LOCUS       NM_003920               5158 bp    mRNA    linear   PRI 12-AUG-2024
DEFINITION  Homo sapiens timeless circadian regulator (TIMELESS), transcript
            variant 1, mRNA.
ACCESSION   NM_003920
VERSION     NM_003920.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5158)
  AUTHORS   Zhang,Y., Wu,Y., Shi,X., Ding,H., Zhou,Y., Chen,H., Shen,F.,
            Chen,Y., Zhou,J., Zhou,D. and Wang,J.
  TITLE     M6A-mediated hsa_circ_0061179 inhibits DNA damage in ovarian cancer
            cells via miR-143-3p/TIMELESS
  JOURNAL   Mol Carcinog 63 (8), 1542-1558 (2024)
   PUBMED   38751015
  REMARK    GeneRIF: M6A-mediated hsa_circ_0061179 inhibits DNA damage in
            ovarian cancer cells via miR-143-3p/TIMELESS.
REFERENCE   2  (bases 1 to 5158)
  AUTHORS   Saldanha,J., Rageul,J., Patel,J.A., Phi,A.L., Lo,N., Park,J.J. and
            Kim,H.
  TITLE     The TIMELESS and PARP1 interaction suppresses
            replication-associated DNA gap accumulation
  JOURNAL   Nucleic Acids Res 52 (11), 6424-6440 (2024)
   PUBMED   38801073
  REMARK    GeneRIF: The TIMELESS and PARP1 interaction suppresses
            replication-associated DNA gap accumulation.
REFERENCE   3  (bases 1 to 5158)
  AUTHORS   Tian,P., Du,D., Yang,L., Zhou,N. and Tao,L.
  TITLE     SP3-induced Timeless transcription contributes to cell growth of
            lung adenocarcinoma cells
  JOURNAL   PLoS One 19 (2), e0298295 (2024)
   PUBMED   38354174
  REMARK    GeneRIF: SP3-induced Timeless transcription contributes to cell
            growth of lung adenocarcinoma cells.
            Publication Status: Online-Only
REFERENCE   4  (bases 1 to 5158)
  AUTHORS   Gao,X., Tang,M., Tian,S., Li,J., Wei,S., Hua,S. and Liu,W.
  TITLE     ncRNAs-mediated TIMELESS overexpression in lung adenocarcinoma
            correlates with reduced tumor immune cell infiltration and poor
            prognosis
  JOURNAL   PLoS One 19 (1), e0296829 (2024)
   PUBMED   38261568
  REMARK    GeneRIF: ncRNAs-mediated TIMELESS overexpression in lung
            adenocarcinoma correlates with reduced tumor immune cell
            infiltration and poor prognosis.
            Publication Status: Online-Only
REFERENCE   5  (bases 1 to 5158)
  AUTHORS   Chen,Y., Han,Z., Zhang,L., Gao,C., Wei,J., Yang,X., Han,Y., Li,Y.,
            Zhang,C., Wei,Y., Dong,J., Xun,W., Sun,W., Zhang,T., Zhang,H.,
            Chen,J. and Yuan,P.
  TITLE     TIMELESS promotes reprogramming of glucose metabolism in oral
            squamous cell carcinoma
  JOURNAL   J Transl Med 22 (1), 21 (2024)
   PUBMED   38178094
  REMARK    GeneRIF: TIMELESS promotes reprogramming of glucose metabolism in
            oral squamous cell carcinoma.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 5158)
  AUTHORS   Pedrazzoli,M., Ling,L., Finn,L., Kubin,L., Young,T., Katzenberg,D.
            and Mignot,E.
  TITLE     A polymorphism in the human timeless gene is not associated with
            diurnal preferences in normal adults
  JOURNAL   Sleep Res Online 3 (2), 73-76 (2000)
   PUBMED   11382904
  REMARK    GeneRIF: Observational study of gene-disease association. (HuGE
            Navigator)
REFERENCE   7  (bases 1 to 5158)
  AUTHORS   Kume,K., Zylka,M.J., Sriram,S., Shearman,L.P., Weaver,D.R., Jin,X.,
            Maywood,E.S., Hastings,M.H. and Reppert,S.M.
  TITLE     mCRY1 and mCRY2 are essential components of the negative limb of
            the circadian clock feedback loop
  JOURNAL   Cell 98 (2), 193-205 (1999)
   PUBMED   10428031
REFERENCE   8  (bases 1 to 5158)
  AUTHORS   Koike,N., Hida,A., Numano,R., Hirose,M., Sakaki,Y. and Tei,H.
  TITLE     Identification of the mammalian homologues of the Drosophila
            timeless gene, Timeless1
  JOURNAL   FEBS Lett 441 (3), 427-431 (1998)
   PUBMED   9891984
REFERENCE   9  (bases 1 to 5158)
  AUTHORS   Zylka,M.J., Shearman,L.P., Levine,J.D., Jin,X., Weaver,D.R. and
            Reppert,S.M.
  TITLE     Molecular analysis of mammalian timeless
  JOURNAL   Neuron 21 (5), 1115-1122 (1998)
   PUBMED   9856466
REFERENCE   10 (bases 1 to 5158)
  AUTHORS   Sangoram,A.M., Saez,L., Antoch,M.P., Gekakis,N., Staknis,D.,
            Whiteley,A., Fruechte,E.M., Vitaterna,M.H., Shimomura,K.,
            King,D.P., Young,M.W., Weitz,C.J. and Takahashi,J.S.
  TITLE     Mammalian circadian autoregulatory loop: a timeless ortholog and
            mPer1 interact and negatively regulate CLOCK-BMAL1-induced
            transcription
  JOURNAL   Neuron 21 (5), 1101-1113 (1998)
   PUBMED   9856465
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff. The
            reference sequence was derived from AC024884.31.
            
            On Nov 23, 2018 this sequence version replaced NM_003920.4.
            
            Summary: The protein encoded by this gene is highly conserved and
            is involved in cell survival after damage or stress, increase in
            DNA polymerase epsilon activity, maintenance of telomere length,
            and epithelial cell morphogenesis. The encoded protein also plays a
            role in the circadian rhythm autoregulatory loop, interacting with
            the PERIOD genes (PER1, PER2, and PER3) and others to downregulate
            activation of PER1 by CLOCK/ARNTL. Changes in this gene or its
            expression may promote prostate cancer, lung cancer, breast cancer,
            and mental disorders. [provided by RefSeq, Feb 2014].
            
            Transcript Variant: This variant (1) represents the longest
            transcript and encodes the longer isoform (1).
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.86329.1, BC050557.1
                                           [ECO:0000332]
            RNAseq introns              :: mixed sample support SAMEA1965299,
                                           SAMEA1966682 [ECO:0006172]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000553532.6/ ENSP00000450607.1
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-117               AC024884.31        17823-17939
            118-275             AC024884.31        33018-33175
            276-429             AC024884.31        33323-33476
            430-544             AC024884.31        33597-33711
            545-607             AC024884.31        33806-33868
            608-709             AC024884.31        34122-34223
            710-865             AC024884.31        34725-34880
            866-999             AC024884.31        35645-35778
            1000-1087           AC024884.31        36281-36368
            1088-1264           AC024884.31        36968-37144
            1265-1482           AC024884.31        38149-38366
            1483-1586           AC024884.31        38597-38700
            1587-1756           AC024884.31        38844-39013
            1757-1894           AC024884.31        42097-42234
            1895-2046           AC024884.31        42336-42487
            2047-2144           AC024884.31        43355-43452
            2145-2268           AC024884.31        43542-43665
            2269-2470           AC024884.31        43774-43975
            2471-2616           AC024884.31        44257-44402
            2617-2702           AC024884.31        45058-45143
            2703-2820           AC024884.31        45233-45350
            2821-2903           AC024884.31        45440-45522
            2904-3046           AC024884.31        45756-45898
            3047-3218           AC024884.31        46115-46286
            3219-3287           AC024884.31        46368-46436
            3288-3406           AC024884.31        46562-46680
            3407-3632           AC024884.31        48890-49115
            3633-3734           AC024884.31        49241-49342
            3735-5158           AC024884.31        49463-50886
FEATURES             Location/Qualifiers
     source          1..5158
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="12"
                     /map="12q13.3"
     gene            1..5158
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /note="timeless circadian regulator"
                     /db_xref="GeneID:8914"
                     /db_xref="HGNC:HGNC:11813"
                     /db_xref="MIM:603887"
     exon            1..117
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            118..275
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     CDS             179..3805
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /note="isoform 1 is encoded by transcript variant 1;
                     protein timeless homolog; Tof1 homolog; timeless circadian
                     clock 1"
                     /codon_start=1
                     /product="protein timeless homolog isoform 1"
                     /protein_id="NP_003911.2"
                     /db_xref="CCDS:CCDS8918.1"
                     /db_xref="GeneID:8914"
                     /db_xref="HGNC:HGNC:11813"
                     /db_xref="MIM:603887"
                     /translation="MDLHMMNCELLATCSALGYLEGDTYHKEPDCLESVKDLIRYLRH
                     EDETRDVRQQLGAAQILQSDLLPILTQHHQDKPLFDAVIRLMVNLTQPALLCFGNLPK
                     EPSFRHHFLQVLTYLQAYKEAFASEKAFGVLSETLYELLQLGWEERQEEDNLLIERIL
                     LLVRNILHVPADLDQEKKIDDDASAHDQLLWAIHLSGLDDLLLFLASSSAEEQWSLHV
                     LEIVSLMFRDQNPEQLAGVGQGRLAQERSADFAELEVLRQREMAEKKTRALQRGNRHS
                     RFGGSYIVQGLKSIGERDLIFHKGLHNLRNYSSDLGKQPKKVPKRRQAARELSIQRRS
                     ALNVRLFLRDFCSEFLENCYNRLMGSVKDHLLREKAQQHDETYYMWALAFFMAFNRAA
                     SFRPGLVSETLSVRTFHFIEQNLTNYYEMMLTDRKEAASWARRMHLALKAYQELLATV
                     NEMDISPDEAVRESSRIIKNNIFYVMEYRELFLALFRKFDERCQPRSFLRDLVETTHL
                     FLKMLERFCRSRGNLVVQNKQKKRRKKKKKVLDQAIVSGNVPSSPEEVEAVWPALAEQ
                     LQCCAQNSELSMDSVVPFDAASEVPVEEQRAEAMVRIQDCLLAGQAPQALTLLRSARE
                     VWPEGDVFGSQDISPEEEIQLLKQILSAPLPRQQGPEERGAEEEEEEEEEEEEELQVV
                     QVSEKEFNFLDYLKRFACSTVVRAYVLLLRSYQQNSAHTNHCIVKMLHRLAHDLKMEA
                     LLFQLSVFCLFNRLLSDPAAGAYKELVTFAKYILGKFFALAAVNQKAFVELLFWKNTA
                     VVREMTEGYGSLDDRSSSRRAPTWSPEEEAHLRELYLANKDVEGQDVVEAILAHLNTV
                     PRTRKQIIHHLVQMGLADSVKDFQRKGTHIVLWTGDQELELQRLFEEFRDSDDVLGHI
                     MKNITAKRSRARIVDKLLALGLVAERRELYKKRQKKLASSILPNGAESLKDFCQEDLE
                     EEENLPEEDSEEEEEGGSEAEQVQGSLVLSNENLGQSLHQEGFSIPLLWLQNCLIRAA
                     DDREEDGCSQAVPLVPLTEENEEAMENEQFQQLLRKLGVRPPASGQETFWRIPAKLSP
                     TQLRRAAASLSQPEEEQKLQPELQPKVPGEQGSDEEHCKEHRAQALRALLLAHKKKAG
                     LASPEEEDAVGKEPLKAAPKKRQLLDSDEEQEEDEGRNRAPELGAPGIQKKKRYQIED
                     DEDD"
     exon            276..429
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            430..544
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            545..607
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            608..709
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            710..865
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            866..999
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1000..1087
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1088..1264
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1265..1482
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1483..1586
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1587..1756
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1757..1894
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            1895..2046
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2047..2144
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2145..2268
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2269..2470
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2471..2616
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2617..2702
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2703..2820
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2821..2903
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            2904..3046
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3047..3218
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3219..3287
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3288..3406
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3407..3632
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3633..3734
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     exon            3735..5158
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /inference="alignment:Splign:2.1.0"
     regulatory      4371..4376
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /note="hexamer: ATTAAA"
     polyA_site      4398
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /note="major polyA site"
     regulatory      5130..5135
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
                     /note="hexamer: AGTAAA"
     polyA_site      5158
                     /gene="TIMELESS"
                     /gene_synonym="FASPS4; hTIM; TIM; TIM1"
ORIGIN      
        1 gcctcgctct tcgcgcaggc ggggaccggt ccagctgagc ctggtggcgg aaaggctgcg
       61 gccccgcgcc agagggccgg tggctcctcc gggcttctga ggacccgcag ggagcgggcc
      121 tcatcatttc tgtctcctgt ttctccactt ccttctctgt tggttggtcc actgatgtat
      181 ggacttgcac atgatgaact gtgaacttct agccacatgt agtgcccttg ggtacttgga
      241 gggagacact taccataagg aaccagattg cttagagagc gtgaaggatc tgatccgcta
      301 tttgaggcat gaggatgaga cacgagatgt gcggcagcag ctgggggcag cccagatcct
      361 acagagcgac cttctgccca tcctcaccca gcaccaccag gacaagcctc tctttgatgc
      421 tgttatcaga ctgatggtga acttgacaca accagccttg ctctgttttg gcaatctgcc
      481 taaggagccc agctttcggc accatttttt gcaggtgcta acttatttgc aggcctacaa
      541 agaggccttt gccagtgaga aggcttttgg agtcctcagt gaaaccttgt atgagctgct
      601 gcagctgggc tgggaggaac ggcaggagga agacaacttg ctgattgaac ggatcctact
      661 gctggtcaga aatattctcc atgtcccagc tgaccttgat caggagaaga agattgatga
      721 tgacgccagt gcccatgacc agctcctctg ggcgattcac ctcagcggcc tggatgacct
      781 gctcctcttt ctggccagct cgtctgctga ggagcaatgg agcctacatg tgctagagat
      841 tgtctccctt atgtttcgtg accagaaccc cgagcagctg gcgggagtag ggcagggacg
      901 cttagctcag gagcggagtg cagattttgc agaactggag gtgttgcgcc agcgagagat
      961 ggcagaaaag aagactcgag ccctccagcg aggcaacagg cattctcgat ttgggggctc
     1021 ctatattgtc caggggttga aatccattgg ggagagggac ctcatctttc acaaaggcct
     1081 tcacaaccta cgaaactaca gttcagattt gggaaagcag ccgaaaaagg tgcctaaacg
     1141 tcgccaggcc gcccgagagc tgtccattca gcgccgttct gccctcaatg tgaggctctt
     1201 cctcagagac ttctgctctg agttcctgga gaactgttac aaccggctca tgggatcagt
     1261 aaaggatcac ctgcttcggg agaaagctca gcagcatgat gagacctatt atatgtgggc
     1321 cttggctttc ttcatggcct tcaaccgagc tgcctccttc cggccaggcc tggtttctga
     1381 gaccctcagt gtccgtacct tccacttcat tgagcagaac ctcaccaact actatgagat
     1441 gatgctgact gaccgcaagg aagctgcctc ctgggcacgc cggatgcact tggctctgaa
     1501 ggcctatcag gagctgctgg caacagtgaa tgagatggac atatctccag atgaggctgt
     1561 gagggagagc agccgcatca tcaagaacaa tattttctat gtgatggagt accgagaact
     1621 attcctggca ctttttcgaa agtttgatga gagatgccag ccccgctctt tccttcgtga
     1681 cctggtggag accacccacc tcttcctcaa aatgttggag cgattctgtc ggagccgtgg
     1741 gaacctggtg gtgcagaaca aacaaaagaa gagaaggaag aagaagaaga aggtcctaga
     1801 ccaggccatt gtttctggta atgtcccatc tagcccagaa gaagtggagg ctgtgtggcc
     1861 agccctggct gagcagctac agtgctgtgc ccagaattct gagctcagca tggactccgt
     1921 ggttcccttt gatgcggcct cagaggtgcc agtggaggag cagcgggcag aagctatggt
     1981 acggatccaa gactgtctcc tggctggcca ggccccacag gccctgactc tcctgaggtc
     2041 tgctcgggag gtgtggcctg aaggagatgt gtttggctct caagacattt ctccagagga
     2101 agagatccag ttgctgaaac aaatcctctc tgctccactt ccccggcagc agggcccaga
     2161 ggaacgtggg gcagaggaag aagaagagga ggaggaggag gaagaggagg agttgcaagt
     2221 ggtccaggtg tcggagaaag aatttaattt tctggactac ctgaaacgct ttgcatgttc
     2281 aactgtcgtt cgagcctatg tgctgctact aaggagctac cagcagaata gtgcccacac
     2341 taaccattgc attgtgaaga tgctgcaccg gctggcccat gacctcaaaa tggaagccct
     2401 actttttcag ctgtcagtct tctgcctctt caatcgtctg cttagtgacc ctgctgctgg
     2461 agcctacaaa gagctagtga cttttgccaa atacatcctg ggcaaatttt ttgcactggc
     2521 tgcagtcaac caaaaagcct ttgtggagct gttgttctgg aagaacacag ctgtggttcg
     2581 agagatgact gagggctatg gctccctgga tgacaggtct tccagtcgca gagcacctac
     2641 atggagcccc gaagaagagg ctcatcttcg ggagctgtac ctcgccaata aggacgtgga
     2701 agggcaggat gtggtggaag ccatcttggc ccacctgaat actgttcctc gaacacgcaa
     2761 gcagatcatc caccatctgg tacagatggg actggctgac agtgtcaagg acttccaaag
     2821 gaaaggaacc catattgtac tgtggacggg ggatcaggag ttggagctgc agcggctttt
     2881 tgaggaattc cgggactcag atgatgtcct gggtcatatc atgaagaata tcacagccaa
     2941 acgctcacgg gcccgaatag tggataaact cttggctctg gggctggtgg ctgagcggcg
     3001 ggagctgtac aagaaacggc agaaaaagtt ggcatcctcc atcttgccaa atggagcgga
     3061 gtccctgaaa gatttttgcc aggaagatct ggaagaagag gaaaacctgc ctgaggaaga
     3121 cagcgaagag gaagaagaag ggggctcaga agcagaacaa gtccagggta gcttagtcct
     3181 ttcaaatgaa aaccttggtc aaagcctgca tcaggaaggc ttttctatcc cgctcctatg
     3241 gctccagaac tgcctgatcc gagcagctga tgatcgggaa gaggatggct gctcccaggc
     3301 cgttccattg gtgccactca cagaggaaaa tgaggaagcc atggaaaacg aacagtttca
     3361 gcagctgttg cgcaagctag gggttcggcc ccctgcctct gggcaggaaa ccttctggcg
     3421 aattccagcc aagctgagtc ctacccagct ccggagggca gcagcttctt tgagtcaacc
     3481 agaggaggaa cagaagctgc agccagagct gcagcctaaa gtccctggag agcaaggctc
     3541 tgatgaggag cactgtaaag agcaccgagc acaagccctg agggccctct tgctagccca
     3601 caagaagaaa gcgggcctgg catccccaga ggaggaagac gctgttggta aagagccgct
     3661 gaaggcagca cccaagaaac gacaattgct ggacagcgac gaggaacagg aagaagatga
     3721 gggcaggaac agagcaccag agttgggagc tccaggaatc caaaagaaga aacgatacca
     3781 gattgaggat gatgaggatg actgaagagc taagaagcct aggggtagag atagacacgt
     3841 ttttagatgg tgcattcaag tcagagttgg aagggtcata caggacccag aagctcctct
     3901 tactggacag agcagtagaa tcccaggctc tttcacggat ttaggctgag aaacttcagc
     3961 agcagtattg gacttctctg ctgtcagtct ttgtttctcc cagtttttat cggtatgccc
     4021 cagcagctct ctggagattt agttctcttc ttctaggaac catttctttt ggttattgga
     4081 gctccttagc aaataagagg agtgagtgaa atagagaaag caccccggac cccttttatt
     4141 ggtctgttcc tttggctttc tcttggaggt gggtcgcagc accagatggg gagctttatg
     4201 acatgacagg cgggagtttt gtaccacttt tagaagatac cagatgcctc tgtcctcatt
     4261 ttgtttccta tgatcatcct ctagatacca gatagaggcc cattcctgca tttgagatag
     4321 ggttggaata tagtactcta gatgatgaat gtgtttgctt tgtgtttggt attaaacatg
     4381 taagattaga agttctcatc tcagtctgac ttggcgatat gtctaagttc cccagccctt
     4441 cccctgctgt gctcttgaaa gaagaactta acaattttag ggtaaaaaga gaccaacaga
     4501 ccggcacagt ggctcaaacc tgttgtccta gcactttggg aggctgaggc gggcggatca
     4561 cctgaggtca ggagtttgag accggcctgg acaatatggc gaaatcccat ctccactaaa
     4621 aatacaaaaa ttagccggcc atggtggcat gcgcctgtaa tcccagccac tcgggtggct
     4681 gaggcaggag aattgcctga acccaggagg cagaggttgc agtgagctaa ggtcacgcca
     4741 gtgcatatgc ctgggcgaca gagcaagact ctgtctcaaa aaaaaagaaa aaaaaaaaag
     4801 accaacaacc ttcccttttc ttccgctttc cctacagaag acacagaaaa gcatttttgc
     4861 ctctagatcc ttttgtctag ggtaaattct tagggtgaca agagtatgcg gcaggaagaa
     4921 ggaggagcca taaaggaaga gaagccagct tgttggcatg gggcatagaa aaggacaaaa
     4981 tctaggcatg aaaaggatgg ataaatactg caaatattat gttcttaccc attcttggaa
     5041 acgtcagctt tcttgcttcc tgtgcttcca gccgaggtag ggcaaaggtg agattgagaa
     5101 aatagccatt cagctcagga aggcttctaa gtaaaggatg gatttggatt gccctgtt
//
