LOCUS       NM_033208               3421 bp    mRNA    linear   PRI 09-FEB-2024
DEFINITION  Homo sapiens tigger transposable element derived 7 (TIGD7), mRNA.
ACCESSION   NM_033208
VERSION     NM_033208.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3421)
  AUTHORS   Dou,T., Gu,S., Zhou,Z., Ji,C., Zeng,L., Ye,X., Xu,J., Ying,K.,
            Xie,Y. and Mao,Y.
  TITLE     Isolation and characterization of a Jerky and JRK/JH8 like gene,
            tigger transposable element derived 7, TIGD7
  JOURNAL   Biochem Genet 42 (7-8), 279-285 (2004)
   PUBMED   15487591
  REMARK    GeneRIF: TIGD7 is a Jerky and JRK/JH8 like gene
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Hugh Robertson. The reference sequence was
            derived from DC351858.1, BX463753.2, AC004232.1, AK308054.1 and
            AI925903.1.
            
            On Nov 22, 2018 this sequence version replaced NM_033208.3.
            
            Summary: The protein encoded by this gene belongs to the tigger
            subfamily of the pogo superfamily of DNA-mediated transposons in
            humans. These proteins are related to DNA transposons found in
            fungi and nematodes, and more distantly to the Tc1 and mariner
            transposases. They are also very similar to the major mammalian
            centromere protein B. The exact function of this gene is not known.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803617.218593.1,
                                           SRR1660803.245381.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA2146411, SAMEA2157437
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000396862.2/ ENSP00000380071.1
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-13                DC351858.1         10-22
            14-166              BX463753.2         1-153
            167-167             AC004232.1         34134-34134         c
            168-850             BX463753.2         155-837
            851-1542            AK308054.1         1-692
            1543-1543           AC004232.1         29556-29556         c
            1544-1813           AK308054.1         693-962
            1814-1814           AC004232.1         29285-29285         c
            1815-3395           AK308054.1         964-2544
            3396-3421           AI925903.1         6-31                c
FEATURES             Location/Qualifiers
     source          1..3421
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="16"
                     /map="16p13.3"
     gene            1..3421
                     /gene="TIGD7"
                     /gene_synonym="Sancho"
                     /note="tigger transposable element derived 7"
                     /db_xref="GeneID:91151"
                     /db_xref="HGNC:HGNC:18331"
                     /db_xref="MIM:612969"
     exon            1..219
                     /gene="TIGD7"
                     /gene_synonym="Sancho"
                     /inference="alignment:Splign:2.1.0"
     exon            220..3421
                     /gene="TIGD7"
                     /gene_synonym="Sancho"
                     /inference="alignment:Splign:2.1.0"
     CDS             1615..3264
                     /gene="TIGD7"
                     /gene_synonym="Sancho"
                     /codon_start=1
                     /product="tigger transposable element-derived protein 7"
                     /protein_id="NP_149985.2"
                     /db_xref="CCDS:CCDS10500.1"
                     /db_xref="GeneID:91151"
                     /db_xref="HGNC:HGNC:18331"
                     /db_xref="MIM:612969"
                     /translation="MNKRGKYTTLNLEEKMKVLSRIEAGRSLKSVMDEFGISKSTFYD
                     IKKNKKLILDFVLKQDMPLVGAEKRKRTTGAKYGDVDDAVYMWYQQKRSAGVPVRGVE
                     LQAAAERFARCFGRTDFKASTGWLFRFRNRHAIGNRKGCGEQVLSSVSENVEPFRQKL
                     SMIIKEEKLCLAQLYSGDETDLFWKSMPENSQASRKDICLPGKKINKERLSAFLCANA
                     DGTHKLKSIIIGKSKLPKSVKEDTSTLPVIYKPSKDVWFTRELFSEWFFQNFVPEVRH
                     FQLNVLRFHDEDVRALLLLDSCPAHPSSESLTSEDGRIKCMFFPHNTSTLIQPMNQGV
                     ILSCKRLYRWKQLEESLVIFEESDDEQEKGDKGVSKIKIYNIKSAIFNWAKSWEEVKQ
                     ITIANAWENLLYKKEPEYDFQGLEHGDYREILEKCGELETKLDDDRVWLNGDEEKGCL
                     LKTKGGITKEVVQKGGEAEKQTAEFKLSAVRESLDYLLDFVDATPEFQRFHFTLKEMQ
                     QEIVKKQFQSKIHSRIGSFLKPRPHNIKDSFSGPSTSGSNH"
     regulatory      3373..3378
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIGD7"
                     /gene_synonym="Sancho"
                     /note="hexamer: TATAAA"
     regulatory      3396..3401
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIGD7"
                     /gene_synonym="Sancho"
                     /note="hexamer: AATACA"
     polyA_site      3397
                     /gene="TIGD7"
                     /gene_synonym="Sancho"
                     /note="major polyA site"
     polyA_site      3421
                     /gene="TIGD7"
                     /gene_synonym="Sancho"
ORIGIN      
        1 gagcccggcc tacttcctcg ccagagaaac tgctgtcttc cccggcggta gggaagggtt
       61 aatgccaccg agtatccaga cccgctgaag cctagagggc cttgtaccgg ctcaccgcgt
      121 ggctgtcgct gtctcgtgtc cccagtgggg gaggcgtcgc actgccgcgt ctgttctgcg
      181 tggctgtcgg gcggcgtttg gtcccgggag cctcgccggc acctggaatg gataaaagtg
      241 gcagtttttg tttcttccca tgaggttgtg tatctggact gagaaccagg aaattaatct
      301 agactaagac atttctaagg acctggaatg gctttgggga gcaccaggag gacccgaaaa
      361 gagtatttga gggcctagag ggacagaaga gtttgccagt aggatttatg agaaacaatt
      421 gatcagaaac agcagcagag aaacctttta gatttcttct gtggaaaagt tgagtcttgg
      481 ttcaaattaa gtaaaataaa cactgaagag aaatcaaaat ctcaaatata aaaagtatgt
      541 tacttatagt gtaaatttag gaaaacaaat gaaaggacag atctttaaaa atttttaact
      601 atggtgaaat atttgtaaaa cttttgggct catctctgag aattgctgtg attctgaaac
      661 ttgataatat ctcaaataga gaacagtttc agtgaaaaat agcacttgag aataaatcag
      721 atgttcccaa gaaagaagat ctgagaatgg taaagtgcca ctgacaaata aattatttac
      781 atacttacat attaccttgg caaacacaag agacattcaa gttaaagcac ggtgcttgac
      841 aatactatat tgaatgcaat aaaagttgga tttcattcat atgtacaaca aactactttc
      901 ttcttcactt caagattcgg tacaactgtt cctgaattcc aactctccat acatcccaat
      961 gtcagggtcc ctgtagctcg gagcccttat ccaggtagat gaactgctgc ccagtgaaca
     1021 ctatgtacaa agcaatttga gcaccattct cttttctggc agtgaggtaa aatcaggtct
     1081 ttttggaagg ggagaagcca cattgcatct ctgctacaca caagattact ctgtcattgc
     1141 ctttgagtct ttcacgctcc cttcttctga agcatcagtt tttatggaaa cttatcacac
     1201 ctgtcttgtg ggcacatctt gctccatccc tcctctcttc atattgtccg ttttccggta
     1261 ttgagttagg gaaagtatgc aggtattcct gtcattcctg actgaggctg ttgtatctgt
     1321 caaaagagag gagaggtagg gggcattctg aaaaatgatc actcatggct tgcaggagca
     1381 agagccagac aggactttgc aactggcagc tttctgagtg cataagacct ccacctctag
     1441 actagctctt cagtcatggt tagccccttc agtccattat cctccaatac aatgcccatg
     1501 ccttctgggg ctttcagcta agttttgttt aaaaaatgtg ggtttttttt ttgccaattc
     1561 attaaggctt ttccctttgt tttctcctgt tggtggttca gagttaaatt cagtatgaat
     1621 aagagaggga aatatacaac actgaatttg gaggagaaaa tgaaggttct aagtagaatt
     1681 gaagctggac gatcacttaa aagtgtaatg gatgaatttg gaatcagtaa gtcaacattt
     1741 tatgacatta aaaaaaataa gaagttaatt ctggactttg tactgaagca ggacatgcca
     1801 ttagtagggg ctgagaagag aaagaggaca acgggagcca aatatggtga tgtagatgat
     1861 gcggtctaca tgtggtacca acagaaacgc tcagccggtg ttccggtaag aggcgtggag
     1921 cttcaggctg ctgcagagag atttgcacgg tgttttgggc gaacagattt caaagctagc
     1981 actggttggc tttttagatt tcgaaatcgg catgcaattg ggaaccgaaa aggatgtggg
     2041 gaacaagtcc taagttcagt ttctgaaaat gttgagccat ttcgacaaaa actgtccatg
     2101 ataatcaaag aggagaaact gtgtctagct cagctataca gtggggatga aacagacctc
     2161 ttttggaagt caatgccaga aaattctcag gcaagtagga aagatatctg cctaccaggg
     2221 aagaaaataa acaaagaaag gttgtctgcc tttttatgtg caaatgcaga cggaactcat
     2281 aaattaaagt caatcattat tggaaaatca aaactgccca aaagtgtgaa agaggacaca
     2341 agtacattgc ctgtgatata taaacccagt aaagatgttt ggttcaccag agaattgttt
     2401 tcagaatggt tttttcaaaa ctttgttcct gaggtccgac attttcaact taatgttcta
     2461 agatttcatg acgaggacgt cagggcattg ttacttctgg acagttgccc ggctcatcct
     2521 tcctctgaat ccctaaccag tgaggatggt cgaataaaat gtatgttctt cccccataac
     2581 acttcaacct tgattcaacc aatgaatcaa ggtgtgatct tgagctgcaa acggctgtat
     2641 agatggaagc aacttgaaga gagtcttgta atatttgaag aaagtgatga tgagcaagag
     2701 aaaggagata aaggagtttc caaaattaaa atctacaata taaaaagtgc aatttttaac
     2761 tgggcaaaaa gttgggaaga agtaaaacaa ataaccatag caaatgcatg ggaaaatctt
     2821 ctttacaaaa aggaacctga atatgatttt caaggcttag aacatgggga ttatagagaa
     2881 attcttgaaa aatgtgggga gttggaaact aagttggatg atgatagggt gtggttaaat
     2941 ggagatgaag aaaagggttg tctcctaaaa accaaaggtg gaataacaaa ggaagttgtt
     3001 caaaaaggag gagaagctga gaagcagact gctgaattta aattatctgc tgtaagagag
     3061 agtttggact accttcttga ctttgttgat gccacacctg agtttcagag attccacttc
     3121 acactgaaag agatgcaaca agaaatagtc aagaaacagt tccagagtaa aatccattct
     3181 agaattggta gctttttgaa acctaggcct cataatatta aggactcctt cagtgggcct
     3241 tcaacttctg gttctaatca ttagattttg tgtttaaaga tttctgccat tatatgatgt
     3301 aggccagctg tgaattgtct tgttttagca actgacatta ttttgtatat cagtgcccat
     3361 ttatataatg gttataaaat ttacagtttg aaaataatac atttgtgttt ctttaaattt
     3421 a
//
