LOCUS       NM_145720               2438 bp    mRNA    linear   PRI 20-SEP-2024
DEFINITION  Homo sapiens tigger transposable element derived 4 (TIGD4), mRNA.
ACCESSION   NM_145720
VERSION     NM_145720.4
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 2438)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Navarrete-Perea,J., Cannon,J.R.,
            Baltier,K., Gebreab,F., Gygi,M.P., Thornock,A., Zarraga,G., Tam,S.,
            Szpyt,J., Gassaway,B.M., Panov,A., Parzen,H., Fu,S., Golbazi,A.,
            Maenpaa,E., Stricker,K., Guha Thakurta,S., Zhang,T., Rad,R.,
            Pan,J., Nusinow,D.P., Paulo,J.A., Schweppe,D.K., Vaites,L.P.,
            Harper,J.W. and Gygi,S.P.
  TITLE     Dual proteome-scale networks reveal cell-specific remodeling of the
            human interactome
  JOURNAL   Cell 184 (11), 3022-3040 (2021)
   PUBMED   33961781
REFERENCE   2  (bases 1 to 2438)
  AUTHORS   Luck,K., Kim,D.K., Lambourne,L., Spirohn,K., Begg,B.E., Bian,W.,
            Brignall,R., Cafarelli,T., Campos-Laborie,F.J., Charloteaux,B.,
            Choi,D., Cote,A.G., Daley,M., Deimling,S., Desbuleux,A., Dricot,A.,
            Gebbia,M., Hardy,M.F., Kishore,N., Knapp,J.J., Kovacs,I.A.,
            Lemmens,I., Mee,M.W., Mellor,J.C., Pollis,C., Pons,C.,
            Richardson,A.D., Schlabach,S., Teeking,B., Yadav,A., Babor,M.,
            Balcha,D., Basha,O., Bowman-Colin,C., Chin,S.F., Choi,S.G.,
            Colabella,C., Coppin,G., D'Amata,C., De Ridder,D., De Rouck,S.,
            Duran-Frigola,M., Ennajdaoui,H., Goebels,F., Goehring,L., Gopal,A.,
            Haddad,G., Hatchi,E., Helmy,M., Jacob,Y., Kassa,Y., Landini,S.,
            Li,R., van Lieshout,N., MacWilliams,A., Markey,D., Paulson,J.N.,
            Rangarajan,S., Rasla,J., Rayhan,A., Rolland,T., San-Miguel,A.,
            Shen,Y., Sheykhkarimli,D., Sheynkman,G.M., Simonovsky,E., Tasan,M.,
            Tejeda,A., Tropepe,V., Twizere,J.C., Wang,Y., Weatheritt,R.J.,
            Weile,J., Xia,Y., Yang,X., Yeger-Lotem,E., Zhong,Q., Aloy,P.,
            Bader,G.D., De Las Rivas,J., Gaudet,S., Hao,T., Rak,J.,
            Tavernier,J., Hill,D.E., Vidal,M., Roth,F.P. and Calderwood,M.A.
  TITLE     A reference map of the human binary protein interactome
  JOURNAL   Nature 580 (7803), 402-408 (2020)
   PUBMED   32296183
REFERENCE   3  (bases 1 to 2438)
  AUTHORS   Huttlin,E.L., Bruckner,R.J., Paulo,J.A., Cannon,J.R., Ting,L.,
            Baltier,K., Colby,G., Gebreab,F., Gygi,M.P., Parzen,H., Szpyt,J.,
            Tam,S., Zarraga,G., Pontano-Vaites,L., Swarup,S., White,A.E.,
            Schweppe,D.K., Rad,R., Erickson,B.K., Obar,R.A., Guruharsha,K.G.,
            Li,K., Artavanis-Tsakonas,S., Gygi,S.P. and Harper,J.W.
  TITLE     Architecture of the human interactome defines protein communities
            and disease networks
  JOURNAL   Nature 545 (7655), 505-509 (2017)
   PUBMED   28514442
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Hugh Robertson. The reference sequence was
            derived from AC106882.5.
            
            On May 17, 2019 this sequence version replaced NM_145720.3.
            
            Summary: The protein encoded by this gene belongs to the tigger
            subfamily of the pogo superfamily of DNA-mediated transposons in
            humans. These proteins are related to DNA transposons found in
            fungi and nematodes, and more distantly to the Tc1 and mariner
            transposases. They are also very similar to the major mammalian
            centromere protein B. The exact function of this gene is not known.
            [provided by RefSeq, Jul 2008].
            
            Sequence Note: The RefSeq transcript and protein were derived from
            genomic sequence to make the sequence consistent with the reference
            genome assembly. The genomic coordinates used for the transcript
            record were based on alignments.
            
            ##Evidence-Data-START##
            Transcript exon combination :: BC037869.2, SRR1660809.169983.1
                                           [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000304337.3/ ENSP00000355162.2
            RefSeq Select criteria :: based on conservation, expression,
                                      longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-249               AC106882.5         159111-159359       c
            250-2438            AC106882.5         148983-151171       c
FEATURES             Location/Qualifiers
     source          1..2438
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q31.3"
     gene            1..2438
                     /gene="TIGD4"
                     /note="tigger transposable element derived 4"
                     /db_xref="GeneID:201798"
                     /db_xref="HGNC:HGNC:18335"
     exon            1..249
                     /gene="TIGD4"
                     /inference="alignment:Splign:2.1.0"
     exon            250..2438
                     /gene="TIGD4"
                     /inference="alignment:Splign:2.1.0"
     CDS             788..2326
                     /gene="TIGD4"
                     /codon_start=1
                     /product="tigger transposable element-derived protein 4"
                     /protein_id="NP_663772.1"
                     /db_xref="CCDS:CCDS34079.1"
                     /db_xref="GeneID:201798"
                     /db_xref="HGNC:HGNC:18335"
                     /translation="MAEASVDASTLPVTVKKKKSLSIEEKIDIINAVESGKKKAEIAA
                     EYGIKKNSLSSIMKNKDKVLEAFESLRFDPKRKRLRTAFYTDLEEALMRWYRIAQCLN
                     VPVNGPMLRLKANDFAQKLGHNDFKCSNGWLDRFKSRYGLVFRAQPVEATGVPVDPST
                     VWYQNVLPYYLNDYHPKNVFNIKETGLLYRMLPTNTFAFKGETCSVGKLCKDRITLVV
                     GTNMDGSEKLPLLVIGKKRTPHCFKGLKSLPVCYEANRMAWMTSDVFEQWMRKLDEEF
                     QAQQRRVVIFVESFPAHPEVKNLKSIELAFFPSCLSSKCIAMKQGVIKSLKIKYRHCL
                     IKKFLSSVEGSKEFTFSLLDAVDTLHLCWRAVTPETIVKSYEEAGFKSQKGESDITNA
                     EKDTGLDLVADALGAGVEFPEGLSIEEYAALDDDLETCEAAPNGDSICTKESKSDETG
                     FYTSDEEDDDGSPGTELPLPSKSEAITALDTLKKFLRSQDMNDGLQNSLADLENFINS
                     LSPK"
     regulatory      2416..2421
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIGD4"
                     /note="hexamer: CATAAA"
     polyA_site      2438
                     /gene="TIGD4"
                     /note="major polyA site"
ORIGIN      
        1 ggccagaggc accggctaga gctgggagct tgcggaaggg cgcccctgcc tggtcttgag
       61 aggtcgaagg tctccaggag gcctccgcct ccctcttttt cattcacaca ccctagcctc
      121 acacgttagg aggacccccc caacagaccg tgagctggtg ccgggagggt ggaggtagat
      181 gtacctcacc tccacgctac cacagaagag cgaaagctgc tttctcagcc accggagagc
      241 acgaagaaga agaagatata ctggcaagtt ctagaaggat tctaccattt tcttctttac
      301 catgaacaaa cttgaaaatt aatgggtaat agttgcatga aaacttttga acgttttttc
      361 ttatctctga ggccttctat ggagaattaa taggaggttg aatgtgtgca tggataaaat
      421 ggatcatctt aaaggattga agttccaaaa atacatcagc aggactggac aggttttata
      481 taatgagatt tctattttag cttgacttct acaactctga ataagctata aactgagcta
      541 tacaaggtac taggaaggaa gtttctcttc taaaatattc tagttgcata taatattttt
      601 cttcagatct ttgaaaaagc atattttgtc atcaagttcc tacaaaataa gactattaga
      661 caccaacttt tagtgtataa agtaggatag aaagcagcaa tctatattat actggaaaac
      721 aaatttaatt aaagaaacag tcaccaggaa gttaagaaga gtaatctcta cataagcact
      781 ggctgagatg gcagaagctt ctgtggatgc ctcaactctg cctgtaacag tgaagaaaaa
      841 gaaaagccta tccattgagg aaaagatcga catcataaat gcagtggaaa gtggcaagaa
      901 aaaagcagag attgctgctg aatatggaat aaagaaaaat tcattgtctt ctattatgaa
      961 gaataaagac aaagttctag aagcctttga atctctaaga tttgatccaa agagaaaaag
     1021 actgagaact gctttttaca cagatctgga agaggcatta atgagatggt atcgaattgc
     1081 tcagtgtcta aatgtaccag ttaatggtcc gatgttacgt ctaaaagcta atgattttgc
     1141 ccagaaactg ggccataatg attttaagtg cagtaatggt tggctggatc gttttaaatc
     1201 caggtatggt ttagtattca gagctcaacc tgtagaagct acaggtgtac cagtagaccc
     1261 ttcgactgtc tggtaccaaa atgtacttcc ttattattta aatgattatc atcctaaaaa
     1321 tgtttttaat ataaaagaga ctgggctgct ttatcgaatg ttacctacca atacatttgc
     1381 atttaaaggc gaaacatgtt cagttggaaa gttatgcaaa gacagaataa ctctggtggt
     1441 tggcacaaac atggatggct cagagaaact tcctttgctt gtcattggaa aaaagagaac
     1501 tccacattgt ttcaaaggtt taaaatcatt gcctgtgtgt tatgaagcta acagaatggc
     1561 atggatgacc tccgatgtat ttgaacaatg gatgcgaaag cttgatgagg aatttcaagc
     1621 ccagcaacga agagtggtga tttttgttga gtcttttcca gcacatccag aggtaaagaa
     1681 cctaaaatcc attgagttag cattctttcc atcatgttta tcttccaaat gtatagctat
     1741 gaaacaaggt gttattaaaa gccttaaaat caaatatcga cactgtctta tcaagaaatt
     1801 tttaagctct gttgaaggta gcaaagaatt tacattttca ctactagatg cagttgatac
     1861 attgcatctt tgctggaggg ctgtaacccc agagactatt gttaaaagct atgaagaggc
     1921 aggattcaaa tctcaaaagg gagaaagtga cataacaaat gcagagaagg atactggtct
     1981 ggatttggtt gctgatgctc tgggggcagg agtagaattt cctgaaggtt tatctataga
     2041 agaatatgct gccctggatg atgatttgga gacatgtgaa gcagcaccaa atggtgattc
     2101 catatgcacc aaagaaagta aatcggatga aactggattt tacacttctg atgaagagga
     2161 tgatgatgga tctccaggaa ctgaactccc tttaccatca aaatctgagg caataactgc
     2221 tttagatact ctgaaaaaat ttctcagaag tcaagatatg aatgacggac ttcaaaattc
     2281 tttagcagac cttgaaaatt ttattaactc tttatcacct aagtaactat gtattgtaca
     2341 tctaaagagt aatagctttt cctgatacat tttattatat aaggtatgta aaggagttgt
     2401 accacaccac ttaaacataa aaaatggaaa actgctaa
//
