LOCUS       NM_030953               3493 bp    mRNA    linear   PRI 08-JUN-2024
DEFINITION  Homo sapiens tigger transposable element derived 6 (TIGD6),
            transcript variant 1, mRNA.
ACCESSION   NM_030953
VERSION     NM_030953.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3493)
  AUTHORS   Simpson,J.C., Wellenreuther,R., Poustka,A., Pepperkok,R. and
            Wiemann,S.
  TITLE     Systematic subcellular localization of novel proteins identified by
            large-scale cDNA sequencing
  JOURNAL   EMBO Rep 1 (3), 287-292 (2000)
   PUBMED   11256614
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Hugh Robertson. The reference sequence was
            derived from AK096325.1, AL136539.1 and AC011406.5.
            
            On Nov 22, 2018 this sequence version replaced NM_030953.3.
            
            Summary: The protein encoded by this gene belongs to the tigger
            subfamily of the pogo superfamily of DNA-mediated transposons in
            humans. These proteins are related to DNA transposons found in
            fungi and nematodes, and more distantly to the Tc1 and mariner
            transposases. They are also very similar to the major mammalian
            centromere protein B. [provided by RefSeq, Oct 2009].
            
            Transcript Variant: This variant (1) represents the allele encoded
            by the GRCh38 reference genome and encodes isoform (1). Variants 1
            and 2 encode the same protein.
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR1803616.240962.1, AL136539.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1968540, SAMEA2155751
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000296736.4/ ENSP00000296736.3
            RefSeq Select criteria :: based on expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: full length.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-1897              AK096325.1         514-2410
            1898-3030           AL136539.1         1822-2954
            3031-3488           AL136539.1         2956-3413
            3489-3493           AC011406.5         59702-59706
FEATURES             Location/Qualifiers
     source          1..3493
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="5"
                     /map="5q32"
     gene            1..3493
                     /gene="TIGD6"
                     /note="tigger transposable element derived 6"
                     /db_xref="GeneID:81789"
                     /db_xref="HGNC:HGNC:18332"
     exon            1..181
                     /gene="TIGD6"
                     /inference="alignment:Splign:2.1.0"
     exon            182..3493
                     /gene="TIGD6"
                     /inference="alignment:Splign:2.1.0"
     CDS             263..1828
                     /gene="TIGD6"
                     /note="isoform 1 is encoded by transcript variant 1;
                     tigger transposable element-derived protein 6"
                     /codon_start=1
                     /product="tigger transposable element-derived protein 6
                     isoform 1"
                     /protein_id="NP_112215.1"
                     /db_xref="CCDS:CCDS4301.1"
                     /db_xref="GeneID:81789"
                     /db_xref="HGNC:HGNC:18332"
                     /translation="MANKGNKKRRQFSLEEKMKVVGAVDSGKRKGDVAKEFGITPSTL
                     STFLKDRTKFEEKVREASVGPQRKRMRSALYDDIDKAVFAWFQEIHAKNILVTGSVIR
                     KKALNLANMLGYDNFQASVGWLNRFRDRHGIALKAVCREDSDRLMNGLGIDKINEWHA
                     GEIIKLIADYSPDDIFNADETGVFFQLLPQHTLAAKGDHCRGGKKAKQRLTALFCCNA
                     SGTEKMRPLIVGRSASPHCLKNIHSLPCDYRANQWAWMTRDLFNEWLMQVDARMKRAE
                     RRILLLIDNCSAHNMLPHLERIQVGYLPSNCTAVLQPLNLGIIHTMKVLYQSHLLKQI
                     LLKLNSSEDQEEVDIKQAIDMIAAAWWSVKPSTVVKCWQKAGIVPMEFAECDTESAAS
                     EPDIAIEKLWHTVAIATCVPNEVNFQDFVTADDDLIISQDTDIIQDMVAGENTSEAGS
                     EDEGEVSLPEQPKVTITEAISSVQKLRQFLSTCVDIPDAIFGQLNGIDEYLMKRVTQT
                     LIDSKITDFLQTK"
     regulatory      1864..1869
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIGD6"
                     /note="hexamer: AATAAA"
     polyA_site      1897
                     /gene="TIGD6"
                     /note="major polyA site"
     polyA_site      1969
                     /gene="TIGD6"
                     /note="major polyA site"
     regulatory      2498..2503
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIGD6"
                     /note="hexamer: AATAAA"
     polyA_site      2519
                     /gene="TIGD6"
     regulatory      3464..3469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIGD6"
                     /note="hexamer: AATAAA"
     polyA_site      3493
                     /gene="TIGD6"
ORIGIN      
        1 gcaacagccc agccctagct tgggagcgga cccacacgaa ctgctcaaag gcttggagcg
       61 ggtctagtaa ggcgaacgga ctgcttccgg ccagaggtcc cgggcggagg aggaagctgt
      121 ggctgccggc ggtgggacgc cccggccgct cagcccccgg gcactgctgt ggggcgttca
      181 gctttccaca cttggggcaa agcaagccgc gaggaggaac cagacagtcc tgttagttgt
      241 ggccagccct cattccctgg aaatggcaaa caaggggaac aagaagcgtc ggcagttctc
      301 tctggaggag aaaatgaaag ttgtgggagc tgtagactca ggcaagagga aaggtgatgt
      361 ggcaaaagaa tttggtatca ctccctctac tttatctaca ttcttaaagg atcgcaccaa
      421 atttgaagaa aaggtgcggg aggcatccgt gggaccccag cggaaaagga tgaggagcgc
      481 tctttatgat gacattgata aggctgtttt tgcttggttt caagaaatcc atgccaaaaa
      541 cattcttgtg actggttctg tcattcggaa aaaagcacta aacttggcca acatgcttgg
      601 ctatgacaat tttcaagcaa gtgtgggctg gctgaacaga tttagagatc gccacggaat
      661 tgctttgaaa gcagtctgta gagaagatag tgacaggtta atgaatggtc taggaataga
      721 taagattaat gagtggcatg caggggaaat tataaaactg attgctgact acagcccaga
      781 tgatatcttt aatgctgatg agacaggagt gtttttccag ttgcttcccc agcacacact
      841 tgctgctaaa ggagaccact gtagaggggg caagaaagca aagcagcggt tgacagcact
      901 cttttgttgc aatgcctcgg ggactgaaaa aatgagacca ttgattgttg gtaggtcagc
      961 cagcccacac tgcctcaaga acattcattc cctcccttgt gattaccgag ccaaccagtg
     1021 ggcttggatg acaagggatc tgtttaatga gtggctgatg caagtggatg ccaggatgaa
     1081 gagggcggaa cgccggatcc tcttgctcat agacaactgc tctgctcata acatgcttcc
     1141 acacttggaa aggattcagg ttgggtatct gccctccaac tgtactgctg tcctgcagcc
     1201 actgaatctt ggcataattc acaccatgaa agtactgtac cagagccacc ttctaaaaca
     1261 gatcctcctc aagctcaaca gcagtgagga tcaagaagag gtggacatca agcaggccat
     1321 cgacatgatt gctgcagcgt ggtggtcagt caagccatcc acagtggtga aatgttggca
     1381 gaaggcaggc atcgtcccta tggaatttgc agaatgtgac acagaatcag cagccagtga
     1441 accagacatt gccattgaaa agttgtggca cacagtggct attgccacct gtgtcccaaa
     1501 tgaagtaaat ttccaggact ttgttactgc agatgatgat ctcattatct ctcaggacac
     1561 agacatcatc caggacatgg tggctggcga aaataccagt gaagcaggaa gtgaagatga
     1621 aggggaggta tctttaccag agcaaccaaa agtcaccatc acagaagcca tatcaagtgt
     1681 acagaaactt agacagttcc tttccacttg tgtagacatt cctgatgcca tttttggaca
     1741 attaaatggc atagatgaat atttaatgaa aagagtgaca caaaccctta ttgattccaa
     1801 aattacagat ttcctccaaa caaaataatg caggaattta tttcagaaaa tgtagtttac
     1861 aagaataaag atttctttag ataggttgtt gagccaattt aagtaaagca atgttattgt
     1921 gacaacattc cagtactctg aaatagccag gaaacttctt tgaatggaat ttgactaata
     1981 tgtgtgtttt cttttctttt gtttttggct gtctctggtc cttgattcaa gatgtatttt
     2041 gattcatcca agggtttcca aacttgtctg caaattagga tcacttgaga atcctttaaa
     2101 aattccaaag ctcaggccat atcccaggcc tattaaatca caatctttgg tgacgggtca
     2161 caggcattgg tagttttgaa gctctccagg tgattccaat gtgcagacaa atttgaaaac
     2221 tgaaccaacc acaggaacat caagtacact gtgggcctgg gtccagcttc tttccagtaa
     2281 gtgtatctca ggggcttcca aatttagctt acatcagaat cacttggaag gcttgttaaa
     2341 acccaaggct gctaggccca cccccagagt ttgatacagt agacctcagg tgggacccaa
     2401 aaatttgcat ttctaacaca ttctcagctg atgcagtcca ggctccatgc tttgaaaacc
     2461 actggtctag ctttagatag gatattgagc caatttaaat aaagcaatat actggtctag
     2521 ctgagttcta gaacttctct ctttagctgg ccatctgaat actcccccat cactaattgt
     2581 taaaaaaaga atcaactgtt cttactctag agctcttttt tcctttctgc tgatttgctg
     2641 gaagcactac aagacttctg tttgttcgtt cgtttgtttg tttgtttgtt tttaaagatg
     2701 gggtcttgtt atattgccta ggctggaatg cagtggttat tcacaggcat gattataaca
     2761 cactactctc tctaactcct ggcctcaagc catcctccca aatagatggg actactgatg
     2821 cacactgcca tgctggcctt acgaaatgtt ttaataggca tttcactaat agggatctgg
     2881 agtacaagga aatacagtgc atttaagaca taggctgggc atggtggctc atgcctgtaa
     2941 tcccagcaca ttgggaagat cacttgaggc aaggagtttg agaccagact ggccaacaca
     3001 gcgagacccc catctctaaa aaaaaaaaaa ttaataagac atggatacaa ccagggaggg
     3061 aggttataat aatagagcat cctgttaatc agaatcatgg gggagaacat acagcccagc
     3121 gtgcctctca ctttccagaa agggtgagag gatcattaga gagttcatta gagagtattt
     3181 attcctaata agtcagataa atgtcagttt catttttaga agtttcacac aatacctgct
     3241 aatggtgtga tgtcattttt ccccctgctt caggttaatt ttttggatat ttcagaaacc
     3301 catagcaatt cagtgatttt tctttttgta gtagctcagt caaaacaggt aacagcagat
     3361 taatcataga aaatgttgct tccacattaa caaaacaatc actgaaaaac agcagatgtt
     3421 taaatagatt attttatagc ttattttgga tattttttct tttaataaac taatatgatc
     3481 atttgaatta aaa
//
