LOCUS       NM_173799               2926 bp    mRNA    linear   PRI 11-DEC-2024
DEFINITION  Homo sapiens T cell immunoreceptor with Ig and ITIM domains
            (TIGIT), mRNA.
ACCESSION   NM_173799
VERSION     NM_173799.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2926)
  AUTHORS   Guo,Y., Yang,X., Xia,W.L., Zhu,W.B., Li,F.T., Hu,H.T. and Li,H.L.
  TITLE     Relationship between TIGIT expression on T cells and the prognosis
            of patients with hepatocellular carcinoma
  JOURNAL   BMC Cancer 24 (1), 1120 (2024)
   PUBMED   39251968
  REMARK    GeneRIF: Relationship between TIGIT expression on T cells and the
            prognosis of patients with hepatocellular carcinoma.
            Publication Status: Online-Only
REFERENCE   2  (bases 1 to 2926)
  AUTHORS   Perales,O., Jilaveanu,L., Adeniran,A., Su,D.G., Hurwitz,M.,
            Braun,D.A., Kluger,H.M. and Schoenfeld,D.A.
  TITLE     TIGIT expression in renal cell carcinoma infiltrating T cells is
            variable and inversely correlated with PD-1 and LAG3
  JOURNAL   Cancer Immunol Immunother 73 (10), 192 (2024)
   PUBMED   39105820
  REMARK    GeneRIF: TIGIT expression in renal cell carcinoma infiltrating T
            cells is variable and inversely correlated with PD-1 and LAG3.
            Publication Status: Online-Only
REFERENCE   3  (bases 1 to 2926)
  AUTHORS   Chen,H., Molberg,K., Carrick,K., Niu,S., Rivera Colon,G., Gwin,K.,
            Lewis,C., Lea,J., Panwar,V., Zheng,W., Castrillon,D.H. and Lucas,E.
  TITLE     Expression and Prognostic Significance of LAG-3, TIGIT, VISTA, and
            IDO1 in Endometrial Serous Carcinoma
  JOURNAL   Mod Pathol 37 (8), 100532 (2024)
   PUBMED   38848896
  REMARK    GeneRIF: Expression and Prognostic Significance of LAG-3, TIGIT,
            VISTA, and IDO1 in Endometrial Serous Carcinoma.
REFERENCE   4  (bases 1 to 2926)
  AUTHORS   Miraki Feriz,A., Khosrojerdi,A., Erfanian,N., Azarkar,S.,
            Sajjadi,S.M., Shojaei,M.J., Vaferi,M.J., Safarpour,H. and
            Racanelli,V.
  TITLE     Targeting the dynamic transcriptional landscape of Treg
            subpopulations in pancreatic ductal adenocarcinoma: Insights from
            single-cell RNA sequencing analysis with a focus on CTLA4 and TIGIT
  JOURNAL   Immunobiology 229 (4), 152822 (2024)
   PUBMED   38852289
  REMARK    GeneRIF: Targeting the dynamic transcriptional landscape of Treg
            subpopulations in pancreatic ductal adenocarcinoma: Insights from
            single-cell RNA sequencing analysis with a focus on CTLA4 and
            TIGIT.
REFERENCE   5  (bases 1 to 2926)
  AUTHORS   Edner,N.M., Houghton,L.P., Ntavli,E., Rees-Spear,C., Petersone,L.,
            Wang,C., Fabri,A., Elfaki,Y., Rueda Gonzalez,A., Brown,R.,
            Kisand,K., Peterson,P., McCoy,L.E. and Walker,L.S.K.
  TITLE     TIGIT+Tfh show poor B-helper function and negatively correlate with
            SARS-CoV-2 antibody titre
  JOURNAL   Front Immunol 15, 1395684 (2024)
   PUBMED   38868776
  REMARK    GeneRIF: TIGIT[+]Tfh show poor B-helper function and negatively
            correlate with SARS-CoV-2 antibody titre.
            Publication Status: Online-Only
REFERENCE   6  (bases 1 to 2926)
  AUTHORS   Ramani,S.R., Tom,I., Lewin-Koh,N., Wranik,B., Depalatis,L.,
            Zhang,J., Eaton,D. and Gonzalez,L.C.
  TITLE     A secreted protein microarray platform for extracellular protein
            interaction discovery
  JOURNAL   Anal Biochem 420 (2), 127-138 (2012)
   PUBMED   21982860
REFERENCE   7  (bases 1 to 2926)
  AUTHORS   Levin,S.D., Taft,D.W., Brandt,C.S., Bucher,C., Howard,E.D.,
            Chadwick,E.M., Johnston,J., Hammond,A., Bontadelli,K., Ardourel,D.,
            Hebb,L., Wolf,A., Bukowski,T.R., Rixon,M.W., Kuijper,J.L.,
            Ostrander,C.D., West,J.W., Bilsborough,J., Fox,B., Gao,Z., Xu,W.,
            Ramsdell,F., Blazar,B.R. and Lewis,K.E.
  TITLE     Vstm3 is a member of the CD28 family and an important modulator of
            T-cell function
  JOURNAL   Eur J Immunol 41 (4), 902-915 (2011)
   PUBMED   21416464
  REMARK    GeneRIF: that soluble Vstm3 attenuates T-cell responses in vitro
            and in vivo
REFERENCE   8  (bases 1 to 2926)
  AUTHORS   Stanietsky,N., Simic,H., Arapovic,J., Toporik,A., Levy,O.,
            Novik,A., Levine,Z., Beiman,M., Dassa,L., Achdout,H.,
            Stern-Ginossar,N., Tsukerman,P., Jonjic,S. and Mandelboim,O.
  TITLE     The interaction of TIGIT with PVR and PVRL2 inhibits human NK cell
            cytotoxicity
  JOURNAL   Proc Natl Acad Sci U S A 106 (42), 17858-17863 (2009)
   PUBMED   19815499
  REMARK    GeneRIF: TIGIT counter inhibits the NK-mediated killing of tumor
            cells and protects normal cells from NK-mediated cytotoxicity thus
            providing an 'alternative self' mechanism for MHC class I
            inhibition.
REFERENCE   9  (bases 1 to 2926)
  AUTHORS   Boles,K.S., Vermi,W., Facchetti,F., Fuchs,A., Wilson,T.J.,
            Diacovo,T.G., Cella,M. and Colonna,M.
  TITLE     A novel molecular interaction for the adhesion of follicular CD4 T
            cells to follicular DC
  JOURNAL   Eur J Immunol 39 (3), 695-703 (2009)
   PUBMED   19197944
  REMARK    GeneRIF: a novel immunoreceptor, Washington University Cell
            Adhesion Molecule, which is expressed on human follicular B helper
            T cells, was described.
REFERENCE   10 (bases 1 to 2926)
  AUTHORS   Yu,X., Harden,K., Gonzalez,L.C., Francesco,M., Chiang,E.,
            Irving,B., Tom,I., Ivelja,S., Refino,C.J., Clark,H., Eaton,D. and
            Grogan,J.L.
  TITLE     The surface protein TIGIT suppresses T cell activation by promoting
            the generation of mature immunoregulatory dendritic cells
  JOURNAL   Nat Immunol 10 (1), 48-57 (2009)
   PUBMED   19011627
  REMARK    GeneRIF: TIGIT exerts immunosuppressive effects by binding to
            poliovirus receptor and modulating cytokine production by dendritic
            cells.
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. The reference sequence was derived from
            EU675310.1, BC101289.1, AC093010.7 and BX640915.1.
            
            On Nov 23, 2018 this sequence version replaced NM_173799.3.
            
            Summary: This gene encodes a member of the PVR (poliovirus
            receptor) family of immunoglobin proteins. The product of this gene
            is expressed on several classes of T cells including follicular B
            helper T cells (TFH). The protein has been shown to bind PVR with
            high affinity; this binding is thought to assist interactions
            between TFH and dendritic cells to regulate T cell dependent B cell
            responses.[provided by RefSeq, Sep 2009].
            
            Sequence Note: This RefSeq record was created from transcript and
            genomic sequence data to make the sequence consistent with the
            reference genome assembly. The genomic coordinates used for the
            transcript record were based on transcript alignments.
            
            Publication Note:  This RefSeq record includes a subset of the
            publications that are available for this gene. Please see the Gene
            record to access additional publications.
            
            ##Evidence-Data-START##
            Transcript exon combination :: AK097192.1, BC101288.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000383671.8/ ENSP00000373167.3
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1                 EU675310.1         43-43
            2-1449              BC101289.1         1-1448
            1450-2658           AC093010.7         135927-137135
            2659-2926           BX640915.1         2584-2851
FEATURES             Location/Qualifiers
     source          1..2926
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="3"
                     /map="3q13.31"
     gene            1..2926
                     /gene="TIGIT"
                     /gene_synonym="VSIG9; VSTM3; WUCAM"
                     /note="T cell immunoreceptor with Ig and ITIM domains"
                     /db_xref="GeneID:201633"
                     /db_xref="HGNC:HGNC:26838"
                     /db_xref="MIM:612859"
     exon            1..95
                     /gene="TIGIT"
                     /gene_synonym="VSIG9; VSTM3; WUCAM"
                     /inference="alignment:Splign:2.1.0"
     CDS             35..769
                     /gene="TIGIT"
                     /gene_synonym="VSIG9; VSTM3; WUCAM"
                     /note="V-set and immunoglobulin domain containing 9; V-set
                     and transmembrane domain containing 3; Washington
                     University cell adhesion molecule; V-set and transmembrane
                     domain-containing protein 3; V-set and immunoglobulin
                     domain-containing protein 9; VSIG9, VSTM3"
                     /codon_start=1
                     /product="T-cell immunoreceptor with Ig and ITIM domains
                     precursor"
                     /protein_id="NP_776160.2"
                     /db_xref="CCDS:CCDS2980.1"
                     /db_xref="GeneID:201633"
                     /db_xref="HGNC:HGNC:26838"
                     /db_xref="MIM:612859"
                     /translation="MRWCLLLIWAQGLRQAPLASGMMTGTIETTGNISAEKGGSIILQ
                     CHLSSTTAQVTQVNWEQQDQLLAICNADLGWHISPSFKDRVAPGPGLGLTLQSLTVND
                     TGEYFCIYHTYPDGTYTGRIFLEVLESSVAEHGARFQIPLLGAMAATLVVICTAVIVV
                     VALTRKKKALRIHSVEGDLRRKSAGQEEWSPSAPSPPGSCVQAEAAPAGLCGEQRGED
                     CAELHDYFNVLSYRSLGNCSFFTETG"
     exon            96..425
                     /gene="TIGIT"
                     /gene_synonym="VSIG9; VSTM3; WUCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            426..532
                     /gene="TIGIT"
                     /gene_synonym="VSIG9; VSTM3; WUCAM"
                     /inference="alignment:Splign:2.1.0"
     exon            533..2926
                     /gene="TIGIT"
                     /gene_synonym="VSIG9; VSTM3; WUCAM"
                     /inference="alignment:Splign:2.1.0"
     regulatory      900..905
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIGIT"
                     /gene_synonym="VSIG9; VSTM3; WUCAM"
                     /note="hexamer: AATAAA"
     polyA_site      922
                     /gene="TIGIT"
                     /gene_synonym="VSIG9; VSTM3; WUCAM"
                     /note="major polyA site"
     regulatory      2909..2914
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIGIT"
                     /gene_synonym="VSIG9; VSTM3; WUCAM"
                     /note="hexamer: AATAAA"
     polyA_site      2926
                     /gene="TIGIT"
                     /gene_synonym="VSIG9; VSTM3; WUCAM"
ORIGIN      
        1 acatctgctt cctgtaggcc ctctgggcag aagcatgcgc tggtgtctcc tcctgatctg
       61 ggcccagggg ctgaggcagg ctcccctcgc ctcaggaatg atgacaggca caatagaaac
      121 aacggggaac atttctgcag agaaaggtgg ctctatcatc ttacaatgtc acctctcctc
      181 caccacggca caagtgaccc aggtcaactg ggagcagcag gaccagcttc tggccatttg
      241 taatgctgac ttggggtggc acatctcccc atccttcaag gatcgagtgg ccccaggtcc
      301 cggcctgggc ctcaccctcc agtcgctgac cgtgaacgat acaggggagt acttctgcat
      361 ctatcacacc taccctgatg ggacgtacac tgggagaatc ttcctggagg tcctagaaag
      421 ctcagtggct gagcacggtg ccaggttcca gattccattg cttggagcca tggccgcgac
      481 gctggtggtc atctgcacag cagtcatcgt ggtggtcgcg ttgactagaa agaagaaagc
      541 cctcagaatc cattctgtgg aaggtgacct caggagaaaa tcagctggac aggaggaatg
      601 gagccccagt gctccctcac ccccaggaag ctgtgtccag gcagaagctg cacctgctgg
      661 gctctgtgga gagcagcggg gagaggactg tgccgagctg catgactact tcaatgtcct
      721 gagttacaga agcctgggta actgcagctt cttcacagag actggttagc aaccagaggc
      781 atcttctgga agatacactt ttgtctttgc tattatagat gaatatataa gcagctgtac
      841 tctccatcag tgctgcgtgt gtgtgtgtgt gtgtatgtgt gtgtgtgttc agttgagtga
      901 ataaatgtca tcctcttctc catcttcatt tccttggcct tttcgttcta ttccattttg
      961 cattatggca ggcctagggt gagtaacgtg gatcttgatc ataaatgcaa aattaaaaaa
     1021 tatcttgacc tggttttaaa tctggcagtt tgagcagatc ctatgtctct gagagacaca
     1081 ttcctcataa tggccagcat tttgggctac aaggttttgt ggttgatgat gaggatggca
     1141 tgactgcaga gccatcctca tctcattttt tcacgtcatt ttcagtaact ttcactcatt
     1201 caaaggcagg ttataagtaa gtcctggtag cagcctctat ggggagattt gagagtgact
     1261 aaatcttggt atctgccctc aagaacttac agttaaatgg ggagacaatg ttgtcatgaa
     1321 aaggtattat agtaaggaga gaaggagaca tacacaggcc ttcaggaaga gacgacagtt
     1381 tggggtgagg tagttggcat aggcttatct gtgatgaagt ggcctgggag caccaagggg
     1441 atgttgaggc tagtctggga ggagcaggag ttttgtctag ggaacttgta ggaaattctt
     1501 ggagctgaaa gtcccacaaa gaaggccctg gcaccaaggg agtcagcaaa cttcagattt
     1561 tattctctgg gcaggcattt caagtttcct tttgctgtga catactcatc cattagacag
     1621 cctgatacag gcctgtagcc tcttccggcc gtgtgtgctg gggaagcccc aggaaacgca
     1681 catgcccaca cagggagcca agtcgtagca tttgggcctt gatctacctt ttctgcatca
     1741 atacactctt gagcctttga aaaaagaacg tttcccacta aaaagaaaat gtggattttt
     1801 aaaataggga ctcttcctag gggaaaaagg ggggctggga gtgatagagg gtttaaaaaa
     1861 taaacacctt caaactaact tcttcgaacc cttttattca ctccctgacg actttgtgct
     1921 ggggttgggg taactgaacc gcttatttct gtttaattgc attcaggctg gatcttagaa
     1981 gacttttatc cttccaccat ctctctcaga ggaatgagcg gggaggttgg atttactggt
     2041 gactgatttt ctttcatggg ccaaggaact gaaagagaat gtgaagcaag gttgtgtctt
     2101 gcgcatggtt aaaaataaag cattgtcctg cttcctaaga cttagactgg ggttgacaat
     2161 tgttttagca acaagacaat tcaactattt ctcctaggat ttttattatt attatttttt
     2221 cacttttcta ccaaatgggt tacataggaa gaatgaactg aaatctgtcc agagctccaa
     2281 gtcctttgga agaaagatta gatgaacgta aaaatgttgt tgtttgctgt ggcagtttac
     2341 agcatttttc ttgcaaaatt agtgcaaatc tgttggaaat agaacacaat tcacaaattg
     2401 gaagtgaact aaaatgtaat gacgaaaagg gagtagtgtt ttgatttgga ggaggtgtat
     2461 attcggcaga ggttggactg agagttgggt gttatttaac ataattatgg taattgggaa
     2521 acatttataa acactattgg gatggtgata aaatacaaaa gggcctatag atgttagaaa
     2581 tgggtcaggt tactgaaatg ggattcaatt tgaaaaaaat ttttttaaat agaactcact
     2641 gaactagatt ctcctctgag aaccagagaa gaccatttca tagttggatt cctggagaca
     2701 tgcgctatcc accacgtagc cactttccac atgtggccat caaccactta agatggggtt
     2761 agtttaaatc aagatgtgct gttataattg gtataagcat aaaatcacac tagattctgg
     2821 agatttaata tgaataataa gaatactatt tcagtagttt tggtatattg tgtgtcaaaa
     2881 atgataatat tttggatgta ttgggtgaaa taaaatatta acatta
//
