembly of Tim9 and Tim10 into a functional chaperone
  JOURNAL   J Biol Chem 277 (39), 36100-36108 (2002)
   PUBMED   12138093
REFERENCE   7  (bases 1 to 668)
  AUTHORS   Rothbauer,U., Hofmann,S., Muhlenbein,N., Paschen,S.A.,
            Gerbitz,K.D., Neupert,W., Brunner,M. and Bauer,M.F.
  TITLE     Role of the deafness dystonia peptide 1 (DDP1) in import of human
            Tim23 into the inner membrane of mitochondria
  JOURNAL   J Biol Chem 276 (40), 37327-37334 (2001)
   PUBMED   11489896
REFERENCE   8  (bases 1 to 668)
  AUTHORS   Bauer,M.F., Rothbauer,U., Muhlenbein,N., Smith,R.J., Gerbitz,K.,
            Neupert,W., Brunner,M. and Hofmann,S.
  TITLE     The mitochondrial TIM22 preprotein translocase is highly conserved
            throughout the eukaryotic kingdom
  JOURNAL   FEBS Lett 464 (1-2), 41-47 (1999)
   PUBMED   10611480
REFERENCE   9  (bases 1 to 668)
  AUTHORS   Jin,H., Kendall,E., Freeman,T.C., Roberts,R.G. and Vetrie,D.L.
  TITLE     The human family of Deafness/Dystonia peptide (DDP) related
            mitochondrial import proteins
  JOURNAL   Genomics 61 (3), 259-267 (1999)
   PUBMED   10552927
REFERENCE   10 (bases 1 to 668)
  AUTHORS   Koehler,C.M., Jarosch,E., Tokatlidis,K., Schmid,K., Schweyen,R.J.
            and Schatz,G.
  TITLE     Import of mitochondrial carriers mediated by essential proteins of
            the intermembrane space
  JOURNAL   Science 279 (5349), 369-373 (1998)
   PUBMED   9430585
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from CB106298.1, AF150089.1 and
            AI498204.1.
            
            On Nov 22, 2018 this sequence version replaced NM_012456.2.
            
            Summary: The mitochondrial protein encoded by this gene belongs to
            a family of evolutionarily conserved proteins that are organized in
            heterooligomeric complexes in the mitochondrial intermembrane
            space. These proteins mediate the import and insertion of
            hydrophobic membrane proteins into the mitochondrial inner
            membrane, functioning as intermembrane space chaperones for the
            highly insoluble carrier proteins. [provided by RefSeq, Nov 2011].
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1163655.430185.1,
                                           SRR5189658.168541.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2149178, SAMEA2150385
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            gene product(s) localized to mito. :: reported by MitoCarta
            MANE Ensembl match                 :: ENST00000257245.9/
                                                  ENSP00000257245.4
            RefSeq Select criteria             :: based on conservation,
                                                  expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-34                CB106298.1         6-39
            35-640              AF150089.1         22-627
            641-648             AI498204.1         78-85               c
            649-668             AF150089.1         628-647
FEATURES             Location/Qualifiers
     source          1..668
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="11"
                     /map="11q12.1"
     gene            1..668
                     /gene="TIMM10"
                     /gene_synonym="TIM10; TIM10A; TIMM10A"
                     /note="translocase of inner mitochondrial membrane 10"
                     /db_xref="GeneID:26519"
                     /db_xref="HGNC:HGNC:11814"
                     /db_xref="MIM:602251"
     exon            1..97
                     /gene="TIMM10"
                     /gene_synonym="TIM10; TIM10A; TIMM10A"
                     /inference="alignment:Splign:2.1.0"
     exon            98..213
                     /gene="TIMM10"
                     /gene_synonym="TIM10; TIM10A; TIMM10A"
                     /inference="alignment:Splign:2.1.0"
     CDS             143..415
                     /gene="TIMM10"
                     /gene_synonym="TIM10; TIM10A; TIMM10A"
                     /note="translocase of inner mitochondrial membrane 10
                     homolog"
                     /codon_start=1
                     /product="mitochondrial import inner membrane translocase
                     subunit Tim10"
                     /protein_id="NP_036588.1"
                     /db_xref="CCDS:CCDS7959.1"
                     /db_xref="GeneID:26519"
                     /db_xref="HGNC:HGNC:11814"
                     /db_xref="MIM:602251"
                     /translation="MDPLRAQQLAAELEVEMMADMYNRMTSACHRKCVPPHYKEAELS
                     KGESVCLDRCVSKYLDIHERMGKKLTELSMQDEELMKRVQQSSGPA"
     exon            214..668
                     /gene="TIMM10"
                     /gene_synonym="TIM10; TIM10A; TIMM10A"
                     /inference="alignment:Splign:2.1.0"
     regulatory      465..470
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMM10"
                     /gene_synonym="TIM10; TIM10A; TIMM10A"
                     /note="hexamer: AATAAA"
     polyA_site      499
                     /gene="TIMM10"
                     /gene_synonym="TIM10; TIM10A; TIMM10A"
                     /note="major polyA site"
     regulatory      645..650
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMM10"
                     /gene_synonym="TIM10; TIM10A; TIMM10A"
                     /note="hexamer: TATAAA"
     polyA_site      668
                     /gene="TIMM10"
                     /gene_synonym="TIM10; TIM10A; TIMM10A"
ORIGIN      
        1 acgtgcttcc gctggagcct ctcgggaggc gggtaacgtt atagtatttg tcagaagttg
       61 gggtctccgt gggcattgtg atccgtccca ggcagtggat taggaggcca gaaggagatc
      121 ccttccacgg tgctaggctg agatggatcc tctcagggcc caacagctgg ctgcggagct
      181 ggaggtggag atgatggccg atatgtacaa cagaatgacc agtgcctgcc accggaagtg
      241 tgtgcctcct cactacaagg aagcagagct ctccaagggc gagtctgtgt gcctggaccg
      301 atgtgtctct aagtacctgg acatccatga gcggatgggc aaaaagttga cagagttgtc
      361 tatgcaggat gaagagctga tgaagagggt gcagcagagc tctgggcctg catgaggtcc
      421 ctgtcagtat acaccctggg gtgtacccca ccccttccca ctttaataaa cgtgctccct
      481 gttgggtgtc atctgtgaag actgccaggc ctaggctctc tgtagagagt cttcaagatc
      541 ccggagtggt agcgctgtct cctggtgaag gagtatttgt cacactggaa tgtgactgtg
      601 tgtgtatgta tgtgtatata tatatatata tatatatata tatatataaa caagtttgtt
      661 gacaccta
//
