LOCUS       NM_032862               5394 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens tigger transposable element derived 5 (TIGD5), mRNA.
ACCESSION   NM_032862
VERSION     NM_032862.5
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 5394)
  AUTHORS   Dai,Y., Kawaguchi,T., Nishio,M., Otani,J., Tashiro,H., Terai,Y.,
            Sasaki,R., Maehama,T. and Suzuki,A.
  TITLE     The TIGD5 gene located in 8q24 and frequently amplified in ovarian
            cancers is a tumor suppressor
  JOURNAL   Genes Cells 27 (11), 633-642 (2022)
   PUBMED   36054307
  REMARK    GeneRIF: The TIGD5 gene located in 8q24 and frequently amplified in
            ovarian cancers is a tumor suppressor.
REFERENCE   2  (bases 1 to 5394)
  AUTHORS   Xie,X., Li,L., Wu,H., Hou,F., Chen,Y., Xue,Q., Zhou,Y., Zhang,J.,
            Gong,J. and Song,R.
  TITLE     Comprehensive Integrative Analyses Identify TIGD5 rs75547282 as a
            Risk Variant for Autism Spectrum Disorder
  JOURNAL   Autism Res 14 (4), 631-644 (2021)
   PUBMED   33393181
  REMARK    GeneRIF: Comprehensive Integrative Analyses Identify TIGD5
            rs75547282 as a Risk Variant for Autism Spectrum Disorder.
REFERENCE   3  (bases 1 to 5394)
  AUTHORS   Haenig,C., Atias,N., Taylor,A.K., Mazza,A., Schaefer,M.H., Russ,J.,
            Riechers,S.P., Jain,S., Coughlin,M., Fontaine,J.F., Freibaum,B.D.,
            Brusendorf,L., Zenkner,M., Porras,P., Stroedicke,M., Schnoegl,S.,
            Arnsburg,K., Boeddrich,A., Pigazzini,L., Heutink,P., Taylor,J.P.,
            Kirstein,J., Andrade-Navarro,M.A., Sharan,R. and Wanker,E.E.
  TITLE     Interactome Mapping Provides a Network of Neurodegenerative Disease
            Proteins and Uncovers Widespread Protein Aggregation in Affected
            Brains
  JOURNAL   Cell Rep 32 (7), 108050 (2020)
   PUBMED   32814053
COMMENT     VALIDATED REFSEQ: This record has undergone validation or
            preliminary review. This record has been curated by NCBI staff in
            collaboration with Hugh Robertson. The reference sequence was
            derived from AC067930.7.
            
            On May 17, 2019 this sequence version replaced NM_032862.4.
            
            Summary: The protein encoded by this gene belongs to the tigger
            subfamily of the pogo superfamily of DNA-mediated transposons in
            humans. These proteins are related to DNA transposons found in
            fungi and nematodes, and more distantly to the Tc1 and mariner
            transposases. They are also very similar to the major mammalian
            centromere protein B. The exact function of this gene is not known.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript is intronless :: AK223583.1 [ECO:0000345]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000504548.4/ ENSP00000421489.2
            RefSeq Select criteria :: based on single protein-coding transcript
            ##RefSeq-Attributes-END##
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-5394              AC067930.7         135996-141389
FEATURES             Location/Qualifiers
     source          1..5394
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="8"
                     /map="8q24.3"
     gene            1..5394
                     /gene="TIGD5"
                     /note="tigger transposable element derived 5"
                     /db_xref="GeneID:84948"
                     /db_xref="HGNC:HGNC:18336"
     exon            1..5394
                     /gene="TIGD5"
                     /inference="alignment:Splign:2.1.0"
     CDS             74..2002
                     /gene="TIGD5"
                     /codon_start=1
                     /product="tigger transposable element-derived protein 5"
                     /protein_id="NP_116251.4"
                     /db_xref="CCDS:CCDS6406.2"
                     /db_xref="GeneID:84948"
                     /db_xref="HGNC:HGNC:18336"
                     /translation="MYPAGPPAGPVPRRGRRPLPGPPAPAPAPVPAARPPPPAPGPRP
                     RVAVKMAFRKAYSIKDKLQAIERVKGGERQASVCRDFGVPGGTLRGWLKDEPKLRWFL
                     EQLGGEVGTQRKKMRLANEEEIDRAVYAWFLALRQHGVPLSGPLIQAQAEAFARQIYG
                     PECTFKASHGWFWRWQKRHGISSQRFYGEAGPPAPSPAPGPPVKEEPALPSGAGPLPD
                     RAPAPPPPAEGGYGDEQIYSASVTGLYWKLLPEQAAPPGAGDPGAGGCGRRWRGDRVT
                     VLLAANLTGSHKLKPLVIGRLPDPPSLRHHNQDKFPASYRYSPDAWLSRPLLRGWFFE
                     EFVPGVKRYLRRSCLQQKAVLLVAHPPCPSPAASMPALDSEDAPVRCRPEPLGPPEEL
                     QTPDGAVRVLFLSKGSSRAHIPAPLEQGVVAAFKQLYKRELLRLAVSCASGSPLDFMR
                     SFMLKDMLYLAGLSWDLVQAGSIERCWLLGLRAAFEPRPGEDSAGQPAQAEEAAEHSR
                     VLSDLTHLAALAYKCLAPEEVAEWLHLDDDGGPPEGCREEVGPALPPAAPPAPASLPS
                     AMGGGEDEEEATDYGGTSVPTAGEAVRGLETALRWLENQDPREVGPLRLVQLRSLISM
                     ARRLGGIGHTPAGPYDGV"
     regulatory      2464..2469
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIGD5"
                     /note="hexamer: ATTAAA"
     polyA_site      2485
                     /gene="TIGD5"
                     /note="major polyA site"
     regulatory      5363..5368
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIGD5"
                     /note="hexamer: AATAAA"
     polyA_site      5394
                     /gene="TIGD5"
ORIGIN      
        1 gagtgccccg ccccgagcgg ctgggcgtgt ggctcccgcg acccgcgcgg cccgggtccc
       61 ccccgccgca gccatgtacc ccgcgggccc cccggccggc ccggtaccgc gccgcggccg
      121 ccgtcccctg cccgggcccc ccgcgcccgc cccagccccc gtccccgctg cacggccgcc
      181 gccccccgcg cccgggccgc ggccccgcgt ggccgtgaag atggccttcc gcaaggccta
      241 ctccatcaag gacaagctgc aggccatcga gcgcgtcaag ggcggcgagc ggcaggccag
      301 tgtgtgccgc gacttcggcg tgccgggcgg gacgctgcgc ggctggctca aggacgagcc
      361 caagctgcgc tggttcctgg agcagctggg cggtgaggtg ggcactcagc gcaagaagat
      421 gcggctggcc aacgaggagg agatcgaccg cgccgtgtac gcctggttcc tggcgctgcg
      481 ccagcacggg gtgccgctgt ctggcccgct catccaggcg caggccgagg ccttcgcgcg
      541 ccagatctac gggcccgagt gcaccttcaa ggccagccac ggctggttct ggcgctggca
      601 gaagcgccac ggcatctcca gccagcgctt ctacggcgag gccgggcccc cagccccgag
      661 ccccgcgccc ggcccgcccg tcaaggagga gcccgcgctg ccctccggcg ccggccccct
      721 gcccgaccgc gccccggccc cgccgccccc ggccgagggc ggctacgggg acgagcagat
      781 ttacagcgcc agcgtcaccg gcctctactg gaagctgctt ccggagcagg ctgcgccccc
      841 gggcgcaggg gaccccgggg cggggggctg tggccggcgc tggcggggcg accgcgtaac
      901 ggtgctgctg gccgcaaacc tgaccggcag ccacaagctg aagccgctgg tcatcgggcg
      961 gctgccggac ccgcccagcc tgcgccacca caaccaggac aagttcccgg cctcctaccg
     1021 ctacagcccc gacgcctggc tcagccgccc gctgctgcgg ggctggttct ttgaggaatt
     1081 tgtcccaggc gtcaaacgct acctgcgccg aagctgcctg cagcagaagg ccgtgctgct
     1141 ggtggcccac ccgccctgcc caagcccagc tgccagtatg cccgccctgg acagcgagga
     1201 tgcccccgtg cggtgcaggc cggagcccct cggtcccccg gaggagctgc agacaccgga
     1261 tggcgctgtg cgggtgctgt tcctgtccaa aggcagcagc cgggcacata tccccgcacc
     1321 gctggagcag ggcgtggtgg ccgccttcaa acagctgtac aagcgcgagc tgctgcgact
     1381 ggctgtgtcc tgcgccagcg gctccccgct ggacttcatg cgcagcttca tgctcaagga
     1441 catgctctac ctggctggcc tctcctggga cctggtgcag gcgggcagca ttgagcgctg
     1501 ctggctgctg ggcctgcggg ctgccttcga gccccggccc ggcgaggaca gtgctgggca
     1561 gccggcccag gccgaggaag ccgccgagca cagcagggtg ctcagcgacc tcacccacct
     1621 ggcggctctg gcctacaagt gcctggctcc ggaggaggtt gcggagtggc tgcacctgga
     1681 cgatgatggg ggtccgcccg agggctgcag ggaggaggtg ggcccagccc tgccccctgc
     1741 agcgcctccg gccccagcca gtctgccctc tgccatgggg ggcggagagg acgaggagga
     1801 ggccaccgac tatggaggga cctcagtgcc gactgccggg gaggccgtgc gggggctaga
     1861 aacagctctg cggtggctgg agaaccagga ccccagagag gtggggccac tgaggctggt
     1921 gcagttgcgc tcactcatca gcatggcccg gaggctgggg ggcatcgggc ataccccagc
     1981 aggcccctat gacggtgtgt gaccaggcca gcccagtgac ctttctcctg ctgcacttgg
     2041 agggagggga catacacaca gtctcccatc tctcctcccc tccccctggg gtggcccacc
     2101 gcatgggtac agggggttcc aggaatccaa atccagcatg gcttggagga gctctgttgg
     2161 tgagaggtcg ccctgcctca ctggcaccct gggggcacag ctggaagaga ggcctggccc
     2221 atgctcctct cagggcaggc acatgtacgg ggcatacaag gcacagcgcc tgttggaaca
     2281 ggtggctgtg ttcctgctct ggcccccgtg gggctgggcc tccgcccctg caccagtcac
     2341 atgcactgga cgagggccga aactcctgtc tgctatcgag ccctggtgct atgtggcccc
     2401 ggagccacag cacaatcatc tcagtggcga agcacaccac ttgattctat ttttttttaa
     2461 cacattaaat ctgtttttaa agatactctt cagaggggcc gtgagaacag gggccgggtg
     2521 ggctggtctc gggccgccct gcggtttctc tggaggtcag aggccccagg tactggagca
     2581 tcactgtgga gtgggagggg tggagccctg tattaggttc tgggtgcagc agggaggtgt
     2641 agagttccgt ttccttggat ttttagtttt ccctaagaaa actgaacaga tctcttattc
     2701 cgtgggattg gcagctgcct ggctttgggc cctggtgact tggccaacgg caggagagtt
     2761 tcccctgctt cctcatcagc cacagaccat tctgtccagt cccagggcct ggagccacct
     2821 gacttacctg gaagcaggcc ctggcattag cccccagggc aatacgcagt gccaccctct
     2881 gtgggctctc ctccccaccc tcagactttt ctgcctctcc tgggactgcc aaggatgtgg
     2941 ctgacaagct gctcctggga ggcctacttt gaaaggagga aagggcccca gggcctgtca
     3001 aaccctggtt ctgttctgct ctggccaggt ctagacctac agtccttctg gttggactgg
     3061 ggccagggat gcccatgcct cctcaggtag ggtgggaact gcctttgcag agatgctgcc
     3121 cgagctggtg tgaggggcag ggagctggcc tgcttgcctc caggtgttga cccctcgtcc
     3181 ccatctgccc ccagtgtcct cctaggagag ggaaccttga aaacccagag ttgtggagtg
     3241 caggggtagg ctggaggcct gcacggggaa gggaagggct gtgcaccagc ttggcagtgg
     3301 ggcagctgga gggtgtcccc caaaagtgac ctttatacag gtccaggaac aaacagttcc
     3361 ttggaactgc ccgcaagtga agaaatatat acatatatat gtatatatct atatctcaaa
     3421 atctgagagc tcagggaggc cgtggaaatt tggggaagaa gaaacagact ccctgagcag
     3481 agctcagggc agcagctcca ggcatgcctg ctgagcccat caggccaccg ccacctgcag
     3541 gaagagcctc tggcctgaac tgctggggat gggctgcaga aagcctgaga catttgggcc
     3601 agcaccttcc caggggcaca ggcccccaag gcggggacac cacctctgct ctgccaggcc
     3661 tgcctccagg gctctgagga gaagctgact tcacggccgc ggtgccagtg agggctgcat
     3721 agccaggcct tgtctgtagt ctgggcggcc cgtggcgctg cccttcagcc caactactca
     3781 ttgccgctgc gtctttggcg aggctttcat ttccaacctt tcttcccatc tcagcccttt
     3841 tgttggcccg ggtcccagga ggctggtgtc ggtgagggca ggcccgctcc tctcatcggg
     3901 gtggctgtgg cctgtccccc agtccctcaa tggccacttt ctataaacaa ggcagcacta
     3961 atttttgcta taagataaaa gaggccaggc acgttggctc acacctgtca tcccagcact
     4021 ttgggaggct gaggcgggtg gatcacctga gattgggagt tcgagaccag cctggccaac
     4081 atggtgaaaa ccccgtctct actaaaaata caaaaattag ctgggcgtgg tggcaggtgc
     4141 ctgtaaccct agctactcag gaggctgagg cacgagaaat gcttgaagcc agaaggcaga
     4201 gattgcagtg agccaagatc acaacaccgc gctccagtct gcgcgacaga gcgagactct
     4261 gtctcaaaaa aaaaaaaaaa aaagtgcagg tgcacgctgg tggggacatt aggagcctgt
     4321 caagagtggg tctgcctgct ggcacttact agacgggaaa taccccctaa agagggctta
     4381 aaaagcatct tctccctagc acggggcatg ctggcacagg gtgctgtgtg acagaggctt
     4441 ggccgctggg ccccgctgct gagaaggctg ctctgcccat gcctggccct gtgggcagtg
     4501 ccagccatgg atccctgaga ccctgggctg gaacctgggg ccccgtccca gccctacctg
     4561 cagctcacta accctctctg ggttctgctc agtgtctgaa gtgatggaaa gaccccaggg
     4621 ttggtggctg tagcggcccc caggggtggc agaacccttt gggaggccaa gtgttctttc
     4681 ccaaagctgc gcgggtgcca tcgcctgcca ggccctggct gtggtgacag acgtgggctg
     4741 gggtgaggct gcatctgctt cctctaacag ccgtggctgc ctgcgggctc tggcctccgc
     4801 tctggcagat tctgcacatt ccctgcaggc gcaggggtgg gtgggggtgc ctgtggcctc
     4861 ggaggtacag ccagctgtcc tcagctcaga tggcccccaa gagcccccag ctcctgttca
     4921 ctgctcttcc agttagtgac ccccgtgtca gcatcattgt cagagttcct gggcttgtgg
     4981 gggctggaga agggaaggcg ctgaggaggg aaagatgagt gcaggttttg ttgaaaccac
     5041 ccgacccgcg ttttcagggg gacgaggcca ctgccttggc ccaaggacct gcaggcttgg
     5101 gggaccccct cgatgtccac tgggctgcgg atgaaacatc acactgtggt aggaaaggaa
     5161 ggggagcacc cccagacggg ggggtcctgc agagacccca accccttacc tacctagttg
     5221 agacacccat ggggagcagc cccaacagca tgtcggagtc cctaggcttg tggggtcatg
     5281 ctctgttgag ggcccttcct ctaactggcg agcttgttta cagctgagct cgcctggtca
     5341 gatgggccca gtggctttat ctaataaagg ctggacatgt ccacttcatg agca
//
