LOCUS       NM_145715               3186 bp    mRNA    linear   PRI 09-JUN-2024
DEFINITION  Homo sapiens tigger transposable element derived 2 (TIGD2),
            transcript variant 1, mRNA.
ACCESSION   NM_145715
VERSION     NM_145715.3
KEYWORDS    RefSeq; MANE Select.
SOURCE      Homo sapiens (human)
  ORGANISM  Homo sapiens
            Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
            Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
            Catarrhini; Hominidae; Homo.
REFERENCE   1  (bases 1 to 3186)
  AUTHORS   Wang,A.G., Yoon,S.Y., Oh,J.H., Jeon,Y.J., Kim,M., Kim,J.M.,
            Byun,S.S., Yang,J.O., Kim,J.H., Kim,D.G., Yeom,Y.I., Yoo,H.S.,
            Kim,Y.S. and Kim,N.S.
  TITLE     Identification of intrahepatic cholangiocarcinoma related genes by
            comparison with normal liver tissues using expressed sequence tags
  JOURNAL   Biochem Biophys Res Commun 345 (3), 1022-1032 (2006)
   PUBMED   16712791
REFERENCE   2  (bases 1 to 3186)
  AUTHORS   Robertson,H.M.
  TITLE     Members of the pogo superfamily of DNA-mediated transposons in the
            human genome
  JOURNAL   Mol Gen Genet 252 (6), 761-766 (1996)
   PUBMED   8917322
REFERENCE   3  (bases 1 to 3186)
  AUTHORS   Smit,A.F. and Riggs,A.D.
  TITLE     Tiggers and DNA transposon fossils in the human genome
  JOURNAL   Proc Natl Acad Sci U S A 93 (4), 1443-1448 (1996)
   PUBMED   8643651
COMMENT     REVIEWED REFSEQ: This record has been curated by NCBI staff in
            collaboration with Hugh Robertson. The reference sequence was
            derived from AC104785.5.
            
            On May 6, 2020 this sequence version replaced NM_145715.2.
            
            Summary: The protein encoded by this gene belongs to the tigger
            subfamily of the pogo superfamily of DNA-mediated transposons in
            humans. These proteins are related to DNA transposons found in
            fungi and nematodes, and more distantly to the Tc1 and mariner
            transposases. They are also very similar to the major mammalian
            centromere protein B. The exact function of this gene is not known.
            [provided by RefSeq, Jul 2008].
            
            ##Evidence-Data-START##
            Transcript exon combination :: SRR14038195.2433472.1,
                                           SRR11853567.23100.1 [ECO:0000332]
            RNAseq introns              :: single sample supports all introns
                                           SAMEA1965299, SAMEA1966682
                                           [ECO:0000348]
            ##Evidence-Data-END##
            
            ##RefSeq-Attributes-START##
            MANE Ensembl match     :: ENST00000603357.3/ ENSP00000486687.1
            RefSeq Select criteria :: based on manual assertion, conservation,
                                      expression, longest protein
            ##RefSeq-Attributes-END##
            COMPLETENESS: complete on the 3' end.
PRIMARY     REFSEQ_SPAN         PRIMARY_IDENTIFIER PRIMARY_SPAN        COMP
            1-351               AC104785.5         53159-53509
            352-3186            AC104785.5         53693-56527
FEATURES             Location/Qualifiers
     source          1..3186
                     /organism="Homo sapiens"
                     /mol_type="mRNA"
                     /db_xref="taxon:9606"
                     /chromosome="4"
                     /map="4q22.1"
     gene            1..3186
                     /gene="TIGD2"
                     /gene_synonym="HEL106"
                     /note="tigger transposable element derived 2"
                     /db_xref="GeneID:166815"
                     /db_xref="HGNC:HGNC:18333"
                     /db_xref="MIM:612973"
     exon            1..351
                     /gene="TIGD2"
                     /gene_synonym="HEL106"
                     /inference="alignment:Splign:2.1.0"
     exon            352..3186
                     /gene="TIGD2"
                     /gene_synonym="HEL106"
                     /inference="alignment:Splign:2.1.0"
     CDS             1260..2837
                     /gene="TIGD2"
                     /gene_synonym="HEL106"
                     /note="epididymis luminal protein 106"
                     /codon_start=1
                     /product="tigger transposable element-derived protein 2"
                     /protein_id="NP_663761.1"
                     /db_xref="CCDS:CCDS3633.1"
                     /db_xref="GeneID:166815"
                     /db_xref="HGNC:HGNC:18333"
                     /db_xref="MIM:612973"
                     /translation="MLGKRKRVVLTIKDKLDIIKKLEEGISFKKLSVVYGIGESTVRD
                     IKKNKERIINYANSSDPTSGVSKRKSMKSSTYEELDRVMIEWFNQQKTDGIPVSGTIC
                     AKQAKFFFDALGMEGDFNASSGWLTRFKQRHGIPKAAGKGTKLKGDETAAREFCGSFQ
                     EFVEKENLQPEQIYGADQTGLFWKCLPSRTLTLETDQSTSGCRSSRERIIIMCCANAT
                     GLHKLNLCVVGKAKKPRAFKGTDLSNLPVTYYSQKGAWIEQSVFRQWFEKYFVPQVQK
                     HLKSKGLLEKAVLLLDFPPARPNEEMLSSDDGRIIVKYLPPNVTSLIQPMSQGVLATV
                     KRYYRAGLLQKYMDEGNDPKIFWKNLTVLDAIYEVSRAWNMVKSSTITKAWKKLFPGN
                     EENSGMNIDEGAILAANLATVLQNTEECEHVDIENIDQWFDSRSSDSSCQVLTDSESA
                     EDQTKAAEQKPSSKSRKTELNPEKHISHKAALEWTENLLDYLEQQDDMLLSDKLVLRR
                     LRTIIRKKQKIQNNKNH"
     regulatory      2938..2943
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIGD2"
                     /gene_synonym="HEL106"
                     /note="hexamer: TATAAA"
     polyA_site      2954
                     /gene="TIGD2"
                     /gene_synonym="HEL106"
     regulatory      3153..3158
                     /regulatory_class="polyA_signal_sequence"
                     /gene="TIGD2"
                     /gene_synonym="HEL106"
                     /note="hexamer: AATAAA"
     polyA_site      3186
                     /gene="TIGD2"
                     /gene_synonym="HEL106"
                     /note="major polyA site"
ORIGIN      
        1 aatcccccgc cttccggctc cggcggcgac gctcgtccct ctccgctcgt ccctcgccgc
       61 tgccgggcca ccagtgccag cctgcctcag gagactccat ttgcgcttag tgtggtctgg
      121 gcgccgcgca ggcggtccca gggcgatgcc cggggccggc ggactggcgt tccctgtgcc
      181 aagcggccgc ccgctggctg gctggctgca gcagtgacat cctggtcgcc ggcgtccagg
      241 cggaatccgg gctccctccg cgggaggaaa gacgtcccgc gctctgaagc tcgcccagcg
      301 gggagaggcc ctcgctaaca cggcttctcc ctgacctctt aatttcagga ggtttcggag
      361 cctccgagta tctctacagc ccccacagga actgcttctg ttggtccatc gaggatcgtc
      421 tttcaccagg attattgtaa catcatcttc accgagcctg ccaccccata gcctctacct
      481 tgggtcctca tttccaccga tgcagttttt ttgatgcttt ctttagtaat gtgacatcac
      541 atgtccacta tcctcctttc cagctgccaa atctagtagg tttaagtcgc ttttaaagta
      601 gagttttctg cctgttccac tttcacctta tttgcactgt tcacttctgt ccgggtcatc
      661 ttctcttgcg tatgatttcc acaagcactc acttgcgcaa cctatagcag agtccgtgcc
      721 tagagagaca gcattccata caatccactg cttgacaaag accacatagt cagagggtga
      781 gttttcccat tgtattttcc tgtatgtcaa gtttgcaagt cctctcttga cttaaactgt
      841 ttactcccta gcacatttcc taaaatactt ccacctgaga tttagtggct attctggcaa
      901 agaacattac ctgcaaggat ggcaagaatt gagtatgcaa tagtactgtt ttagaagcct
      961 taccagtaca gtttctagcc tctagtgtga ttgcacttca tgaaagaccc tgaaccctga
     1021 ggaggaagaa agatagaaga taagagttaa ttggcgctag gctttgttgt aggaagtttg
     1081 taagttttaa aatagcaagt agattcacgt agaccttgtc aggaaattgg tcactatcca
     1141 tctaggccct agaagtgaga ggaggaatct tacgaactca ttttctagtt gctttgtatt
     1201 caaatcttag ttgttaatta tcttgttcta gtaatcacct aaaatattag acacttaaaa
     1261 tgttggggaa acgtaagcgt gtggtgttga caattaagga caagcttgac attattaaga
     1321 aacttgagga aggcatctct ttcaaaaaac tttccgtggt gtacggaatt ggtgaatcca
     1381 cagttcgtga tattaaaaag aacaaagaaa ggattataaa ctatgcaaac agttcagatc
     1441 ctaccagtgg agtatccaaa cgtaaatcta tgaagtcatc aacatacgag gagcttgata
     1501 gagttatgat agagtggttt aaccaacaga aaacagatgg gattccagtg tccggaacga
     1561 tttgtgcaaa acaagccaag ttcttttttg atgctttggg aatggaaggt gattttaatg
     1621 catcgtcagg ctggctaact cgatttaagc agcgccatgg tattccaaag gctgctggta
     1681 aaggaacaaa attaaaagga gatgaaactg ctgccagaga attttgtggt agctttcagg
     1741 aatttgttga aaaagagaat ctacaaccag agcaaattta tggtgctgat caaactggat
     1801 tgttttggaa atgtctacca tcaaggacat taactcttga aactgaccaa agtacttctg
     1861 ggtgtaggtc aagcagagag agaatcatca ttatgtgttg cgcaaatgcc acaggtttac
     1921 acaaacttaa tctttgtgtt gtggggaagg ccaaaaagcc ccgagcattc aaaggcactg
     1981 acctttcaaa ccttcctgtg acatattaca gtcaaaaagg tgcatggata gaacagtctg
     2041 ttttcagaca gtggtttgaa aagtactttg tgccacaggt acagaagcat ttgaaatcca
     2101 agggactttt agaaaaagca gtgcttcttt tagatttccc cccagcacgt ccaaatgaag
     2161 aaatgttgag ttcagatgat ggcagaataa ttgtgaagta tttgccacca aatgtcacaa
     2221 gtctgattca accaatgagc cagggagttc tagccactgt aaaaagatac tatcgagcag
     2281 gacttctcca gaaatacatg gatgaaggaa atgacccaaa aatattttgg aagaacttga
     2341 cagtgttgga tgcaatttat gaagtgtcaa gagcttggaa catggtaaaa tcaagtacca
     2401 taaccaaagc atggaaaaaa cttttccctg gcaatgaaga gaattcaggt atgaacattg
     2461 atgaaggagc cattttagca gctaatttag caacagtttt acagaacaca gaagaatgtg
     2521 aacatgttga cattgagaat attgatcagt ggttcgactc tcggagcagt gactcaagct
     2581 gtcaggtgct gactgacagt gaaagtgctg aggaccagac caaggctgct gagcaaaagc
     2641 cttccagtaa gagtagaaaa acagaactga atccagagaa gcatattagc cataaagcgg
     2701 cacttgaatg gactgaaaat ttactggatt atcttgaaca acaagatgac atgcttctgt
     2761 ctgataaatt ggtattaagg aggcttcgga ccataataag aaaaaaacag aagatccaaa
     2821 ataacaaaaa tcattaataa ggctcttaag tatttcagtg tatctgcatc tttgtgacta
     2881 tctgcagtga aactttgctt gtttgaagtc ctgtggattc caaagccaaa tacattttat
     2941 aaatgatttt ggaattagat gtcagtttgg attacttaaa ttacaactct ttaatgttga
     3001 ctctagtcat tgggcattga cgtgtaactt gtctttctac tgtttctaat atctattaat
     3061 tagatcataa ggtacctgag gccagggatc ttgtgtctgt tgtgcctgaa tttggcgtgt
     3121 ctaataaagg cccatgcaca ctataggcac tcaataaaac ttacattttt atgatttttc
     3181 tttgaa
//
